Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06046 | Target Info | |||
| Target Name | Nitric-oxide synthase endothelial (NOS3) | ||||
| Synonyms |
Nitric oxide synthase, endothelial; NOSIII; NOS,type III; NOS type III; Endothelial nitric oxide synthase; Endothelial NOS; ENOS; EC-NOS; Constitutive NOS; CNOS
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| Target Type | Clinical trial Target | ||||
| Gene Name | NOS3 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 253 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nilotinib
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|
Approved | Compound Info | ||
| Synonyms |
NIL; Nilotinibum; Tasigna (Novartis); Nilotinib (INN/USAN); Nilotinib, AMN107, Tasigna; Tasigna, AMN-107, Nilotinib; L-1-yl)-3-(trifluoromethyl)phenyl]benzamide; Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-(9CI); 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazo; 4-Methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide; 4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzamide; 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide; Nilotinib (BCR-ABL inhibitor 2nd gen)
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| Activity |
IC50 = 78000 nM
|
[1] | |||
| Compound Name |
Aminoguanidine
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Phase 1 | Compound Info | ||
| Synonyms |
aminoguanidine; Pimagedine; Hydrazinecarboximidamide; Guanyl hydrazine; Monoaminoguanidine; 2-aminoguanidine; 79-17-4; Imino semicarbazide; Aminate base; 2-azanylguanidine; Pimagedine [INN]; GUANIDINE, AMINO-; 1-aminoguanidine; UNII-SCQ4EZQ113; Hydrazinecarboximidamide(9CI); CCRIS 3511; EINECS 201-183-1; Aminoguanidine, Hemisulfate; SCQ4EZQ113; CHEMBL225304; CHEBI:40618; HAMNKKUPIHEESI-UHFFFAOYSA-N; guanylhydrazine; GER-11; AGU; amino guanidine; 1-amino-guanidine; Aminoguanidine (AG); Tocris-0787; Carbonohydrazonic diamide; INCB3284
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| Activity |
IC50 = 72000 nM
|
[2] | |||
| Compound Name |
Hexahydro-cyclopenta[b]pyrrol-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL361419; Hexahydro-cyclopenta[b]pyrrol-(2Z)-ylideneamine; BDBM50150921
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-Butyl-thiazolidin-(2E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363049; 4-Butyl-thiazolidin-(2E)-ylideneamine; SCHEMBL7090223
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186985; (R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
3-Propyl-[1,4]thiazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186969; 3-Propyl-[1,4]thiazepan-(5E)-ylideneamine; SCHEMBL7675949
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
Azocan-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
Azocan-(2Z)-ylideneamine; CHEMBL329431; 2-Iminooctahydroazocine; SCHEMBL3928259; BDBM50049249
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| Activity |
IC50 = 58900 nM
|
[5] | |||
| Compound Name |
3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185919; 3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine
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| Activity |
IC50 = 60000 nM
|
[4] | |||
| Compound Name |
4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184798; 4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine; BDBM50150930
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| Activity |
IC50 = 60600 nM
|
[3] | |||
| Compound Name |
[1,4]Oxazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL330548; [1,4]Oxazepan-(5E)-ylideneamine; SCHEMBL2590253; 5-Iminohexahydro-1,4-oxazepine; [1,4]Oxazepan-(5Z)-ylideneamine; BDBM50104659
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| Activity |
IC50 = 72680 nM
|
[5] | |||
| Compound Name |
3-Butyl-[1,4]thiazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186091; 3-Butyl-[1,4]thiazepan-(5E)-ylideneamine; SCHEMBL7679025
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| Activity |
IC50 = 77000 nM
|
[4] | |||
| Compound Name |
3,4-Dihydro-1H-quinolin-(2E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL6656; 2-amino-3,4-dihydroquinoline; 1,2,3,4-tetrahydroquinolin-2-imine; AC1N2ULT; 3,4-Dihydro-1H-quinolin-(2E)-ylideneamine; 3,4-dihydroquinolin-2-amine; SCHEMBL2075410; RREBANHDFAXBEZ-UHFFFAOYSA-N; MolPort-005-905-447; HMS1726J17; 3,4-Dihydroquinolin-2(1H)-imine; ZINC13014981; BDBM50062129; AKOS006221851; AKOS008024789; MCULE-1322063466; 3,4-Dihydro-1H-quinolin-(2Z)-ylideneamine
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| Activity |
IC50 = 85000 nM
|
[6] | |||
| Compound Name |
Tetrahydro-pyrimidin-2-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
1,4,5,6-tetrahydropyrimidin-2-amine; 41078-65-3; 1,4,5,6-tetrahydro-2-Pyrimidinamine; 1,4,5,6-tetrahydro-pyrimidin-2-ylamine; 2-amino-1,4,5,6-tetrahydropyrimidine; CHEMBL158626; Tetrahydro-pyrimidin-2-ylideneamine; Tetrahydropyrimidinimin; 2(1h)-pyrimidinimine; AC1MMKIU; tetrahydro-2(1H)-pyrimidinimine; DTXSID90391075; PEHDFSFYZKSKGH-UHFFFAOYSA-N; ZINC1728936; hexahydro-pyrimidin-2-ylidene-amine; BDBM50049248; AKOS024618750; AKOS011559938; MCULE-1407334516; 2-amino-3,4,5,6-tetrahydropyrimidine
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| Activity |
IC50 = 87000 nM
|
[7] | |||
| Compound Name |
4-Isopropyl-pyrrolidin-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL365637; 4-Isopropyl-pyrrolidin-(2Z)-ylideneamine; SCHEMBL7598537; SCHEMBL10077978; BDBM50150914
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| Activity |
IC50 = 87800 nM
|
[3] | |||
| Compound Name |
Azonan-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
Azonan-(2Z)-ylideneamine; CHEMBL158641; SCHEMBL8466372; SCHEMBL2661739; BDBM50049256; AKOS006356817
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| Activity |
IC50 = 90000 nM
|
[7] | |||
| Compound Name |
AR-C102222
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Investigative | Compound Info | ||
| Synonyms |
AR-C102222; CHEMBL447183; 5-(4-Amino-5,8-difluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carbonyl)pyridine-2-carbonitrile; 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE; SCHEMBL7806912; ZINC1489460; BDBM50124535; DB07405; NCGC00371031-01; 5-[(4'-amino-5',8'-difluoro-1H,1'H-spiro[piperidine-4,2'-quinazolin]-1-yl)carbonyl]pyridine-2-carbonitrile; 5-(4-Amino-5,8-difluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carbonyl)pyridine-2-carbonitrile, 3
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
AR-C133057XX
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL114500; 4-({4-[(4-Methoxypyridin-2-Yl)amino]piperidin-1-Yl}carbonyl)benzonitrile; 4-[4-[(4-Methoxypyridin-2-yl)amino]piperidine-1-carbonyl]benzonitrile; 4-{4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carbonyl}benzonitrile; AR-C133057XX; SCHEMBL7824352; CHEBI:95013; BDBM50148167; DB07002; BRD-K40892394-001-01-9; 4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carbonyl)benzonitrile; 4-[4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carbonyl]-benzonitrile
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7-Butyl-azepan-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89288; CHEMBL543514; SCHEMBL7628313; BDBM50064011; 2-Imino-7-butylhexahydro-1H-azepine; 7-Butyl-azepan-(2Z)-ylideneamine
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| Activity |
IC50 = 102500 nM
|
[5] | |||
| Compound Name |
5-Methyl-4-propyl-pyrrolidin-(2Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362366; 5-Methyl-4-propyl-pyrrolidin-(2Z)-ylideneamine; BDBM50150912
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| Activity |
IC50 = 104000 nM
|
[3] | |||
| Compound Name |
BYK-191023
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Investigative | Compound Info | ||
| Synonyms |
INOS inhibitors (inflammatory diseases); INOS inhibitors (inflammatory diseases), Altana; INOS inhibitors (inflammatory diseases), Nycomed
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| Activity |
IC50 = 112201.85 nM
|
[8] | |||
| Compound Name |
[1,5]Thiazocan-(4E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL92422; [1,5]Thiazocan-(4E)-ylideneamine; 4-Iminohexahydro-2H-1,5-thiazocine; BDBM50104658
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| Activity |
IC50 = 186300 nM
|
[5] | |||
| Compound Name |
2-Methyl-octahydro-benzo[b][1,4]thiazepin-(4E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186360; BDBM50155781
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N'-[4-(Dimethylamino)phenyl]ethanimidamide;dihydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL544789
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
6-Methyl-[1,4]thiazepan-(5E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188073; BDBM50155791; AKOS006379603
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6,7-Dihydro-5H-cyclopenta[b]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
2-amino-6,7-dihydro-5h-1-pyrindine; CHEMBL292690; 5H,6H,7H-cyclopenta[b]pyridin-2-amine; 5H-Cyclopenta[b]pyridin-2-amine, 6,7-dihydro-; SCHEMBL3162510; BDBM50091795; ZINC18531795; AKOS004120953; 6,7-Dihydro-5H-[1]pyrindin-2-ylamine; Z1198183883
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N'-[4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)phenyl]ethanimidamide;dihydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542910
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| Activity |
Ki ~ 50000 nM
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[10] | |||
| Compound Name |
Hexahydro-indolizin-(3E)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185600; BDBM50150925
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
2-[4-(1-Aminoethylideneamino)phenyl]acetic acid;hydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL555389
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| Activity |
Ki ~ 50000 nM
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[10] | |||
| Compound Name |
Tetrahydro-pyrrolo[1,2-c]thiazol-(3Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360669; BDBM50150932
