Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T26500 | Target Info | |||
| Target Name | Histamine H4 receptor (H4R) | ||||
| Synonyms |
SP9144; Pfi-013; HH4R; H4 receptor; GPRv53; GPCR105; G protein-coupled receptor 105; AXOR35
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| Target Type | Clinical trial Target | ||||
| Gene Name | HRH4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Pitolisant
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|
Approved | Compound Info | ||
| Synonyms |
Pitolisant; 362665-56-3; TIPROLISANT; BF2.649; UNII-4BC83L4PIY; 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine; Pitolisant (BF2.649); 1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine; 4BC83L4PIY; Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-; CHEMBL462605; wakix; 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride; 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine; Tirolisant; Pitolisant (INN); tiprolisant [USAN]; Wakix (TN); Pitolisant [USAN:INN]; SCHEMBL117648; GTPL8924; CTK1B6404; HBS-101
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[2-(3H-Imidazol-4-yl)-ethyl]-pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310360; CTK4I9661; DTXSID30458656; AKOS015839560
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|
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| Activity |
EC50 = 58884.37 nM
|
[2] | |||
| Compound Name |
4-[4-(Dimethylamino)phenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290583; BDBM50021558
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|
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| Activity |
Ki = 64490 nM
|
[3] | |||
| Compound Name |
6-(4-Fluorophenyl)-7-methyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314768; BDBM50424317
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| Activity |
Ki = 67870 nM
|
[4] | |||
| Compound Name |
N-[(4-Methoxyphenyl)methyl]-2-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754008; BDBM50137643
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| Activity |
Ki = 72443.6 nM
|
[5] | |||
| Compound Name |
(2R)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2beta-methanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107877; BDBM50474239
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| Activity |
EC50 = 75857.76 nM
|
[6] | |||
| Compound Name |
(2S)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2alpha-methanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319658; BDBM50474246
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|
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| Activity |
EC50 = 85113.8 nM
|
[6] | |||
| Compound Name |
3-(1H-Imidazol-5-yl)propyl N-(3-phenoxypropyl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413360; BDBM50492995
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
3-(1H-Imidazol-5-yl)propyl N-(4-phenoxybutyl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413361; BDBM50492984
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|
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
6-(4-Fluorophenyl)-N,7-dimethyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314769; BDBM50424316
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|
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| Activity |
Ki ~ 100000 nM
|
[4] | |||
| Compound Name |
1H-Indol-2-yl-[4-[2-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-methylamino]ethyl]piperazin-1-yl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910381; BDBM50419326
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|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1H-Indol-2-yl-[4-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl]piperazin-1-yl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910378; BDBM50419329
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| Activity |
EC50 = 104712.85 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 42 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
VUF-5297
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL13795; SCHEMBL7508989; BDBM50127605; AKOS006351626; (1S,2S)-2-(3H-Imidazol-4-yl)-cyclopropylamine
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| Activity |
Ki = 9.12E+14 nM
|
[9] | |||
| Compound Name |
VUF 5681
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78498; 4-[3-(1h-imidazol-4-yl)propyl]piperidine; 768358-61-8; VUF-5681; 4-[3-(1H-IMIDAZOL-4-YL)-PROPYL]-PIPERIDINE; SCHEMBL15139142; CHEBI:93084; ZINC13530263; BDBM50409817; AKOS006290761; NCGC00167742-01; KB-333611
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| Activity |
Ki = 1.62E+15 nM
|
[9] | |||
| Compound Name |
impentamine
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|
Investigative | Compound Info | ||
| Synonyms |
PDSP1_000940; PDSP2_000926
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| Activity |
Ki = 2.69E+15 nM
|
[9] | |||
| Compound Name |
Immepip
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Investigative | Compound Info | ||
| Synonyms |
