Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32880 | Target Info | |||
| Target Name | HIF-prolyl hydroxylase 2 (HPH-2) | ||||
| Synonyms |
SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12
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| Target Type | Patented-recorded Target | ||||
| Gene Name | EGLN1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 150 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Succinic acid
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|
Approved | Compound Info | ||
| Synonyms |
Asuccin; Bernsteinsaeure; Bernsteinsaure; Butandisaeure; Katasuccin; SIN; Succ; Succinellite; Wormwood; Acid of amber; Acide butanedioique; Acide succinique; Acidum succinicum; Amber acid; Bernsteinsaure [German]; Butanedioic acid diammonium salt; Butanedionic acid; Dihydrofumaric acid; Ethanedicarboxylic acid; Ethylene dicarboxylic acid; Ethylene succinic acid; Ethylenesuccinic acid; Kyselina jantarova; Kyselina jantarova [Czech]; Potassium Succinate; Sal succini; Spirit of amber; Succinicum acidum; Succinicun acidum; Wormwood acid; A 12084; Butanedioic acid (9CI); SUCCINIC ACID, ACS; Succinate, 9; Succinic acid (8CI); Amber acid, Butanedioic acid, Ethylenesuccinic acid; 1,2-Ethanedicarboxylic acid; 1,4-BUTANEDIOIC ACID (SUCCINIC ACID); 1,4-Butanedioic acid
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| Activity |
IC50 = 85300 nM
|
[1] | |||
| Compound Name |
PMID25468267-Compound-46
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Patented | Compound Info | ||
| Activity |
IC50 = 83000 nM
|
[2] | |||
| Compound Name |
daminozide
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Investigative | Compound Info | ||
| Synonyms |
DMASA; SADH; B 995; Alar; Kylar; B-NINE
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1'-(Pyrimidin-2-ylmethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042270; BDBM50385828
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1'-(1,2,4-Oxadiazol-3-ylmethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042269; BDBM50385835
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1'-(1-Methylimidazole-2-carbonyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042720; SCHEMBL19210882; BDBM50385877
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1'-(1-Pyridin-2-ylethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042841; BDBM50385838
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Phenyl-1'-pyridin-2-ylsulfonylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042840; BDBM50385837
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1'-[(4-Methyl-1,2,4-triazol-3-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042268; BDBM50385872
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1'-(Pyrazin-2-ylmethyl)-1-quinolin-3-ylspiro[indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040865; BDBM50385873
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-2-[[4,6-Bis(trifluoromethyl)-1H-benzimidazole-2-carbonyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688400; SCHEMBL17137650; BDBM50418039
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|
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| Activity |
IC50 = 50118.72 nM
|
[5] | |||
| Compound Name |
2-[(6-Methoxy-1H-benzimidazole-2-carbonyl)amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688398; SCHEMBL4310717; SCHEMBL13625961; BDBM50418037
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| Activity |
IC50 = 50118.72 nM
|
[5] | |||
| Compound Name |
(3R)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112295; SCHEMBL15268763; BDBM240953; US9409892, 48; (R)-3-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-3-phenyl-propionic acid
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| Activity |
IC50 = 50150 nM
|
[6] | |||
| Compound Name |
3-{[1-Benzyl-5-(5-fluoro-pyridin-3-yl)-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl]-amino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671943; SCHEMBL12503012; BDBM141625; US8921389, 81
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| Activity |
IC50 = 51000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Hydroxy-3-[[4-hydroxy-7-(phenylcarbamoylamino)isoquinoline-3-carbonyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976287; SCHEMBL15268772; BDBM241022; US9409892, 117; (S)-2-Hydroxy-3-{[4-hydroxy-7-(3-phenyl-ureido)-isoquinoline-3-carbonyl]-amino}-propionic acid
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| Activity |
IC50 = 51440 nM
|
[6] | |||
| Compound Name |
4-[[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl]oxane-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931611; SCHEMBL15268485; BDBM240920; US9409892, 15
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| Activity |
IC50 = 51520 nM
|
[6] | |||
| Compound Name |
1-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676816; SCHEMBL12502438; BDBM141731; US8921389, 189
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| Activity |
IC50 = 51800 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911115; SCHEMBL15268603; BDBM240991; US9409892, 86; 2-(S)-Amino-3-[(1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-propionic acid
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| Activity |
IC50 = 51920 nM
|
[6] | |||
| Compound Name |
(2S)-2-Hydroxy-4-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909207; SCHEMBL15268825; BDBM240912; US9409892, 7; 2-(S)-Hydroxy-4-[(4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-butyric acid
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| Activity |
IC50 = 52740 nM
|
[6] | |||
| Compound Name |
3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-5-methylhexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928868; SCHEMBL15268581; BDBM240971; US9409892, 66; 3-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-5-methyl-hexanoic acid
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| Activity |
IC50 = 53520 nM
|
[6] | |||
| Compound Name |
3-[[1-Benzyl-5-hydroxy-8-(2-methylsulfanylpyrimidin-5-yl)-2-oxo-3-phenyl-1,7-naphthyridine-6-carbonyl]amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676833; SCHEMBL12502374; BDBM141748; US8921389, 208
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| Activity |
IC50 = 54000 nM
|
[7] | |||
| Compound Name |
3-[(1-Cyano-4-hydroxy-7-phenylmethoxyisoquinoline-3-carbonyl)amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942878; SCHEMBL15268605; BDBM241057; US9409892, 152; 3-[(7-Benzyloxy-1-cyano-4-hydroxy-isoquinoline-3-carbonyl)-amino]-3-methyl-butyric acid
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| Activity |
IC50 = 55050 nM
|
[6] | |||
| Compound Name |
1-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-cyclopropanecarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676817; SCHEMBL12503144; BDBM141732; US8921389, 190
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|
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| Activity |
IC50 = 55200 nM
|
[7] | |||
| Compound Name |
3-[(5-Hydroxy-2-oxo-1,3-diphenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671996; SCHEMBL12502923; BDBM141679; US8921389, 136; 3-[(5-hydroxy-2-oxo-1,3-diphenyl-1,7-naphthyridine-6-carbonyl)amino]propanoic acid