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N'-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]ethanimidamide;dihydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542913
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| Activity |
Ki ~ 50000 nM
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[10] | |||
| Compound Name |
5-Methyloxazolo[5,4-b]pyridin-2-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97163; SCHEMBL15046535; BDBM50290813; ZINC26724637; 5-Methyl-1H-oxazolo[5,4-b]pyridin-2-one; 5-methyloxazolo[5,4-b]pyridin-2(1H)-one; 5-methyl[1,3]oxazolo[5,4-b]pyridin-2-ol
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
5-Fluorobenzo[d]oxazol-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
5-Fluoro-1,3-benzoxazol-2(3H)-one; 5-Fluoro-2(3H)-benzoxazolone; 5-fluoro-3H-1,3-benzoxazol-2-one; 5-Fluoro-3H-benzooxazol-2-one; CHEMBL101266; MFCD08059539; 5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one; 5-Fluorobenzoxazol-2(3H)-one; NSC146763; ACMC-20am3n; 5-fluoro-benzoxazol-2-one; 5-Fluoro-2-benzoxazolinone; 5-Fluorobenzoxazolin-2-one; SCHEMBL244162; 5-Fluoro-3H-benzoxazol-2-one; CTK4B9228; KS-00000SFR; 2(3H)-Benzoxazolone,5-fluoro-; DTXSID50301852; 5-fluoro-3-hydrobenzoxazol-2-one; 5-Fluoro-2-hydroxybenzo[d]oxazole; ZINC1728885; BDBM50290804; EBD177944; SBB086882; AKOS011655126; 5-Fluoro-2(3H)-benzoxazolone, 96%; CCG-339791; DS-9112; NSC-146763; 5-fluoranyl-3H-1,3-benzoxazol-2-one; 5-Fluoro-2,3-dihydrobenzoxazole-2-one; AK157798; BP-13411; SY101449; CS-0038220; Z9761; A-8554; A806789; J-006548; Z1889710358
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
(3R)-3-(1,2,3,4-Tetrahydroisoquinolin-6-yloxymethyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221704
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| Activity |
IC50 = 50000 nM
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[9] | |||
| Compound Name |
4-Acetimidoylamino-Benzoic Acid HCl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540555
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| Activity |
Ki ~ 50000 nM
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[10] | |||
| Compound Name |
5-Methyl-4,5-dihydro-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185505; 5-methyl-4,5-dihydro-thiazol-2-ylamine; 2-amino-5-methylthiazoline; SCHEMBL6637787; SCHEMBL9870593; 2-amino-5-methyl-2-thiazoline; 5-methyl-1,3-thiazolidin-2-imine; BDBM50150913; AKOS006220699; MCULE-5641549444; 5-Methyl-thiazolidin-(2E)-ylideneamine; Thiazole, 2-amino-4,5-dihydro-5-methyl-; 5-Methyl-4,5-dihydro-1,3-thiazol-2-amine #
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Hexahydro-thiazolo[3,4-a]pyridin-(3Z)-ylideneamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185867; BDBM50150934
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N'-(4-Nitrophenyl)ethanimidamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540299
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| Activity |
Ki ~ 50000 nM
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[10] | |||
| Compound Name |
Methyl 2-[4-(1-aminoethylideneamino)phenyl]acetate;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL545256
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| Activity |
Ki ~ 50000 nM
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[10] | |||
| Compound Name |
Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL420671; SCHEMBL7821472; BDBM50148162; AKOS010994757; DB07388; Q27096607; ethyl 4-(4-methylpyridin-2-ylamino)piperidine-1-carboxylate; Ethyl 4-[(4-methylpyridin-2-yl)amino]piperidine-1-carboxylate, 9; 4-(4-Methyl-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
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| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
4-Methyl-1,3-benzoxazol-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
4-Methylbenzoxazol-2(3H)-one; 4-Methyl-3H-benzooxazol-2-one; CHEMBL320850; 4-methyl-3H-benzoxazol-2-one; MFCD16742805; 4-methyl-2,3-dihydro-1,3-benzoxazol-2-one; methyl-benzoxazolinone; SCHEMBL1285749; 4-Methylbenzoxazole-2(3H)-one; 4-methyl-3H-benz-oxazol-2-one; 2(3H)-Benzoxazolone, 4-methyl-; 2-Hydroxy-4-methylbenzo[d]oxazole; KS-00003T1Q; 4-methylbenzo[d]oxazol-2(3H)-one; BDBM50290809; ZINC26728949; AKOS011655123; SB22918; SY130158; TS-01951; DB-123531; 4-METHYL-3H-1,3-BENZOXAZOL-2-ONE
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
6-Methyl-1,3-benzoxazol-2(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
6-methylbenzo[d]oxazol-2(3H)-one; 6-methyl-3H-1,3-benzoxazol-2-one; 6-Methylbenzoxazol-2(3H)-one; 6-Methyl-3H-benzooxazol-2-one; 2(3H)-Benzoxazolone, 6-methyl-; CHEMBL95524; MFCD02090051; NSC280712; 6-methylbenzoxazolin-2-one; SCHEMBL244119; CTK1A3737; DTXSID80314112; ZINC163636; 2-Hydroxy-6-methylbenzo[d]oxazole; ALBB-013599; 7799AD; BDBM50290819; AKOS005174094; NSC-280712; BP-20116; SC-32249; SY081557; DS-009133; R5460; 6-Methyl-1,3-benzoxazol-2(3H)-one, AldrichCPR
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
4-Phenyl-4,5-dihydro-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183268; SCHEMBL6257456; 4-phenyl-1,3-thiazolidin-2-imine; BDBM50150917; MCULE-6223280688; 4-Phenyl-thiazolidin-(2E)-ylideneamine
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N'-[3-(Aminomethyl)phenyl]ethanimidamide;dihydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542678
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
N-[3-(Aminomethyl)phenyl]-N'-methylethanimidamide;dihydrobromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL544559
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
5-Chloro-2-mercaptobenzoxazole
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Investigative | Compound Info | ||
| Synonyms |
5-chlorobenzo[d]oxazole-2-thiol; 5-chloro-1,3-benzoxazole-2-thiol; 5-Chlorobenzooxazole-2-thiol; 5-Chlorobenzo[d]oxazole-2(3H)-thione; 5-chloro-benzooxazole-2-thiol; 2(3H)-Benzoxazolethione, 5-chloro-; 5-chloro-3H-1,3-benzoxazole-2-thione; 2-Mercapto-5-chlorobenzoxazole; 5-Chloro-2-thioxobenzoxazoline; 2-Benzoxazolethiol, 5-chloro-; BENZOXAZOLE, 5-CHLORO-2-MERCAPTO-; 5-Chloranyl-3~{h}-1,3-Benzoxazole-2-Thione; CHEMBL99703; 5-CHLOROBENZOXAZOLE-2-THIOL; MFCD00175241; 5-chloro-3-hydrobenzoxazole-2-thione; 2-Benzoxazolinethione, 5-chloro-; NSC 26187; NSC26187; PubChem8704; ACMC-20am4o; Maybridge1_007032; SCHEMBL777690; 5-chloro-2-mercapto-benzoxazol; CTK6H2118; HMS561H14; DTXSID10177419; ZINC349058; 5-Chloro-2-mercaptobenzo[d]oxazole; 5-Chloro-3H-benzooxazole-2-thione; ACT09314; ALBB-004124; BCP15804; CS-M1396; EBD24321; BBL025677; BDBM50290805; CCG-54507; NSC-26187; SBB003707; STK502094; 5-Chloro-2-mercaptobenzoxazole, 97%; 5-Chlorobenzo[d]oxazole-2(3H)thione; AKOS000116656; AKOS015912994; AB04398; AS07121; DS-2753; MCULE-7527631705; KS-00000F42; 2-Benzoxazolinethione, 5-chloro- (8CI); 5-Chloro-1,3-benzoxazole-2(3H)-thione; AK111072; AM803553; BP-10021; ST059829; AB0005810; DB-021258; DB-029117; BB 0240843; FT-0638260; Z4453; 2(3H)-Benzoxazolethione, 5-chloro- (9CI); EN300-04022; 4B-098; M-7804; 5-chloro-2,3-dihydro-1,3-benzoxazole-2-thione; 876C193; SR-01000643599-1; W-201953; Q27456066; Z56824483
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
3-Phenyl-3,4-dihydro-2h-pyrrol-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364781; BRN 0472717; 3,4-Dihydro-3-phenyl-2H-pyrrol-5-amine; 2H-Pyrrol-5-amine, 3,4-dihydro-3-phenyl-; 4-Phenylpyrrolidin-2-imine; 5-22-10-00040 (Beilstein Handbook Reference); SCHEMBL11497728; DTXSID80945001; BDBM50150918; 4-Phenyl-pyrrolidin-(2Z)-ylideneamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N'-[4-[(Hydroxyamino)methyl]phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538021
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
N'-(4-Bromophenyl)ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544790; SCHEMBL2860585
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
Tert-butyl 4-(1-aminoethylideneamino)benzoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542909
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
2,3,6,7-Tetrahydro-1H-1,4-diazepin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361049; SCHEMBL2760930; [1,4]Diazepan-(5E)-ylideneamine; BDBM50155793; AKOS006379981
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-Oxo-2,3-dihydrobenzo[d]oxazole-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Oxo-2,3-dihydro-benzooxazole-5-carbonitrile; CHEMBL319485; 2-OXO-3H-1,3-BENZOXAZOLE-5-CARBONITRILE; 2-oxo-2,3-dihydro-1,3-benzoxazole-5-carbonitrile; 5-Benzoxazolecarbonitrile, 2,3-dihydro-2-oxo-; SCHEMBL1423023; 5-Cyano-2-hydroxybenzo[d]oxazole; 1843AJ; BDBM50290817; MFCD11845136; ZINC26742571; AKOS022794309; SB35165; DA-08511; 2,3-dihydro-2-oxo-5-benzoxazolecarbonitrile; FT-0719546; Z-5879; Z2752201053
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
N'-[4-(2-Morpholin-4-yl-2-oxoethyl)phenyl]ethanimidamide;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539802
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
4-Acetimidoylamino-Benzamide HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540558
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
N'-[4-[(Pyridin-2-ylamino)methyl]phenyl]ethanimidamide;dihydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557337
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
N'-[3-(1-Benzoylpiperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122167; CHEMBL3645469; BDBM106708; US8586620, 70
Click to Show/Hide
|
||||
| Activity |
IC50 = 50900 nM
|
[14] | |||
| Compound Name |
Chembl1957349
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1121961; CHEMBL1963527; BDBM106698; US8586620, 42; N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 51100 nM
|
[14] | |||
| Compound Name |
N'-[3-[4-(Dimethylamino)cyclohexen-1-yl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036264
Click to Show/Hide
|
||||
| Activity |
IC50 = 51400 nM
|
[15] | |||
| Compound Name |