Immepip; 151070-83-6; 4-(1H-Imidazol-4-ylmethyl)piperidine; 4-(1H-imidazol-5-ylmethyl)piperidine; CHEBI:81390; Piperidine,4-(1H-imidazol-5-ylmethyl)-; 4-(1H-Imidazol-4-ylmethyl)-piperidine; 4-((1H-imidazol-4-yl)methyl)piperidine; Immepip, Dihydrobromide; 4-IMP; Tocris-0932; AC1MI02O; CHEMBL18661; ACMC-20n643; ZINC5777; SCHEMBL3338054; GTPL1251; BDBM22542; CTK4C6867; DTXSID10164703; FCH842654; BDBM50150945; AKOS006273473; AKOS015964158; 4-(3H-imidazol-4-ylmethyl)piperidine; NCGC00024883-01; NCGC00024883-02; CC-16184; KB-33506
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| Activity |
Ki = 4.57E+16 nM
|
[9] | |||
| Compound Name |
imbutamine
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|
Investigative | Compound Info | ||
| Synonyms |
Imbutamine; 4-(1H-imidazol-5-yl)butan-1-amine; 40546-47-2; 1H-Imidazole-4-butanamine; imidazole-4-butanamine; 4-(4-aminobutyl)imidazole; CHEMBL90019; GTPL1249; SCHEMBL3885328; CTK8I6140; BDBM22907; DTXSID90542303; 4-(1H-imidazol-4-yl)butanamine; VJSUMPPMFYQOMP-UHFFFAOYSA-N; VUF-4701; 4-(1H-Imidazol-4-yl)-butylamine; BDBM50170164; AKOS032954093; AKOS006310860
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| Activity |
Ki = 6.92E+16 nM
|
[9] | |||
| Compound Name |
(2S)-2-[[4-(3-Piperidin-1-ylpropoxy)phenyl]methylamino]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238446; BDBM50001753
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|
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| Activity |
Ki = 331131.12 nM
|
[10] | |||
| Compound Name |
4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)methyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594266; BDBM50304522
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|
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| Activity |
Ki = 376600 nM
|
[11] | |||
| Compound Name |
2,4-Imidazolidinedione, 5,5-diphenyl-3-(3-(1-piperidinyl)propyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233067; 5,5-Diphenyl-3-(3-(1-piperidinyl)propyl)-2,4-imidazolidinedione; 3-(3-(1-Piperidyl)propyl)-5,5-diphenylhydantoin; 5,5-diphenyl-3-[3-(1-piperidinyl)propyl]-2,4-imidazolidinedione; SCHEMBL11713773; DTXSID90202253; 5,5-diphenyl-3-(3-piperidin-1-ylpropyl)imidazolidine-2,4-dione; BDBM50001755; ZINC33823602
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|
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| Activity |
Ki = 489778.82 nM
|
[10] | |||
| Compound Name |
3-[5-Methyl-4-[4-(3-piperidin-1-ylpropoxy)phenyl]-1,2,4-triazol-3-yl]pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3238445; BDBM50001752; 3-(5-methyl-4-(4-(3-(piperidin-1-yl)propoxy)phenyl)-4h-1,2,4-triazol-3-yl)pyridine
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|
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| Activity |
Ki = 1412537.54 nM
|
[10] | |||
| Compound Name |
(5,7-Dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338937; SCHEMBL604650; (5,7-dichloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133011; (5,7-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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|
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| Activity |
Ki = 5000345.35 nM
|
[12] | |||
| Compound Name |
(4,5-Dichloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129436; SCHEMBL6130844; (4,5-dichloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133018; DB-102274; (4,5-Dichloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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|
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| Activity |
Ki = 5000345.35 nM
|
[12] | |||
| Compound Name |
(7-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129488; SCHEMBL2167036; (7-methyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50132999; ZINC13526677; DB-102344; (7-methyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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| Activity |
Ki = 6998419.96 nM
|
[12] | |||
| Compound Name |
(5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128613; SCHEMBL604107; (5-bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133005; ZINC13526656; AKOS017188762; (5-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
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| Activity |
Ki = 7998342.55 nM
|
[12] | |||
| Compound Name |
(7-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129540; SCHEMBL6130862; (7-amino-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133004; ZINC13526674; AKOS012418634; DB-102341; (7-amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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| Activity |
Ki = 7998342.55 nM
|
[12] | |||
| Compound Name |
(5,7-Difluoro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129444; SCHEMBL604377; (5,7-difluoro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133019; (5,7-Difluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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|
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| Activity |
Ki = 13995873.23 nM
|
[12] | |||
| Compound Name |
(5-Fluoro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL436381; (5-fluoro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; MLS001214246; SCHEMBL603452; HMS2871N19; BDBM50132996; STK298869; ZINC20028330; AKOS005428853; MCULE-6862698414; SMR000543901; (5-Fluoro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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| Activity |