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| Activity |
IC50 = 56100 nM
|
[7] | |||
| Compound Name |
2-[1-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclohexyl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960131; SCHEMBL15268927; BDBM240995; US9409892, 90; {1-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-cyclohexyl}-acetic acid
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| Activity |
IC50 = 56310 nM
|
[6] | |||
| Compound Name |
4-[[7-[(4-Fluorophenyl)carbamoylamino]-4-hydroxyisoquinoline-3-carbonyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898469; SCHEMBL15268482; BDBM241047; US9409892, 142
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| Activity |
IC50 = 56350 nM
|
[6] | |||
| Compound Name |
2-[1-[[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]methyl]cyclohexyl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986270; SCHEMBL15268806; BDBM240941; US9409892, 36; (1-{[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl}-cyclohexyl)-acetic acid
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| Activity |
IC50 = 56550 nM
|
[6] | |||
| Compound Name |
3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923583; SCHEMBL15268719; BDBM240916; US9409892, 11; 3-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]butyric acid
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| Activity |
IC50 = 56640 nM
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[6] | |||
| Compound Name |
3-{[1-Benzyl-5-hydroxy-8-(6-methoxy-pyridin-3-yl)-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676808; SCHEMBL12502800; BDBM141723; US8921389, 181
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| Activity |
IC50 = 57000 nM
|
[7] | |||
| Compound Name |
5-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3918140; SCHEMBL15268531; BDBM240910; US9409892, 5; 5-[(4-Hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-pentanoic acid
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| Activity |
IC50 = 61690 nM
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[6] | |||
| Compound Name |
3-[(4-Hydroxy-7-phenylsulfanylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935577; SCHEMBL15270936; BDBM241032; US9409892, 127; 3-[(4-Hydroxy-7-phenylsulfanyl-isoquinoline-3-carbonyl)-amino]-2,2-dimethyl-propionic acid
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| Activity |
IC50 = 63120 nM
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[6] | |||
| Compound Name |
(2R,3R)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4106832; SCHEMBL15268459; BDBM240974; US9409892, 69; (2R,3R)-3-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-2-methyl-butyric acid
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| Activity |
IC50 = 64080 nM
|
[6] | |||
| Compound Name |
1-Benzyl-5-hydroxy-N-[2-(methanesulfonamido)ethyl]-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671990; SCHEMBL18043882; BDBM141673; US8921389, 130
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| Activity |
IC50 = 64800 nM
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[7] | |||
| Compound Name |
3-[(1-Benzyl-5-cyano-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671955; SCHEMBL12502768; BDBM141637; US8921389, 94; 3-[(1-benzyl-5-cyano-8-hydroxy-2-oxo-1,6-naphthyridine-7-carbonyl)amino]propanoic acid
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| Activity |
IC50 = 65000 nM
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[7] | |||
| Compound Name |
5-[(1-Cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928851; SCHEMBL15268567; BDBM241033; US9409892, 128; 5-[(1-Cyano-4-hydroxy-6-phenoxy-isoquinoline-3-carbonyl)-amino]-pentanoic acid
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| Activity |
IC50 = 65150 nM
|
[6] | |||
| Compound Name |
3-[[5-Hydroxy-1-(oxan-4-ylmethyl)-2-oxo-3-phenyl-8-pyridin-3-yl-1,7-naphthyridine-6-carbonyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676809; SCHEMBL12502862; BDBM141724; US8921389, 182
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| Activity |
IC50 = 65300 nM
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[7] | |||
| Compound Name |
(2S,3R)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897840; SCHEMBL15268902; BDBM240975; US9409892, 70; (2S,3R)-3-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-2-methyl-butyric acid
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| Activity |
IC50 = 65810 nM
|
[6] | |||
| Compound Name |
4-Thioxo-L-proline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800368; L-4-Thioproline; SCHEMBL1115994; BDBM50348089; AKOS006375750; (2S)-4-sulfanylidenepyrrolidine-2-carboxylic acid
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| Activity |
IC50 = 69700 nM
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[8] | |||
| Compound Name |
3-[(5-Hydroxy-1-methyl-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676792; SCHEMBL12502654; BDBM141707; US8921389, 165
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| Activity |
IC50 = 69800 nM
|
[7] | |||
| Compound Name |
4-[[4-Hydroxy-7-(phenylcarbamoylamino)isoquinoline-3-carbonyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984344; SCHEMBL15268926; BDBM241024; US9409892, 119
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| Activity |
IC50 = 72270 nM
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[6] | |||
| Compound Name |
2-[1-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclobutyl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938773; SCHEMBL15268913; BDBM241011; US9409892, 106; {1-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-cyclobutyl}-acetic acid
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| Activity |
IC50 = 74450 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671983; SCHEMBL12503152; BDBM141665; US8921389, 122; 3-[(1-benzyl-5-hydroxy-2-oxo-1,7-naphthyridine-6-carbonyl)amino]propanoic acid
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| Activity |
IC50 = 75000 nM
|
[7] | |||
| Compound Name |
5-[[1-(5-Fluoropyridin-3-yl)-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl]amino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924721; SCHEMBL15268794; BDBM241052; US9409892, 147; 5-{[1-(5-Fluoro-pyridin-3-yl)-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl]-amino}-pentanoic acid
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| Activity |
IC50 = 76960 nM
|
[6] | |||
| Compound Name |
4-[[7-(Cyclohexylcarbamoylamino)-4-hydroxyisoquinoline-3-carbonyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942423; SCHEMBL15268843; BDBM241036; US9409892, 131
Click to Show/Hide
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| Activity |
IC50 = 77600 nM
|
[6] | |||
| Compound Name |
2-(2-Ethoxy-2-oxoacetamido)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572739; SCHEMBL12521171; BDBM50299126; 2-[(2-ethoxy-2-oxoacetyl)amino]acetic acid
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| Activity |
IC50 = 78000 nM
|
[9] | |||
| Compound Name |
N-[(1-Chloro-4-hydroxyisoquinolin-3-YL)carbonyl]glycine
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Investigative | Compound Info | ||
| Synonyms |