N'-[3-[4-(Dimethylamino)cyclohexen-1-yl]-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1121973; CHEMBL2079330; SCHEMBL12621064; BDBM106722; US8586620, 114; N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 51400 nM
|
[14] | |||
| Compound Name |
4-Methyl-6-[2-[3-[3-(methylamino)propyl]-5-(trifluoromethyl)phenyl]ethyl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065564; BDBM50250566
Click to Show/Hide
|
||||
| Activity |
Ki = 51542 nM
|
[16] | |||
| Compound Name |
(3Ar,9bS)-7-[2-(methylamino)ethoxy]-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-amine;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538997
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[17] | |||
| Compound Name |
Chembl2203711
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217218; BDBM50401273
Click to Show/Hide
|
||||
| Activity |
IC50 = 52200 nM
|
[18] | |||
| Compound Name |
4-Propyl-pyrrolidin-(2Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361909; SCHEMBL7592097; SCHEMBL13750953; BDBM50150931; AKOS006376872; 3-propyl-3,4-dihydro-2H-pyrrol-5-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
N-{(3R,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1233715; CHEMBL1277952; SCHEMBL10454760; BDBM50330883; Q27461617
Click to Show/Hide
|
||||
| Activity |
Ki = 53400 nM
|
[19] | |||
| Compound Name |
2-[(4-Methoxypyridin-2-yl)methylsulfanyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800348; BDBM50418845
Click to Show/Hide
|
||||
| Activity |
IC50 = 53703.18 nM
|
[8] | |||
| Compound Name |
4-Amino-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinoline-8-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83455; BDBM50117560; (3aR)-4-Amino-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-8-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 54000 nM
|
[20] | |||
| Compound Name |
Chembl1957350
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122065; CHEMBL1963528; BDBM106699; US8586620, 46; N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 54000 nM
|
[14] | |||
| Compound Name |
6-(4-Methoxyphenyl)-4-N,4-N-dipropyl-5,6,7,8-tetrahydropteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100716; BDBM50115168; 6-(4-Methoxy-phenyl)-N*4*,N*4*-dipropyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 54640 nM
|
[21] | |||
| Compound Name |
1-Amino-3-(4-fluorophenyl)-7-fluoro-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL275955; SCHEMBL8060978; BDBM50098945; 7-fluoro-3-(4-fluorophenyl)-3,4-dihydroisoquinolin-1-amine; 7-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
N'-[1-(2-Piperidin-1-ylethyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216552
Click to Show/Hide
|
||||
| Activity |
IC50 = 56300 nM
|
[22] | |||
| Compound Name |
6-(4-Chloro-phenyl)-N*4*,N*4*-diethyl-5,6,7,8-tetrahydro-pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319722; BDBM50115159; 6-(4-chlorophenyl)-4-N,4-N-diethyl-5,6,7,8-tetrahydropteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 56660 nM
|
[21] | |||
| Compound Name |
8-Trifluoromethyl-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313001; BDBM50117557; (3aR)-8-(Trifluoromethyl)-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[20] | |||
| Compound Name |
N'-[3-(1-Ethylpiperidin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122152; CHEMBL3645468; BDBM106705; US8586620, 62; N-(3-(1-ethylpiperidin-4-yl)-1H-indol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 57300 nM
|
[14] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-5,5-difluorohexanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL535134; SCHEMBL6871676
Click to Show/Hide
|
||||
| Activity |
IC50 = 57500 nM
|
[23] | |||
| Compound Name |
5-Methyl-3,4,5,6-tetrahydropyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269330; 2-PYRIDINAMINE, 3,4,5,6-TETRAHYDRO-5-METHYL-; 5-Methyl-2-piperidinimine; SCHEMBL7622411; SCHEMBL18309012; DTXSID30572927; BDBM50062139; 5-Methyl-piperidin-(2Z)-ylideneamine; AKOS006359528; 3-methyl-2,3,4,5-tetrahydropyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[24] | |||
| Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216313
Click to Show/Hide
|
||||
| Activity |
IC50 = 58700 nM
|
[25] | |||
| Compound Name |
4-(4-{6-[(Thiophene-2-carboximidoyl)-amino]-benzothiazol-2-ylamino}-piperidin-1-ylmethyl)-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234499; BDBM50206063
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[26] | |||
| Compound Name |
N'-[1-(1-Methylpyrrolidin-3-yl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216558
Click to Show/Hide
|
||||
| Activity |
IC50 = 60500 nM
|
[22] | |||
| Compound Name |
N'-[1-[2-[2-Hydroxyethyl(methyl)amino]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216120
Click to Show/Hide
|
||||
| Activity |
IC50 = 63900 nM
|
[27] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216314
Click to Show/Hide
|
||||
| Activity |
IC50 = 64400 nM
|
[25] | |||
| Compound Name |
N'-[[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]methyl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122314; CHEMBL3216320
Click to Show/Hide
|
||||
| Activity |
IC50 = 64700 nM
|
[28] | |||
| Compound Name |
5-Methyl-N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216114
Click to Show/Hide
|
||||
| Activity |
IC50 = 65300 nM
|
[28] | |||
| Compound Name |
(3As,9bR)-3a-Fluoro-7-methylaminomethyl-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354230; BDBM50139526
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[29] | |||
| Compound Name |
N'-[3-(1-Azabicyclo[2.2.2]octan-3-yl)-1H-indol-5-yl]furan-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122308; CHEMBL3645485; BDBM106727; US8586620, 127
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[14] | |||
| Compound Name |
2-[2-(4-Methoxypyridin-2-yl)ethyl]-7-(2-phenylethoxy)-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800532; SCHEMBL5036433; BDBM50418854
Click to Show/Hide
|
||||
| Activity |
IC50 = 66069.34 nM
|
[8] | |||
| Compound Name |
N'-(1-Piperidin-4-yl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215662
Click to Show/Hide
|
||||
| Activity |
IC50 = 66200 nM
|
[22] | |||
| Compound Name |
N'-[3-(8-Methyl-8-azabicyclo[3.2.1]oct-3-en-3-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122038; CHEMBL3645474; BDBM106714; US8586620, 90; N-(3-(8-Methyl-8-azabicyclo[3.2.1]oct-3-en-3-yl)-1H-indol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 67900 nM
|
[14] | |||
| Compound Name |
4-Methyl-6-[2-(5-{4-[(methylamino)methyl]phenyl}pyridin-3-yl)ethyl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084332; W80; BDBM50250573
Click to Show/Hide
|
||||
| Activity |
Ki = 68539 nM
|
[16] | |||
| Compound Name |
N'-[1-[2-(1-Methylpyrrolidin-2-yl)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216111
Click to Show/Hide
|
||||
| Activity |
IC50 = 68900 nM
|
[25] | |||
| Compound Name |
6-[2-[3-Fluoro-5-[4-(methylaminomethyl)phenyl]phenyl]ethyl]-4-methylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061573; BDBM50250574
Click to Show/Hide
|
||||
| Activity |
Ki = 69888 nM
|
[16] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethoxy)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155413; BDBM50086459
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[1] | |||
| Compound Name |
8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314186; BDBM50117562; (3aR)-6-Fluoro-8-chloro-2,3,3a,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine; (3aR,9bS)-8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[20] | |||
| Compound Name |
2-Amino-4-(trifluoromethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(trifluoromethyl)pyridin-2-amine; 2-Pyridinamine, 4-(trifluoromethyl)-; 2-amino-4-trifluoromethylpyridine; 4-Trifluoromethyl-pyridin-2-ylamine; MFCD00077455; 4-trifluoromethyl-2-pyridinamine; CHEMBL294044; 4-(trifluoromethyl)-2-pyridinamine; 4-(trifluoromethyl)-2-pyridylamine; 2-Amino-4-(trifluoromethyl)pyridine, 97%; 4-Trifluoromethylpyridin-2-amine; PubChem2977; ACMC-1BTOY; SCHEMBL59927; KSC495C5P; CTK3J5157; DTXSID70380861; 2-amino-4-trifluormethyl-pyridine; 4-trifluoromethyl-pyridin-2-amine; 2-amino-4-trifluoromethyl pyridine; 2-amino-4-trifluoromethyl-pyridine; ACN-S003754; ACT01432; BCP07249; CS-M0293; KS-00000A1F; 4-Trifluoromethyl pyridine-2-ylamine; ANW-15349; BDBM50091804; QC-937; SBB028350; ZINC19616079; AKOS005063369; AB02966; AC-4388; AT-2483; DG-0065; EF10147; LS20417; MCULE-2537510751; AK-28230; BR-28230; CS-10503; SC-00249; SY005140; AB0001337; DB-005923; AM20050648; FT-0601087; ST50408475; A-4361; 447A976; A801440; Q-101462; Z1741959630
Click to Show/Hide
|
||||
| Activity |
IC50 = 72400 nM
|
[11] | |||
| Compound Name |
4-Methyl-6-(2-(5-(4-Methylpiperazin-1-Yl)pyridin-3-Yl)ethyl)pyridin-2-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
nNOS inhibitor, 3; CHEMBL3818545; SCHEMBL17708563; BDBM190665; Q27467186
Click to Show/Hide
|
||||
| Activity |
Ki = 73006 nM
|
[30] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216542
Click to Show/Hide
|
||||
| Activity |
IC50 = 73600 nM
|
[25] | |||
| Compound Name |
1400W Dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1400 W; N-(3-(Aminomethyl)Benzyl)Acetimidamide Dihydrochloride; 1400W HCl; UNII-K1BH573TYJ; K1BH573TYJ; 1400W 2HCl; 1400W (dihydrochloride); 214358-33-5 (HCl); N'-[[3-(aminomethyl)phenyl]methyl]ethanimidamide;dihydrochloride; N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride; N//'-[[3-(aminomethyl)phenyl]methyl]ethanimidamide;dihydrochloride; N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE; CHEMBL544788; SR-01000076199; n-(3-(aminomethyl)benzyl)acetamidine dihydrochloride; N-((3-(Aminomethyl)phenyl)methyl)-ethanimidamide dihydrochloride; N-(3-Aminomethyl)benzylacetamidine, 2HCl; W-1400 dihydrochloride; EU-0101258; SCHEMBL3115594; 1400 W DIHYDROCHLORIDE; CTK8E9562; EX-A1262; 1204AH; s8337; AKOS024456584; CCG-266961; CS-6983; 1400W dihydrochloride, >98%, solid; NCGC00094497-01; AS-69543; HY-18731; DB-082752; B6730; FT-0661894; ST50825934; 1400-W; W 4262; J-014060; SR-01000076199-1; SR-01000076199-3; {[3-(aminomethyl)phenyl]methyl}(iminoethyl)amine, chloride, chloride; Ethanimidamide, N-((3-(aminomethyl)phenyl)methyl)-, hydrochloride (1:2); N-{[3-(AMINOMETHYL)PHENYL]METHYL}ETHANIMIDAMIDE DIHYDROCHLORIDE
