Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T11388 | Target Info | |||
| Target Name | Cathepsin K (CTSK) | ||||
| Synonyms |
Cathepsin X; Cathepsin O2; Cathepsin O; CTSO2; CTSO
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | CTSK | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 90 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(2-naphthylsulfonyl)-glycyl-glycine-nitrile
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|
Investigative | Compound Info | ||
| Synonyms |
dipeptide-derived nitrile, 38; CHEMBL200338; BDBM20117
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[2-Imino-4-(4-methylphenyl)-1,3-thiazol-3-yl]-1-morpholin-4-ylethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437299; BDBM50441917
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|
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| Activity |
Ki = 51240 nM
|
[2] | |||
| Compound Name |
N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]-2-phenylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209294; BDBM50410970
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|
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| Activity |
Ki = 52000 nM
|
[3] | |||
| Compound Name |
(S)-Tert-Butyl (3,3-dimethyl-1-oxobutan-2-yl)carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94782; SCHEMBL806058; BDBM50137799; ZINC13588581; X5485; (S)-2-(N-Boc-Amino)-3,3-dimethylbutyraldehyde; tert-butyl N-[(2S)-3,3-dimethyl-1-oxobutan-2-yl]carbamate; ((S)-1-Formyl-2,2-dimethyl-propyl)-carbamic acid tert-butyl ester; Carbamic acid, [(1S)-1-formyl-2,2-dimethylpropyl]-, 1,1-dimethylethyl ester
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|
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| Activity |
IC50 = 52000 nM
|
[4] | |||
| Compound Name |
2,4-Dimethylpentan-3-yl N-[(3S)-1-[[(1R)-1-(1,3,4-oxadiazol-2-yl)ethyl]amino]-1,2-dioxoheptan-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87946; BDBM50145455
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|
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| Activity |
IC50 = 59000 nM
|
[5] | |||
| Compound Name |
Arylaminoethyl amide, 20
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198450; BDBM19582
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|
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| Activity |
Ki ~ 65000 nM
|
[6] | |||
| Compound Name |
Arylaminoethyl amide, 5j
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436756; SCHEMBL5841980; BDBM19556; N-[(2S)-1-[2-(4-methoxyanilino)ethylamino]-3-(4-methylphenyl)-1-oxopropan-2-yl]-3-methylbenzamide
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|
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| Activity |
Ki ~ 65000 nM
|
[7] | |||
| Compound Name |
Dipeptide-derived nitrile, 33
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200285; BDBM20112; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-(naphthalen-1-yl)ethyl]carbamate
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|
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| Activity |
Ki = 66000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354498; BDBM50042852
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|
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| Activity |
IC50 = 73000 nM
|
[8] | |||
| Compound Name |
Dipeptide-derived nitrile, 34
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200557; BDBM20113; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-(naphthalen-2-yl)ethyl]carbamate
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|
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| Activity |
Ki = 83000 nM
|
[1] | |||
| Compound Name |
Tert-butyl N-[(S)-[(cyanomethyl)carbamoyl](phenyl)methyl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
dipeptide-derived nitrile, 15; CHEMBL200574; BDBM20094; ZINC13676556; AKOS034792525; MCULE-8511322715; Z1051731716
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|
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| Activity |
Ki = 90000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354497; BDBM50042854
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|
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| Activity |
IC50 = 95000 nM
|
[8] | |||
| Compound Name |
Arylaminoethyl carbamate, 17
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214431; SCHEMBL3019335; BDBM19686
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Succinamide peptidomimetic, 6
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240617; SCHEMBL3024590; BDBM19640; (3R)-3-(cyclohexylmethyl)-N-[2-(4-fluoroanilino)ethyl]-4-morpholin-4-yl-4-oxobutanamide; (3R)-3-(cyclohexylmethyl)-N-{2-[(4-fluorophenyl)amino]ethyl}-4-(morpholin-4-yl)-4-oxobutanamide; 3-(R)-Cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide
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|
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide, 5h