FG-2216; FG2216; UNII-RU921DS4Z5; CHEMBL426560; IOX3;YM311; N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine; RU921DS4Z5; Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-; 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid; (((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid; 1-Chloro-N-(hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide; 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide; (1-chloro-4-hydroxyisoquinoline-3-carbonyl)glycine; Isoquinoline 3; SCHEMBL522744; ZINC7670; 2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid; AOB87331; BCP15220; EX-A2247; BIQ, >=98% (HPLC); BDBM50193145; MFCD23136998; s7979; YM 311; AKOS026750490; CCG-267248; CS-4210; DB08687; FG-2216; YM-311; AK323688; AS-17015; HY-15641; DB-096638; B5851; Q27097876; N-((1-Chloro-4-hydroxyisoquinoline-3-yl)carbonyl)glycine; [(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonylamino]acetic acid; 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid; 2-[(1-chloro-4-hydroxyisoquinolin-3-yl)formamido]acetic acid; [(1-Chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino]-acetic acid
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| Activity |
EC50 = 79000 nM
|
[10] | |||
| Compound Name |
(2R)-2-[[4,6-Bis(trifluoromethyl)-1H-benzimidazole-2-carbonyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688401; SCHEMBL17137737; BDBM50418040
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| Activity |
IC50 = 79432.82 nM
|
[5] | |||
| Compound Name |
Oc1cccnc1-c1nc(CC(=O)NCc2ccccc2)cs1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3310253; SCHEMBL3371417; BDBM50044980
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| Activity |
IC50 = 81000 nM
|
[11] | |||
| Compound Name |
5-[(4-Hydroxy-7-phenylsulfanylisoquinoline-3-carbonyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931006; SCHEMBL15268873; BDBM241019; US9409892, 114; 5-[(4-Hydroxy-7-phenylsulfanyl-isoquinoline-3-carbonyl)-amino]-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 86620 nM
|
[6] | |||
| Compound Name |
1-Benzyl-8-cyano-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671991; SCHEMBL18043897; BDBM141674; US8921389, 131
Click to Show/Hide
|
||||
| Activity |
IC50 = 86900 nM
|
[7] | |||
| Compound Name |
5-[[7-(4-Fluorophenyl)-4-hydroxyisoquinoline-3-carbonyl]amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930135; SCHEMBL15268818; BDBM241054; US9409892, 149
Click to Show/Hide
|
||||
| Activity |
IC50 = 86950 nM
|
[6] | |||
| Compound Name |
(R)-3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672002; SCHEMBL12502871; BDBM141685; US8921389, 142; (3R)-3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,7-naphthyridine-6-carbonyl)amino]butanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 87900 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671981; SCHEMBL12502387; BDBM141663; US8921389, 120; 3-[(1-benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,7-naphthyridine-6-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[7] | |||
| Compound Name |
3-[(4-Hydroxy-7-phenoxy-1-phenylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897397; SCHEMBL15268816; BDBM241048; US9409892, 143; 3-[(4-Hydroxy-7-phenoxy-1-phenyl-isoquinoline-3-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 88420 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671975; SCHEMBL12502344; BDBM141657; US8921389, 114
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyrazin-2-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676787; SCHEMBL12502959; BDBM141702; US8921389, 160
Click to Show/Hide
|
||||
| Activity |
IC50 = 92600 nM
|
[7] | |||
| Compound Name |
trans-4-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905554; SCHEMBL16428189; SCHEMBL16428190; BDBM240993; US9409892, 88
Click to Show/Hide
|
||||
| Activity |
IC50 = 93290 nM
|
[6] | |||
| Compound Name |
4-(Hydroxyamino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
butanoic acid, 4-(hydroxyamino)-4-oxo-; N-Hydroxy-succinamic acid; CHEMBL51979; Bernsteinsaureoxim; NSC74375; N-hydroxysuccinamic acid; N-Hydroxysuccinamidic acid; SCHEMBL240068; CTK4I9972; DTXSID20291236; BDBM50129197; MFCD01209360; NSC-74375; AKOS006374419; AK604764; DS-19751
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[9] | |||
| Compound Name |
(1R)-2-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclopentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4106681; SCHEMBL16436079; BDBM240938; US9409892, 33
Click to Show/Hide
|
||||
| Activity |
IC50 = 94810 nM
|
[6] | |||
| Compound Name |
Glycine, N-(2-methoxy-2-oxoacetyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89286; N-Carboxymethyl-oxalamic acid methyl ester; SCHEMBL16133035; BDBM50299125; N-(2-Methoxy-1,2-dioxoethyl)glycine; 2-(2-methoxy-2-oxoacetamido)acetic acid; DS-018066; 2-[(2-methoxy-2-oxoacetyl)amino]acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[9] | |||
| Compound Name |
3-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671911; SCHEMBL12503100; BDBM141593; US8921389, 49; 3-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-2,7-naphthyridine-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[7] | |||
| Compound Name |
5-Chloro-7-[benzoylamino(3-methyl-2-thienyl)methyl]-8-quinolinol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785164; BDBM50158849
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[12] | |||
| Compound Name |
(3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903918; SCHEMBL15268909; BDBM240983; US9409892, 78; 3-(S)-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 96750 nM
|
[6] | |||
| Compound Name |
2-[[3-Hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3646219; SCHEMBL12985445
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[13] | |||
| Compound Name |
2-Cyclopropyl-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965644; SCHEMBL15268671; BDBM241072; US9409892, 167; 2-Cyclopropyl-3-[(4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 99980 nM
|
[6] | |||
| Compound Name |
2-[(6-Fluoro-1H-benzimidazole-2-carbonyl)amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688397; BDBM50418036
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-[8-(Dimethylamino)octyl-hydroxyamino]-4-oxobutanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215587
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[[5-(3-Chlorophenyl)pyridine-2-carbonyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221815; BDBM50370796
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1229308; CHEMBL1215519; NCDM-32; BDBM50324535; BRD-K37429342-003-01-4; 3-{[9-(Dimethylamino)nonanoyl](hydroxy)amino}propanoicAcid Hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-({9-[Butyl(Methyl)]Amino}Nonanoyl(Hydroxy)Amino)Propanoicacid HCl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215588
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-(Isopropylamino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164248; N-isopropylsuccinamic acid; 3-(propan-2-ylcarbamoyl)propanoic acid; NSC56468; 4-oxo-4-(propan-2-ylamino)butanoic acid; Butanoic acid, 4-[(1-methylethyl)amino]-4-oxo-; SCHEMBL94233; CTK2F3983; DTXSID20288540; ALBB-033190; ZINC1687428; BDBM50395081; MFCD02675045; NSC-56468; AKOS002675066; 4-Oxo-4-(isopropylamino)butanoic acid; MCULE-6515821068
