Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T19160 | Target Info | |||
| Target Name | Group IIA phospholipase A2 (GIIA sPLA2) | ||||
| Synonyms |
RASF-A; Phospholipase A2, membrane associated; Phosphatidylcholine 2-acylhydrolase 2A; PLA2L; PLA2B; Non-pancreatic secretory phospholipase A2; NPS-PLA2; GIIC sPLA2
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| Target Type | Clinical trial Target | ||||
| Gene Name | PLA2G2A | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 50 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MANOALIDE
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|
Phase 2 | Compound Info | ||
| Synonyms |
manoalide; UNII-E1DK0157K9; 75088-80-1; CHEMBL463914; CHEBI:66666; E1DK0157K9; 2(5H)-Furanone, 4-(3,6-dihydro-6-hydroxy-5-(4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-; 2(5H)-Furanone, 4-((2R,6R)-3,6-dihydro-6-hydroxy-5-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-, (5R)-; AC1O5NJS; SCHEMBL20551728; MolPort-020-000-975
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| Activity |
IC50 = 93200 nM
|
[1] | |||
| Compound Name |
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
7-Benzyloxytryptamine; 31677-75-5; 2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine; CHEMBL460302; 2-[7-(benzyloxy)-1h-indol-3-yl]ethanamine; JOYGWYISRWPUIM-UHFFFAOYSA-N; 3-(2-AMINOETHYL)-7-BENZYLOXYINDOLE; 1H-Indole-3-ethanamine,7-(phenylmethoxy)-; B-2160; NSC92541; 7-Benzyloxytriptamine; AC1Q57HL; SCHEMBL5167328; AC1L63X1; CTK4G7564; ZINC39096; 7-Benzyloxytryptamine, free base; DTXSID60293835; 6038AH; NSC-92541; BDBM50247069; AKOS024282335; 7-(Benzyloxy)-1H-indole-3-ethanamine; MCULE-8072963757; ACM31677755; ST055630
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| Activity |
IC50 = 52500 nM
|
[2] | |||
| Compound Name |
[6,4''']biflavone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL205326; [6,4'''''']biflavone; BDBM50183245
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| Activity |
IC50 = 63900 nM
|
[3] | |||
| Compound Name |
(4As,6S,6aS,7S,10bR)-7,8-Bis-hydroxymethyl-1,1,4a,6a,10b-pentamethyl-1,2,3,4,4a,4b,5,6,6a,7,10,10a,10b,11,12,12a-hexadecahydro-chrysen-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL56332; BDBM50282920
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
3-[4-(2,3-Diheptoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374284; BDBM50206922; (+/-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-1,2-O-di-n-heptylglycerol
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| Activity |
IC50 = 50900 nM
|
[5] | |||
| Compound Name |
5-Benzyloxytryptamine hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
5-Benzyloxytryptamine HCl; 2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine Hydrochloride; MFCD00012685; 5-Benzyloxytryptamine hydrochloride, 98%; 2-(5-(benzyloxy)-1H-indol-3-yl)ethanamine hydrochloride; 2-[5-(benzyloxy)-1H-indol-3-yl]ethanamine hydrochloride; 5-Benzyloxy-3-(2-ethylamino)indole hydrochloride; 5-Benzyloxytryptamine, HCl; Cambridge id 5119598; C17H18N2O.HCl; SCHEMBL2540855; CHEMBL2316068; CTK8I9921; 5-benzyloxy-tryptamine hydrochloride; NSC73394; NSC-73394; 5-(Benzyloxy)tryptamine hydrochloride; AKOS015888136; AC-9171; ACN-051117; MCULE-9626466399; AS-36368; SC-18538; DB-052068; FT-0620056; ST50319686; 055B239; 3-(2-aminoethyl)-5-benzyloxyindole hydrochloride; A814873; 2-[5-(phenylmethoxy)indol-3-yl]ethylamine, chloride; 2-(5-phenylmethoxy-1H-indol-3-yl)ethanamine;hydrochloride
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| Activity |
IC50 = 52000 nM
|
[6] | |||
| Compound Name |
{2-[((4S,5R)-3-Dodecanoyl-2-oxo-4-propyl-oxazolidin-5-ylmethoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL419955; BDBM50073198
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| Activity |
IC50 = 52900 nM
|
[7] | |||
| Compound Name |
2-(1-Benzyl-2-ethyl-4-methoxy-1H-indol-3-yl)-2-hydroxy-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149595; SCHEMBL7963404; BDBM50055784; 2-(1-benzyl-2-ethyl-4-methoxyindol-3-yl)-2-hydroxyacetamide; 2-ethyl-4-methoxy-alpha-hydroxy-1-(phenylmethyl)-1H-indole-3-acetamide
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| Activity |
