Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31514 | Target Info | |||
| Target Name | Lysosomal alpha-glucosidase (GAA) | ||||
| Synonyms |
GAA; Aglucosidase alfa; Acid maltase
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| Target Type | Successful Target | ||||
| Gene Name | GAA | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miglustat
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|
Approved | Compound Info | ||
| Synonyms |
BuDNJ; Butyldeoxynojirimycin; Miglustatum; NBV; Vevesca; Zavesca; Miglustat [USAN]; OGT 918; SC 48334; SC48334; Miglustat, Hydrochloride; N-Butyl deoxynojirimycin; N-Butyl dnj; N-Butyldeoxynojirimycin; N-Butylmoranoline; NB-DNJ; OGT-918; SC-48334; Zavesca (TN); Miglustat (USAN/INN); N-Bu-DNJ; N-Butyl-DNJ; N-Butyl-deoxynojirimycin; N-(n-Butyl)deoxynojirimycin; N-butyl-1-deoxynojirimycin; N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-N-butylimino-D-glucitol
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| Activity |
IC50 = 158000 nM
|
[1] | |||
| Compound Name |
N-Methyl-1-deoxynojirimycin
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Investigative | Compound Info | ||
| Synonyms |
2-(hydroxymethyl)-1-methylpiperidine-3,4,5-triol; N-Methylmoranoline; CHEMBL418746; N-Methylmoranolin; 3,4,5-Piperidinetriol,2-(hydroxymethyl)-1-methyl-, (2R,3R,4R,5S)-; 1,5-Dideoxy-1,5-imino-1-methyl-D-sorbitol; MOR 14;N-Methyl-1-deoxynojirimycin;N-Methylmoranolin; MeDNJ; N-Methyl-DNJ; NMDNJ; N-Methyldesoxynojirimycin; Lopac0_000773; SCHEMBL11159128; CTK5D0460; HMS3261I17; Tox21_500368; BDBM50076963; AKOS030240812; CCG-204858; LP00368; SDCCGSBI-0050751.P002; NCGC00015651-02; NCGC00261053-01; 1,5-dideoxy-1,5-(methylimino)-d-glucitol; FT-0671655; M 1777; 1,5-Dideoxy-1,5-(methylimino)-D-glucitol, 9CI; 2-Hydroxymethyl-1-methyl-piperidine-3,4,5-triol; SR-01000075982; 2-(Hydroxymethyl)-1-methyl-3,4,5-piperidinetriol; 2-hydroxymethyl-3,4,5-trihydroxy-N-methylpiperidine; SR-01000075982-1; (3R,5R)-2-Hydroxymethyl-1-methyl-piperidine-3,4,5-triol
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| Activity |
Ki = 54000 nM
|
[2] | |||
| Compound Name |
(2Z)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one O-(anilinocarbonyl)oxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62552; BDBM50070029; FT-0668988
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| Activity |
Ki = 75000 nM
|
[3] | |||
| Compound Name |
Pinazaphilone A
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593564; Pinophilin F; BDBM50104726; J3.501.542F
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| Activity |
IC50 = 81700 nM
|
[4] | |||
| Compound Name |
5-Epi-Isofagomine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1818432; (3R,4R,5S)-5-(Hydroxymethyl)piperidine-3,4-diol; (3R,4R,5S)-5-(Hydroxymethyl)-3,4-piperidinediol; CTK8F0864; DTXSID50445285; ZINC6361564; BDBM50350757; AKOS006293416
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| Activity |
Ki = 86000 nM
|
[5] | |||
| Compound Name |
5-[4-(4-Chlorophenyl)piperazin-1-yl]sulfonyl-1,3-dihydroindol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2181091; SCHEMBL2716754; BDBM50398026; NCGC00187777-01
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| Activity |
IC50 = 94310 nM
|
[6] | |||
| Compound Name |
Orsellinic acid
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Investigative | Compound Info | ||
| Synonyms |
2,4-Dihydroxy-6-methylbenzoic acid; o-Orsellinic acid; Orsellic acid; Orcinolcarboxylic acid; Benzoic acid, 2,4-dihydroxy-6-methyl-; 2,4-dihydroxy-6-methyl-benzoic acid; 4,6-Dihydroxy-o-toluic acid; UNII-11XLA0494B; 11XLA0494B; Orsellinate; 4,6-Dihydroxy-2-methylbenzoic acid; 2,4-Dihydroxy-6-methyl benzoic acid; 2,4-Dihydroxy-6-methylbenzenecarboxylic acid; 6-Methyl-beta-resorcylic acid; Orcinolcarboxylic acid; o-Orsellinic acid monohydrate, 98%; 2,4-Dihydroxy-6-methylbenzoate; 2,4-Dihydroxy-6-methylbenzoic acid hydrate; Orsellinsaeure; Spectrum_000594; ACMC-20a2aq; SpecPlus_000120; Spectrum2_000305; Spectrum3_001284; Spectrum4_001598; Spectrum5_000316; 6-Methyl- -resorcylic acid; BSPBio_002887; KBioGR_002216; KBioSS_001074; SPECTRUM300001; DivK1c_006216; SCHEMBL522294; SPBio_000270; CHEMBL457583; MEGxm0_000096; CTK1D5882; KBio1_001160; KBio2_001074; KBio2_003642; KBio2_006210; KBio3_002107; KS-00000MNK; 6-Methyl-.beta.-resorcylic acid; DTXSID20197385; ZINC901157; .beta.-Resorcylic acid, 6-methyl-; 6587AB; ANW-53904; BBL103122; BDBM50104645; CCG-38582; LMPK13010001; MFCD00210536; MFCD16661187; STL556932; AKOS000349074; MCULE-3047851108; SDCCGMLS-0066472.P001; NCGC00095565-01; NCGC00095565-02; AK-77256; DS-17030; SC-91572; AM20040543; BB 0218020; CS-0023315; FT-0693806; C01839; 480D648; Q414421; SR-05000002400; SR-05000002400-1