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199070; BDBM19554; (2S)-3-(3-chlorophenyl)-N-{2-[(4-methoxyphenyl)amino]ethyl}-2-[(3-methylphenyl)formamido]propanamide
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Arylaminoethyl amide, 11
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437323; SCHEMBL5844309; BDBM19573; (2S)-3-cyclohexyl-N-{2-[(4-methoxyphenyl)amino]ethyl}-2-[(3-phenoxyphenyl)formamido]propanamide; N-[(2S)-3-cyclohexyl-1-[2-(4-methoxyanilino)ethylamino]-1-oxopropan-2-yl]-3-phenoxybenzamide
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397973; SCHEMBL3958229; BDBM50201707; 5-[(2,3-dimethylphenoxy)methyl]-3-methyl-1,3-oxazolidin-2-one
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Arylaminoethyl amide, 8i
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204125; SCHEMBL4800493; BDBM19601
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|
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Arylaminoethyl carbamate, 24
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213712; SCHEMBL3010786; BDBM19690
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Dipeptide-derived nitrile, 22
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197130; BDBM20101; tert-butyl N-[(1S)-2-(benzyloxy)-1-[(cyanomethyl)carbamoyl]ethyl]carbamate
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230479; SCHEMBL3961271; BDBM50201706; trans-4-(2,3-dimethylphenoxy)-3-hydroxypiperidine
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Arylaminoethyl carbamate, 26
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424904; SCHEMBL3021491; BDBM19692
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Succinamide peptidomimetic, 36
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239369; SCHEMBL3022642; BDBM19670
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|
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide, 5r
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198299; SCHEMBL5844704; BDBM19564; N-[(2S)-1-[2-(4-methoxyanilino)ethylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-3-methylbenzamide
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Arylaminoethyl carbamate, 27
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444645; SCHEMBL3021814; BDBM19693
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Arylaminoethyl amide, 8g
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383648; BDBM19599
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|
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(3S)-1-[methyl-[(1R)-1-phenylethyl]amino]-1,2-dioxoheptan-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165345; BDBM50139488; {(S)-1-[Methyl-((R)-1-phenyl-ethyl)-aminooxalyl]-pentyl}-carbamic acid tert-butyl ester
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|
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Arylaminoethyl carbamate, 15
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386382; BDBM19684
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354496; BDBM50042855
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Diethylcyanamide
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|
Investigative | Compound Info | ||
| Synonyms |
N,N-Diethylcyanamide; CYANAMIDE, DIETHYL-; N-Cyanodiethylamine; Diethylkyanamid; USAF EK-6326; Diethyl-cyanamide; MFCD00001769; CHEMBL274120; aminodiethylcarbonitrile; Diethylcyanamide, 99+%; Diethylkyanamid [Czech]; cyanodiethylamine; (Diethylamino)carbonitrile; NSC 7768; EINECS 210-532-7; BRN 1741595; NSC7768; Diethylcyanamide, 99%; cyanamide, N,N-diethyl-; ACMC-1B2S1; 4-04-00-00381 (Beilstein Handbook Reference); WLN: NCN2&2; CTK2F3540; DTXSID20210705; ALBB-025897; NSC-7768; ZINC1688361; BDBM50095484; SBB060416; AKOS015915817; MCULE-5340167535; AS-56776; D4965; R1024; ST45029069; J-802191
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|
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Arylaminoethyl amide, 5t
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198318; SCHEMBL5843733; BDBM19566; (S)-N-{2-Biphenyl-4-yl-1-[2-(4-methoxy-phenylamino)-ethylcarbamoyl]-ethyl}-3-methyl-benzamide; N-[(2S)-1-[2-(4-methoxyanilino)ethylamino]-1-oxo-3-(4-phenylphenyl)propan-2-yl]-3-methylbenzamide
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Arylaminoethyl carbamate, 29
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425079; SCHEMBL3022810; BDBM19695
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354493; BDBM50042858
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Succinamide peptidomimetic, 8
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392682; SCHEMBL3015274; BDBM19642; (2R)-2-(cyclohexylmethyl)-4-morpholin-4-yl-4-oxo-N-[2-[4-(trifluoromethoxy)anilino]ethyl]butanamide
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|
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Tert-butyl (2S)-2-[(cyanomethyl)carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