IC50 = 53000 nM
|
[8] | |||
| Compound Name |
2-[5-[(4-Phenylphenyl)methoxy]-1H-indol-3-yl]ethylcarbamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316065; BDBM50424426
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| Activity |
IC50 = 53000 nM
|
[6] | |||
| Compound Name |
3-[4-(3-Hydroxy-2-tetradecoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219946; BDBM50206919; (+/-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-O-tetradecylglycerol
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| Activity |
IC50 = 56000 nM
|
[5] | |||
| Compound Name |
Methyl 2-(4-butoxyphenyl)-6-methoxyquinoline-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814420; BDBM50349893
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| Activity |
IC50 = 57000 nM
|
[9] | |||
| Compound Name |
1-[[4-(5-Oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methyl]-4-tetradecylpiperazine-2,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096553; BDBM50316448; 1-[4-(4,5-Dihydro-1,2,4(4H)-5-oxo-oxadiazol-3-yl)benzyl]-4-tetradecylpiperazine-2,5-dione
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| Activity |
IC50 = 57000 nM
|
[10] | |||
| Compound Name |
2-[5-[(3-Phenoxyphenyl)methoxy]-1H-indol-3-yl]ethylcarbamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316066; BDBM50424425
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| Activity |
IC50 = 58000 nM
|
[6] | |||
| Compound Name |
4-(1-Benzyl-3-oxamoylindol-5-yl)oxybutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL345962; SCHEMBL2156832; BDBM50055400; 4-(3-Aminooxalyl-1-benzyl-1H-indol-5-yloxy)-butyric acid
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| Activity |
IC50 = 62000 nM
|
[11] | |||
| Compound Name |
2-(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)-acetamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL148670; BDBM50055786
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| Activity |
IC50 = 64700 nM
|
[8] | |||
| Compound Name |
[3-(1-Benzyl-3-carbamoylmethyl-2-methyl-1H-indol-5-yloxy)-propyl-]-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149502; hnpsPLA2-IIa Inhibitor, 1; SCHEMBL5001034; CTK7D3115; BDBM50055341; DB02504; Q27093490
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| Activity |
IC50 = 67000 nM
|
[12] | |||
| Compound Name |
4-(1-Benzyl-3-carbamoylmethyl-2-methyl-1H-indol-5-yloxy)-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL356752; 4-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-methyl-1h-indol-5-yl]oxy}butanoic acid; SCHEMBL4317828; CTK7D3114; BDBM50055291; DB02936; Q27093916; 2-[1-Benzyl-2-methyl-5-[(3-carboxypropyl)oxy]-1H-indol-3-yl]acetamide
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| Activity |
IC50 = 69000 nM
|
[12] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] sulfone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL406814; SCHEMBL8855718; BDBM50055420
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| Activity |
IC50 = 69000 nM
|
[13] | |||
| Compound Name |
6-(4-Oxo-2-phenyl-chromen-6-yl)-2-phenyl-chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
NSC668407; CHEMBL439687; [6,6'']biflavone; [6,6'''']biflavone; CTK7H2714; [6,6'-Bi-4H-1-benzopyran]-4,4'-dione, 2,2'-diphenyl-; BDBM50183249; NSC-668407; NCI60_023849; 2,2''-Diphenyl-[6,6'']bichromenyl-4,4''-dione; 2,2'-Diphenyl-6,6'-bi[4H-1-benzopyran-4-one]; 2,2'-diphenyl-4h,4'h-6,6'-bichromene-4,4'-dione
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| Activity |
IC50 = 69300 nM
|
[3] | |||
| Compound Name |
(1-Benzyl-5-methoxy-2-propyl-1H-indol-3-yl)-acetic acid hydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149265; SCHEMBL7965531; BDBM50055736; 2-(1-benzyl-5-methoxy-2-propylindol-3-yl)acetohydrazide
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| Activity |
IC50 = 70500 nM
|
[8] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[(2R)-2-[[2-[[(2R)-2-[[2-[[5-(2-Benzamido-4-methyl-1,3-thiazol-5-yl)-1H-pyrazole-3-carbonyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]butanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335207; BDBM50428495
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| Activity |