Ki = 14996848.36 nM
|
[12] | |||
| Compound Name |
(5-Amino-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340740; (5-Amino-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone; SCHEMBL6141960; (5-amino-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133001; ZINC13526669; AKOS012419079; DB-102308
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| Activity |
Ki = 14996848.36 nM
|
[12] | |||
| Compound Name |
(7-Chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL338051; SCHEMBL605903; (7-chloro-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133016; (7-Chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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| Activity |
Ki = 19010782.8 nM
|
[12] | |||
| Compound Name |
(5-Hydroxy-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL128958; SCHEMBL6130834; (5-hydroxy-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133007; ZINC13526666; DB-102317; (5-hydroxy-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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| Activity |
Ki = 23014418.17 nM
|
[12] | |||
| Compound Name |
(5,7-Dimethyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129026; SCHEMBL6130873; (5,7-dimethyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133008; DB-102307; (5,7-Dimethyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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| Activity |
Ki = 30974192.99 nM
|
[12] | |||
| Compound Name |
(4-Bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128505; SCHEMBL6130876; (4-bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone; BDBM50133009; (4-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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| Activity |
Ki = 31988951.1 nM
|
[12] | |||
| Compound Name |
(5-Methyl-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128088; (5-methyl-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone; SCHEMBL601515; BDBM50133017; STK166449; ZINC19859265; AKOS005409247; MCULE-6140668924; (5-methyl-1H-indol-2-yl)(4-methylpiperazino)methanone; (5-Methyl-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone
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| Activity |
Ki = 46025657.36 nM
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[12] | |||
| Compound Name |
(7-Bromo-1H-indol-2-yl)-(4-methylpiperazin-1-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL128252; SCHEMBL602369; CTK1D2077; DTXSID50433460; BDBM50133015; (7-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone; (7-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone; Piperazine, 1-[(7-bromo-1H-indol-2-yl)carbonyl]-4-methyl-
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| Activity |
Ki = 61094202.49 nM
|
[12] | |||
| Compound Name |
1H-Imidazol-5-yl(piperidin-4-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL345954; BDBM50474432
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|
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| Activity |
Ki = 2.09E+12 nM
|
[9] | |||
| Compound Name |
4-(1H-Imidazol-5-yl)-1,2,3,6-tetrahydropyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150243; BDBM50474429; ZINC14985637
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| Activity |
Ki = 3.80E+12 nM
|
[9] | |||
| Compound Name |
2-(1H-Imidazol-4-ylmethyl)piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150703; BDBM50474434; L009041
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| Activity |
Ki = 1.12E+14 nM
|
[9] | |||
| Compound Name |
2-[2-(1H-Imidazol-5-yl)ethyl]piperidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150512; BDBM50474431; AKOS006313058
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| Activity |
Ki = 2.24E+14 nM
|
[9] | |||
| Compound Name |
4-[1-(1H-Imidazol-4-yl)vinyl]piperidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL152936; BDBM50474428; ZINC13530299
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| Activity |
Ki = 3.55E+14 nM
|
[9] | |||
| Compound Name |
4-(1H-Imdazol-4-yl)piperidine
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Investigative | Compound Info | ||
| Synonyms |
4-(1H-imidazol-5-yl)piperidine; 4-(1H-imidazol-4-yl)piperidine; 4-(1H-Imidazole-4(5)-yl) piperidine; 4-(4-imidazolyl)piperidine; Piperidine, 4-(1H-imidazol-4-yl)-; CHEMBL358028; 4-(1H-IMIDAZOL-5-YL)-PIPERIDINE; SCHEMBL3308039; SCHEMBL8515054; 4-(4-piperidyl)-1H-imidazole; 4-(4-piperidyl)1-H-imidazole; DTXSID40443316; 4-(4-piperidyl) 1-H-imidazole; 4-(4-piperidyl)-1-H-imidazole; KS-00000NQ9; ZINC2577862; BDBM50474422; MFCD02179572; AKOS006352052; AKOS022634729; AB62367; CS-W005814; FS-3355; GT-2035; MCULE-2144343716; NE25541; VP80155; AC-11983; AK-49020; BR-49020; AB0034619; FT-0687467; X8797; EN300-89815; S-7343; F2167-2439; METHYLTHIENO[3,2-B!THIOPHENE-2-CARBOXYLATE,97
Click to Show/Hide
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| Activity |
Ki = 4.57E+14 nM
|
[9] | |||
| Compound Name |
Piperidine, 4-(1H-imidazol-4-ylmethylene)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL356666; CTK0J7802; DTXSID80472625; BDBM50474425; L009047