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[10] | |||
| Compound Name |
N'-[3-[3-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036273
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[15] | |||
| Compound Name |
N'-(1-Pyrrolidin-3-yl-2,3,4,5-tetrahydro-1-benzazepin-7-yl)thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215663
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[22] | |||
| Compound Name |
(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfanyl]-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965083
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[31] | |||
| Compound Name |
N'-[3-[(1R,3S)-3-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036272
Click to Show/Hide
|
||||
| Activity |
IC50 = 77600 nM
|
[15] | |||
| Compound Name |
(2R)-2-Amino-2-[2-(diaminomethylideneamino)ethylsulfanylmethyl]butanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899623
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[31] | |||
| Compound Name |
N'-(3-Piperidin-4-yl-1H-indol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122146; CHEMBL3645473; BDBM106713; US8586620, 88
Click to Show/Hide
|
||||
| Activity |
IC50 = 78100 nM
|
[14] | |||
| Compound Name |
N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-(2-phenylethyl)ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517995; CHEMBL1187747; SCHEMBL12385247; BDBM50255363
Click to Show/Hide
|
||||
| Activity |
Ki = 78450 nM
|
[19] | |||
| Compound Name |
(3As,9bR)-3a-Fluoro-7-(2-methylamino-ethyl)-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162365; BDBM50139528
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[29] | |||
| Compound Name |
4-[(3-Chloro-N-pyrimidin-5-ylanilino)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944719; SCHEMBL4056381; BDBM50363264
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[32] | |||
| Compound Name |
1-Amino-3-phenyl-8-fluoro-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL414608; 8-fluoro-3-phenyl-3,4-dihydroisoquinolin-1-amine; SCHEMBL8063228; BDBM50098932; 8-Fluoro-3-phenyl-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[2] | |||
| Compound Name |
N'-(1-Phenylpropyl)ethanimidamide;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450583
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[33] | |||
| Compound Name |
(S)-6-Acetimidoylamino-2-(S)-amino-5-fluoro-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL171327; BDBM50139793
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[23] | |||
| Compound Name |
N'-[1-(2-Pyrrolidin-1-ylethyl)-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216115
Click to Show/Hide
|
||||
| Activity |
IC50 = 82200 nM
|
[22] | |||
| Compound Name |
6-(2-{3-[3-(Dimethylamino)propyl]-5-fluorophenyl}ethyl)-4-methylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094689; W69; SCHEMBL19379174; BDBM50250568
Click to Show/Hide
|
||||
| Activity |
Ki = 83976 nM
|
[16] | |||
| Compound Name |
N'-[1-(Oxan-4-yl)-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1955934; BDBM50365332
Click to Show/Hide
|
||||
| Activity |
IC50 = 84800 nM
|
[34] | |||
| Compound Name |
N-{(3s,4s)-4-[(6-Amino-4-Methylpyridin-2-Yl)methyl]pyrrolidin-3-Yl}-N'-(4-Chlorobenzyl)ethane-1,2-Diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
aminopyridine-pyrrolidine, 6; CHEMBL474637; SCHEMBL8364063; BDBM29234; DB08018; Q27097248
Click to Show/Hide
|
||||
| Activity |
Ki = 85160 nM
|
[19] | |||
| Compound Name |
1-Amino-3-(4-chlorophenyl)-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7873; SCHEMBL8045541; BDBM50098946; 3-(4-chlorophenyl)-3,4-dihydroisoquinolin-1-amine; 3-(4-Chloro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[2] | |||
| Compound Name |
N'-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122048; CHEMBL3645467; BDBM106704; US8586620, 59
Click to Show/Hide
|
||||
| Activity |
IC50 = 86200 nM
|
[14] | |||
| Compound Name |
6-Butyl-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800533; BDBM50418855
Click to Show/Hide
|
||||
| Activity |
IC50 = 87096.36 nM
|
[8] | |||
| Compound Name |
2-[2-(4-Methoxypyridin-2-yl)ethyl]-6-bromo-3H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800526; SCHEMBL5041184; BDBM50418860; 6-bromo-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 = 87096.36 nM
|
[8] | |||
| Compound Name |
N'-[4-[2-(1-Methylpyrrolidin-2-yl)ethyl]-3-oxo-1,4-benzoxazin-7-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4572081; CHEMBL3675229; BDBM111475; US8618286, 1
Click to Show/Hide
|
||||
| Activity |
IC50 = 87200 nM
|
[35] | |||
| Compound Name |
Ethyl 4-(1-aminoethylideneamino)piperidine-1-carboxylate;hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL473674
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[33] | |||
| Compound Name |
3,4-Dihydro-2H-pyrrol-5-amine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-AMINO-1-PYRROLINE HYDROCHLORIDE; pyrrolidin-2-imine hydrochloride; 3,4-DIHYDRO-2H-PYRROL-5-AMINE HCL; 4,5-Dihydro-3H-pyrrol-2-ylamine hydrochloride; 2H-Pyrrol-5-amine, 3,4-dihydro-, monohydrochloride; MFCD00790772; 5-Amino-3,4-dihydro-2H-pyrrole Hydrochloride; CHEMBL543888; 2-Amino-1-pyrroline HCl; 2-amino-4,5-dihydro-3H-pyrrole (HCl salt); C4H8N2.HCl; SCHEMBL990656; 2-iminopyrrolidine hydrochloride; 2-imino-pyrrolidine hydrochloride; CTK7D1289; CTK8B5017; KS-00000KQF; DTXSID20509646; Pyrrolidin-(2E)-ylideneamine HCl; Pyrrolidin-2-imine (hydrochloride); BCP11252; CS-B0123; EBD14818; ANW-47045; AKOS006223432; AKOS016896214; 3,4-Dihydro-2h-pyrrol-5-ylamine hcl; MCULE-6089369366; AC-23074; AK-81762; AS-18538; SC-68430; SY030217; AB0026578; DB-049881; FT-0689912; W8276; 3,4-dihydro-2H-pyrrol-5-amine;hydrochloride; EN300-25419; M-8499; J-511182; 2H-Pyrrol-5-amine,3,4-dihydro-,hydrochloride(1:1); 3,4-Dihydro-2H-pyrrol-5-amine--hydrogen chloride (1/1)
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[36] | |||
| Compound Name |
N'-[4-[2-(Dimethylamino)ethyl]-2,3-dihydro-1,4-benzothiazin-7-yl]furan-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL499671; CHEMBL3675247; BDBM111493; US8618286, 19; N-(4-(2-(dimethylamino)ethyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-7-yl)furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 94700 nM
|
[35] | |||
| Compound Name |
Chembl1957354
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122273; CHEMBL1963156; BDBM106700; US8586620, 47; N'-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 97400 nM
|
[14] | |||
| Compound Name |
N'-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216321
Click to Show/Hide
|
||||
| Activity |
IC50 = 97400 nM
|
[28] | |||
| Compound Name |
N'-(1-Piperidin-4-yl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1955939; BDBM50365337
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[34] | |||
| Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]-2,3,4,5-tetrahydro-1-benzazepin-7-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2677347; CHEMBL3216322
Click to Show/Hide
|
||||
| Activity |
IC50 = 99100 nM
|
[22] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrol-1-yl]-N-methylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911980; BDBM50356499
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Quinolinone, 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490936; BDBM29240
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
4-Methyl-N-((2-oxo-1,2-dihydroquinolin-4-yl)methyl)-N-phenylthiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 9; CHEMBL491126; SCHEMBL3989894; BDBM29238; 4-methyl-N-[(2-oxo-1H-quinolin-4-yl)methyl]-N-phenyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 11633531
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1912001; SCHEMBL3559095; BDBM50356483
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-[[2-Cyclobutyl-7-(dimethylamino)imidazo[4,5-b]pyridin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801502; SCHEMBL4044061; BDBM50348728
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
2-[3-(1,3-Benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]-N,N-dimethylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911995; SCHEMBL3558781; BDBM50356493
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
5-Methoxy-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800527; SCHEMBL5033970; BDBM50418850
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
N-Benzyl-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911885; SCHEMBL3567859; BDBM50356507
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 11590027
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911994; SCHEMBL3562966; BDBM50356491
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
n-Methyl-3,4,5,6-tetrahydropyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268294; NSC157920; 2-PYRIDINAMINE, 3,4,5,6-TETRAHYDRO-N-METHYL-; N-methyliminopiperidine; N-Methyl-2-piperidinimine; N-methyl-2,3,4,5-tetrahydropyridin-6-amine; SCHEMBL7623417; SCHEMBL10070969; CTK4G8884; DTXSID60303342; ZINC5158898; BDBM50062144; Methyl-piperidin-(2Z)-ylidene-amine; AKOS006349763; MCULE-3924232585; NE60857; NSC-157920; 2,3,4,5-tetrahydro-6-(methylamino)pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
CID 11596934
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911985; SCHEMBL4888882; BDBM50356486
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-[(7-Chloro-2-cyclobutylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801500; SCHEMBL4050060; BDBM50348726
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
CID 57394615
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1912004; SCHEMBL3569097; BDBM50356495
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