IC50 = 71000 nM
|
[14] | |||
| Compound Name |
2-[5-[2-(4-Phenoxyphenoxy)ethoxy]-1H-indol-3-yl]ethylcarbamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316067; BDBM50424424
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| Activity |
IC50 = 71000 nM
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[6] | |||
| Compound Name |
(1-Benzyl-3-carbamoylmethyl-2-methyl-1H-indol-4-yloxymethyl)-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL359067; SCHEMBL13484795; BDBM50055309; [3-(2-amino-2-oxoethyl)-1-benzyl-2-methylindol-4-yl]oxymethylphosphonic acid
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| Activity |
IC50 = 73500 nM
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[12] | |||
| Compound Name |
2-(1-Benzyl-2-methyl-5-methoxy-1H-indol-3-yl)thioacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL148443; BDBM50055747; 2-(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)-thioacetamide
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| Activity |
IC50 = 74100 nM
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[8] | |||
| Compound Name |
3-[4-[(2-Oxo-4-tetradecanoylpiperazin-1-yl)methyl]phenyl]-4H-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096816; BDBM50316446; 1-[4-(4,5-Dihydro-1,2,4(4H)-5-oxo-oxadiazol-3-yl)benzyl]-4-tetradecanoylpipe razin-2-one
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| Activity |
IC50 ~ 75000 nM
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[10] | |||
| Compound Name |
4-[4-[3-[[5-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dihydroxy-3,6-dimethylphenyl]methyl]-2,4-dihydroxy-6-methylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL384002; BDBM50055413
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| Activity |
IC50 = 76000 nM
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[13] | |||
| Compound Name |
3-[4-[2,3-Bis(4-phenylbutoxy)propoxy]phenyl]-4H-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219892; BDBM50206907; (+/-)-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-1,2-O-di(4-phenylbutyl)glycerol
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| Activity |
IC50 = 76700 nM
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[5] | |||
| Compound Name |
1-Benzyl-5-methoxy-2-methyl-3-(2H-tetrazol-5-ylmethyl)-1H-indole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150531; BDBM50055797
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| Activity |
IC50 = 84700 nM
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[8] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-4-Amino-2-[[(2R)-2-[[(2R)-2-[(3-chloro-5H-indazolo[2,3-a][3,1]benzoxazine-8-carbonyl)amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335203; BDBM50428497
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| Activity |
IC50 = 85000 nM
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[14] | |||
| Compound Name |
(3-{[3-(2-Amino-2-Oxoethyl)-1-Benzyl-2-Ethyl-1h-Indol-5-Yl]oxy}propyl)phosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
Ly 311727; LY311727; LY-311727; CHEMBL146186; SCHEMBL7965980; BDBM23771; CTK8E7560; DTXSID80167706; ZINC1543374; MFCD00943218; AKOS024457722; 3-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxypropylphosphonic acid; NCGC00370857-01; DS-015941; B7447; LY311727, >=98% (HPLC), powder; J-010111; Q27466824; 3-[3-(2-amino-2-oxo-ethyl)-1-benzyl-2-ethyl-indol-5-yl]oxypropylphosphonic acid; LY 311727
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| Activity |
IC50 = 91100 nM
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[12] | |||
| Compound Name |
4-(1-Benzyl-3-carbamoylmethyl-2-ethyl-1H-indol-5-yloxy)-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146571; SCHEMBL7953150; BDBM50055337; 4-[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethylindol-5-yl]oxybutanoic acid; 4-[[3-(2-amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1-H-indol-5-yl]oxy]butanoic acid
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| Activity |
IC50 = 94000 nM
|
[12] | |||
| Compound Name |
3-{4-[(4-Hexadecylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL270511; BDBM23752; PMS 1062 piperazine deriv., 23b
