Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D00YEV
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| Former ID |
DNC007144
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| Drug Name |
BAICALEIN
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| Synonyms |
baicalein; 491-67-8; 5,6,7-Trihydroxyflavone; 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one; Noroxylin; Biacalein; BaiKalein; Baicelein; UNII-49QAH60606; NSC661431; NSC 661431; CHEMBL8260; 5,6,7-trihydroxy-2-phenylchromen-4-one; CHEBI:2979; FXNFHKRTJBSTCS-UHFFFAOYSA-N; MFCD00017459; 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-phenyl-; 49QAH60606; 5,7-Trihydroxyflavone; 5,6,7-trihydroxy-2-phenyl-chromen-4-one; Sho-saiko-to; SMR000112462; SR-01000597499; Baicalein, 8; Baicalein,(S); 3WL; Baicalein, 14; Baicalein, 98%; AC1NQYPP; Tocris-1761
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| Drug Type |
Small molecular drug
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| Indication | Influenza virus infection [ICD-11: 1E30-1E32] | Phase 2 | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H10O5
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| Canonical SMILES |
C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
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| InChI |
1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
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| InChIKey |
FXNFHKRTJBSTCS-UHFFFAOYSA-N
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| CAS Number |
CAS 491-67-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
12209, 509734, 596570, 5403906, 8142409, 8147158, 8616665, 10319020, 11113153, 11114203, 11342029, 11362212, 11363321, 11365883, 11368445, 11372534, 11374312, 11376607, 11484308, 11487614, 11488282, 11491423, 11492352, 11494241, 11537766, 14824071, 22395190, 24870246, 26612582, 26679906, 26747176, 26747177, 26758283, 29203872, 39290387, 46499858, 47515418, 47810866, 48035247, 48110555, 48421895, 48428137, 49889783, 50104952, 50122813, 50786403, 53787168, 53800848, 57358247, 71822546
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| ChEBI ID |
CHEBI:2979
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| References | Top | |||
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| REF 1 | ClinicalTrials.gov (NCT03830684) A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase IIa Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of Improve Other Aspects of Healthy Adult With Influenza Fever. U.S. National Institutes of Health. | |||
| REF 2 | Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. | |||
| REF 3 | Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. | |||
| REF 4 | Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. | |||
| REF 5 | Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008 Aug 1;16(15):7516-24. | |||
| REF 6 | Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6195-8. | |||
| REF 7 | Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. | |||
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