7,8-Difluoro-4-((2-(thiazol-5-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801475; SCHEMBL4117934; BDBM50348711; 7,8-difluoro-4-[[2-(1,3-thiazol-5-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
4-[(2-Cyclobutylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801498; SCHEMBL13905062; BDBM50348724
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Quinolinone, 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490764; BDBM29242
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 11575808
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911996; SCHEMBL3565001; BDBM50356501
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-[(2-Oxo-1H-quinolin-4-yl)methyl]-N-phenylfuran-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 7; Oprea1_215299; CHEMBL470706; SCHEMBL3989368; BDBM29236; N-((2-oxo-1,2-Dihydroquinolin-4-yl)methyl)-N-phenylfuran-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 57401588
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911893; SCHEMBL3567357; BDBM50356474
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
1-[4-(Aminomethyl)benzoyl]-5'-fluoro-1'H-spiro[piperidine-4,2'-quinazolin]-4'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221657; SCHEMBL21067818; BDBM36397; AR-C120011; DB08750; CID24894149; Q27097936
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
7,8-Difluoro-4-((2-(4-methylpyridin-3-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801477; SCHEMBL4105158; BDBM50348713; 7,8-difluoro-4-[[2-(4-methylpyridin-3-yl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
1-Methyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-Methylpiperidin-2-imine; CHEMBL266980; 1-methyl-piperidin-2-ylideneamine; 2-imino-1-methylpiperidine; 2-imino-1 -methylpiperidine; SCHEMBL7622419; DTXSID00498746; BDBM50062141; 1-Methyl-piperidin-(2Z)-ylideneamine; AKOS010784835
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-[(2-Cyclobutyl-7-methylimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801499; SCHEMBL4038367; BDBM50348725
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
CID 57403339
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1912005; SCHEMBL3561018; BDBM50356496
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
7,8-Difluoro-4-((2-isobutyl-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801490; SCHEMBL4112004; BDBM50348721; 7,8-difluoro-4-[[2-(2-methylpropyl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911997; SCHEMBL3567034; BDBM50356503
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-N'-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)propan-2-yl]ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911979; SCHEMBL13037156; BDBM50356500
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
8-Fluoro-4-[[2-(2-methylpropyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801061; SCHEMBL4052043; BDBM50348731
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
CID 11523510
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911891; SCHEMBL3561903; BDBM50356513; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-(1H-indol-5-ylmethyl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112246; SCHEMBL7822522; BDBM50148164; ethyl 4-(4-methoxypyridin-2-ylamino)piperidine-1-carboxylate; Ethyl 4-[(4-methoxypyridin-2-yl)amino]piperidine-1-carboxylate, 11; 4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
CID 57394614
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1912003; SCHEMBL3570569; BDBM50356489
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-((2-Tert-Butyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801484; SCHEMBL4106170; BDBM50348717; 4-[(2-tert-butylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Quinolinone, 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470705; SCHEMBL3995276; BDBM29237; N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-N-phenylfuran-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N-[(2,2-Difluoro-1,3-benzodioxol-5-yl)methyl]-N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911892; BDBM50356515
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-(4-Ethoxy-pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112198; BDBM50148166
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[2-[1,3-Benzodioxol-5-ylmethyl(methyl)amino]ethyl]-2-imidazol-1-yl-6-methylpyrimidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911988; BDBM50356502
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 11496223
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911999; SCHEMBL3559311; BDBM50356477
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-(4'-Amino-1'-ethyl-5'-fluorospiro[piperidine-4,2'-quinazoline]-1-carbonyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221658; BDBM36398; CID24894150; 4-(4'-Amino-1'-ethyl-5'-fluorospiro[piperidine-4,2'-quinazoline]-1-carbonyl)benzonitrile, 5
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3,4-Dimethoxy-2-(methylsulfanylmethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800525; BDBM50418848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Quinolinone, 35
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491723; BDBM29265
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
4-[(2-Cyclopentylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801488; SCHEMBL4118042; BDBM50348719
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidin-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911987; SCHEMBL3560178; BDBM50356488
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
7,8-Difluoro-4-((2-isopentyl-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801491; SCHEMBL4123405; BDBM50348722; 7,8-difluoro-4-[[2-(3-methylbutyl)benzimidazol-1-yl]methyl]-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Ethyl 4-(pyridin-2-ylamino)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112247; ethyl 4-(2-pyridinylamino)-1-piperidinecarboxylate; ethyl 4-(2-pyridinylamino]-1-piperidinecarboxylate; SCHEMBL5879617; BDBM50148171; ZINC13580405; AKOS008921980; ethyl 4-(pyridin-2-ylamino)piperidin-1-carboxylate; 4-(Pyridin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-2-methylnicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 19; CHEMBL492088; SCHEMBL3995505; BDBM29248; N-(3-chlorophenyl)-N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-2-methylpyridine-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
4-[[2-(3,3-Difluorocyclobutyl)imidazo[4,5-b]pyrazin-3-yl]methyl]-8-fluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801062; SCHEMBL4048404; BDBM50348709
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Quinolinone, 16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490763; SCHEMBL3992502; BDBM29245; N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-4-methyl-N-(3-methylphenyl)-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
5-[4-[(4-Methoxypyridin-2-yl)amino]piperidine-1-carbonyl]pyridine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800347; BDBM50418844
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1185460; SCHEMBL232295; BDBM50418843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-[(2-Cyclobutylimidazo[4,5-c]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801497; BDBM50348723
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
CID 11631971
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911889; SCHEMBL3566838; BDBM50356511
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-ylmethylamino)-N-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911983; SCHEMBL13037135; BDBM50356498
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-((2-(Cyclopentylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801494; SCHEMBL4114941; BDBM50348718; 4-[[2-(cyclopentylmethyl)benzimidazol-1-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-[2-(1,3-Benzodioxol-5-ylmethoxy)ethyl]-1-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911989; SCHEMBL3569287; BDBM50356497
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-(1,3-Benzodioxol-5-ylmethyl)-4-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)butan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911981; SCHEMBL20435490; BDBM50356484
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-(3-Chlorophenyl)-N-((5-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-methylthiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 39; CHEMBL490560; SCHEMBL3986393; BDBM29269; N-(3-chlorophenyl)-N-[(5-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
Ethyl 4-[(4-chloropyridin-2-yl)amino]piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221660; SCHEMBL21067374; BDBM36400; DB07306; CID24894151; Q27096533; Ethyl 4-[(4-chloropyridin-2-yl)amino]piperidine-1-carboxylate, 10
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-(1,3-Benzodioxol-5-yl)ethyl]-2-(2-imidazol-1-yl-6-methylpyrimidin-4-yl)pyrrolidine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911986; SCHEMBL13037132; BDBM50356478
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 57396371
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911998; SCHEMBL3570547; BDBM50356476
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Quinolinone, 38
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522954; BDBM29268
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 11654166
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911991; SCHEMBL3571839; BDBM50356490
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(S)-3-(3-Acetimidoylamino-propoxy)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157074; BDBM50086471; O-[3-(1-Iminoethylamino)propyl]-L-serine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R)-3-(3-Acetimidoylamino-propylsulfanyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158297; BDBM50086465; S-[3-(1-Iminoethylamino)propyl]-L-cysteine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]ethanimidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217211
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909665; SCHEMBL3557670; BDBM50356481
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
