Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T27445 | Target Info | |||
| Target Name | Bacterial Isoleucyl-tRNA synthetase (Bact ileS) | ||||
| Synonyms |
ileS; Isoleucine--tRNA ligase of Escherichia coli; IRS of Escherichia coli
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| Target Type | Successful Target | ||||
| Gene Name | Bact ileS | ||||
| Biochemical Class | Carbon-oxygen ligase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(2R,3S,4R,5S)-5-[(6-Aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161561
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| Activity |
IC50 ~ 128000 nM
|
[1] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[(6-aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161581
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| Activity |
IC50 ~ 128000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(2R,3S,5R)-5-(6-Aminopurin-9-yl)-3-hydroxyoxolan-2-yl] N-[(2S,3S)-2-amino-3-methylpentanoyl]sulfamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1789972; BDBM50370457
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| Activity |
IC50 = 280000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 1'-Homonucleosides and their structural analogues: A review. Eur J Med Chem. 2016 Aug 8;118:121-42. | ||||
| REF 2 | Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3389-93. | ||||
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