Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T29500 | Target Info | |||
| Target Name | Adrenergic receptor alpha-1B (ADRA1B) | ||||
| Synonyms |
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor; Alpha-1B adrenergic receptor; Alpha 1B-adrenoreceptor; Alpha 1B-adrenoceptor
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| Target Type | Successful Target | ||||
| Gene Name | ADRA1B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-fluoronorepinehprine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40317; Lopac-B-012; AC1O7G01; CTK2G6131; BDBM50087513; NCGC00015118-01; 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-5-fluoro-; 4-[(1R)-2-amino-1-hydroxyethyl]-5-fluorobenzene-1,2-diol; (R)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
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| Activity |
Ki = 134000 nM
|
[1] | |||
| Compound Name |
N-(5-Bromoquinoxalin-6-yl)-4,5-dihydro-1,3-thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73392; BDBM50213350
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| Activity |
Ki = 60255.96 nM
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[2] | |||
| Compound Name |
3-[2-[4-(4-Propan-2-ylphenyl)piperazin-1-yl]ethyl]-1H-[1]benzothiolo[3,2-d]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95986
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| Activity |
Ki = 100000 nM
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[3] | |||
| Compound Name |
N-[(3Ar,7aS)-3a,4,5,6,7,7a-hexahydro-1H-benzimidazol-2-yl]-5-bromoquinoxalin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL74342; BDBM50213349
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| Activity |
Ki = 104712.85 nM
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[2] | |||
| Compound Name |
N-(5-Bromoquinoxalin-6-yl)-4,5-dihydro-1,3-oxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73164; BDBM50213346
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| Activity |
Ki = 141253.75 nM
|
[2] | |||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Clonidine
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Approved | Compound Info | ||
| Synonyms |
clonidine; Clonidin; Duraclon; Chlornidinum; 4205-90-7; Catapres-TTS; Catarpresan; Catarpres; Adesipress; Catapres; Catapressan; Catapresan; ST 155BS; ST-155-BS; Clonidinum; Clonidina; Clonidinum [INN-Latin]; Clonidinhydrochlorid; CATAPRES-TTS-3; CATAPRES-TTS-1; CATAPRES-TTS-2; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; Isoglaucon; 2-(2,6-Dichloroanilino)-2-imidazoline; Dixarit; SKF 34427; Catapres- TTS; Clonidina [INN-Spanish]; M-5041T; Hemiton; CLORPRES; clonidine (amino form); Adesipress; Clofenil; Clopheline; Duraclont; Gemiton; Klofelin; Klofenil; M 5041T; Catapres (TN); Catarpres-TTS; ST-155BS; Tenso-Timelets; Catarpres-TTS (TN); Clonidine [USAN:BAN:INN]; Clonidine (JAN/USAN/INN); 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-(9CI); 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine; 2,6-dichloro-N-(2-imidazolidinylidene)aniline; 2,6-dichloro-N-2-imidazolidinylidenebenzenamide; 2,6-dichloro-N-imidazolidin-2-ylideneaniline; 2-((2,6-Dichlorophenyl)imino)imidazolidine; 2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2);2-(2,6-Dichloroanilino)-2-imidazoline; 2-(2,6-Dichlorophenylamino)-2-imidazoline; 2-(2,6-Dichlorophenylimino)imidazolidine; 2-Imidazoline, 2-(2,6-dichloroanilino)-(7CI,8CI); 2-[(2,6-Dichlorophenyl)imino]imidazoline; 2-[(2,6-dichlorophenyl)imino]-2-imidazoline; 734571A; 2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE
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| Activity |
Ki = 4.17E+14 nM
|
[4] | |||
| Compound Name |
3-[2-[4-(4-Tert-butylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319972; BDBM50418745
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| Activity |
Ki = 1.00E+11 nM
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[3] | |||
| Compound Name |
4-(4,5-Dihydro-1,3-oxazol-2-yl)morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL75201; 2-Morpholino-2-oxazoline; SCHEMBL11738855; CTK1J5480; DTXSID50612910; BDBM50212994; Morpholine, 4-(4,5-dihydro-2-oxazolyl)-
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| Activity |
Ki = 1.00E+12 nM
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[4] | |||
| Compound Name |
3-[2-[4-(4-Butan-2-ylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95191; BDBM50418746
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| Activity |
Ki = 1.00E+13 nM
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[3] | |||