7,8-Difluoro-4-((2-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801478; SCHEMBL4105373; BDBM50348714; 7,8-difluoro-4-[(2-pyridin-2-ylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
CID 11703771
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911888; SCHEMBL3562304; BDBM50356510
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfinyl]-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970153
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
[4-(4-Methoxy-pyridin-2-ylamino)-piperidin-1-yl]-phenyl-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112747; BDBM50148163
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
CID 11639946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911990; SCHEMBL3567371; BDBM50356479
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-Propyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6657; BDBM50062130; 4-Propyl-piperidin-(2Z)-ylideneamine; DA-09530; FT-0751966; 4-propyl-2,3,4,5-tetrahydropyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157846; SCHEMBL5515300; BDBM50086460; 2-amino-4-[2-(1-aminoethylideneamino)ethylsulfonyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-3-[2-(diaminomethylideneamino)ethylsulfanyl]-2-methylpropanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967477
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
7-Acetimidoylamino-2-amino-heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127739; SCHEMBL8065968; BDBM50030276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)thiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 18; CHEMBL522478; SCHEMBL3995069; BDBM29247; N-(3-chlorophenyl)-N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 11561546
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1912000; SCHEMBL3566224; BDBM50356480
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
3-[3-(1-Iminoethylamino)propylsulfonyl]-L-alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157190; BDBM50086463; (R)-3-(3-Acetimidoylamino-propane-1-sulfonyl)-2-amino-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[2-Cyclobutyl-7-(trifluoromethyl)imidazo[4,5-b]pyridin-3-yl]methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801503; SCHEMBL4047191; BDBM50348729
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
7,8-Difluoro-4-((2-(pyridin-3-yl)-1H-benzo[d]imidazol-1-yl)methyl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801479; SCHEMBL4118358; BDBM50348715; 7,8-difluoro-4-[(2-pyridin-3-ylbenzimidazol-1-yl)methyl]-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Quinolinone, 36
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491902; SCHEMBL3990039; BDBM29261; N-[(8-chloro-2-oxo-1H-quinolin-4-yl)methyl]-N-(3-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
Quinolinone, 25
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512501; SCHEMBL3989941; BDBM29254; N-(3-chlorophenyl)-N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]cyclopentanecarboxamide; N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)cyclopentane carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N'-Benzo[1,3]dioxol-5-ylmethyl-N-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-N-methyl-propane-1,3-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911882; SCHEMBL3560291; BDBM50356505; KD7040
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4,5-Dimethoxy-2-(methylsulfanylmethyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800524; BDBM50418858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)isobutyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 26; CHEMBL470908; SCHEMBL3988258; BDBM29255; N-(3-chlorophenyl)-N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-2-methylpropanamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 57391112
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1912002; SCHEMBL3570852; BDBM50356492
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Ethyl 4''-amino-1H,1''H-spiro[piperidine-4,2''-thieno[3,2-d]pyrimidine]-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL170176; BDBM50124528; ethyl 4''-aminospiro[hexahydropyridine-4,2''-(1'',2''-dihydrothieno[3,2-d]pyrimidine)]-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[41] | |||
| Compound Name |
2-[2-(4-Methoxypyridin-2-yl)ethyl]-5,7-dimethyl-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800529; SCHEMBL5036508; BDBM50418852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[3-[(3-Imidazol-1-yl-1,2,4-thiadiazol-5-yl)-methylamino]propyl]-1,3-benzodioxole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909664; SCHEMBL13037136; BDBM50356514
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-({1H-Imidazo[4,5-c]pyridin-2-ylsulfanyl}methyl)-4-methoxypyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800349; BDBM50418857
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
4-[(2-Cyclopentylimidazo[4,5-b]pyrazin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801505; SCHEMBL13905180; BDBM50348730
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
4-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155318; SCHEMBL5512623; BDBM50086469; 2-amino-4-[2-(1-aminoethylideneamino)ethylsulfinyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-Pyrrolidine-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1783098; SCHEMBL13070967; (2S)-pyrrolidine-2-carboximidamide; BDBM50346533; ZINC71280869
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
Ethyl 4-amino-5-fluorospiro[1H-quinazoline-2,4'-piperidine]-1'-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174290; SCHEMBL7940883; BDBM50124521; ethyl 4''-amino-5''-fluorospiro[hexahydropyridine-4,2''-(1'',2''-dihydroquinazoline)]-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[41] | |||
| Compound Name |
N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-3-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinolinone, 22; CHEMBL522467; SCHEMBL3989865; BDBM29251; N-(3-chlorophenyl)-N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 11538267
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911886; SCHEMBL3561841; BDBM50356508
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(R)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL155316; SCHEMBL120694; BDBM50086470; s-[2-(1-iminoethylamino)ethyl]-d-homocysteine; (2R)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Quinolinone, 15
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522290; SCHEMBL3990037; BDBM29244; N-(3-cyanophenyl)-N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
1-[2-(1,3-Benzodioxol-5-yl)ethyl]-3-[(2-imidazol-1-yl-6-methylpyrimidin-4-yl)methyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911982; SCHEMBL3556339; BDBM50356482
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Ethyl 2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911993; SCHEMBL3570716; BDBM50356487
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Quinolinone, 17
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490919; SCHEMBL3990401; BDBM29246; N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-N-(3-methoxyphenyl)-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 11624646
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911887; SCHEMBL3562730; BDBM50356509; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N-[(4-methoxyphenyl)methyl]-N'-methylpropane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N'-[1-(2-Phenylethyl)indol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122127; CHEMBL3645488; BDBM106733; US8586620, 115
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-Amino-3-(4-fluorophenyl)-6-fluoro-3,4-dihydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7946; SCHEMBL8058476; BDBM50098938; 6-fluoro-3-(4-fluorophenyl)-3,4-dihydroisoquinolin-1-amine; 6-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
CID 11502103
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911894; SCHEMBL3563611; BDBM50356485
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-[{3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propyl}-(3-imidazol-1-yl-[1,2,4]thiadiazol-5-yl)-amino]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911992; SCHEMBL3565457; BDBM50356494; 2-[3-(1,3-benzodioxol-5-ylmethylamino)propyl-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)amino]acetamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-(2-(2-(1H-Imidazol-1-yl)-6-methylpyrimidin-4-yl)pyrrolidin-1-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911984; SCHEMBL4886654; BDBM50356475
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 11609610
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1911890; SCHEMBL3562106; BDBM50356512; N'-(3-imidazol-1-yl-1,2,4-thiadiazol-5-yl)-N'-methyl-N-(pyridin-4-ylmethyl)propane-1,3-diamine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Quinolinone, 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491127; SCHEMBL3990511; BDBM29239; N-[(8-fluoro-2-oxo-1H-quinolin-4-yl)methyl]-4-methyl-N-phenyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
S-{2-[(E)-(1-Aminoethylidene)amino]ethyl}-L-cysteine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL351787; SCHEMBL5511756; CTK0A7450; DTXSID10658511; BDBM50086461; S-[2-(1-Iminoethylamino)ethyl]-L-cysteine; L-Cysteine, S-[2-[(1-iminoethyl)amino]ethyl]-; (R)-3-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-propionic acid; (2R)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-((2-Cyclohexyl-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801489; SCHEMBL4117520; BDBM50348720; 4-[(2-cyclohexylbenzimidazol-1-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
4-[(2-Cyclobutyl-7-methoxyimidazo[4,5-b]pyridin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1801501; SCHEMBL4046835; BDBM50348727
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Chembl1957358
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122312; CHEMBL1963535; BDBM106707; US8586620, 67; Ethyl 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-ylcarbamimidothioate; ethyl N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]carbamimidothioate