dipeptide-derived nitrile, 14; CHEMBL200007; BDBM20093
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Dipeptide-derived nitrile, 27
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200576; BDBM20106; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-(2,3,4,5,6-pentafluorophenyl)ethyl]carbamate
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Succinamide peptidomimetic, 33
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238748; SCHEMBL3016710; BDBM19667
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|
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide deriv. 32
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386797; BDBM19718
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|
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Succinamide peptidomimetic, 7
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239579; BDBM19641; (3S)-3-(cyclohexylmethyl)-N-{2-[(4-fluorophenyl)amino]ethyl}-4-(morpholin-4-yl)-4-oxobutanamide
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|
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Dipeptide-derived nitrile, 40
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197498; BDBM20116; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-(2-phenylphenyl)ethyl]carbamate
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1-Cyanoazetidin-3-yl)methyl]cyclohexanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8796; SCHEMBL6851750; Cyclohexanecarboxamide, N-[(1-cyano-3-azetidinyl)methyl]-; BDBM50095487; 3-[(Cyclohexylcarbonylamino)methyl]azetidine-1-carbonitrile; Cyclohexanecarboxylic acid (1-cyano-azetidin-3-ylmethyl)-amide
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|
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-[(1S)-2-[2-(4-Methoxyanilino)ethylamino]-2-oxo-1-pyridin-4-ylethyl]-3-methylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199019
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Phenylalanine derivative, 37
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200743; BDBM20121; tert-butyl N-[(1S)-1-[(cyanomethyl)(methyl)carbamoyl]-2-phenylethyl]carbamate
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Arylaminoethyl amide, 16
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199134; BDBM19578
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Arylaminoethyl amide, 8j
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380712; SCHEMBL4799134; BDBM19602
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Arylaminoethyl amide, 17
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198550; BDBM19579
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|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354499; BDBM50042851
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Succinamide peptidomimetic, 41
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394207; BDBM19675
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Azetidine-1-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8123; 1-Azetidinecarbonitrile; BDBM50095485
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Arylaminoethyl amide, 5u
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372081; BDBM19567
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[(1R)-1-[(Benzylsulfonyl)methyl]-2-{[(1S)-1-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}ethyl]amino}-2-oxoethyl]morpholine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
arylaminoethyl amide deriv. 37; CHEMBL212604; SCHEMBL8290912; BDBM19723; Q27460810
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|
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| Activity |
Ki ~ 100000 nM
|
[15] | |||
| Compound Name |
Arylaminoethyl carbamate, 25
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214626; SCHEMBL3006645; BDBM19691
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441907; SCHEMBL3959125; BDBM50201704; (3S,4R)-4-(2,3-Dimethylphenoxy)-3-piperidinol; UNII-LHH887104B component ZHFIAFNZGWCLHU-WCQYABFASA-N
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Arylaminoethyl amide, 5s
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435116; BDBM19565; (2S)-3-(1H-indol-2-yl)-N-{2-[(4-methoxyphenyl)amino]ethyl}-2-[(3-methylphenyl)formamido]propanamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354492; BDBM50042850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Succinamide peptidomimetic, 39
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394206; SCHEMBL3015580; BDBM19673
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
(3S)-3-[(2S)-2-[(6-Chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380538; SCHEMBL5353469; BDBM19635; Heterocyclic arylaminoethyl amide, 13g
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|
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| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
Arylaminoethyl carbamate, 33
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215198; SCHEMBL3021674; BDBM19699