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| Activity |
IC50 ~ 100000 nM
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[15] | |||
| Compound Name |
3-[Acetyl-(1-benzyl-2-ethyl-3-oxamoylindol-4-yl)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL346641; BDBM50055410; 3-[Acetyl-(3-aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yl)-amino]-propionic acid
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-{4-[(4-Tetradecylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL271571; BDBM23750; PMS 1062 piperazine deriv., 23a
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| Activity |
IC50 ~ 100000 nM
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[15] | |||
| Compound Name |
3-{4-[(4-Tetradecylpiperazin-1-yl)carbonyl]phenyl}-4,5-dihydro-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL272209; BDBM23757; PMS 1062 piperazine deriv., 25a
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| Activity |
IC50 ~ 100000 nM
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[15] | |||
| Compound Name |
3-{4-[(4-Hexadecylpiperazin-1-yl)carbonyl]phenyl}-4,5-dihydro-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL272207; BDBM23758; PMS 1062 piperazine deriv., 25b
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| Activity |
IC50 ~ 100000 nM
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[15] | |||
| Compound Name |
[Acetyl-(3-aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yl)-amino]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL348462; BDBM50055397
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
3-[4-(3-Phenylmethoxy-2-tetradecoxypropoxy)phenyl]-4H-1,2,4-oxadiazol-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223233; BDBM50206904; (+/-)-1-O-benzyl-3-O-[4-(4,5-dihydro-5-oxo-1,2,4-4H-oxadiazol-3-yl)phenyl]-2-Otetradecylglycerol
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] ether
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL409657; BDBM50055431
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| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
Ubenimex
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Investigative | Compound Info | ||
| Synonyms |
Bestatin; Ubenimex (Bestatin); UNII-I0J33N5627; MFCD00083262; NK-421; CHEMBL29292; 58970-76-6 (free base); I0J33N5627; Ubenimexum [Latin]; Ubenimexum; Ubenimex [INN:JAN]; Ubenimex(Bestatin); SMR000059165; EINECS 261-529-2; NK 421; NSC 265489; BRN 4704312; Ubestatin; Ubenimex, solid; NSC-265489; Ubenimex, Bestatin; Ubenimex,(S); SCHEMBL7944; (3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine; Lopac0_000214; BSPBio_001553; KBioGR_000273; KBioSS_000273; MLS000028649; MLS001424177; MLS006010137; BCBcMAP01_000178; BDBM23971; KBio2_000273; KBio2_002841; KBio2_005409; KBio3_000545; KBio3_000546; Bio2_000273; Bio2_000753; HMS1361N15; HMS1791N15; HMS1989N15; HMS2052A03; HMS2232H13; HMS3268O06; HMS3402N15; HMS3412N16; HMS3676N16; HMS3715B20; EX-A1292; HY-B0134; KS-00000JJ0; ZINC1542895; BDBM50367209; KM0266; s1591; AKOS016339610; CCG-101071; CS-1910; DB03424; KS-5207; NC00321; QC-8204; SDCCGSBI-0050202.P003; IDI1_034023; SMP1_000030; NCGC00025323-01; NCGC00025323-02; NCGC00025323-03; NCGC00025323-04; NCGC00025323-05; NCGC00025323-06; NCGC00025323-08; NCGC00025323-14; AT-11558; BCP0726000308; AB0010690; ST50405897; AB00698345_05; 970B766; SR-01000075724-3; W-105351; BRD-K59574735-001-02-7; BRD-K59574735-001-05-0; Q10909912
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)-octanoic acid hydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL146814; BDBM50055780
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| Activity |
IC50 = 101200 nM
|
[8] | |||
| Compound Name |
3-(1-Benzyl-3-carbamoylmethyl-2-methyl-1H-indol-5-yloxy)-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL345720; BDBM50055285
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 110000 nM
|
[12] | |||
| Compound Name |
