Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07303 | Target Info | |||
| Target Name | Vascular endothelial growth factor receptor 3 (FLT-4) | ||||
| Synonyms |
VEGFR3; VEGFR-3; VEGF-3 receptor; Tyrosine-protein kinase receptor FLT4; Fms-like tyrosine kinase 4
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| Target Type | Successful Target | ||||
| Gene Name | FLT4 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(2-Methoxyethyl)phenol
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Investigative | Compound Info | ||
| Synonyms |
p-(2-Methoxyethyl)phenol; p-(2-Methoxyethyl) phenol; Phenol, 4-(2-methoxyethyl)-; 4-METHOXYETHYLPHENOL; UNII-PY1W0AKW8I; Metoprolol Impurity B; Metoprolol IMpurity 02; MFCD00017537; PY1W0AKW8I; CHEMBL1094369; 4-Hydroxyphenylethyl methyl ether; 4-(2'-METHOXYETHYL)PHENOL; Metoprolol Impurity I; 4-(2-methoxyethyl)-phenol; 4-(2-Methoxy ethyl)-phenol; EINECS 260-354-9; 4-Methoxy ethyl phenol; ACMC-1AUK5; 4-(2'Methoxyethyl)Phenol; EC 260-354-9; 4-(2-methoxy ethyl)phenol; 4-(2-methoxyethyl) phenol; 4-(2-methoxy ethyl) phenol; 4-(2-methoxy-ethyl)-phenol; KSC495I9L; SCHEMBL303516; p-Hydroxyphenethyl methyl ether; DTXSID2073564; CTK3J5495; ATTERCOP-CHM AT108983; 4-(2-Methoxyethyl)phenol, 97%; CS-M3678; KS-000009AQ; ZINC2566176; ANW-32571; BDBM50316786; AKOS000120544; AS00207; MCULE-8081983402; NE10781; AC-23553; TS-02027; DB-052961; FT-0616546; FT-0652026; M1167; ST50824360; W-105505; Q27286814
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine
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Investigative | Compound Info | ||
| Synonyms |
isoquinoline-pyridine, 1; isoquinoline-pyridine, 3; 5-isoquinolinyl pyridine 2; pyridine-base inhibitor 13a; CHEMBL383264; SCHEMBL6855488; BDBM15067; 13a (S-); 6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinoline
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Serotonin hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
5-Hydroxytryptamine hydrochloride; Serotonin HCl; 3-(2-aminoethyl)-1H-indol-5-ol hydrochloride; 5-Hydroxytryptamine HCl; 1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride; UNII-GKN429M9VS; MFCD00012686; 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride; GKN429M9VS; CHEMBL535832; 5-Hydroxytryptamine hydrochioride; 3-(2-aminoethyl)indol-5-ol, chloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride; Serotonin hydrochloride, 98+%; SMR000875214; Prestwick_447; CCRIS 4420; SR-01000075577; Serotonin, HCl; 5-HT hydrochloride; 3-(2-Aminoethyl)indol-5-ol hydrochloride; MLS001332607; MLS001332608; MLS002153834; SCHEMBL379650; Serotonin hydrochloride(5-HT); Serotonin hydrochloride, powder; 3-(2-AMINO-ETHYL)-1H-INDOL-5-OL HYDROCHLORIDE; CTK3J3022; DTXSID80165186; 5-hydroxy tryptamine hydrochloride; HMS1569B03; 3-(2-Aminoethyl)indol-5-ol HCl; BCP20357; HY-B1473; KS-00000FV4; EINECS 244-464-4; Tox21_500607; ANW-43151; s4244; SBB003418; 5-Hydroxytryptamine Hydrochloride,(S); AKOS016010442; CCG-214216; GS-3130; LP00607; MCULE-8194058321; QC-1340; 3-(2-Aminoethyl)-1H-indol-5-ol HCl; NCGC00093982-01; NCGC00093982-02; NCGC00261292-01; SC-80561; ST056223; SY061788; AB0013658; DB-043206; CS-0013171; EU-0100607; FT-0631852; S0370; SW196666-3; A16699; H 9523; H-8140; X-1770; 3-(2-aminoethyl)-1H-indol-5-ol, hydrochloride; 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.; 3-(2-azanylethyl)-1H-indol-5-ol hydrochloride; 153S980; A809482; 5-Hydroxytryptamine hydrochloride;5-HT hydrochloride; SR-01000075577-1; SR-01000075577-5; Q27279146
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Tert-Butyl-2-{5-(4-hydroxyphenethoxy)-1-{5-[4-(methylthio)phenyl]pentyl}-1H-indole-3-yl}ethyl carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099339; BDBM50316778
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
(1S)-2-(1H-Indol-3-YL)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-YL}oxy)methyl]ethylamine
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Investigative | Compound Info | ||
| Synonyms |
bispyridinylethylene, 2; pyridine-base inhibitor 1b; CHEMBL383541; SCHEMBL6853457; BDBM15022; trans-bispyridinylethylene analog 2q; Q27096021
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
2-(2-(2-(2-((4-(1-Methylpiperidin-4-yl)-2-(trifluoromethoxy)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3689079; SCHEMBL14635846; BDBM176597; US9120761, 11
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| Activity |
IC50 = 59763 nM
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[3] | |||
| Compound Name |
(4S,6R,12Z)-6-Bromo-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668417; BDBM50336463
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| Activity |
IC50 = 65000 nM
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[4] | |||
| Compound Name |
2-(2-(2-(2-((4-(Piperidin-4-yl)-2-(trifluoromethoxy)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3689078; SCHEMBL14635829; BDBM176596; US9120761, 10
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| Activity |
IC50 ~ 66000 nM
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[3] | |||
| Compound Name |
(4S,6R,12E)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668412; BDBM50336466
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(4S,6R,12Z)-6-Chloro-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668416; BDBM50336464
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(Pyridin-3-ylmethyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290178; BDBM50331614
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| Activity |
Ki > 1000000 nM
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[5] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
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[5] | |||
| Compound Name |
N-(3-Chlorobenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290073; BDBM50331615
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| Activity |
Ki > 1000000 nM
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[5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2010 May 15;18(10):3387-402. | ||||
| REF 2 | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2000-7. | ||||
| REF 3 | US patent application no. 9120761B2, Selective FAK inhibitors | ||||
| REF 4 | Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1167-70. | ||||
| REF 5 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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