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Phenylalanine derivative, 36
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200815; BDBM20122; tert-butyl N-[(1R)-1-[(cyanomethyl)carbamoyl]-2-phenylethyl]carbamate
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Arylaminoethyl amide, 5m
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199239; SCHEMBL5842850; BDBM19559
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Succinamide peptidomimetic, 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240616; BDBM19639; (2S)-2-(cyclohexylmethyl)-N-{2-[(4-fluorophenyl)amino]ethyl}-4-(morpholin-4-yl)-4-oxobutanamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide, 5g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198016; SCHEMBL5842141; BDBM19553; N-[(2S)-3-(4-chlorophenyl)-1-[2-(4-methoxyanilino)ethylamino]-1-oxopropan-2-yl]-3-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Ethyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205320; SCHEMBL5357938; BDBM19636; Heterocyclic arylaminoethyl amide, 13h
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
Arylaminoethyl carbamate, 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424891; SCHEMBL8290919; BDBM19697
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Arylaminoethyl amide, 8c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206512; SCHEMBL4802686; BDBM19595
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Heterocyclic arylaminoethyl amide, 12e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381940; SCHEMBL5357588; BDBM19626
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
Arylaminoethyl carbamate, 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424894; BDBM19687
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Arylaminoethyl amide, 5d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198147; SCHEMBL5842539; BDBM19550; (2S)-4-cyclohexyl-N-{2-[(4-methoxyphenyl)amino]ethyl}-2-[(3-methylphenyl)formamido]butanamide; N-[(2S)-4-cyclohexyl-1-[2-(4-methoxyanilino)ethylamino]-1-oxobutan-2-yl]-3-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Succinamide peptidomimetic, 38
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239781; BDBM19672
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Succinamide peptidomimetic, 40
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240444; SCHEMBL3013785; BDBM19674
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide, 5k
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195999; SCHEMBL5841931; BDBM19557
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Arylaminoethyl amide, 5q
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425211; BDBM19563
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Succinamide peptidomimetic, 37
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393151; BDBM19671
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide, 8a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203326; SCHEMBL4797880; BDBM19593
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Succinamide peptidomimetic, 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238963; SCHEMBL3839931; BDBM19658
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl carbamate, 32
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386488; SCHEMBL3027669; BDBM19698
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Phenylalanine derivative, 48
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381659; BDBM20123; 2-({N-benzyl-N''-[(tert-butoxy)carbonyl]hydrazinecarbonyl}amino)acetonitrile
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Arylaminoethyl amide, 8o
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381388; SCHEMBL4800545; BDBM19607
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Arylaminoethyl amide, 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198438; BDBM19572
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Tert-butyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407941; SCHEMBL5357612; BDBM19637; Heterocyclic arylaminoethyl amide, 13i
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
(3S)-N-Tert-Butyl-2-oxo-3-(tert-butoxycarbonylamino)heptanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159869; BDBM50139501; ((S)-1-tert-Butylaminooxalyl-pentyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Arylaminoethyl carbamate, 28
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214757; SCHEMBL3011651; BDBM19694
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Arylaminoethyl amide, 8e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206239; SCHEMBL4796403; BDBM19597
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Heterocyclic arylaminoethyl amide, 12g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383119; BDBM19628
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
Arylaminoethyl amide, 8d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204236; SCHEMBL4798013; BDBM19596