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[14] | |||
| Compound Name |
N-(3-(1-Azabicyclo[2.2.2]oct-2-en-3-yl)-1H-indol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122034; CHEMBL3645483; SCHEMBL12305070; BDBM106725; US8586620, 125; N'-[3-(1-azabicyclo[2.2.2]oct-2-en-3-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[14] | |||
| Compound Name |
Ethyl N'-[3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]carbamimidothioate;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216776
Click to Show/Hide
|
||||
| Activity |
IC50 = 105200 nM
|
[28] | |||
| Compound Name |
N'-(1-Cyclohexyl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1955933; BDBM50365331
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[34] | |||
| Compound Name |
N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]-N-[[3-(trifluoromethyl)phenyl]methyl]ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL479280; CHEMBL1186802; SCHEMBL12385647; BDBM50255310
Click to Show/Hide
|
||||
| Activity |
Ki = 116000 nM
|
[19] | |||
| Compound Name |
N'-[1-[2-(Diethylamino)ethyl]-2-[(4-ethoxyphenyl)methyl]benzimidazol-5-yl]furan-3-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216560
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[40] | |||
| Compound Name |
N'-(1-Piperidin-4-yl-3,4-dihydro-2H-quinolin-6-yl)thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3217198
Click to Show/Hide
|
||||
| Activity |
IC50 = 119000 nM
|
[25] | |||
| Compound Name |
6-[[(3S,4S)-1-Benzyl-4-(3-phenylpropylamino)pyrrolidin-3-yl]methyl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3701182; SCHEMBL10325876; BDBM172320; US9090589, 2
Click to Show/Hide
|
||||
| Activity |
Ki = 122000 nM
|
[19] | |||
| Compound Name |
trans Rac-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)pyrrolidin-3-yl)-N2-phenethylethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1277786; SCHEMBL12385254; BDBM50330873
Click to Show/Hide
|
||||
| Activity |
Ki = 123900 nM
|
[19] | |||
| Compound Name |
N-Iminoethyl-L-lysine dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
L-N6-(1-Iminoethyl)lysine dihydrochloride; UNII-8BL5V0T01Y; L-NIL, Dihydrochloride; 8BL5V0T01Y; CHEMBL1744034; L-NIL (dihydrochloride); (2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;dihydrochloride; L-NIL.2HCl; C8H17N3O2.2HCl; SCHEMBL677147; (S)-6-Acetimidamido-2-aminohexanoic acid dihydrochloride; DTXSID3040562; CTK8E7009; BCP16613; 1837AH; MFCD00270890; AKOS025294562; N(6)-acetimidoyllysine dihydrochloride; N(6)-acetimidoyl-L-lysine hydrochloride; N6-ethanimidoyl-L-lysine dihydrochloride; HY-12118; L-Lysine omega-acetamidine dihydrochloride; N(6)-acetimidoyl-L-lysine dihydrochloride; N(6)-ethanimidoyl-L-lysine dihydrochloride; n6-(1-iminoethyl)-l-lysine dihydrochloride; CS-0003090; L-N(6)-(1-iminoethyl)lysine dihydrochloride; L-Lysine, N6-(1-iminoethyl)-, dihydrochloride; L-Lysine,n6-(1-iminoethyl)-,hydrochloride(1:1); J-009575; L-Lysine, N6-(1-iminoethyl)-, hydrochloride (1:2); Q27132937; (1-{[(5S)-5-ammonio-5-carboxypentyl]amino}ethylidene)ammonium dichloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[43] | |||
| Compound Name |
2-Amino-6-(1-aminoethylideneamino)-5,5-difluorohexanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536253
Click to Show/Hide
|
||||
| Activity |
IC50 = 139000 nM
|
[23] | |||
| Compound Name |
6-Cyclohexyl-2-piperidinimine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7133; BDBM50062143; 6-Cyclohexyl-piperidin-(2Z)-ylideneamine; 2-cyclohexyl-2,3,4,5-tetrahydropyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 142000 nM
|
[24] | |||
| Compound Name |
N'-[3-(3-Fluoro-1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1122089; CHEMBL3645486; BDBM106728; US8586620, 134; N-(3-(3-fluoro-1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 143000 nM
|
[14] | |||
| Compound Name |
N'-[1-[3-(Dimethylamino)propyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216544
Click to Show/Hide
|
||||
| Activity |
IC50 = 154000 nM
|
[25] | |||
| Compound Name |
(S)-3-(2-Acetimidoylamino-ethanesulfinyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157958; BDBM50086468
Click to Show/Hide
|
||||
| Activity |
IC50 = 155000 nM
|
[1] | |||
| Compound Name |
N',N'-Dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100659; SCHEMBL5518262; BDBM50081585; 4-N,4-N-dibenzyl-6-(4-methoxyphenyl)pteridine-2,4-diamine; N*4*,N*4*-Dibenzyl-6-(4-methoxy-phenyl)-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[21] | |||
| Compound Name |
6-Acetimidoylamino-2-amino-5-fluoro-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172867; BDBM50139792; 2-amino-6-(1-aminoethylideneamino)-5-fluorohexanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 182000 nM
|
[23] | |||
| Compound Name |
N'-[1-[2-(Dimethylamino)ethyl]-8-fluoro-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216771
Click to Show/Hide
|
||||
| Activity |
IC50 = 194000 nM
|
[25] | |||
| Compound Name |
N'-[1-[4-(Methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956107; CHEMBL1956108; SCHEMBL19379236; SCHEMBL19379239; BDBM50365330; BDBM50365339
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[34] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 57 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GW274150
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Synonyms |
GW274150; GW-274150; UNII-0ZZF1V8G63; 0ZZF1V8G63; CHEMBL114551; SCHEMBL120693; L-Homocysteine, S-(2-((1-iminoethyl)amino)ethyl)-; GTPL9849; ZINC2004483; BDBM50086467; AKOS030526714; DB12237; CS-5419; HY-12119; GW-274150;GW 274150; [2-[(1-iminoethyl) amino]ethyl]-L-homocysteine; (S)-4-(2-Acetimidoylamino-ethylsulfanyl)-2-amino-butyric acid; (2S)-2-amino-4-[2-(1-aminoethylideneamino)ethylsulfanyl]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 466000 nM
|
[1] | |||
| Compound Name |
((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89459; ((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine; BDBM50104655
Click to Show/Hide
|
||||
| Activity |
IC50 = 205900 nM
|
[5] | |||
| Compound Name |
5-Ethyl-4-propyl-pyrrolidin-(2Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360009; 5-Ethyl-4-propyl-pyrrolidin-(2Z)-ylideneamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 227000 nM
|
[3] | |||
| Compound Name |
3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89735; 3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane; SCHEMBL8551346; BDBM50104651
Click to Show/Hide
|
||||
| Activity |
IC50 = 247800 nM
|
[5] | |||
| Compound Name |
(S)-N-(1-phenylethyl)acetimidamide hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448703; 1-[(1-Phenylethyl)amino]ethaniminium bromide
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[33] | |||
| Compound Name |
N-benzylacetimidamide hydrobromide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Benzylacetamidine Hydrobromide; 186545-76-6; CHEMBL462334; 1-(Benzylamino)ethaniminium bromide; N-benzylacetimidamide hydrobromide; C9H12N2.HBr; CTK8E6104; DTXSID10649404; MolPort-009-019-600; 1916AH; AKOS025294782; RT-023317; J-011977; (1E)-N'-Benzylethanimidamide--hydrogen bromide (1/1)
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[33] | |||
| Compound Name |
3-Butyl-[1,4]oxazepan-(5Z)-ylideneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89282; 3-Butyl-[1,4]oxazepan-(5Z)-ylideneamine; SCHEMBL8550109; BDBM50104656
Click to Show/Hide
|
||||
| Activity |
IC50 = 1363000 nM
|
[5] | |||
| Compound Name |
8-Chloro-6,7-difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87219; BDBM50117553; (3aR)-6,7-Difluoro-8-chloro-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
6,8-Dichloro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87968; BDBM50117571; (3aR)-6,8-Dichloro-2,3,3aalpha,9balpha-tetrahydro-1H-cyclopenta[c]quinoline-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
7-(2-Methoxyethoxy)-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800531; SCHEMBL5036601; BDBM50418859
Click to Show/Hide
|
||||
| Activity |
IC50 = 204173.79 nM
|
[8] | |||
| Compound Name |
7-Methoxy-2-[2-(4-methoxypyridin-2-yl)ethyl]-1H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800530; BDBM50418853
Click to Show/Hide
|
||||
| Activity |
IC50 = 204173.79 nM
|
[8] | |||
| Compound Name |
4-(1-Diazo-2,2,2-trifluoro-ethyl)-benzoic acid 2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364546; BDBM50170717
Click to Show/Hide
|
||||
| Activity |
IC50 = 208600 nM
|
[21] | |||
| Compound Name |
2-Pentyl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545059
Click to Show/Hide
|
||||
| Activity |
IC50 = 212000 nM
|
[36] | |||
| Compound Name |
Hexahydro-7-phenyl-1H-azepin-2-imine, monohydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL554445
Click to Show/Hide
|
||||
| Activity |
IC50 = 215000 nM
|
[44] | |||
| Compound Name |
N'-[3-[4-(Ethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036270; CHEMBL2036271
Click to Show/Hide
|
||||
| Activity |
IC50 = 216000 nM
|
[15] | |||
| Compound Name |
N'-[5-Fluoro-1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956109; CHEMBL1956110; BDBM50365340; BDBM50365341
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[34] | |||
| Compound Name |
(2R,3R)-3-Methyl-2-pentyl-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322480
Click to Show/Hide
|
||||
| Activity |
IC50 = 226000 nM
|
[45] | |||
| Compound Name |
3-Methyl-2-pentyl-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542710
Click to Show/Hide
|
||||
| Activity |
IC50 = 226000 nM
|
[36] | |||
| Compound Name |
N'-(5-Fluoro-1-piperidin-4-yl-2,3-dihydroindol-6-yl)thiophene-2-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956106; BDBM50365338
Click to Show/Hide
|
||||
| Activity |
IC50 = 243000 nM
|
[34] | |||
| Compound Name |
N'-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]benzenecarboximidamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215879
Click to Show/Hide
|
||||