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Penicidone D
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593569; BDBM50104670; J3.501.544B
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Orcinol
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Investigative | Compound Info | ||
| Synonyms |
3,5-Dihydroxytoluene; 5-methylbenzene-1,3-diol; 5-METHYLRESORCINOL; 1,3-Dihydroxy-5-methylbenzene; Orcin; 5-Methyl-1,3-benzenediol; 1,3-Benzenediol, 5-methyl-; 5-Methylresorcin; 3,5-Toluenediol; 3-Hydroxy-5-methylphenol; Resorcinol, 5-methyl-; Orcinol, 5-methylresorcinol; 5-Methyl Resorcinol; MFCD00002291; Oricinol; Orcinol anhydrous; NSC 12441; 5-Methyl-1,3-dihydroxybenzene; UNII-534PMB3438; 3,5-Dihydroxy-toluene; 5-Methylresorcinol anhydrous; 5-Methyl-benzene-1,3-diol; 534PMB3438; Orcinol, 98%; EINECS 207-984-2; BRN 1071903; Orcine; AI3-23954; 5-methyl-resorcinol; resorcinol monohydrate; Orcinol, 97%; PubChem15386; 5-methylbenzen-1,3-diol; Methylresorcinol (Related); WLN: QR CQ E1; SCHEMBL68497; 4-06-00-05892 (Beilstein Handbook Reference); 5-Methylresorcinol, anhydrous; KSC269I4F; CHEMBL110059; DTXSID2060123; CTK1G9442; KS-00000JFA; ZINC391826; HY-D0168; NSC12441; ANW-30987; BBL027377; BDBM50104667; c0155; NSC-12441; s9329; SBB006928; STL146540; AKOS000280922; 1,5-DIHYDROXY-3-METHYLBENZENE; CCG-266088; CS-W008652; MCULE-5278471842; NE10165; SC10142; AC-10290; AK-40748; AS-14515; SC-13774; ST058419; SY002780; DB-022064; FT-0620669; M0426; M1235; C00727; O-2990; 153D395; 504M154; A828110; Q412476; F0001-1314
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(3,5-Dihydroxyphenyl)-3-methyl-5alpha-hydroxy-2-cyclopentene-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593567; BDBM50104672; J3.501.540J
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3R,4S,5R)-2-(Hydroxymethyl)-6-[[(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methylimino]piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2368788; BDBM50285809
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|
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| Activity |
Ki = 100000 nM
|
[7] | |||
| Compound Name |
3-O-Methylfunicone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593571; Methylfunicone; SCHEMBL902950; MEGxm0_000103; ACon0_000934; ACon1_000360; BDBM50104668; ZINC31156764; MCULE-9569164128; Q15410219
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Precose
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|
Investigative | Compound Info | ||
| Synonyms |
acarbose; Glucobay; Bay-g-5421; Prandase; Beta-Acarbose; BAY-g 5421; CHEMBL1566; Bay g 5421; DSSTox_CID_26034; DSSTox_RID_81300; DSSTox_GSID_46034; Glucor; Arcabose; Ascarbose; NCGC00159353-02; Acarbose, >=95%; SCHEMBL16848; GTPL6791; DTXSID8046034; BCPP000442; HMS3269L19; HMS3413P19; HMS3677P19; HMS3713B18; Tox21_111597; BDBM50333465; s1271; ZINC85537042; AKOS024457233; Tox21_111597_1; BCP9000224; CCG-220568; NCGC00160515-02; AB01274765-01; AB01274765_02; Q338005; BRD-K44276885-001-01-7; BRD-K44276885-001-07-4; Acarbose, European Pharmacopoeia (EP) Reference Standard; UNII-T58MSI464G component XUFXOAAUWZOOIT-SXARVLRPSA-N; Acarbose, United States Pharmacopeia (USP) Reference Standard; Acarbose for identification, European Pharmacopoeia (EP) Reference Standard; Acarbose, Pharmaceutical Secondary Standard; Certified Reference Material
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| Activity |
IC50 = 102000 nM
|
[8] | |||
| Compound Name |
3-Anilino-5,7a-bis(hydroxymethyl)-2,4a,6,7-tetrahydrocyclopenta[b][1,4]oxazine-5,6,7-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL314403; BDBM50283599; 5,7a-Bis-hydroxymethyl-3-phenylamino-2,4a,5,6,7,7a-hexahydro-cyclopenta[1,4]oxazine-5,6,7-triol
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|
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| Activity |