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[[6-(3-Methylphenyl)imidazo[1,2-a]pyridine-2-carbonyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413662; BDBM50370834
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4,6-Dioxoheptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Succinylacetone; Heptanoic acid, 4,6-dioxo-; succinyl acetone; NSC 174804; UNII-KZ0KV2Q190; CHEMBL222824; KZ0KV2Q190; MFCD00002797; 4.6-dioxoheptanoic acid; CCRIS 1387; Spectrum_001999; SpecPlus_000704; Heptanoic acid,6-dioxo-; Spectrum2_000467; Spectrum3_000763; Spectrum4_001249; Spectrum4_001266; BSPBio_002406; KBioGR_001778; KBioGR_001852; KBioSS_002574; DivK1c_006800; SCHEMBL503918; SPBio_000574; CTK8B9814; KBio1_001744; KBio2_002565; KBio2_005133; KBio2_007701; KBio3_001626; 4,6-Dioxoheptanoic acid, powder; DTXSID50199519; BCP17098; 7197AB; ANW-63187; BDBM50197063; CCG-39960; NSC174804; AKOS006282601; ZINC100036983; CS-W010900; HY-W010184; NSC-174804; NCGC00178670-01; AK-87990; AS-57899; DA-05297; NCI60_001428; FT-0674727; FT-0674728; 33908-EP2275420A1; 33908-EP2284148A1; 33908-EP2289882A1; 33908-EP2289886A1; 33908-EP2295055A2; 33908-EP2295416A2; 33908-EP2298748A2; 33908-EP2298764A1; 33908-EP2298765A1; 33908-EP2305627A1; 33908-EP2305642A2; 33908-EP2305661A1; 33908-EP2308855A1; 33908-EP2311453A1; 33908-EP2371797A1; 33908-EP2371798A1; 33908-EP2371800A1; 33908-EP2371802A1; 33908-EP2371804A1; 568D184; Q25324500
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[9-(Dimethylamino)nonanoyl-hydroxyamino]propanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215519
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3-Carboxypropanoylamino)-trimethylazanium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164244; BDBM50395079
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(1H-Benzimidazole-2-carbonylamino)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688395; SCHEMBL4307360; BDBM50418033; [(1h-benzoimidazole-2-carbonyl)-amino]-acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N'1,N'1,N'4,N'4-Tetramethylsuccinohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164250; SCHEMBL584428; Succinic acid dimethyl hydrazide; BDBM50395077; AKOS002685593; MCULE-9315956570
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[10-(Dimethylamino)decanoyl-hydroxyamino]propanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215520
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Picolinoylglycine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(picolinamido)acetic acid; 2-(pyridin-2-ylformamido)acetic acid; 2-[(pyridin-2-yl)formamido]acetic acid; [(pyridin-2-ylcarbonyl)amino]acetic acid; CHEMBL221255; N-(pyridin-2-ylcarbonyl)glycine; N-[(pyridin-2-yl)carbonyl]glycine; SCHEMBL1219736; BDBM50328020; MFCD08444886; ZINC20284658; AKOS000133442; MCULE-4073681274; NE13896; EN300-83280; Q27162068; Z228588744
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-Hydrazinyl-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
succinic acid Monohydrazide; Butanedioic acid, monohydrazide; CHEMBL2164246; 4-diazanyl-4-oxidanylidene-butanoic acid; NSC9925; ACMC-20d2l3; SCHEMBL960529; CTK1D8820; DTXSID10278758; 3-(hydrazinecarbonyl)propanoic acid; NSC-9925; ZINC1700248; BDBM50395083; AKOS006379804
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-Hydroxyquinoline-7-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-Hydroxy-7-quinolinecarboxylic acid; 7-Quinolinecarboxylic acid, 8-hydroxy-; MLS000738075; CHEMBL374569; MFCD00671539; NSC27445; ACMC-1C3IO; 7-carboxy-8-hydroxyquinoline; SCHEMBL1759043; CTK0I0112; DTXSID20282700; HMS2762E14; 8-hydroxyquinolin-7-carboxylic acid; 8-Hydroxyquinoline-7-carboxylicAcid; NSC35082; ZINC1641403; 0195AB; 8-hydroxyquinoline 7-carboxylic acid; ANW-23813; BBL102771; BDBM50370827; NSC-27445; NSC-35082; STL556577; 7-Quinolinecarboxylicacid, 8-hydroxy-; AKOS006230410; MCULE-3710426304; KS-0000122J; AS-37866; SC-26084; SMR000393747; AB0076465; DB-044997; FT-0637915; EN300-45043; Z-0666; 8-Hydroxy-7-quinolinecarboxylic acid, AldrichCPR; 829H799; Z1695797797
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
3-[8-(Dimethylamino)octanoyl-hydroxyamino]propanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215518
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[[4-(4-Chlorophenyl)pyridine-2-carbonyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376214; SCHEMBL1921935; BDBM50370798; ZINC40762236
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
3-[Acetyl(hydroxy)amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215449; 3-(N-Hydroxyacetamido)Propanoic Acid; SCHEMBL10045696; BDBM50324531; AKOS006387734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[Dimethylamino(methyl)amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164247; BDBM50395082
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-Quinolinecarboxylic acid, 8-hydroxy-, octyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785984; cmp5;compound 5; BDBM50158888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-[[4-Hydroxy-7-phenoxy-1-(trifluoromethyl)isoquinoline-3-carbonyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915731; SCHEMBL15268558; BDBM241050; US9409892, 145; 3-[(4-Hydroxy-7 phenoxy-1-trifluoromethyl-isoquinoline-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 101240 nM
|
[6] | |||
| Compound Name |
(R)-2-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676779; SCHEMBL12503277; BDBM141694; US8921389, 152
Click to Show/Hide
|
||||
| Activity |
IC50 = 102700 nM
|
[7] | |||
| Compound Name |
3-[[1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-[6-(trifluoromethyl)pyridin-3-yl]-1,7-naphthyridine-6-carbonyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676807; SCHEMBL12502851; BDBM141722; US8921389, 180
Click to Show/Hide
|
||||
| Activity |
IC50 = 106600 nM
|
[7] | |||
| Compound Name |
(2S,3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925927; SCHEMBL15268601; BDBM240976; US9409892, 71; (2S,3S)-3-[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-2-methyl-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 107220 nM
|
[6] | |||
| Compound Name |
Cn1nc(cc1-c1nc(C(=O)NCC(C)(C)C(O)=O)c(O)c2ccc(Oc3ccccc3)cc12)C(F)(F)F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908087; SCHEMBL15268734; BDBM241056; US9409892, 151
Click to Show/Hide
|
||||
| Activity |
IC50 = 111450 nM
|
[6] | |||
| Compound Name |
5-[[1-Cyano-6-(2,6-dimethylphenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960753; SCHEMBL15268793; BDBM241016; US9409892, 111; 5-{[1-Cyano-6-(2,6-dimethyl-phenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 111990 nM
|
[6] | |||
| Compound Name |
2-(S)-Tert-Butoxycarbonylamino-3-[(1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942538; SCHEMBL16427882; BDBM240990; US9409892, 85
Click to Show/Hide
|
||||
| Activity |
IC50 = 112250 nM
|
[6] | |||
| Compound Name |
3-[[7-[(4-Fluorobenzoyl)amino]-4-hydroxyisoquinoline-3-carbonyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909167; SCHEMBL15268989; BDBM241023; US9409892, 118; 3-{[7-(4-Fluoro-benzoylamino)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 112940 nM
|
[6] | |||
| Compound Name |
3-[[7-(4-Fluorophenyl)-4-hydroxyisoquinoline-3-carbonyl]amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902157; SCHEMBL15268478; BDBM241055; US9409892, 150