| Activity |
IC50 = 249000 nM
|
[28] | |||
| Compound Name |
2-Amino-4-hydroxy-6-(4-fluorophenyl)pteridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98102; SCHEMBL3760493; BDBM50115154; 2-amino-6-(4-fluorophenyl)-1H-pteridin-4-one; 2-Amino-6-(4-fluoro-phenyl)-3H-pteridin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 253000 nM
|
[21] | |||
| Compound Name |
1-Benzyl-3-(2-isobutyrylamino-4-oxo-6,7-diphenyl-4,6,7,8-tetrahydro-3H-pteridine-5-carbonyl)-pyridinium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321741; PHS-72; BDBM50115130
Click to Show/Hide
|
||||
| Activity |
IC50 = 253200 nM
|
[21] | |||
| Compound Name |
(2R)-2-Amino-3-[(2R)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951128
Click to Show/Hide
|
||||
| Activity |
IC50 = 266000 nM
|
[31] | |||
| Compound Name |
N'-[(3S,4S)-4-[(6-Amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl]ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL481465; CHEMBL1186876; SCHEMBL12385414; BDBM50255194
Click to Show/Hide
|
||||
| Activity |
Ki = 282900 nM
|
[19] | |||
| Compound Name |
N'-[3-[4-(Dimethylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2034995; CHEMBL2036267
Click to Show/Hide
|
||||
| Activity |
IC50 = 284000 nM
|
[15] | |||
| Compound Name |
N'-[[3-[[(4-Methylphenyl)sulfonylamino]methyl]phenyl]methyl]ethanimidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490886
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[33] | |||
| Compound Name |
(2R)-2-Amino-2-[2-(diaminomethylideneamino)ethylsulfanylmethyl]-3-methoxypropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916075
Click to Show/Hide
|
||||
| Activity |
IC50 = 302000 nM
|
[31] | |||
| Compound Name |
2-[(4-Ethoxyphenyl)methyl]-1-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-nitrobenzimidazole;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215669
Click to Show/Hide
|
||||
| Activity |
IC50 = 317000 nM
|
[40] | |||
| Compound Name |
N',N'-Dibenzyl-6-phenylpteridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101399; SCHEMBL5514521; BDBM50081589; 4-N,4-N-dibenzyl-6-phenylpteridine-2,4-diamine; N*4*,N*4*-Dibenzyl-6-phenyl-pteridine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 343400 nM
|
[21] | |||
| Compound Name |
2-Amino-6-naphthalen-1-yl-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188157; BDBM50170721
Click to Show/Hide
|
||||
| Activity |
IC50 = 350700 nM
|
[21] | |||
| Compound Name |
(S)-6-Acetimidoylamino-2-(R)-amino-5-fluoro-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL170864; BDBM50139795
Click to Show/Hide
|
||||
| Activity |
IC50 = 374000 nM
|
[23] | |||
| Compound Name |
2-Imino-6-cyclohexylmethylpiperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269560; SCHEMBL6967333; 6-Cyclohexylmethyl-2-piperidinimine; 6-cyclohexylmethyl-2-iminopiperidine; BDBM50062134; 6-Cyclohexylmethyl-piperidin-(2Z)-ylideneamine; 2-(cyclohexylmethyl)-2,3,4,5-tetrahydropyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 375000 nM
|
[24] | |||
| Compound Name |
Hexahydro-3-(2-propenyl)-1H-azepin-2-imine, monohydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543745
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[44] | |||
| Compound Name |
N-(1-(Piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216328; CHEMBL2203713; CHEMBL2206929; SCHEMBL2675849; BDBM50401271
Click to Show/Hide
|
||||
| Activity |
IC50 = 415000 nM
|
[18] | |||
| Compound Name |
2-Benzyl-3-methyl-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552936
Click to Show/Hide
|
||||
| Activity |
IC50 = 458000 nM
|
[36] | |||
| Compound Name |
2-Amino-6-(ethoxymethyl)pteridin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188475; 4(1H)-Pteridinone, 2-amino-6-(ethoxymethyl)-; ACMC-20m77o; SCHEMBL10849935; CTK0G6338; DTXSID20545468; BDBM50170720; 2-Amino-6-ethoxymethyl-3H-pteridin-4-one; 2-AMINO-6-(ETHOXYMETHYL)-1H-PTERIDIN-4-ONE
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
2-Amino-5-benzoyl-5,6,7,8-tetrahydro-3H-pteridin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101495; BDBM50115136
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
2-Amino-propionic acid 2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359988; BDBM50170719
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
7-(2-Ethylbutyl)hexahydro-1H-azepin-2-imine, monohydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553992
Click to Show/Hide
|
||||
| Activity |
IC50 = 660000 nM
|
[44] | |||
| Compound Name |
2-Imino-4-methyl-5-pentyl-pyrrolidin-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321446; SCHEMBL8551035; BDBM50120679; (3R)-2-Imino-4beta-methyl-5beta-pentylpyrrolidine-3alpha-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 695000 nM
|
[45] | |||
| Compound Name |
3-(2-Butenyl)-5-iminohexahydro-1,4-oxazepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89431; SCHEMBL8552252; BDBM50104657; ((E)-3-But-2-enyl)-[1,4]oxazepan-(5Z)-ylideneamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 709000 nM
|
[5] | |||
| Compound Name |
L-Ornithine, N5-[hydrazino(methylthio)methylene]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53060; BDBM50077251; (2S)-2-amino-5-{[(1Z)-hydrazino(methylthio)methylene]amino}pentanoic acid; (S)-2-Amino-5-[[(hydrazino)(methylthio)methylene]amino]pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 752000 nM
|
[46] | |||
| Compound Name |
(3S)-2-Imino-4alpha-methyl-5alpha-pentylpyrrolidine-3beta-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327133; BDBM50120681
Click to Show/Hide
|
||||
| Activity |
IC50 = 930000 nM
|
[45] | |||
| Compound Name |
5-(2-Methyl-1-isothioureido)-L-Nva-L-Phe-OH
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL196720; BDBM50167728; 2-[(S)-2-Amino-5-(2-methyl-isothioureido)-pentanoylamino]-3-(S)-phenyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[47] | |||
| Compound Name |
Tert-butyl (2S,3S)-2-amino-3-[2-[[amino(methylsulfanyl)methylidene]amino]ethyl]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197055; BDBM50167730; (S)-2-(S)-Amino-3-[2-(2-methyl-isothioureido)-ethyl]-hexanoic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[47] | |||
| Compound Name |
(S)-3-(2-Acetimidoylamino-ethanesulfonyl)-2-amino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154895; GW273629; SCHEMBL6381735; BDBM50086464; (2S)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfonyl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
(R)-2-(S)-Amino-3-methyl-5-(2-methyl-isothioureido)-pentanoic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL196721; BDBM50167727
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[47] | |||
| Compound Name |
(R)-5-Acetimidoylamino-2-(S)-amino-3-methyl-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370170; BDBM50167726
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[47] | |||
| Compound Name |
2-Benzyl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553678
Click to Show/Hide
|
||||
| Activity |
IC50 = 1010000 nM
|
[36] | |||
| Compound Name |
(2R)-2-Amino-3-[2-(diaminomethylideneamino)ethylsulfonyl]-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933622
Click to Show/Hide
|
||||
| Activity |
IC50 = 1080000 nM
|
[31] | |||
| Compound Name |
(2R)-2-Amino-3-[(2S)-1-(diaminomethylideneamino)propan-2-yl]sulfanyl-2-methylpropanoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953808
Click to Show/Hide
|
||||
| Activity |
IC50 = 1100000 nM
|
[31] | |||
| Compound Name |
(2R,3S,4S)-5-Amino-3-methyl-2-pentyl-3,4-dihydro-2H-pyrrol-4-ol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL114534
Click to Show/Hide
|
||||
| Activity |
IC50 = 1980000 nM
|
[45] | |||
| Compound Name |
(2S)-2-Amino-6-(1-aminoethylideneamino)-N-(2H-tetrazol-5-yl)hexanamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416103
Click to Show/Hide
|
||||
| Activity |
IC50 = 2420000 nM
|
[43] | |||
| Compound Name |
(3R)-2-Imino-4alpha-methyl-5alpha-pentylpyrrolidine-3alpha-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116162; BDBM50120683
Click to Show/Hide
|
||||
| Activity |
IC50 = 2930000 nM
|
[45] | |||
| Compound Name |
L-Ornithine, N5-(hydrazinothioxomethyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57111; BDBM50077252; (S)-2-Amino-5-[hydrazino(thiocarbonyl)amino]pentanoic acid; (2S)-2-amino-5-[(hydrazinocarbonothioyl)amino]pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 3065000 nM
|
[46] | |||
| Compound Name |
(2S)-2-Amino-5-[carbamoyl(methyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408088; SCHEMBL12493127; BDBM50375815
Click to Show/Hide
|
||||
| Activity |
IC50 = 4000000 nM
|
[48] | |||
| Compound Name |
N-((5S,6R)-5-Amino-6,7-dihydroxy-heptyl)-acetamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164596; BDBM50063301; (2R,3S)-3-Amino-7-[(1-iminoethyl)amino]-1,2-heptanediol
Click to Show/Hide
|
||||
| Activity |
IC50 = 8420000 nM
|
[49] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine. Bioorg Med Chem Lett. 2000 Mar 20;10(6):597-600. | ||||
| REF 2 | 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6. | ||||
| REF 3 | Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. | ||||
| REF 4 | Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. | ||||
| REF 5 | Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. | ||||
| REF 6 | Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. | ||||
| REF 7 | 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. | ||||
| REF 8 | Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4228-32. | ||||
| REF 9 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. | ||||
| REF 10 | N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J Med Chem. 1998 Jul 16;41(15):2858-71. | ||||
| REF 11 | Substituted 2-aminopyridines as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1975-8. | ||||
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| REF 13 | 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J Med Chem. 2004 Jun 3;47(12):3320-3. | ||||
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