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[(1S)-2-[2-(4-Methoxyanilino)ethylamino]-2-oxo-1-pyridin-3-ylethyl]-3-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199052
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Arylaminoethyl carbamate, 30
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385719; SCHEMBL3014813; BDBM19696
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Arylaminoethyl amide, 5l
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425379; SCHEMBL5843003; BDBM19558; N-[(2S)-1-[2-(4-methoxyanilino)ethylamino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
Carbamic acid, [2-[(cyanomethyl)amino]-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (s)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
dipeptide-derived nitrile, 3; CHEMBL200635; BDBM20083; ZINC13676535; tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]ethyl]carbamate; tert-Butyl 2-[(cyanomethyl)amino]-1-methyl-2-oxoethylcarbamate #
Click to Show/Hide
|
||||
| Activity |
Ki = 136000 nM
|
[1] | |||
| Compound Name |
Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382082; BDBM50491291
Click to Show/Hide
|
||||
| Activity |
Ki = 147000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382081; BDBM50491301
Click to Show/Hide
|
||||
| Activity |
Ki = 213000 nM
|
[16] | |||
| Compound Name |
Benzyl N-[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382083; BDBM50491311
Click to Show/Hide
|
||||
| Activity |
Ki = 284000 nM
|
[16] | |||
| Compound Name |
[(S)-1-(1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid (S)-2,2-dimethyl-1-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-propyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191588; SCHEMBL6602896; BDBM50169494
Click to Show/Hide
|
||||
| Activity |
IC50 = 460000 nM
|
[17] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382080; BDBM50491300
Click to Show/Hide
|
||||
| Activity |
Ki = 639000 nM
|
[16] | |||
| Compound Name |
Tert-butyl N-{[(cyanomethyl)carbamoyl]methyl}carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
dipeptide-derived nitrile, 1; CHEMBL200005; BDBM20080; ZINC13676531; tert-butyl (2-((cyanomethyl)amino)-2-oxoethyl)carbamate; tert-butyl N-[2-(cyanomethylamino)-2-oxoethyl]carbamate; tert-butyl(2-((cyanomethyl)amino)-2-oxoethyl)carbamate
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
(S)-Tert-Butyl (1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200150; SCHEMBL16254385; BDBM20126; phenylalanine derived propargyl, 54; ZINC13676617; AKOS034792464; MCULE-8258246873; Z1051142838; tert-butyl N-[(1S)-2-phenyl-1-(prop-2-yn-1-ylcarbamoyl)ethyl]carbamate; tert-butyl N-[(1S)-2-phenyl-1-[(prop-2-yn-1-yl)carbamoyl]ethyl]carbamate; tert-butyl N-[(2S)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl]carbamate
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
Phenylalanine derived allylamide, 55
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197975; SCHEMBL9826752; BDBM20127; tert-butyl N-[(1S)-2-phenyl-1-(prop-2-en-1-ylcarbamoyl)ethyl]carbamate
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
Dipeptide-derived nitrile, 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200006; BDBM20082; ZINC13676533; benzyl N-{[(cyanomethyl)carbamoyl]methyl}carbamate
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. | ||||
| REF 2 | Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation. Eur J Med Chem. 2013 Nov;69:908-19. | ||||
| REF 3 | Keto-1,3,4-oxadiazoles as cathepsin K inhibitors. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2909-14. | ||||
| REF 4 | Exploration of the P1 SAR of aldehyde cathepsin K inhibitors. Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. | ||||
| REF 5 | Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2004 May 17;14(10):2543-6. | ||||
| REF 6 | Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1975-80. | ||||
| REF 7 | Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4979-84. | ||||
| REF 8 | Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg Med Chem Lett. 2015 Feb 1;25(3):438-43. | ||||
| REF 9 | Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5107-11. | ||||
| REF 10 | Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett. 2007 May 15;17(10):2899-903. | ||||
| REF 11 | Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1254-9. | ||||
| REF 12 | Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1486-90. | ||||
| REF 13 | Design of small molecule ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2004 Feb 9;14(3):719-22. | ||||
| REF 14 | Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. J Med Chem. 2001 Jan 4;44(1):94-104. | ||||
| REF 15 | Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5112-7. | ||||
| REF 16 | Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors?. Bioorg Med Chem Lett. 2013 May 15;23(10):2968-73. | ||||
| REF 17 | P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3540-6. | ||||
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