Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T24836 | Target Info | |||
| Target Name | Vitamin K-dependent protein C (PROC) | ||||
| Synonyms |
Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; PROC; Blood coagulation factor XIV; Autoprothrombin IIA; Anticoagulant protein C; Activation peptide
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| Target Type | Successful Target | ||||
| Gene Name | PROC | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 35 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Hexamethylene amiloride
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|
Preclinical | Compound Info | ||
| Synonyms |
5-(N,N-Hexamethylene)amiloride; 5-HMA; BIDD; BSPBio_003443; C12H18ClN7O; DivK1c_006875; HMA; HMA-5; Hexamethyleneamiloride; KBioGR_001206; KBioSS_002076; Lopac-A-9561; Lopac0_000104; MLS002153208; N,N-HEXAMETHYLENEAMILORIDE; SPECTRUM1504215; SpecPlus_000779; Spectrum2_001669; Spectrum3_001662; Spectrum4_000623; Spectrum5_001388; Spectrum_001596
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
GRASSYSTATIN A
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|
Investigative | Compound Info | ||
| Synonyms |
Grassystatin A; CHEMBL567893; GTPL8674
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Chembl4217043
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Investigative | Compound Info | ||
| Synonyms |
3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide; BDBM50459059; 30I
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059991; BDBM50256261
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094403; BDBM50256260
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl4207715
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459055
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4213248; 50I; BDBM50459054
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(7R,10S,13S,16S,22S,25S,28S,31R,34S,37S,45S,48S,51R)-51-Acetamido-45-benzyl-10-[(2S)-butan-2-yl]-34-(4-carbamimidamidobutyl)-13-(carboxymethyl)-48-(hydroxymethyl)-22,25,37-tris[(4-hydroxyphenyl)methyl]-9,12,15,21,24,27,30,33,36,39,44,47,50-tridecaoxo-28-propan-2-yl-5,53,58-trithia-8,11,14,20,23,26,29,32,35,38,43,46,49-tridecazapentacyclo[29.25.3.13,55.016,20.040,43]hexaconta-1(56),2,55(60)-triene-7-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070056; BDBM50256262
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|
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
{1-[2-(4-Carbamimidoyl-benzylcarbamoyl)-indan-2-ylcarbamoyl]-cyclopentylamino}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378083; BDBM50193244
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| Activity |
IC50 = 53000 nM
|
[4] | |||
| Compound Name |
4-[[(2S)-2-[[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]amino]-3-[4-[(4-methylpiperazine-1-carbonyl)amino]phenyl]propanoyl]amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752047; BDBM50136573
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| Activity |
Ki ~ 60000 nM
|
[5] | |||
| Compound Name |
N-[(1s)-1-Benzyl-2-[2-[5-Chloro-2-(Tetrazol-1-Yl)phenyl]ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2-Oxo-1h-Quinoline-6-Carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754781; SCHEMBL3012551; BDBM50136579; Q27456753
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| Activity |
Ki ~ 64000 nM
|
[5] | |||
| Compound Name |
4-[(N-{(2e)-3-[5-Chloro-2-(1h-Tetrazol-1-Yl)phenyl]prop-2-Enoyl}-L-Phenylalanyl)amino]benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754069; SCHEMBL3004773; SCHEMBL3004779; BDBM50136608; Q27455801
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| Activity |
Ki ~ 64000 nM
|
[5] | |||
| Compound Name |
Chembl4227743
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL10264235; BDBM50460457
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| Activity |
Ki ~ 64400 nM
|
[6] | |||
| Compound Name |
Chembl4226631
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8008313; BDBM50460468
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| Activity |
Ki ~ 64400 nM
|
[6] | |||
| Compound Name |
Chembl4228006
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL8005631; BDBM50460459
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| Activity |
Ki = 68000 nM
|
[6] | |||
| Compound Name |
(3S)-N-[2'-(Aminosulfonyl)-4-biphenylyl]-2-(3-amidinobenzoyl)-1,2,3,4-tetrahydroisoquinoline-3alpha-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL98858; BDBM50106064
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| Activity |
IC50 = 73000 nM
|
[7] | |||
| Compound Name |
1-(3-Amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3,5-dimethyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386463; BDBM12861; Pyrazolo[4,3-d]pyrimidinone 19g