1H-Indole-3-acetic acid, 5-methoxy-2-methyl-1-(phenylmethyl)-, methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436423; BRN 0497622; methyl 2-(1-benzyl-5-methoxy-2-methylindol-3-yl)acetate; Methyl 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetate; SCHEMBL8645997; DTXSID90206554; BDBM50055805; Estere metilico dell'acido 1-benzil-2-metil-5-metossi-3-indolilacetico; (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)-acetic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 = 115800 nM
|
[8] | |||
| Compound Name |
2-(1-Benzyl-6-methoxy-2-methyl-1H-indol-3-yl)-2-hydroxy-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445382; SCHEMBL7963220; BDBM50055804; 2-(1-benzyl-6-methoxy-2-methylindol-3-yl)-2-hydroxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 120900 nM
|
[8] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] sulfide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264973; SCHEMBL9057347; BDBM50055433
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[13] | |||
| Compound Name |
3-(1-Benzyl-3-carbamoylmethyl-2-ethyl-1H-indol-5-yloxy)-propane-1-sulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149030; SCHEMBL13484801; BDBM50055316
Click to Show/Hide
|
||||
| Activity |
IC50 = 135000 nM
|
[12] | |||
| Compound Name |
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[[(2-oxo-2-phenylmethoxyethyl)amino]methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706743
Click to Show/Hide
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||||
| Activity |
IC50 = 140000 nM
|
[13] | |||
| Compound Name |
N-Methyl-2-(1-benzyl-2-methyl-5-methoxy-1H-indol-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436265; BDBM50055794; 2-(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)-N-methyl-acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 141800 nM
|
[8] | |||
| Compound Name |
(2R)-2-[[2-[[(2R)-2-[[2-[[5-(2-Benzamido-4-methyl-1,3-thiazol-5-yl)-1H-pyrazole-3-carbonyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335198; BDBM50428491
Click to Show/Hide
|
||||
| Activity |
IC50 = 155000 nM
|
[14] | |||
| Compound Name |
4-[4-[5-[[5-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dimethoxy-3,6-dimethylphenyl]methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8855442; CHEMBL3706742
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 26 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Zileuton
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Leutrol; Zileutonum; Ziluton; Zyflo; Abbott brand of zileuton; Zyflo CR; Zyflo Filmtab; A 64077; Abbot 64077; Abbott 64077; A-64077; ABBOTT-64077; ABT-077; CTI-02; ZYFLO (TN); ZYFLO, Zileuton; Zileutonum [INN-Latin]; Zyflo (TN); Zileuton (USP/INN); Zileuton [USAN:INN:BAN]; N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea; N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea; (+-)-1-(1-Benzo(b)thien-2-ylethyl)-1-hydroxyurea; (+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; (+/-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea; 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea; 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
PHENIDONE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenidone; 92-43-3; 1-phenylpyrazolidin-3-one; 1-Phenyl-3-pyrazolidone; 1-PHENYL-3-PYRAZOLIDINONE; Fenidon; 3-Pyrazolidinone, 1-phenyl-; 1-Phenyl-3-oxopyrazolidine; 2-Pyrazolin-3-ol, 1-phenyl-; 1-P-3-P; Pyrazolidinone, 1-phenyl-; 1-Phenyl-pyrazolidin-3-one; UNII-H0U5612P6K; CCRIS 3624; 1-Phenylpyrazolid-3-one; EINECS 202-155-1; NSC 30306; 3-Pyrazolidinone,1-phenyl-; CHEMBL7660; 1-phenyl-4,5-dihydro-1H-pyrazol-3-ol; MLS002639322; CMCWWLVWPDLCRM-UHFFFAOYSA-N; H0U5612P6K; MFCD00003094; Phenidone A (1-Phenyl-3-pyrazolidinone)
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
Mepacrine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
quinacrine; mepacrine; atabrine; Acrinamine; Acriquine; 83-89-6; Quinactine; Antimalarina; Haffkinine; Akrichin; Italchine; acrichine; Erion; Mepacrinum; Quinacrine hydrochloride; Mepacrine [INN:BAN]; St 439; Mepacrinum [INN-Latin]; Mepacrina [INN-Spanish]; atebrin; Malaricida; Methoquine; Palacrin; Italchin; Pentilen; Palusan; Atebrine; Metochin; Mecryl; Quinacrine, Mepacrine; 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine; 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine; HSDB 3253