IC50 ~ 118000 nM
|
[9] | |||
| Compound Name |
5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetrol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88413; 5-amino-1-C-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol; SCHEMBL7109677; BDBM50283598; 5-amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol; 5-Amino-1-hydroxymethyl-cyclopentane-1,2,3,4-tetraol; 5-amino-1 -(hydroxymethyl)cyclopentane-1,2,3,4-tetraol
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| Activity |
IC50 = 162000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 29 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Acarbose
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|
Approved | Compound Info | ||
| Synonyms |
acarbose; 56180-94-0; Glucobay; Precose; Prandase; C25H43NO18; CHEBI:2376; CHEMBL3734896; BAY-g 5421; 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-D-glucopyranose; SMR000466376; SR-01000759407; Acarbose/; Acarbose [USAN:BAN:INN:JAN]; Acarbose,(S); Precose (TN); AC1L26GM; Acarbose (JAN/USAN/INN); MLS006011898; MLS000759506; MLS001424056; SPECTRUM1505172; SCHEMBL5316305; CHEMBL404271; BDBM23406; MolPort-002-507-369
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| Activity |
IC50 = 817380 nM
|
[10] | |||
| Compound Name |
BAICALEIN
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Phase 2 | Compound Info | ||
| Synonyms |
baicalein; 491-67-8; 5,6,7-Trihydroxyflavone; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; Noroxylin; Biacalein; BaiKalein; Baicelein; UNII-49QAH60606; NSC661431; NSC 661431; CHEMBL8260; 5,6,7-trihydroxy-2-phenylchromen-4-one; CHEBI:2979; FXNFHKRTJBSTCS-UHFFFAOYSA-N; MFCD00017459; 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-phenyl-; 49QAH60606; 5,7-Trihydroxyflavone; 5,6,7-trihydroxy-2-phenyl-chromen-4-one; Sho-saiko-to; SMR000112462; SR-01000597499; Baicalein, 8; Baicalein,(S); 3WL; Baicalein, 14; Baicalein, 98%; AC1NQYPP; Tocris-1761
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| Activity |
IC50 = 500000 nM
|
[11] | |||
| Compound Name |
1,5-Dideoxy-1,5-imino-D-xylitol
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|
Investigative | Compound Info | ||
| Synonyms |
PIPERIDINE-3,4,5-TRIOL; (3R,4r,5S)-piperidine-3,4,5-triol; CHEMBL110830; 13042-55-2; 1,5-dideoxy-1,5-imino-xylitol; XYLOSE-DERIVED 1-DEOXY-NOJIRIMYCIN; XDN; dideoxyiminoxylitol; 1,5-Dideoxy-1,5-imino-D-xylitol; AC1L9IA9; SCHEMBL955713; SCHEMBL2435095; SCHEMBL2435099; 1,5-dideoxy-1,5-iminoxylitol; MolPort-042-605-431; 172588-13-5; 3alpha,4beta,5alpha-Piperidinetriol; FCH951710; 3alpha,4alpha,5alpha-Piperidinetriol; BDBM50182798; (3S,5R)-piperidine-3,4,5-triol; AKOS006351347; ZINC104595290; ZINC100872034; AKOS006294154
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| Activity |
IC50 > 1000000 nM
|
[12] | |||
| Compound Name |
2,5-Dideoxy-2,5-Imino-D-Glucitol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL259905; (2R,3R,4R,5S)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol; 2,5-Pyrrolidinedimethanol, 3,4-dihydroxy-, (2S,3R,4R,5R)-; 2,5-Anhydro-2,5-imino-D-glucitol; (+)-DGDP; SCHEMBL4319863; ZINC3870709; BDBM50234564; (+)-2,5-dideoxy-2,5-imino-d-glucitol; W-201072; Q63390510; (2S,3R,4R,5R)-2,5-bis(hydroxymethyl)pyrrolidine-3,4-diol
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|
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| Activity |
IC50 = 300000 nM
|
[13] | |||
| Compound Name |
5-Aminocyclopentane-1,2,3,4-tetrol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL87120; SCHEMBL10824967; BDBM50283600; AKOS006338476; 5-Amino-cyclopentane-1,2,3,4-tetraol
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| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86865; BDBM50283601; 2-anilino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]oxazole-4,5,6-triol
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|
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| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
2-Anilino-6a-(hydroxymethyl)-3a,4,5,6-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86772; BDBM50283602; 6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol
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| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
