Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10383 | Target Info | |||
| Target Name | Phospholipase D2 (PLD2) | ||||
| Synonyms |
hPLD2; Phosphatidylcholine-hydrolyzing phospholipase D2; PLD1C; PLD 2; Choline phosphatase 2
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| Target Type | Clinical trial Target | ||||
| Gene Name | PLD2 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Afimoxifene
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Investigative | Compound Info | ||
| Synonyms |
(Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)-phenyl)-2-phenylbut-1-en-1-yl)phenol; (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol; (E/Z)-4-Hydroxytamoxifen; 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol; DSSTox_CID_28161; DSSTox_RID_79302; DSSTox_GSID_37094; MLS003106263; CHEMBL2137046; DTXSID3037094; BCBcMAP01_000199; CTK8E2879; CTK8E7487; HMS3370G08; BCP04749; BCP23058; Tox21_303657; BDBM50276802; s7827; AKOS028114525; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-; CCG-268491; 4-Hydroxytamoxifen (4-HT, Afimoxifene; SMP1_000161; NCGC00249622-01; NCGC00257332-01; SMR001819827; FT-0647372; FT-0670138; FT-0670142; FT-0670146; KS-00001838; Q27163871; (E)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
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| Activity |
IC50 = 74000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. | ||||
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