Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28330 | Target Info | |||
| Target Name | Cholecystokinin receptor type A (CCKAR) | ||||
| Synonyms |
CCKAR; CCK-AR; CCK-A receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | CCKAR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217957; H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo
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| Activity |
IC50 = 8.51E+11 nM
|
[1] | |||
| Compound Name |
(3S)-3-Amino-4-[[(2S)-1-[[(2S)-1-[[(3S,6S,9S,12S,15S,18S)-6-benzyl-9-(carboxymethyl)-15-(1H-indol-3-ylmethyl)-3-methyl-12-(2-methylsulfanylethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,16-hexazacyclononadec-18-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372074
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(3S)-3-{[(2S)-1-[(2S)-2-{2-[(2R)-2-[(2S)-2-Amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanehydrazido]-1-oxo-3-phenylpropan-2-yl]carbamoyl}-3-[(2S)-2-[(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-(1H-indol-2-yl)propanamido]hexanamido]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414087; BDBM50202108
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| Activity |
IC50 = 2.82E+13 nM
|
[1] | |||
| Compound Name |
(3S)-3-[(2S)-2-[(2R)-2-Amino-3-(1H-indol-2-yl)propanamido]hexanamido]-3-{[(2S)-1-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanehydrazido]-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407198; BDBM50202112
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| Activity |
IC50 = 9.77E+13 nM
|
[1] | |||
| Compound Name |
H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-Boc
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL386186; BDBM50202111
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| Activity |
IC50 = 1.12E+14 nM
|
[1] | |||
| Compound Name |
H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-Boc
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218600; BDBM50202107
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| Activity |
IC50 = 7.59E+15 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. | ||||
| REF 2 | Synthesis and biological evaluation of cyclic and branched peptide analogues as ligands for cholecystokinin type 1 receptor. Bioorg Med Chem. 2007 Sep 1;15(17):5845-53. | ||||
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