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000000 nM
|
[13] | |||
| Compound Name |
2-[[(2R)-2-[[2-[[5-(2-Benzamido-4-methyl-1,3-thiazol-5-yl)-1H-pyrazole-3-carbonyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335197; BDBM50428492
Click to Show/Hide
|
||||
| Activity |
IC50 = 217000 nM
|
[14] | |||
| Compound Name |
Isophthalic acid bis[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenyl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358582; BDBM50055419
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[13] | |||
| Compound Name |
4-[4-[5-[3-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-methoxy-5-methylphenoxy]-2,4-dimethoxybenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384003; BDBM50055422
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[13] | |||
| Compound Name |
2-[[5-(2-Benzamido-4-methyl-1,3-thiazol-5-yl)-1H-pyrazole-3-carbonyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335195; BDBM50428494
Click to Show/Hide
|
||||
| Activity |
IC50 = 241000 nM
|
[14] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenoxy]carbonyl]-4-methoxyphenyl] sulfoxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428448; SCHEMBL8855600; BDBM50055426
Click to Show/Hide
|
||||
| Activity |
IC50 = 260000 nM
|
[13] | |||
| Compound Name |
(2R)-2-[[2-[[5-(2-Benzamido-4-methyl-1,3-thiazol-5-yl)-1H-pyrazole-3-carbonyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335196; BDBM50428493
Click to Show/Hide
|
||||
| Activity |
IC50 = 262000 nM
|
[14] | |||
| Compound Name |
Phosphoric acid (R)-2-acetylamino-9-hydroxy-nonyl ester methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328330; BDBM50073968
Click to Show/Hide
|
||||
| Activity |
IC50 = 350000 nM
|
[17] | |||
| Compound Name |
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[[[(1S)-1-phenylethyl]amino]methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706745
Click to Show/Hide
|
||||
| Activity |
IC50 = 840000 nM
|
[13] | |||
| Compound Name |
Succinic acid bis[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenyl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146849; SCHEMBL8855515; BDBM50055424
Click to Show/Hide
|
||||
| Activity |
IC50 = 940000 nM
|
[13] | |||
| Compound Name |
(Z)-1-(4-Fluorophenyl)-3-[cyclohexyl(hydroxy)amino]-2-propen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL274373; BDBM50003447; ZINC100642426; 3-(Cyclohexyl-hydroxy-amino)-1-(4-fluoro-phenyl)-propenone; (Z)-3-(Cyclohexyl-hydroxy-amino)-1-(4-fluoro-phenyl)-propenone
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(Z)-1-(4-Fluorophenyl)-3-[benzyl(acetyloxy)amino]-2-propen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11807; BDBM50003448; 1-(4-fluorophenyl)-3-benzyl-3-acetyloxyamino-propenone; (2Z)-3-[(acetyloxy)(benzyl)amino]-1-(4-fluorophenyl)prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(Z)-1-(4-Fluorophenyl)-3-[benzyl(hydroxy)amino]-2-propen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11308; BDBM50003446; ZINC26020412; 3-(Benzyl-hydroxy-amino)-1-(4-fluoro-phenyl)-propenone; (Z)-3-(Benzyl-hydroxy-amino)-1-(4-fluoro-phenyl)-propenone
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(Z)-1-(4-Fluorophenyl)-3-[benzyl(methoxy)amino]-2-propen-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11858; BDBM50003410; ZINC100642378; 3-(Benzyl-methoxy-amino)-1-(4-fluoro-phenyl)-propenone; (Z)-3-(Benzyl-methoxy-amino)-1-(4-fluoro-phenyl)-propenone
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
4-[4-[2,4-Dihydroxy-3,6-dimethyl-5-[(1-phenylethylamino)methyl]benzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3085276; BDBM50055412
Click to Show/Hide
|
||||
| Activity |
IC50 = 1800000 nM
|
[13] | |||
| Compound Name |
Fumaric acid bis[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]-3-methoxy-2,5,6-trimethylphenyl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357772; SCHEMBL8855414; BDBM50055414
Click to Show/Hide
|
||||
| Activity |
IC50 = 2200000 nM
|
[13] | |||
| Compound Name |
4-[4-[5-[[5-[4-(4-Carboxy-3-hydroxy-2,5,6-trimethylphenoxy)carbonyl-3-hydroxy-2,5,6-trimethylphenoxy]carbonyl-2,4-dihydroxy-3,6-dimethylphenyl]methyl]-2,4-dihydroxy-3,6-dimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoyl]oxy-2-hydroxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9043305; CHEMBL3706744