Click to Show/Hide
|
||||
| Activity |
IC50 = 113830 nM
|
[6] | |||
| Compound Name |
4-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979450; SCHEMBL15268653; BDBM240913; US9409892, 8; 4-[(4-Hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-2,2-dimethyl-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 118550 nM
|
[6] | |||
| Compound Name |
(R)-2-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671904; SCHEMBL15610676; BDBM141586; US8921389, 42
Click to Show/Hide
|
||||
| Activity |
IC50 = 129000 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2,3,4-tetrahydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671982; SCHEMBL12502551; BDBM141664; US8921389, 121; 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-3,4-dihydro-1,7-naphthyridine-6-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 132000 nM
|
[7] | |||
| Compound Name |
N-(2-Acetamidoethyl)-1-benzyl-5-cyano-8-hydroxy-2-oxo-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671956; SCHEMBL18043926; BDBM141638; US8921389, 95
Click to Show/Hide
|
||||
| Activity |
IC50 = 134000 nM
|
[7] | |||
| Compound Name |
N-(2-Acetamidoethyl)-1-benzyl-8-hydroxy-2-oxo-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671957; SCHEMBL18043906; BDBM141639; US8921389, 96
Click to Show/Hide
|
||||
| Activity |
IC50 = 137000 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-thiazol-2-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676821; SCHEMBL12503160; BDBM141736; US8921389, 195
Click to Show/Hide
|
||||
| Activity |
IC50 = 137500 nM
|
[7] | |||
| Compound Name |
1-Benzyl-8-hydroxy-2-oxo-N-(2H-tetrazol-5-ylmethyl)-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671944; SCHEMBL18043877
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[7] | |||
| Compound Name |
(S)-2-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671905; SCHEMBL15610407; BDBM141587; US8921389, 43
Click to Show/Hide
|
||||
| Activity |
IC50 = 144000 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671887; SCHEMBL12502441; BDBM141569; US8921389, 25
Click to Show/Hide
|
||||
| Activity |
IC50 = 149000 nM
|
[7] | |||
| Compound Name |
3-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958522; SCHEMBL15268681; BDBM241074; US9409892, 169; 3-[(4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-2-phenyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 152700 nM
|
[6] | |||
| Compound Name |
(R)-2-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671920; SCHEMBL12503149; BDBM141602; US8921389, 58; (2R)-2-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-2,7-naphthyridine-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 153000 nM
|
[7] | |||
| Compound Name |
4-Carboxymethyl-4-[(1-cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970083; SCHEMBL15268932; BDBM241001; US9409892, 96
Click to Show/Hide
|
||||
| Activity |
IC50 = 157720 nM
|
[6] | |||
| Compound Name |
5-[[4-Hydroxy-7-[(4-methoxyphenyl)methylamino]isoquinoline-3-carbonyl]amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963476; SCHEMBL15268680; BDBM241030; US9409892, 125; 5-{[4-Hydroxy-7-(4-methoxy-benzylamino)-isoquinoline-3-carbonyl]amino}-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 158180 nM
|
[6] | |||
| Compound Name |
(R)-3-(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-4-hydroxybutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111031; SCHEMBL15268862; BDBM240942; US9409892, 37; (3R)-3-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-4-hydroxybutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 158640 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-2-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676820; SCHEMBL12502843; BDBM141735; US8921389, 193
Click to Show/Hide
|
||||
| Activity |
IC50 = 163800 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671932; SCHEMBL12502912; BDBM141614; US8921389, 70; 3-[(1-benzyl-8-hydroxy-2-oxo-1,6-naphthyridine-7-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 167000 nM
|
[7] | |||
| Compound Name |
3-{[1-Benzyl-5-hydroxy-8-(6-methyl-pyridin-3-yl)-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676806; SCHEMBL12502925; BDBM141721; US8921389, 179
Click to Show/Hide
|
||||
| Activity |
IC50 = 176500 nM
|
[7] | |||
| Compound Name |
7-Benzyl-1-cyano-4-hydroxy-8-oxo-N-(pyridazin-4-ylmethyl)-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671922; SCHEMBL18043901; BDBM141604; US8921389, 60
Click to Show/Hide
|
||||
| Activity |
IC50 = 177000 nM
|
[7] | |||
| Compound Name |
3-[(4-Hydroxy-7-phenylisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904269; SCHEMBL15268572; BDBM241034; US9409892, 129; 3-[(4-Hydroxy-7-phenyl-isoquinoline-3-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 179680 nM
|
[6] | |||
| Compound Name |
3-[(7-Benzyl-4-hydroxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985474; SCHEMBL15268476; BDBM241051; US9409892, 146; 3-[(7-Benzyl-4-hydroxy-isoquinoline-3-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 180770 nM
|
[6] | |||
| Compound Name |
3-[(6-Benzyl-4-hydroxy-5-oxo-5,6-dihydro-[2,6]naphthyridine-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671916; SCHEMBL12503053; BDBM141598; US8921389, 54; 3-[(6-benzyl-4-hydroxy-5-oxo-2,6-naphthyridine-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 181000 nM
|
[7] | |||
| Compound Name |
(1R)-2-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]cyclohexane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4113583; SCHEMBL16436081; BDBM240937; US9409892, 32
Click to Show/Hide
|
||||
| Activity |
IC50 = 181550 nM
|
[6] | |||
| Compound Name |
1-{[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-methyl}-cyclobutanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671924; SCHEMBL12502861; BDBM141606; US8921389, 62
Click to Show/Hide
|
||||
| Activity |
IC50 = 182000 nM
|
[7] | |||
| Compound Name |
3-[(1-Cyano-4-hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3975703; SCHEMBL15268953; BDBM241028; US9409892, 123; 3[(1-Cyano-4-hydroxy-6-phenoxy-isoquinoline-3-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 183240 nM
|
[6] | |||
| Compound Name |
3-[(4-Hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984390; SCHEMBL15268474; BDBM240911; US9409892, 6; 3-[(4-Hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-3-methyl-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 191920 nM
|
[6] | |||
| Compound Name |
2-(3-Hydroxy-2-pyridinyl)-4-thiazoleacetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3310252; SCHEMBL3368044; BDBM50044981; ZINC147547503; 2-[2-(3-oxopyridin-2-ylidene)-3H-1,3-thiazol-4-yl]acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[11] | |||
| Compound Name |
7-Benzyl-1-cyano-4-hydroxy-8-oxo-N-(pyridin-4-ylmethyl)-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671910; SCHEMBL18043947; BDBM141592; US8921389, 48
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[7] | |||
| Compound Name |
(R)-3-{[5-Hydroxy-2-oxo-3-phenyl-1-(1-phenyl-ethyl)-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676803; SCHEMBL12502656; BDBM141718; US8921389, 176
Click to Show/Hide
|
||||
| Activity |
IC50 = 195500 nM
|
[7] | |||
| Compound Name |
