Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22285 | Target Info | |||
| Target Name | Glutamate receptor ionotropic NMDA 2A (NMDAR2A) | ||||
| Synonyms |
NR2A; NMDA receptor NR2A; N-methyl D-aspartate receptor subtype 2A; HNR2A; Glutamate receptor ionotropic, NMDA 2A; Glutamate [NMDA] receptor subunit epsilon-1; GluN2A
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | GRIN2A | ||||
| Biochemical Class | Glutamate-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 21 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[3-(4-Benzylpiperidino)propylthio]-2H-1,2,4-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151428; BDBM50086385; 4-Benzyl-1-[3-(2H-[1,2,4]triazol-3-ylsulfanyl)-propyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
2-[3-(4-Benzylpiperidino)propylthio]-5-nitro-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147200; BDBM50086371; 2-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-5-nitro-1H-benzoimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[1] | |||
| Compound Name |
2-[3-(4-Benzylpiperidino)propylthio]-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147295; BDBM50086374; 2-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-1H-benzoimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[1] | |||
| Compound Name |
5-[3-(4-Benzylpiperidino)propylthio]-1,3,4-thiadiazole-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150403; BDBM50086372; 5-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-[1,3,4]thiadiazol-2-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[1] | |||
| Compound Name |
2-[2-(4-Benzylpiperidino)ethylthio]-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL148767; BDBM50086376; 2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-1H-benzoimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[1] | |||
| Compound Name |
2-[3-(4-Benzylpiperidino)propylthio]-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151339; BDBM50086388; 4-Benzyl-1-[3-(1H-imidazol-2-ylsulfanyl)-propyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[1] | |||
| Compound Name |
5-[3-(4-Benzylpiperidino)propylthio]-1H-1,2,4-triazole-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151389; BDBM50086384; 5-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-1H-[1,2,4]triazol-3-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[1] | |||
| Compound Name |
1-[3-(Phenylthio)propyl]-4-benzylpiperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL149054; BDBM50086370; 4-Benzyl-1-(3-phenylsulfanyl-propyl)-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
2-Methyl-5-[2-(4-benzylpiperidino)ethylthio]-1,3,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422139; BDBM50086373; 4-Benzyl-1-[2-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-ethyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-(4-Benzylpiperidino)-1-butynyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83781; SCHEMBL6968395; BDBM50078480; 4-[4-(4-benzylpiperidin-1-yl)but-1-ynyl]phenol; 4-[4-(4-Benzyl-piperidin-1-yl)-but-1-ynyl]-phenol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[2-(4-Benzylpiperidino)ethylthio]-1H-imidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147355; BDBM50086377; 4-Benzyl-1-[2-(1H-imidazol-2-ylsulfanyl)-ethyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[2-(4-Benzylpiperidino)ethylthio]-3H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150641; BDBM50086378; 2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-3H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-[2-(4-Benzylpiperidino)ethylthio]-1H-1,2,4-triazole-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151901; BDBM50086387; 5-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-1H-[1,2,4]triazol-3-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-[2-(4-Benzylpiperidino)ethylthio]-1H-1,2,4-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL347753; BDBM50086368; 4-Benzyl-1-[2-(2H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Methyl-5-[3-(4-benzylpiperidino)propylthio]-1,3,4-thiadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147201; BDBM50086369; 2-(3-(4-benzylpiperidin-1-yl)propylthio)-5-methyl-1,3,4-thiadiazole; 4-Benzyl-1-[3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanyl)-propyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-[2-(4-Benzylpiperidino)ethylthio]-1,3,4-thiadiazole-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358256; BDBM50086386; 5-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-[1,3,4]thiadiazol-2-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[2-(Phenylthio)ethyl]-4-benzylpiperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151489; BDBM50086382; 4-benzyl-1-(2-phenylsulfanylethyl)piperidine; 4-Benzyl-1-(2-phenylsulfanyl-ethyl)-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[3-(4-Benzylpiperidino)propylthio]-3H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150640; BDBM50086380; 2-[3-(4-Benzyl-piperidin-1-yl)-propylsulfanyl]-3H-imidazo[4,5-b]pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Methyl-5-[3-(4-benzylpiperidino)propylthio]-1H-1,2,4-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL358601; BDBM50086381; 4-Benzyl-1-[3-(5-methyl-2H-[1,2,4]triazol-3-ylsulfanyl)-propyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Methyl-5-[2-(4-benzylpiperidino)ethylthio]-1H-1,2,4-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL146764; BDBM50086375; 4-Benzyl-1-[2-(5-methyl-2H-[1,2,4]triazol-3-ylsulfanyl)-ethyl]-piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[2-(4-Benzylpiperidino)ethylthio]-5-nitro-1H-benzimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150491; BDBM50086379; 2-[2-(4-Benzyl-piperidin-1-yl)-ethylsulfanyl]-5-nitro-1H-benzoimidazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Parallel synthesis of a series of subtype-selective NMDA receptor antagonists. Bioorg Med Chem Lett. 2000 Mar 20;10(6):527-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.