Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31992 | Target Info | |||
| Target Name | Carbonic anhydrase XIV (CA-XIV) | ||||
| Synonyms |
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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| Target Type | Successful Target | ||||
| Gene Name | CA14 | ||||
| Biochemical Class | Alpha-carbonic anhydrase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Phenyl Boronic acid
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Investigative | Compound Info | ||
| Synonyms |
Phenylboronic acid
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| Activity |
Ki ~ 50000 nM
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[1] | |||
| Compound Name |
Phenylarsonic acid
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Investigative | Compound Info | ||
| Synonyms |
BENZENEARSONIC ACID; 1998/5/5; Monophenylarsonic acid; Arsonic acid, phenyl-; UNII-57F9KU116M; Kyselina benzenarsonova [Czech]; HSDB 6381; EINECS 202-631-9; NSC 15566; Arsonic acid, As-phenyl-; BRN 2935741; AI3-16050; CHEMBL364571; CHEBI:29851; 57F9KU116M; Kyselina benzenarsonova; C6H7AsO3; benzenarsonic acid; Benzenearsonie acid; ACMC-20ajwq; PhAsO3H2; PhAsO(OH)2; AC1Q1HDM; AC1L1OLG; KSC489M9F; 4-16-00-01183 (Beilstein Handbook Reference); SCHEMBL707127; WLN: Q-AS-QO & DTXSID6059158; CTK3I9692; BDBM26997
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| Activity |
Ki = 84000 nM
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[2] | |||
| Compound Name |
Tert-butyl N-(dipropylsulfamoyl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL375030; BDBM50428813
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| Activity |
Ki = 52600 nM
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[3] | |||
| Compound Name |
2,5-Dihydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
gentisic acid; Benzoic acid, 2,5-dihydroxy-; Hydroquinonecarboxylic acid; Gentisate; 5-Hydroxysalicylic acid; Gensigen; Gensigon; 2,5-Dioxybenzoic acid; 2,5-Dhba; Gentisinic acid; Salicylic acid, 5-hydroxy-; Kyselina gentisinova; Gentisinate; UNII-VP36V95O3T; MFCD00002460; NSC 27224; Kyselina 2,5-dihydroxybenzoova; 3,6-dihydroxybenzoic acid; 2,5-Dihydroxy benzoic acid; CHEMBL1461; VP36V95O3T; BENZOIC ACID,2,5-DIHYDROXY; Gentinatre; Gentalpin; Gentasol; Gentidol; Gentisan; Gentisod; Legential; Nagentis; Casate; Gabail; Nagent; Carboxyhydroquinone; Casate sodium; Gensalate sodium; Sodium-Gent; WLN: QVR BQ EQ; GENTISATE SODIUM; 2,5-Dihydroxybenzoic acid, 99%; Acido gentisico; Acide gentisique; Acidum gentisicum; Kyselina gentisinova [Czech]; NSC8512; Acide gentisique [INN-French]; Acido gentisico [INN-Spanish]; Acidum gentisicum [INN-Latin]; Gentisic acid [INN]; EINECS 207-718-5; Acido 2,5-diidrossibenzoico [Italian]; BRN 2209119; Kyselina 2,5-dihydroxybenzoova [Czech]; Acido 2,5-diidrossibenzoico; AI3-60431; Dihydroxybenzoicacid; 2,5-Dioxybenzoate; GENOP; 5-hydroxy-Salicylate; Mesalamine Impurity G; 3,6-Dihydroxybenzoate; Gentisinic acid polymer; PubChem14414; Spectrum_001241; 2,5dihydroxybenzoic acid; 5-hydroxy-Salicylic acid; Spectrum2_000773; Spectrum3_001326; Spectrum4_001821; Spectrum5_000581; 2,5-DihydroxybenzoicAcid; ACMC-1AP4E; 2,5,dihydroxybenzoic acid; bmse000326; SCHEMBL3690; 2,5-dihydroxy-benzoic acid; 2,5-Dihydroxybenzoate, VI; NCIOpen2_000913; Oprea1_039290; BSPBio_003051; KBioGR_002487; KBioSS_001721; 4-10-00-01441 (Beilstein Handbook Reference); KSC236E9L; MLS002207134; Benzoicacid, 2,5-dihydroxy-; DivK1c_000538; SPBio_000846; ZINC1507; DTXSID4060078; CTK1D6295; HMS501K20; KBio1_000538; KBio2_001721; KBio2_004289; KBio2_006857; KBio3_002271; KS-00000COX; NINDS_000538; 2,5-Dihydroxybenzoic acid, 98%; NSC27224; NSC49098; ANW-30725; BBL013232; BDBM50335808; CCG-40154; NSC-27224; NSC-49098; s3799; SBB058777; STK426343; AKOS003267857; AS04641; CS-W001179; HY-W001179; MCULE-7171470745; PS-6232; VZ22769; IDI1_000538; NCGC00178325-01; AC-23625; AK-49825; SC-46608; SMR000393742; SY014321; gentisic acid (2,5-dihydroxybenzoic acid); DB-051598; D0569; D2933; FT-0610382; FT-0667079; ST50824443; EN300-81715; 2,5-Dihydroxybenzoic acid, analytical standard; C00628; K-9198; AE-562/40605400; Q417831; W-106033; 26A2CD0F-7EBD-431F-8BDA-168766205AE1; Z275164274