3-{[1-Benzyl-5-hydroxy-8-(2-methyl-pyridin-3-yl)-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676805; SCHEMBL12503200; BDBM141720; US8921389, 178
Click to Show/Hide
|
||||
| Activity |
IC50 = 198900 nM
|
[7] | |||
| Compound Name |
3-[(7-Benzyl-4-hydroxy-8-oxo-1-pyridin-3-yl-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676831; SCHEMBL12502984; BDBM141746; US8921389, 206; 3-[(7-benzyl-4-hydroxy-8-oxo-1-pyridin-3-yl-2,7-naphthyridine-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
1-[[(1-Cyano-7-cyclohexylsulfonyl-4-hydroxyisoquinoline-3-carbonyl)amino]methyl]cyclobutane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4106799; SCHEMBL15268720; BDBM241066; US9409892, 161
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
3-[(1-Cyclohexylmethyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-4-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676824; SCHEMBL12502350; BDBM141739; US8921389, 198
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671969; BDBM141651; US8921389, 108
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
3-[(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894890; SCHEMBL15268469; BDBM241013; US9409892, 108; 3-[(4-Hydroxy-1-methyl-7 phenoxy-isoquinoline-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridazin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676845; SCHEMBL12502714; BDBM47090; US8921389, 203
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
5-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676790; SCHEMBL12502986; BDBM141705; US8921389, 163
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-5-hydroxy-8-methyl-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(methanesulfonyl-methyl-amino)-ethyl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671992; SCHEMBL18043904; BDBM141675; US8921389, 132
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
4-[(4-Hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958511; SCHEMBL15268547; BDBM241018; US9409892, 113; 4-[(4-Hydroxy-6-phenoxy-isoquinoline-3-carbonyl)-amino]-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-thiazol-4-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676828; SCHEMBL12502681; BDBM141743; US8921389, 202
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3,8-diphenyl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671993; SCHEMBL18043908; BDBM141676; US8921389, 133
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
3-[(4-Hydroxy-6-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957455; SCHEMBL15268471; BDBM241017; US9409892, 112; 3-[(4-Hydroxy-6-phenoxy-isoquinoline-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
5-[(7-Anilino-4-hydroxyisoquinoline-3-carbonyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965983; SCHEMBL15268499; BDBM241029; US9409892, 124; 5-[(4-Hydroxy-7-phenylamino-isoquinoline-3-carbonyl)-amino]-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
3-[(1-Cyano-4-hydroxy-2-oxido-7-phenoxyisoquinolin-2-ium-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899677; SCHEMBL15268645; BDBM241062; US9409892, 157
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
4-{[(1-Cyano-4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-methyl}-1-oxo-hexahydro-1lambda4-thiopyran-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906123; SCHEMBL16427735; BDBM240935; US9409892, 30
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-5-hydroxy-2-oxo-3-phenyl-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676818; SCHEMBL12502955; BDBM141733; US8921389, 191
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
3-[[4-Hydroxy-7-[(4-methoxyphenyl)methylamino]isoquinoline-3-carbonyl]amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971099; SCHEMBL15268576; BDBM241031; US9409892, 126; 3-{[4-Hydroxy-7-(4-methoxy-benzylamino)-isoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
3-[[1-Cyano-7-[(4-fluorobenzoyl)amino]-4-hydroxyisoquinoline-3-carbonyl]amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981062; SCHEMBL15268432; BDBM241044; US9409892, 139
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
(2R,3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111543; SCHEMBL15268875; BDBM240977; US9409892, 72
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
1-Benzyl-5-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-3-phenyl-8-pyridin-3-yl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671994; SCHEMBL18043967; BDBM141677; US8921389, 134
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
3-[(1-Cyano-7-cyclohexylsulfonyl-4-hydroxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900769; SCHEMBL15268507; BDBM241065; US9409892, 160
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
1-Benzyl-N-[2-(ethylcarbamoylamino)ethyl]-5-hydroxy-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671971; SCHEMBL18044097; BDBM141653; US8921389, 110
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
3-[(5-Hydroxy-2-oxo-1,3-diphenyl-8-pyridin-4-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676825; SCHEMBL12503048; BDBM141740; US8921389, 199
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Compound Name |
4-[[7-[(4-Fluorobenzoyl)amino]-4-hydroxyisoquinoline-3-carbonyl]amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914519; SCHEMBL15268892; BDBM241025; US9409892, 120
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
5-[[7-(2,6-Difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953733; SCHEMBL15268710; BDBM241005; US9409892, 100
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
(S)-3-{[5-Hydroxy-2-oxo-3-phenyl-1-(1-phenyl-ethyl)-8-pyridin-3-yl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl]amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676802; SCHEMBL12502890; BDBM141717; US8921389, 175
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 50 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Fumaric acid
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
Fum; Fumarsaeure; Acidum fumaricum; Allomaleic acid; Allomalenic acid; Ammonium fumarate; Boletic acid; Butenedioic acid; Kyselina fumarova; Kyselina fumarova [Czech]; Lichenic acid; Tumaric acid; F0067; OR17920; FC 33 (acid); Fumarate, 10; Fumaric acid (8CI); Fumaric acid (NF); Lichenic acid (VAN); S04-0167; Trans-Butenedioic acid; U-1149; E-2-Butenedioic acid; Trans-2-Butenedioic acid; USAF EK-P-583; Trans-1,2-Ethylenedicarboxylic acid; Trans-but-2-enedioic acid; (2E)-2-butenedioic acid; (2E)-but-2-enedioic acid; (E)-2-Butenedioic acid; 1,2-Ethylenedicarboxylic acid, (E); 2-(E)-Butenedioic acid; 2-Butenedioic acid; 2-Butenedioic acid (2E-(9CI)
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[18] | |||
| Compound Name |
5-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671914; SCHEMBL12502889; BDBM141596; US8921389, 52; 5-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-2,7-naphthyridine-3-carbonyl)amino]pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-Benzyl-1-cyano-4-hydroxy-N-methyl-8-oxo-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671900; SCHEMBL12502859; BDBM141582; US8921389, 38; 7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methylamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-8-hydroxy-N-[2-(methanesulfonamido)ethyl]-2-oxo-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671972; SCHEMBL18043898; BDBM141654; US8921389, 111