2-Anilino-4-(hydroxymethyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]oxazole-5,6-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313375; BDBM50283603; 4-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-5,6-diol
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| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
2-Anilino-6-(hydroxymethyl)-3a,4,5,6a-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88408; BDBM50283604; 6-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol
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| Activity |
IC50 > 300000 nM
|
[9] | |||
| Compound Name |
(2S,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088291; N-Butyl-L-altro-1-deoxynojirimycin; BDBM50312530; ZINC11681341; 1-Butyl-2beta-(hydroxymethyl)piperidine-3alpha,4alpha,5beta-triol
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| Activity |
IC50 = 500000 nM
|
[14] | |||
| Compound Name |
N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-altro-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088292; BDBM50312531
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| Activity |
IC50 = 500000 nM
|
[14] | |||
| Compound Name |
(6-Benzyliminopiperidin-2-yl)methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160579
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|
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| Activity |
Ki = 700000 nM
|
[7] | |||
| Compound Name |
N-((1S,3R,4S,5R,6R,7S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-yl)5-(adamant-1-yl-methoxy)pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL577370; BDBM50299754
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| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
(1S,3R,4S,5R,6R,7S)-7-[5-(1-Adamantylmethoxy)pentylamino]-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptane-4,5-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL573995; BDBM50299752
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| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
N-Butyl-L-ido-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1076754; SCHEMBL20576705; ZINC3957104; BDBM50312526; (2S,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
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| Activity |
IC50 > 1000000 nM
|
[14] | |||
| Compound Name |
5-Methylpiperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357108; SCHEMBL6432951; AKOS006378114
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|
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| Activity |
IC50 > 1000000 nM
|
[12] | |||
| Compound Name |
N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1086996; SCHEMBL17132912; BDBM50312527; ZINC49054534; (2S)-1-[5-(1-Adamantylmethoxy)pentyl]-2beta-(hydroxymethyl)piperidine-3beta,4alpha,5beta-triol
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|
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| Activity |
IC50 > 1000000 nM
|
[14] | |||
| Compound Name |
(1S,3R,4S,5R,6R,7S)-N-Butyl-4,5-dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL583176; BDBM50299751
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| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
5-Methylene-piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150938; BDBM50288854
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| Activity |
IC50 > 1000000 nM
|
[12] | |||
| Compound Name |
1-Butyl-5-methyl-piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL356023; BDBM50288853
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|
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| Activity |
IC50 > 1000000 nM
|
[12] | |||
| Compound Name |
N-((1S,3R,4S,5R,6R,7S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-yl)butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL584580; BDBM50299753
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|
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| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3R,4R,5S)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
1-deoxy-L-idonojirimycin; CHEMBL175901; L-ido-1-Deoxynojirimycin; SCHEMBL4330678; 1,5-dideoxy-1,5-imino-l-iditol; ZINC3870514; BDBM50312525; (2S,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; (2S,3R,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
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| Activity |