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| Activity |
Ki = 67000 nM
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[4] | |||
| Compound Name |
2,4-Dihydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
beta-Resorcylic acid; Benzoic acid, 2,4-dihydroxy-; 4-Carboxyresorcinol; 4-Hydroxysalicylic acid; p-Hydroxysalicylic acid; beta-Resorcinolic acid; 2,4-Dhba; RESORCYLIC ACID, BETA; 2,4-Dihydroxy benzoic acid; 2,4-Dihydroxy-benzoic acid; 2,4-Resorcylic acid; .beta.-Resorcylic acid; UNII-LU39SC9JYL; MFCD00002451; NSC 13564; .beta.-Resorcinolic acid; LU39SC9JYL; MLS001055408; FEMA 3798; 2,4-Dihydroxybenzoic acid, 97%; RESORCINOL-4-CARBOXYLIC ACID; SMR001227190; EINECS 201-946-9; BRN 1946213; AI3-24366; ss--Resorcylic acid; Coupler 320; BETA-RESORCYCLIC; b-Resorcylic acid, 8CI; Resorcylic acid, .beta.; DSSTox_CID_5074; 2,4-dihyrdoxybenzoic acid; beta resoryclic acid form I; cid_1491; 2,4- dihydroxybenzoic acid; DSSTox_RID_77652; DSSTox_GSID_25074; Oprea1_259729; SCHEMBL28080; 4-10-00-01420 (Beilstein Handbook Reference); KSC448I6H; Benzoicacid, 2,4-dihydroxy-; ACMC-209r37; RESORCYLIC ACID, BETA-; 2,4-bis(oxidanyl)benzoic acid; CHEMBL328910; PARAGOS 500011; RARECHEM AL BE 0221; DTXSID0025074; BDBM74208; CTK3E8463; 2,4-hidyroxybenzoic acid form I; NSC4740; HMS3039A13; HMS3604D11; LABOTEST-BB LTBB002154; ZINC388544; KS-00000JR6; NSC-4740; NSC13564; Tox21_202471; ANW-39377; BBL011673; LABOTEST-BB LT03329713; LABOTEST-BB LT03333379; NSC-13564; s6293; SBB058728; STK299216; 2,4-Dihydroxybenzoic acid, >=97%; AKOS001434143; AS00962; CS-W013291; DB02839; HY-W012575; MCULE-8411449236; VZ34380; NCGC00090922-01; NCGC00090922-02; NCGC00260020-01; AC-10404; AK-88714; DS-18507; SC-25753; ST097458; 2 4-DIHYDROXYBENZENECARBOXYLIC ACID; D0568; FT-0614326; T8270; 115808-EP2295416A2; 115808-EP2298748A2; AE-562/41921969; L001160; Q209206; 2,4-Dihydroxybenzoic acid; 4-Hydroxysalicylic acid; W-100355; F1995-0247; 2,4-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 97%
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| Activity |
Ki = 70000 nM
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[4] | |||
| Compound Name |
N1,N12-Bis(trifluoroacetyl)-N4,N8-bis(t-butoxycarbonyl)spermine
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Investigative | Compound Info | ||
| Synonyms |
NSC685983; CHEMBL1212954; SCHEMBL1274571; CTK8C8096; BDBM50323745; NSC-685983; NCI60_030965; di-tert-butyl butane-1,4-diylbis({3-[(trifluoroacetyl)amino]propyl}carbamate)
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| Activity |
Ki = 85000 nM
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[5] | |||
| Compound Name |
(E)-4-(4-Hydroxyphenyl)-1-[(2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]but-3-en-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323140; BDBM50426823; (E)-1-(beta-D-Galactopyranosyl)-4-(4-hydroxyphenyl)-3-butene-2-one
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
(E)-4-(3-Hydroxyphenyl)-1-[(2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]but-3-en-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323139; BDBM50426824; (E)-1-(beta-D-Galactopyranosyl)-4-(3-hydroxyphenyl)-3-butene-2-one
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
Spermine(hbbh)
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Investigative | Compound Info | ||
| Synonyms |