Click to Show/Hide
|
||||
| Activity |
IC50 = 2400000 nM
|
[13] | |||
| Compound Name |
4-[5-[[5-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-2,4-dimethoxy-3,6-dimethylphenyl]methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341607; BDBM50055415; Bis[5-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl]2,4-dimethoxy-36-dimethylphenyl]methane
Click to Show/Hide
|
||||
| Activity |
IC50 = 2800000 nM
|
[13] | |||
| Compound Name |
4-[4-[5-[(2,4-Dimethoxy-3,6-dimethylphenyl)methyl]-2,4-dimethoxy-3,6-dimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706746
Click to Show/Hide
|
||||
| Activity |
IC50 = 3000000 nM
|
[13] | |||
| Compound Name |
2-Methoxy-4-[2-methoxy-4-[2-methoxy-5-(4-methoxyphenyl)sulfanylbenzoyl]oxy-3,5,6-trimethylbenzoyl]oxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL345972; BDBM50055428
Click to Show/Hide
|
||||
| Activity |
IC50 = 4100000 nM
|
[13] | |||
| Compound Name |
Bis[3-[[4-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)-carbonyl]-4-methoxyphenyl]sulfide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433939; SCHEMBL8855388; BDBM50055425
Click to Show/Hide
|
||||
| Activity |
IC50 = 4800000 nM
|
[13] | |||
| Compound Name |
4-[4-[6-[4-(4-Carboxy-3-methoxy-2,5,6-trimethylphenoxy)carbonyl-3-methoxy-2,5,6-trimethylphenoxy]carbonyl-4-oxopyran-2-carbonyl]oxy-2-methoxy-3,5,6-trimethylbenzoyl]oxy-2-methoxy-3,5,6-trimethylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348303; BDBM50055418
Click to Show/Hide
|
||||
| Activity |
IC50 = 5800000 nM
|
[13] | |||
| Compound Name |
Thielocin A1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407586; BDBM50055417
Click to Show/Hide
|
||||
| Activity |
IC50 = 12000000 nM
|
[13] | |||
| Compound Name |
Bis[3-[(4-carboxy-3-methoxy-2,5,6-trimethylphenoxy)-carbonyl]-4-methoxyphenyl]ether
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436619; SCHEMBL8855399; BDBM50055416
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. | ||||
| REF 2 | Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8. | ||||
| REF 3 | Synthesis of phospholipase A2 inhibitory biflavonoids. Bioorg Med Chem Lett. 2006 May 1;16(9):2373-5. | ||||
| REF 4 | Analogs of the marine natural product scalaradial lacking the alpha,beta-unsaturated aldehyde: effects on human synovial fluid phospholipase A2 and macrophage lipid mediator production. Bioorg Med Chem Lett. 1994 Aug 11;4(15):1873-8. | ||||
| REF 5 | Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities. J Med Chem. 2007 Apr 5;50(7):1618-26. | ||||
| REF 6 | Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase. Eur J Med Chem. 2013 Jan;59:160-7. | ||||
| REF 7 | Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3495-8. | ||||
| REF 8 | Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides. J Med Chem. 1996 Dec 20;39(26):5119-36. | ||||
| REF 9 | Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A1 inhibitors. Bioorg Med Chem. 2011 Jun 1;19(11):3361-6. | ||||
| REF 10 | Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives. Bioorg Med Chem. 2010 May 15;18(10):3588-600. | ||||
| REF 11 | Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem. 1996 Dec 20;39(26):5159-75. | ||||
| REF 12 | Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality. J Med Chem. 1996 Dec 20;39(26):5137-58. | ||||
| REF 13 | Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives. J Med Chem. 1996 Dec 20;39(26):5183-91. | ||||
| REF 14 | Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin alphav3. Bioorg Med Chem Lett. 2013 Jan 1;23(1):340-5. | ||||
| REF 15 | Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines. Bioorg Med Chem. 2008 Feb 1;16(3):1242-53. | ||||
| REF 16 | Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors. Bioorg Med Chem Lett. 1992 Sep;2(9):1079-84. | ||||
| REF 17 | Synthesis and PLA2-inhibitory properties of 2(R)-acetamido-alkylphosphomethanols with a variable aggregate anchor. Bioorg Med Chem Lett. 1999 Jan 18;9(2):261-4. | ||||
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