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid [2-(2,2,2-trifluoro-acetylamino)-ethyl]amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671970; SCHEMBL15611163; BDBM141652; US8921389, 109
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-(2,4-Dimethoxy-benzyl)-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid 4-fluoro-benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671940; SCHEMBL12502324; BDBM141622; US8921389, 78
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid (3-propylcarbamoyl-propyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671935; SCHEMBL18043885; BDBM141617; US8921389, 73; 7-benzyl-1-cyano-4-hydroxy-8-oxo-N-[4-oxo-4-(propylamino)butyl]-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-Benzyl-4-hydroxy-8-oxo-N-[2-(propan-2-ylcarbamoylamino)ethyl]-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671951; SCHEMBL18043981; BDBM141633; US8921389, 89
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(S)-2-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671918; SCHEMBL12502738; BDBM141600; US8921389, 56
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932529; SCHEMBL15268521; BDBM240914; US9409892, 9; 2-(S)-Amino-3-[(4-hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
3-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671912; SCHEMBL12502765; BDBM141594; US8921389, 50; 3-[(7-benzyl-1-cyano-4-hydroxy-8-oxo-2,7-naphthyridine-3-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-Benzyl-1-cyano-4-hydroxy-N-(2-morpholin-4-ylethyl)-8-oxo-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671921; SCHEMBL18043889; BDBM141603; US8921389, 59
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-5-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895011; SCHEMBL16436088; BDBM241068; US9409892, 163
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
3-[(1-Benzyl-8-hydroxy-5-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671973; SCHEMBL12502976; BDBM141655; US8921389, 112; 3-[(1-benzyl-8-hydroxy-5-methyl-2-oxo-1,6-naphthyridine-7-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
3-[(1-Benzyl-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carbonyl)-amino]-2,2-dimethyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671933; SCHEMBL12502848; BDBM141615; US8921389, 71; 3-[(1-benzyl-8-hydroxy-2-oxo-1,6-naphthyridine-7-carbonyl)amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(R)-2-[(7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carbonyl)-amino]-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671913; SCHEMBL12503168; BDBM141595; US8921389, 51
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(3S)-3-[(1-Cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2,4-trimethylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986190; SCHEMBL16436082; BDBM240966; US9409892, 61
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
1-Benzyl-5-cyano-8-hydroxy-N-methyl-2-oxo-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671941; SCHEMBL12503010; BDBM141623; US8921389, 79; 1-Benzyl-5-cyano-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid methylamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-8-hydroxy-N-[2-[methyl(methylsulfonyl)amino]ethyl]-2-oxo-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671966; BDBM141648; US8921389, 105
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
5-[(1-Benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671886; SCHEMBL12503062; BDBM141568; US8921389, 24; 5-[(1-benzyl-8-cyano-5-hydroxy-2-oxo-3-phenyl-1,7-naphthyridine-6-carbonyl)amino]pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
3-[[7-Benzyl-1-(5-fluoropyridin-3-yl)-4-hydroxy-8-oxo-2,7-naphthyridine-3-carbonyl]amino]-2,2-dimethylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671950; SCHEMBL12502607; BDBM141632; US8921389, 88
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-8-cyano-5-hydroxy-N-methyl-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671903; SCHEMBL12502792; BDBM141585; US8921389, 41
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-8-hydroxy-N-methyl-2-oxo-1,6-naphthyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671937; SCHEMBL12503086; BDBM141619; US8921389, 75; 1-Benzyl-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid methylamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-5-cyano-8-hydroxy-2-oxo-1,2-dihydro-[1,6]naphthyridine-7-carboxylic acid (2-sulfamoyl-ethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671967; SCHEMBL18043949; BDBM141649; US8921389, 106
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-5-hydroxy-N-methyl-2-oxo-3-phenyl-1,7-naphthyridine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671945; SCHEMBL12502995; BDBM141627; US8921389, 83; 1-Benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid methylamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-Benzyl-1-cyano-N-cyclopropyl-4-hydroxy-8-oxo-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671901; SCHEMBL12502370; BDBM141583; US8921389, 39; 7-Benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid cyclopropylamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
7-[(2,4-Dimethoxyphenyl)methyl]-4-hydroxy-8-oxo-N-(2-phenylethyl)-2,7-naphthyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671938; SCHEMBL12502867; BDBM141620; US8921389, 76
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485023; SCHEMBL523186; BDBM50277936; (2R)-2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[1] | |||
| Compound Name |
2-[4-[[4-[(1S,2R)-2-Aminocyclopropyl]phenyl]carbamoyl]pyridin-2-yl]pyridine-4-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3108958; BDBM50495468
Click to Show/Hide
|
||||
| Activity |
IC50 = 278000 nM
|
[19] | |||
| Compound Name |
2,5-Pyridinedicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Isocinchomeronic acid; PYRIDINE-2,5-DICARBOXYLIC ACID; 2,5-pyridinedicarboxylicacid; UNII-4K1KGR926X; Pyridinedicarboxylic acid-(2,5); CHEMBL88972; 4K1KGR926X; 2,5-Pyridinedicarboxylic acid, 98%; Pyridine 2,5-dicarboxylate; NSC 177; EINECS 202-834-2; PubChem12991; 2,5-Dicarboxy-pyridine; AI3-19238; 6-carboxy-nicotinic acid; pyridine carboxylate, 6b; ACMC-2097nz; ISOCINCHLOMERONIC ACID; SCHEMBL70231; KSC174Q6D; NSC177; ZINC5284; Pyridine 2,5-dicarboxylic acid; DTXSID3059210; BDBM26114; CTK0H4861; KS-00000IKW; pyridine-2,5- dicarboxylic acid; NSC-177; ACT07453; ANW-14205; BBL011510; MFCD00006297; SBB003886; STL146625; AKOS000119637; ACN-051112; FG-0457; MCULE-4931082325; MP-0263; NCGC00336418-01; AK-41175; BR-41175; SC-22647; DB-002412; AM20050593; FT-0610502; FT-0674189; FT-0674190; FT-0674191; P0552; ST50307920; AB00376873-03; W-204355; Q27120714; F0001-0013
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[20] | |||
| Compound Name |
3-(Carboxymethylamino)-3-oxopropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573153; SCHEMBL6471153; BDBM50299134; AKOS011512779; N-Malonylglycine, analytical reference material
Click to Show/Hide
|
||||
| Activity |
IC50 = 398000 nM
|
[9] | |||
| Compound Name |
3-(2-Fluoroanilino)pyridine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938896; SCHEMBL2880402; BDBM50361472