NSC685984; CHEMBL209126; di-boc-spermine; SCHEMBL1274075; CTK8C8100; ZINC5713956; BDBM50184773; MFCD08274632; N4,N8-Bis(t-butoxycarbonyl)spermine; AKOS030214416; NSC-685984; NCI60_030966; di-tert-butyl butane-1,4-diylbis[(3-aminopropyl)carbamate]; N2,N3-Bis-(t-butyloxycarbonyl)-1,5,10,14-tetra-aza-quatrodecan; Carbamic acid, 1,4-butanediylbis[(3-aminopropyl)-,bis(1,1-dimethylethyl) ester
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| Activity |
Ki = 115000 nM
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[5] | |||
| Compound Name |
N1,N3-Bis(2-(2,2,2-trifluoroacetamido)ethyl)-propane-1,3-diaminium trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214249; BDBM50323746
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| Activity |
Ki = 125000 nM
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[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Foscavir
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Approved | Compound Info | ||
| Synonyms |
Foscarmet; Foscarnet; Phosphonoformate; Triapten; Virudin; Carboxyphosphonic acid; Dihydroxyphosphanecarboxylic acid oxide; Dihydroxyphosphinecarboxylic acid oxide; Dihydroxyphosphinecarboxylic acid oxide trisodium salt; Dihydroxyphosphinecarboxylic acid oxide trisodium salt hexahydrate; FOSCARNET SODIUM; Forscarnet sodium; Foscarnet sodico; Foscarnet sodico [Spanish]; Foscarnet sodique; Foscarnet sodique [French]; Foscarnet sodium hexahydrate; Foscarnet sodium hydrate; Foscarneto sodico; Foscarnetum natricum; Foscarnetum natricum [Latin]; Phgosphonocarboxylic acid; Phosphonoformic acid; Phosphonomethanoic acid; Trisodium carboxyphosphate; Trisodium dioxidophosphanecarboxylate oxide; Trisodium dioxidophosphinecarboxylate oxide; Trisodium phosphonatoformate; Trisodium phosphonatoformate hexahydrate; Trisodium phosphonoformate; Trisodium phosphonoformate hexahydrate; Trisodium phosphonoformte hexahydrate; A 29622; EHB 776; A-29622; DRG-0017; Dihydroxyphosphinecarboxylic acid oxide and MSL, neutralizing monoclonal antibody; EHB-776; Foscarnet sodique [INN-French]; Foscarnet sodium hydrate (JAN); Foscarneto sodico [INN-Spanish]; Foscarnetum natricum [INN-Latin]; Foscavir (TN); HS-0008; MSL & PFA; Phosphonoformic acid, trisodium salt; Trisodium carboxyphosphate (anhydrous); Trisodium phosphonoformate (anhydrous); Foscarnet & IFN-ALPHA; Foscarnet sodium (USAN/INN); Foscarnet sodium [USAN:INN:BAN]; Phosphonoformic acid & IFN-ALPHA; Phosphonoformic acid, trisodium salt, hexahydrate; PFA & rIFN.alpha.A; Phosphinecarboxylic acid, dihydroxy-, oxide; Phosphonoformate(trisodium) & Recombinant Alpha-A Interferon; Sodium dioxidophosphanecarboxylate oxide hydrate(3:1:6); Formic acid, phosphono-, trisodium salt, hexahydrate; Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt; Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt, hexahydrate
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| Activity |
Ki = 3600000 nM
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[7] | |||
| Compound Name |
SULFAMIDE
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Phase 1 | Compound Info | ||
| Synonyms |
Sulfuric diamide; 7803-58-9; Sulfamamide; Sulfuryl amide; Sulfuryl diamide; Sulfonyl diamide; sulfamoylamine; sulphamide; Sulphuric diamide; UNII-VS7TZW634V; Imidosulfamic acid; H4N2O2S; H2NSO2NH2; VS7TZW634V; CHEMBL355001; CHEBI:29368; NVBFHJWHLNUMCV-UHFFFAOYSA-N; MFCD00011606; Sulfamide, 98+%; Imidosulfamic acid (VAN); aminosulfonamide; NSC 252; diamidodioxidosulfur; EINECS 232-262-9; Sulfamide, 99%; AI3-30237; NH2SO2NH2; AC1Q55HN; KSC377O7F; NSC252; AC1L332P; DTXSID5064885; CTK2H7772; BDBM26995; NSC-252; MolPort-000-146-081
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| Activity |
Ki = 750000 nM
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[8] | |||
| Compound Name |
N-(Dipropylsulfamoyl)-N-propylpropan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL441884; BDBM50428805