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| Activity |
Ki = 5.75E+14 nM
|
[9] | |||
| Compound Name |
6-(1H-Imidazol-5-yl)hexan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL554031; SCHEMBL9220957; VUF-4732; BDBM50407522
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| Activity |
Ki = 1.32E+15 nM
|
[9] | |||
| Compound Name |
3-(1H-Imidazol-5-ylmethyl)piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151467; SCHEMBL15944212; CTK9A2066; BDBM181143; US9138393, Immepip dihydrobromide; US9144538, Immepip dihydrobromide; piperidine,3-(1h-imidazol-4-ylmethyl)-; 3-((1H-Imidazol-4-yl)methyl)piperidine; L009043
Click to Show/Hide
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| Activity |
Ki = 1.62E+15 nM
|
[9] | |||
| Compound Name |
2-[3-(1H-Imidazol-5-yl)propyl]piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152948; BDBM50474430
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|
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| Activity |
Ki = 1.74E+15 nM
|
[9] | |||
| Compound Name |
3-[3-(1H-Imidazol-5-yl)propyl]piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL154529; BDBM50150943
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| Activity |
Ki = 2.57E+15 nM
|
[9] | |||
| Compound Name |
4-[2-(1H-Imidazol-4-yl)ethyl]piperidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150701; 4-[2-(1H-imidazol-5-yl)ethyl]piperidine; Piperidine, 4-[2-(1H-imidazol-5-yl)ethyl]-; SCHEMBL6353897; CTK8I0996; VUF-4929; BDBM50409216; AKOS006312757
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| Activity |
Ki = 2.69E+15 nM
|
[9] | |||
| Compound Name |
3-[2-(1H-Imidazol-4-yl)ethyl]piperidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL153207; BDBM50150944; AKOS006312758
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||||
| Activity |
Ki = 3.09E+15 nM
|
[9] | |||
| Compound Name |
(S)-4-(Pyrrolidin-3-ylmethyl)-1H-imidazole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL153051; BDBM50474424
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||||
| Activity |
Ki = 7.08E+15 nM
|
[9] | |||
| Compound Name |
[2-(1H-Imidazol-5-yl)cyclopropyl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153284; SCHEMBL6136828; BDBM50474423; AKOS006350308; L021278
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||||
| Activity |
Ki = 8.91E+15 nM
|
[9] | |||
| Compound Name |
5-(Pyrrolidin-3-ylmethyl)-1H-imidazole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL153061; SCHEMBL8515210; BDBM50474427
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||||
| Activity |
Ki = 1.95E+16 nM
|
[9] | |||
| Compound Name |
(R)-4-(Pyrrolidin-3-ylmethyl)-1H-imidazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440730; BDBM50474433
Click to Show/Hide
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||||
| Activity |
Ki = 2.69E+16 nM
|
[9] | |||
| Compound Name |
1H-Imidazole-4-propanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Imidazolyl-4-propylamine; 3-(1H-imidazol-5-yl)propan-1-amine; 1H-Imidazole-4-propylamine; Homohistamine; 3-(1h-imidazol-4-yl)propan-1-amine; 3-(1H-IMIDAZOL-4-YL)PROPYLAMINE; EINECS 254-968-6; 4-(3-aminopropyl) imidazole; CHEMBL91353; 3-(5-imidazolyl)-propylamine; 3-(imidazol-4-yl)propylamine; SCHEMBL1073990; SCHEMBL8609440; 3-(imidazol-4-yl)-propylamine; 3-(imidazole-4-yl)-propylamine; BDBM22906; CTK1D7617; CTK7E7803; DTXSID20193569; 4-(3-aminopropyl)-1H-imidazole; 3-(1H-imidazol-4-yl)propanamine; 1H-IMIDAZOLE-5-PROPANAMINE; 3-(1h-imidazol-4-yl)propyl amine; VUF-8326; ZINC5116857; 3-(1H-Imidazol-4-yl)-propylamine; BDBM50474435; AKOS006240507; AKOS022633180; AB10031; BB 0261525
Click to Show/Hide
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||||
| Activity |
Ki = 2.88E+16 nM
|
[9] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
Ki = 2.63E+14 nM
|
[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H 3 R ligands. Eur J Med Chem. 2018 May 25;152:223-234. | ||||
| REF 2 | Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist. J Med Chem. 2004 May 6;47(10):2414-7. | ||||
| REF 3 | Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands. Eur J Med Chem. 2014 Aug 18;83:534-46. | ||||
| REF 4 | Synthesis and evaluation of novel ligands for the histamine H1 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold. Bioorg Med Chem Lett. 2013 Jan 1;23(1):132-7. | ||||
| REF 5 | 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity. Bioorg Med Chem Lett. 2016 Jan 15;26(2):292-300. | ||||
| REF 6 | A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. J Med Chem. 2003 Jul 3;46(14):3162-5. | ||||
| REF 7 | Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4886-91. | ||||
| REF 8 | Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6274-80. | ||||
| REF 9 | Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists. J Med Chem. 2003 Dec 4;46(25):5445-57. | ||||
| REF 10 | Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties. Eur J Med Chem. 2014 Apr 22;77:269-79. | ||||
| REF 11 | 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96. | ||||
| REF 12 | STUDIES ON NOVEL NON-IMIDAZOLE HUMAN H4?RECEPTOR ANTAGONISTS USING GFA AND FREE-WILSON ANALYSIS. Med Chem Res. 2004;13:619-30. | ||||
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