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| Activity |
Ki ~ 76000 nM
|
[8] | |||
| Compound Name |
6-{2-Fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213352; BDBM12720; pyrazolo[4,3-d]pyrimidinone 39b
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| Activity |
Ki ~ 76000 nM
|
[9] | |||
| Compound Name |
1-(4-Methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384526; BDBM12719; pyrazolo[4,3-d]pyrimidinone 39a
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| Activity |
Ki ~ 76000 nM
|
[9] | |||
| Compound Name |
3-(3-Amidinophenyl)-2-[[[(4-cyanophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135998; BDBM50067524
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|
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| Activity |
Ki = 80000 nM
|
[10] | |||
| Compound Name |
3-[(R)-3-(4-Methyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107911; BDBM50060031
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|
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| Activity |
Ki = 94000 nM
|
[11] | |||
| Compound Name |
(2S)-N-[(5-Chloro-2-prop-2-enyl-1H-indol-3-yl)methyl]-2-[[(2R)-2-cyclohexyl-2-[[(2S)-2-phenylpent-4-enoyl]amino]acetyl]amino]-4-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288925; BDBM50331666
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|
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| Activity |
IC50 = 103500 nM
|
[12] | |||
| Compound Name |
(3E,6S,9R,12S)-19-Chloro-9-cyclohexyl-12-(2-methylpropyl)-6-phenyl-8,11,14,23-tetrazatricyclo[14.7.0.017,22]tricosa-1(16),3,17(22),18,20-pentaene-7,10,13-trione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1288926; BDBM50331665
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|
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| Activity |
IC50 = 144500 nM
|
[12] | |||
| Compound Name |
(S)-Ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL211561; BDBM50187800
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| Activity |
Ki ~ 150000 nM
|
[13] | |||
| Compound Name |
N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536972
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|
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| Activity |
Ki ~ 150000 nM
|
[14] | |||
| Compound Name |
2-[4-(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423810; BDBM50124975
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|
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| Activity |
IC50 = 169000 nM
|
[15] | |||
| Compound Name |
2-[4-(5-Chloro-naphthalene-2-sulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350587; BDBM50124979
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|
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| Activity |
IC50 = 170000 nM
|
[15] | |||
| Compound Name |
3-(4-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341933; BDBM50067526; 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(4-carbamimidoyl-phenyl)-propionic acid
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| Activity |
Ki = 180000 nM
|
[10] | |||
| Compound Name |
3-[(R)-3-(4-Methanesulfonyl-piperazin-1-yl)-3-oxo-2-(2,2,5,7,8-pentamethyl-chroman-6-sulfonylamino)-propyl]-benzamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107743; BDBM50060019
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|
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| Activity |
Ki = 180000 nM
|
[11] | |||
| Compound Name |
N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[2-oxo-4-(quinoline-8-sulfonyl)-piperazin-1-yl]-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL355376; BDBM50124990
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| Activity |
IC50 ~ 180000 nM
|
[15] | |||
| Compound Name |
3-(3-Amidinophenyl)-2-[[[(4-amidinophenylsulfonyl)amino]acetyl]amino]propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL133027; BDBM50067523; 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(3-carbamimidoyl-phenyl)-propionic acid
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| Activity |
Ki = 180000 nM
|
[10] | |||
| Compound Name |
N-[(R)-4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-(2-oxo-4-phenylmethanesulfonyl-piperazin-1-yl)-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL162461; BDBM50124992
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|
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| Activity |
IC50 ~ 180000 nM
|
[15] | |||
| Compound Name |
N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[4-(naphthalene-2-sulfonyl)-2-oxo-piperazin-1-yl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL163174; BDBM50124972; N-[(1S)-1-(2-Thiazolylcarbonyl)-4-guanidinobutyl]-2-oxo-4-(2-naphthylsulfonyl)piperazine-1-acetamide