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| Activity |
Ki > 200000 nM
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[3] | |||
| Compound Name |
N,N,N',N'-Tetrabutylsulfamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229902; BDBM50428804; N,N,N'''',N''''-Tetrabutylsulfamide; N-butyl-N-(dibutylsulfamoyl)butan-1-amine
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| Activity |
Ki > 200000 nM
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[3] | |||
| Compound Name |
N,N'-Dipropylsulfamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229740; N,N''''-Dipropylsulfamide; SCHEMBL9651043; N-(propylsulfamoyl)propan-1-amine; BDBM50428809
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| Activity |
Ki > 200000 nM
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[3] | |||
| Compound Name |
2-Phenyl-N-(2-phenylethylsulfamoyl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630902; BDBM50428811
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| Activity |
Ki > 200000 nM
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[3] | |||
| Compound Name |
Di-tert-butylethane-1,2-diylbis(2-(2,2,2-trifluoroacetamido)ethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214322; SCHEMBL10231797; BDBM50323749; 1,10-Bis(trifluoroacetyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7,10-tetraazadecane
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| Activity |
Ki > 500000 nM
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[5] | |||
| Compound Name |
Di-tert-butylpropane-1,3-diylbis(2-(2,2,2-trifluoroacetamido)-ethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214320; BDBM50323747
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| Activity |
Ki > 500000 nM
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[5] | |||
| Compound Name |
N1,N2-(2-(2,2,2-Trifluoroacetamido)ethyl)ethane-1,2-diaminium Trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214321; SCHEMBL10231803; BDBM50323748; 2,2,2-trifluoro-N-[2-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethylamino]ethyl]acetamide
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| Activity |
Ki > 500000 nM
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[5] | |||
| Compound Name |
2-Hydroxycinnamic acid
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Investigative | Compound Info | ||
| Synonyms |
o-Coumaric acid; trans-2-Hydroxycinnamic acid; 2-Coumaric acid; trans-o-Coumaric acid; trans-o-Hydroxycinnamic acid; 2-Hydroxycinnamate; 2-Coumarate; (E)-o-Hydroxycinnamic acid; trans-2-Hydroxycinnamate; (2E)-3-(2-hydroxyphenyl)prop-2-enoic acid; o-Hydroxy-trans-cinnamic acid; 3-(2-hydroxyphenyl)acrylic acid; (E)-3-(2-Hydroxyphenyl)-2-propenoic acid; (2E)-3-(2-HYDROXYPHENYL)ACRYLIC ACID; 2-Hydroxycinamic acid; (E)-3-(2-hydroxyphenyl)prop-2-enoic acid; trans-2-coumaric acid; (2E)-3-(2-Hydroxyphenyl)-2-propenoic acid; 2-Hydroxycinnamic acid, (E)-; CINNAMIC ACID, o-HYDROXY-, (E)-; UNII-23AU5FZB9C; (E)-2-hydroxycinnamic acid; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (2E)-; trans-ortho-coumaric acid; MFCD00004379; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E)-; 23AU5FZB9C; (2E)-2-hydroxycinnamic acid; 2-Propenoic acid, 3-(2-hydroxyphenyl)-; CHEMBL52564; 2-Hydroxycinnamic acid, predominantly trans; 3-(2-hydroxyphenyl)prop-2-enoic acid; o-coumarate; (E)-3-(2-hydroxyphenyl)acrylic acid; 2-Hydroxy Cinnamic Acid; (E)-3-(2-HYDROXY-PHENYL)-ACRYLIC ACID; 3-(2-hydroxyphenyl)prop-2-enoate; CCRIS 5834; cis-2-hydroxycinnamic acid; EINECS 210-386-4; NSC 32952; BRN 1100900; o-Hydroxycinnamate; 3-(2-Hydroxyphenyl)-2-propenoic acid; trans-o-Coumarate; (2Z)-3-(2-hydroxyphenyl)acrylic acid; ortho-Hydroxycinnamate; PubChem8214; (E)-Coumarinic Acid; (2Z)-3-(2-hydroxyphenyl)acrylate; trans-o-Hydroxycinnamate; (E)-ortho-coumaric acid; o-Hydroxy-trans-cinnamate; (E)-o-Hydroxycinnamicacid; bmse000347; Cinnamic