Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T07806 | Target Info | |||
| Target Name | 5-HT 1B receptor (HTR1B) | ||||
| Synonyms |
Serotonin receptor 1B; Serotonin 1D beta receptor; S12; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT1B receptor; 5-HT1B; 5-HT-1D-beta; 5-HT-1B
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| Target Type | Successful Target | ||||
| Gene Name | HTR1B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[2-Fluoro-3-[4-(methylbenzylamino)piperidino]propyl]-5-(4H-1,2,4-triazole-4-yl)-1H-indole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL416688; SCHEMBL7486422; BDBM50065416; L016681; Benzyl-{1-[2-fluoro-3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-methyl-amine; N-benzyl-1-[2-fluoro-3-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]propyl]-N-methylpiperidin-4-amine
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| Activity |
EC50 = 103000 nM
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[1] | |||
| Compound Name |
3-[(Dipropylamino)methyl]-5-methoxy-N,N-dipropyl-2,4-dihydrochromen-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL416336; BDBM50421374
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| Activity |
IC50 = 138038.43 nM
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[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899832; SCHEMBL3163790; BDBM50207400
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| Activity |
Ki > 3580000 nM
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[3] | |||
| References | Top | ||||
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| REF 1 | Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles. J Med Chem. 1999 Jun 17;42(12):2087-104. | ||||
| REF 2 | Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives. Bioorg Med Chem Lett. 1996 May 21;6(10):1077-82. | ||||
| REF 3 | Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett. 2017 Jan 15;27(2):323-328. | ||||
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