| Compound Name |
N-(2-Oxazolin-2-yl)cycloheptanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL305928; NSC162259; CTK5J7123; ZINC1623683; BDBM50212993; NSC-162259
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| Activity |
Ki = 3.55E+13 nM
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[4] | |||
| Compound Name |
Rilmenidine
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Investigative | Compound Info | ||
| Synonyms |
Oxaminozoline; Hyperium; N-(Dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine; Rilmenidine [INN]; Rilmenidia [Spanish]; Rilmenidinum [Latin]; N-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine; 2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-; UNII-P67IM25ID8; Oxazolidine, 2-((dicyclopropylmethyl)imino)-; P67IM25ID8; Rilmenidine (INN); NSC664312; NCGC00015884-09; DSSTox_CID_25194; DSSTox_RID_80741; DSSTox_GSID_45194; NSC 664312; Oxaminozoline; Rilmenidene;S 3341; SR-01000002992; EINECS 259-021-0; S 3341; BRN 1211287; Hyperium (TN); Methylamine, 1,1-dicyclopropyl-N-(2-oxazolinyl)-; 2-Oxazolamine, 4,5-dihydro-N-(dicyclopropylmethyl)-; Tocris-0790; ARSENICTRIFLUORIDE; Lopac-R-134; Prestwick0_000982; Prestwick1_000982; Prestwick2_000982; Prestwick3_000982; Lopac0_001104; BSPBio_001043; SCHEMBL114420; SPBio_002944; BPBio1_001149; CHEMBL289480; ZINC9708; DTXSID3045194; HMS2089G15; HMS3263M10; Tox21_110254; Tox21_501104; BDBM50070328; MFCD00865924; 2-(dicyclopropylmethylamino) oxazoline; AKOS006273431; Tox21_110254_1; AB07513; CCG-205180; DB11738; LP01104; NSC-664312; SDCCGSBI-0051073.P002; NCGC00015884-01; NCGC00015884-02; NCGC00015884-03; NCGC00015884-04; NCGC00015884-05; NCGC00015884-06; NCGC00015884-07; NCGC00015884-08; NCGC00015884-10; NCGC00015884-11; NCGC00015884-13; NCGC00015884-19; NCGC00021689-02; NCGC00021689-04; NCGC00021689-05; NCGC00021689-06; NCGC00261789-01; (N-dicyclopropylmethyl)-amino-2-oxazoline; NCI60_022181; SY267932; DB-052512; HY-100490; AB00514648; CS-0019423; EU-0101104; FT-0630668; R-134; C11120; D08482; AB00513728-09; 187R041; L001230; Q967973; N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine;; SR-01000002992-3; SR-01000002992-4; W-105661; N-(Dicyclopropylmethyl)-N-(4,5-dihydro-1,3-oxazol-2-yl)amine
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| Activity |
Ki = 4.68E+13 nM
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[4] | |||
| Compound Name |
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-5,6-dihydro-4H-1,3-oxazin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306377; BDBM50212996
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| Activity |
Ki = 1.48E+14 nM
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[4] | |||
| Compound Name |
N-[(2S)-2-Propylcyclohexyl]-4,5-dihydro-1,3-oxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310335; BDBM50212997
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| Activity |
Ki = 2.51E+14 nM
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[4] | |||
| Compound Name |
2-(1,2,3,4-Tetrahydro-1-naphthylamino)-2-oxazoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL75030; N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1,3-oxazol-2-amine; SCHEMBL1724062; 1,2,3,4-Tetrahydro-N-(2-oxazolinyl)-1-naphthylamine; CTK1D6720; DTXSID20960930; 1-Naphthylamine, 1,2,3,4-tetrahydro-N-(2-oxazolin-2-yl)-; BDBM50212995; 1,2,3,4-Tetrahydro-N-(2-oxazolin-2-yl)-1-naphthalenamine
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| Activity |
Ki = 4.07E+14 nM
|
[4] | |||
| Compound Name |
3-[2-[4-(4-Butylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL330198; BDBM50418772
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| Activity |
Ki = 1.00E+15 nM
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[3] | |||
| Compound Name |
3-[2-[4-(4-Cyclohexylphenyl)piperazin-1-yl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99397
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| Activity |
Ki = 1.00E+27 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. | ||||
| REF 2 | Pharmacological evaluation of UK-14,304 analogs at cloned human alpha adrenergic receptors. Bioorg Med Chem Lett. 1995 Oct 5;5(19):2255-8. | ||||
| REF 3 | New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes. J Med Chem. 2003 Jul 3;46(14):2877-94. | ||||
| REF 4 | A convenient synthesis of 2-amino-2-oxazolines and their pharmacological evaluation at cloned human alpha adrenergic receptors. Bioorg Med Chem Lett. 1994 Oct 6;4(19):2317-22. | ||||
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