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| Activity |
IC50 ~ 180000 nM
|
[15] | |||
| Compound Name |
2-[4-(4-Chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[(R)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL159695; BDBM50124995
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| Activity |
IC50 ~ 180000 nM
|
[15] | |||
| Compound Name |
N-[2-(3-Carbamimidoylphenoxy)phenyl]-4-(2-sulfamoylphenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL297835; SCHEMBL890761; BDBM50114479; N-[2-(3-Amidinophenoxy)phenyl]-2'-sulfamoylbiphenyl-4-carboxamide; 2''-Sulfamoyl-biphenyl-4-carboxylic acid [2-(3-carbamimidoyl-phenoxy)-phenyl]-amide
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| Activity |
IC50 ~ 181000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-N-[(5-Chloro-2-prop-2-enyl-1H-indol-3-yl)methyl]-2-[[(2R)-2-cyclohexyl-2-(pent-4-enoylamino)acetyl]amino]-4-methylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290074; BDBM50331667
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|
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| Activity |
IC50 = 284100 nM
|
[12] | |||
| Compound Name |
(9R,12S)-19-Chloro-9-cyclohexyl-12-(2-methylpropyl)-8,11,14,23-tetrazatricyclo[14.7.0.017,22]tricosa-1(16),17(22),18,20-tetraene-7,10,13-trione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290179; BDBM50331664
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| Activity |
IC50 = 395300 nM
|
[12] | |||
| Compound Name |
Mupain-1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734777; BDBM50499239
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| Activity |
Ki > 1000000 nM
|
[17] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-11-(carboxymethyl)-23-(hydroxymethyl)-17,26-bis[(4-hydroxyphenyl)methyl]-29-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735080; BDBM50499240
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|
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| Activity |
Ki > 1000000 nM
|
[17] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-23-benzyl-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-26-[3-(diaminomethylideneamino)propyl]-11-(1H-indol-3-ylmethyl)-17,29-dimethyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735263; BDBM50499238
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| Activity |
Ki > 1000000 nM
|
[17] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-11,23-dibenzyl-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-26-[3-(diaminomethylideneamino)propyl]-17,29-dimethyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735513; BDBM50499241
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| Activity |
Ki > 1000000 nM
|
[17] | |||
| Compound Name |
3-(4-Amidinophenyl)-2-[[[(4-cyanophenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135198; BDBM50067530
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|
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| Activity |
Ki > 1000000 nM
|
[10] | |||
| Compound Name |
(3R,8R,11S,14S,17S,20S,23S,26S,29S,32S)-3-Amino-29-(4-aminobutyl)-11,23-dibenzyl-20-[(1-carbamimidoylpiperidin-4-yl)methyl]-26-[3-(diaminomethylideneamino)propyl]-17-methyl-14-(2-methylpropyl)-2,10,13,16,19,22,25,28,31-nonaoxo-5,6-dithia-1,9,12,15,18,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-8-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735217; BDBM50499237
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|
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| Activity |
Ki > 1000000 nM
|
[17] | |||
| Compound Name |
3-(4-Amidinophenyl)-2-[[[(4-thiocarbamoylphenylsulfonyl)amino]acetyl]amino]propionic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137311; BDBM50067527
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|
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| Activity |
Ki > 1000000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. J Med Chem. 2018 Sep 27;61(18):8299-8320. | ||||
| REF 2 | Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. | ||||
| REF 3 | Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema. J Med Chem. 2018 Apr 12;61(7):2823-2836. | ||||
| REF 4 | Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders. J Med Chem. 2006 Aug 24;49(17):5047-50. | ||||
| REF 5 | Novel phenylalanine derived diamides as Factor XIa inhibitors. Bioorg Med Chem Lett. 2016 Jan 15;26(2):472-478. | ||||
| REF 6 | Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. Bioorg Med Chem Lett. 2018 Apr 1;28(6):987-992. | ||||
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| REF 8 | Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulat... Bioorg Med Chem Lett. 2006 Oct 1;16(19):5176-82. | ||||
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