IC50 > 1000000 nM
|
[14] | |||
| Compound Name |
(1S,3R,4S,5R,6R,7S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL574865; BDBM50299750
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| Activity |
IC50 > 1000000 nM
|
[15] | |||
| Compound Name |
5-Methoxy-piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414447; BDBM50288852
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| Activity |
IC50 > 1000000 nM
|
[12] | |||
| Compound Name |
1-Butyl-piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152232; SCHEMBL3378984; 1-butylpiperidine-3,4,5-triol; BDBM50288855
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||||
| Activity |
IC50 > 1000000 nM
|
[12] | |||
| Compound Name |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5S)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL179409; 1-Deoxy-L-altrostatin; L-altro-1-Deoxynojirimycin; SCHEMBL4619759; BDBM50163445; ZINC13612564; (2s,3s,4r,5s)-2-(hydroxymethyl)piperidin-3,4,5-triol; (2S,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; (2S,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
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||||
| Activity |
IC50 > 1000000 nM
|
[14] | |||
| Compound Name |
[(2R,3R)-4-[(2S,3S,4S)-3,4-Dihydroxy-2-(hydroxymethyl)thiolan-1-ium-1-yl]-1,3-dihydroxybutan-2-yl] sulfate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3349573; BDBM50219337
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||||
| Activity |
IC50 = 3400000 nM
|
[16] | |||
| Compound Name |
2-Benzyliminopiperidine
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Investigative | Compound Info | ||
| Synonyms |
ChemDiv3_003637; N-benzyl-N-[(2E)-piperidin-2-ylidene]amine; benzyliminopiperidine; SCHEMBL7626970; CHEMBL1160578; HMS1483F07; ZINC198159; AKOS015867898; MCULE-7530408734; IDI1_021547; 2-benzylamino-3,4,5,6-tetrahydropyridine
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||||
| Activity |
Ki = 3700000 nM
|
[7] | |||
| Compound Name |
(5-Benzyliminopyrrolidin-2-yl)methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160576
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||||
| Activity |
Ki = 4000000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N-Butyl-l-deoxynojirimycin (l-NBDNJ): Synthesis of an Allosteric Enhancer of alpha-Glucosidase Activity for the Treatment of Pompe Disease. J Med Chem. 2017 Dec 14;60(23):9462-9469. | ||||
| REF 2 | Isotope edited NMR studies of glycosidases: design and synthesis of a novel glycosidase inhibitor. Bioorg Med Chem Lett. 1999 May 3;9(9):1255-60. | ||||
| REF 3 | A new strong inhibitor of beta-mannosidase. Bioorg Med Chem Lett. 1998 Feb 17;8(4):371-2. | ||||
| REF 4 | Polyketides with alpha-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1. J Nat Prod. 2015 Aug 28;78(8):1816-22. | ||||
| REF 5 | Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors. Bioorg Med Chem Lett. 1999 Feb 22;9(4):615-8. | ||||
| REF 6 | Discovery of a novel noniminosugar acid alpha glucosidase chaperone series. J Med Chem. 2012 Sep 13;55(17):7546-59. | ||||
| REF 7 | Inhibition of glycosidases by substituted amidines. Bioorg Med Chem Lett. 1995 Nov 16;5(22):2655-60. | ||||
| REF 8 | Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one. Eur J Med Chem. 2013 Jan;59:304-9. | ||||
| REF 9 | Potent glycosidase inhibitors, N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-1-C-(hydroxymethyl)-cyclopentane-1,2,3,4-tetraols. Bioorg Med Chem Lett. 1994 Nov;4(22):2643-8. | ||||
| REF 10 | Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential alpha-glucosidase inhibitors. Eur J Med Chem. 2017 Jan 5;125:423-429. | ||||
| REF 11 | Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1659-62. | ||||
| REF 12 | Synthesis of a new inhibitor of alpha-fucosidase. Bioorg Med Chem Lett. 1996 Mar 5;6(5):553-8. | ||||
| REF 13 | Iminosugar-producing Thai medicinal plants. J Nat Prod. 2005 Aug;68(8):1238-42. | ||||
| REF 14 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010 Jan 28;53(2):689-98. | ||||
| REF 15 | Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. | ||||
| REF 16 | Glycosidase inhibition by cyclic sulfonium compounds. Bioorg Med Chem Lett. 2001 May 7;11(9):1137-9. | ||||
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