acid, o-hydroxy-; WLN: QV1U1R BQ; SCHEMBL64885; QSPL 150; trans-o-HydroxyzimtsA currencyure; 2-Hydroxycinnamic acid, (2E)-; DTXSID10883240; ZINC895911; ALBB-025832; NSC32952; BBL013048; BDBM50146462; NSC-32952; SBB065726; STK301745; AKOS003790794; CS-W013247; DB01650; MCULE-5451854573; (E)-3-(2-hydroxyphenyl)-acrylic acid; CINNAMIC ACID,2-HYDROXY (TRANS); trans-3-(2-hydroxyphenyl)propenoic acid; AS-12449; ST097457; R1101; C01772; 2-Hydroxycinnamic acid, predominantly trans, 97%; 614H608; 3-(4-OXOQUINAZOLIN-3(4H)-YL)PROPANOICACID; Q7072006; TRANS-2-HYDROXYCINNAMIC ACID; O-COUMARIC ACID; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E)- (9CI); F2191-0203; (2E)-3-(2-hydroxyphenyl)acrylic acid predominately trans-; 90E8F55A-AB69-4720-95AF-747C2DCA5471; UNII-2S0H1PX3LM component PMOWTIHVNWZYFI-AATRIKPKSA-N
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| Activity |
Ki > 1000000 nM
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[9] | |||
| Compound Name |
Sulfamic acid
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Investigative | Compound Info | ||
| Synonyms |
Amidosulfonic acid; Aminosulfonic acid; Sulphamic acid; Amidosulfuric acid; Imidosulfonic acid; Sulfamidic acid; Sulfaminic acid; Jumbo; Sulphamidic acid; Aminosulfuric acid; Kyselina sulfaminova; Kyselina amidosulfonova; sulfuramidic acid; NSC 1871; MFCD00011603; UNII-9NFU33906Q; amidohydroxidodioxidosulfur; H2NSO3H; CHEMBL68253; [S(NH2)O2(OH)]; 9NFU33906Q; Sulfamic acid, 99%; DSSTox_CID_14005; DSSTox_RID_79107; DSSTox_GSID_34005; Caswell No. 809; Kyselina sulfaminova [Czech]; HSDB 795; Kyselina amidosulfonova [Czech]; EINECS 226-218-8; UN2967; SULFAMIC ACID, ACS; EPA Pesticide Chemical Code 078101; SULFAMIC ACID, REAG; sulfoamine; Sulfamidsaeure; AI3-15024; Sulphamic-acid-; Amidoschwefelsaeure; amidosulphuric acid; sulfamic acid group; Sulfamic acid [UN2967] [Corrosive]; WLN: ZSWQ; sulfuric acid amide group; NH2SO3H; Sulfamic acid, ACS grade; ACMC-20a47z; NH3SO3; EC 226-218-8; NCIOpen2_000675; KSC269M4H; ARONIS25155; Molybdenum, Quant Test Strips; DTXSID6034005; BDBM26994; CTK1G9643; NSC1871; Sulfamic acid, p.a., 99.5%; Sulfamic acid, analytical standard; NS([O])(=O)=O; KS-000000UE; NSC-1871; Sulfamic acid, reagent grade, 98%; Tox21_201905; Tox21_303482; 8894AF; ANW-56397; STL282725; 7773-06-0 (mono-ammonium salt); AKOS005287325; Sulfamic acid, ACS reagent, 99.3%; ZINC238809066; MCULE-8047713803; UN 2967; KS-0000472G; NCGC00090927-01; NCGC00090927-02; NCGC00257489-01; NCGC00259454-01; Sulfamic acid [UN2967] [Corrosive]; Sulfamic acid, ReagentPlus(R), >=99%; Sulfamic acid, >=99.5% (alkalimetric); FT-0688102; Sulfamic acid, 99.999% trace metals basis; Sulfamic acid, SAJ first grade, >=99.0%; Sulfamic acid, JIS special grade, >=99.5%; Q412304; W-105754; Sulfamic acid, analytical standard (for acidimetry), ACS reagent
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| Activity |
Ki = 1090000 nM
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[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Bortezomib inhibits mammalian carbonic anhydrases. Bioorg Med Chem. 2017 Oct 1;25(19):5064-5067. | ||||
| REF 2 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1532-7. | ||||
| REF 3 | Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV. Bioorg Med Chem. 2013 Mar 15;21(6):1410-8. | ||||
| REF 4 | Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15;21(6):1564-9. | ||||
| REF 5 | Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. | ||||
| REF 6 | Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1489-94. | ||||
| REF 7 | Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2210-5. | ||||
| REF 8 | Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. | ||||
| REF 9 | Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. | ||||
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