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
(S)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL569062; SCHEMBL523069; BDBM50303764; (2S)-2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[1] | |||
| Compound Name |
(R)-2-(1-Chloro-4-hydroxyisoquinoline-3-carboxamido)-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568873; SCHEMBL523381; BDBM50303763; (2R)-2-[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]-3-methylbutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[1] | |||
| Compound Name |
[[5-(2-Naphthyl)pyridine-2-yl]carbonylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115297; SCHEMBL15482045; BDBM50446899
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
2-(2,3-Dioxo-3-phenylpropanamido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573195; BDBM50299136; N-(3-Phenyl-2,3-dioxopropionyl)glycine
Click to Show/Hide
|
||||
| Activity |
IC50 = 538000 nM
|
[9] | |||
| Compound Name |
2-(3-Hydroxyureido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573239; glycyl hydroxamic acid; 3-hydroxy-ureido-acetic acid; SCHEMBL10801282; 2-(hydroxycarbamoylamino)acetic acid; BDBM50299131; AKOS006356672
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-(3-Oxo-3-phenylpropanamido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574825; BDBM50299133
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
N-Oxalyl-D-homophenylalanine, 1c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452623; SCHEMBL13383787; BDBM26108; (2R)-2-(oxaloamino)-4-phenylbutanoic acid; (2R)-2-(formamidoformic acid)-4-phenylbutanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[22] | |||
| Compound Name |
2-(2,3-Dioxopiperazin-1-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572972; SCHEMBL8177700; BDBM50299130
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-(2-(Benzylamino)-2-oxoacetamido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573258; BDBM50299128
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
(2R)-3-(Naphthalen-1-ylmethylsulfanyl)-2-(oxaloamino)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030873; BDBM50383013
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
N-(Carboxycarbonyl)-S-(Naphthalen-2-Ylmethyl)-L-Cysteine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030872; BDBM50383012; Q27463093; MD3
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
5-(Ethylamino)-4,5-dioxopenthanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573259; BDBM50299129
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-(3-Ethoxy-3-oxopropanamido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573194; BDBM50299135
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-(2-Methoxy-2-oxoethylamino)-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573196; SCHEMBL18039446; BDBM50299137
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
N-(Carboxycarbonyl)-S-(3-Nitrobenzyl)-L-Cysteine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030869; BDBM50383011; Q27463094; MD5
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[23] | |||
| Compound Name |
Glycine, N-(1,3-dioxobutyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(Acetoacetyl)glycine; 2-(3-Oxobutanamido)acetic acid; Acetoacetamide, N-carboxymethyl-; CHEMBL573193; 2-(3-oxobutanoylamino)acetic acid; EINECS 221-459-5; SCHEMBL1055886; (Acetoacetylamino)acetic acid #; DTXSID0062846; (-)-CAMPHORCARBOXYLICACID; STR00569; ZINC5196434; BDBM50299132; AKOS010501571; FT-0629262
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-(2-(Ethylamino)-2-oxoacetamido)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572969; BDBM50299127
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| Activity |
IC50 > 1000000 nM
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[9] | |||
| Compound Name |
Isocitric acid
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Investigative | Compound Info | ||
| Synonyms |
isocitrate; 1-Hydroxypropane-1,2,3-tricarboxylic acid; DL-Isocitric acid; I-CIT; 3-carboxy-2,3-dideoxypentaric acid; 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid; UNII-9RW6G5D4MQ; 1-Hydroxytricarballylic acid; 9RW6G5D4MQ; 1-Hydroxy-1,2,3-propanetricarboxylic acid; D-isocitrate; pentaric acid, 3-carboxy-2,3-dideoxy-; 1-Hydroxy-1,2,3-propanetricarboxylate; EINECS 206-282-3; isocitric acid(8ci); 1-hydroxytricarballylate; Isocitric acid (8CI); threo-d(s)-iso-citrate; SCHEMBL8373; CHEMBL539669; BDBM92496; CTK7J1585; DTXSID60861871; 3-carboxy-2,3-dideoxy-Pentarate; NSC203797; 3-carboxy-2,3-dideoxy-Pentaric acid; AKOS006227850; NSC-203797; DB-005441; FT-0775163; C00311; Pentaric acid, 3-carboxy-2,3-dideoxy- (9CI); Q288927; 3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylate; 91BDE4FE-7872-4F5E-B191-62956199D37C
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| Activity |
IC50 > 10000000 nM
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[18] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 2 | Lysine demethylases inhibitors. J Med Chem. 2011 Dec 22;54(24):8236-50. | ||||
| REF 3 | Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. | ||||
| REF 4 | 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem. 2012 Apr 12;55(7):2945-59. | ||||
| REF 5 | Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. ACS Med Chem Lett. 2010 Oct 5;1(9):526-9. | ||||
| REF 6 | US patent application no. 9409892B2, 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors | ||||
| REF 7 | US patent application no. 8921389B2, Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase | ||||
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| REF 9 | 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6192-5. | ||||
| REF 10 | Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325. | ||||
| REF 11 | Discovery of novel 2-[2-(3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetamide derivatives as HIF prolyl 4-hydroxylase inhibitors; SAR, synthesis and modeling evaluation. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3142-5. | ||||
| REF 12 | Recent Progress in Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1308-29. | ||||
| REF 13 | US patent application no. 8722895B2, Prolyl hydroxylase inhibitors and method of use | ||||
| REF 14 | Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone de... J Med Chem. 2010 Aug 12;53(15):5629-38. | ||||
| REF 15 | Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5616-20. | ||||
| REF 16 | A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5598-601. | ||||
| REF 17 | Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5517-22. | ||||
| REF 18 | Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. J Med Chem. 2013 Jan 24;56(2):547-55. | ||||
| REF 19 | Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem. 2014 Jan 9;57(1):42-55. | ||||
| REF 20 | Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem. 2008 Nov 27;51(22):7053-6. | ||||
| REF 21 | Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. J Med Chem. 2013 Dec 12;56(23):9369-402. | ||||
| REF 22 | Inhibitors of histone demethylases. Bioorg Med Chem. 2011 Jun 15;19(12):3625-36. | ||||
| REF 23 | Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. J Med Chem. 2012 Mar 8;55(5):2173-84. | ||||
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