Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34296 | Target Info | |||
| Target Name | Matrix metalloproteinase-13 (MMP-13) | ||||
| Synonyms |
Matrix metalloproteinase 13; Collagenase-3; Collagenase 3
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MMP13 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 56 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
US9206139, 4
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|
Patented | Compound Info | ||
| Synonyms |
CHEMBL3955404; SCHEMBL15692527; BDBM194645; US9206139, 4
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574666; SCHEMBL5613445; BDBM50300481; 5-(3''-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid
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|
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| Activity |
IC50 = 52000 nM
|
[2] | |||
| Compound Name |
2-(2-(biphenyl-4-yl)ethylthio)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572980; 2-(2-(biphenyl-4-yl)ethylthio)acetic acid
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|
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| Activity |
IC50 = 95200 nM
|
[2] | |||
| Compound Name |
2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572947; 2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid
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|
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| Activity |
IC50 = 95900 nM
|
[2] | |||
| Compound Name |
5-(biphenyl-4-yl)-3-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572979; 5-(biphenyl-4-yl)-3-oxopentanoic acid
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|
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| Activity |
IC50 ~ 98000 nM
|
[2] | |||
| Compound Name |
5-(biphenyl-4-yl)-3-methoxypentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL583771; 5-(biphenyl-4-yl)-3-methoxypentanoic acid
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|
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| Activity |
IC50 ~ 98000 nM
|
[2] | |||
| Compound Name |
Cis-2-aminocyclohexylcarbamoylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
cis-ACCP; cis-2-aminocyclohexylcarbamoylphosphonic acid; 777075-44-2; CHEMBL270083; SCHEMBL569075; C7H15N2O4P; CTK8E9417; MolPort-039-139-066; BDBM50234465; 1683AH; ZINC29134634
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Furan-2-carboxamide deriv., 18
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568644; BDBM32409
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
CID 66559934
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164120; SCHEMBL17814861; BDBM50395680
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-Methyl-4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796282; BDBM50418815
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|
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| Activity |
IC50 = 50118.72 nM
|
[6] | |||
| Compound Name |
N-(Cyclohexylmethyl)-4-(4-methylphenoxy)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796284; BDBM50418814
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|
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| Activity |
IC50 = 50118.72 nM
|
[6] | |||
| Compound Name |
5-(4-(Benzofuran-2-yl)phenyl)-3-hydroxypentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574444; BDBM50300480
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|
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| Activity |
IC50 = 50200 nM
|
[2] | |||
| Compound Name |
2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585376; BDBM50299069
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|
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| Activity |
IC50 = 55000 nM
|
[7] | |||
| Compound Name |
trans-2-Aminocyclohexylcarbamoylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL270296; SCHEMBL4854279; BDBM50372742; ZINC29134636; [(1R,2R)-2-aminocyclohexyl]carbamoylphosphonic acid
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|
||||
| Activity |
IC50 = 55000 nM
|
[8] | |||
| Compound Name |
(5Z)-5-(3-Phenoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL161669; SCHEMBL8308267; ZINC2779401; STK899182; AKOS001112966; 2-Thioxo-5-(3-phenoxybenzylidene)thiazolidine-4-one
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|
||||
| Activity |
IC50 = 55270 nM
|
[9] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(4-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL410649; BDBM50359896
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|
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| Activity |
IC50 = 55880 nM
|
[10] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(3-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261267; BDBM50359895
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|
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| Activity |
IC50 = 55880 nM
|
[10] | |||
| Compound Name |
5-[5-[(4-Carboxyphenyl)methylcarbamoyl]-2-methylpyrazol-3-yl]-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939879; SCHEMBL1313634; BDBM50361636
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|
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| Activity |
IC50 = 56000 nM
|
[11] | |||
| Compound Name |
(2S)-2-(Dibenzothiophen-2-ylsulfonylamino)-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551190; BDBM50295481; (S)-2-(Dibenzo[b,d]thiophene-2-sulfonamido)-3-methylbutanoic acid
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|
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| Activity |
IC50 = 60000 nM
|
[12] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(2-nitrophenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407151; BDBM50359894
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|
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| Activity |
IC50 = 64000 nM
|
[10] | |||
| Compound Name |
4-[[6-(3-Morpholin-4-ylprop-1-ynyl)-4-oxoquinazolin-3-yl]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL273114; SCHEMBL6833710; BDBM50372634
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|
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| Activity |
IC50 = 65000 nM
|
[13] | |||
| Compound Name |
2-[2-[(E)-(5-Oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]phenoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927185; BDBM50359723
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|
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| Activity |
IC50 = 67000 nM
|
[14] | |||
| Compound Name |
N-[(5-Chloro-8-hydroxyquinolin-7-yl)-(2-chlorophenyl)methyl]-2-phenoxyacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL481894; Oprea1_120906; SCHEMBL1813190; BDBM50256157; N-((5-chloro-8-hydroxyquinolin-7-yl)(2-chlorophenyl)methyl)-2-phenoxyacetamide
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|
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| Activity |
IC50 ~ 67000 nM
|
[15] | |||
| Compound Name |
4-[[4-Oxo-6-(3-piperidin-1-ylprop-1-ynyl)quinazolin-3-yl]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL271616; SCHEMBL6834151; BDBM50372650
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|
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| Activity |
IC50 = 75000 nM
|
[13] | |||
| Compound Name |
5-Pyridin-4-yl-1H-indole-2-carboxylic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939870; SCHEMBL15642864; BDBM50361628; DB-124067; ethyl 5-pyridin-4-yl-1H-indole-2-carboxylate
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|
||||
| Activity |
IC50 = 82000 nM
|
[11] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(2-chlorophenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL264164; BDBM50359897
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|
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| Activity |
IC50 = 89430 nM
|
[10] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(methylsulfonyl)amino]-methyl}-1,2,4-oxadiazol-5-yl)hexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389020; SCHEMBL5411951; BDBM50216802; (R)-6-cyclohexyl-N-hydroxy-3-(3-(methylsulfonamidomethyl)-1,2,4-oxadiazol-5-yl)hexanamide; (3R)-6-cyclohexyl-N-hydroxy-3-[3-(methanesulfonamidomethyl)-1,2,4-oxadiazol-5-yl]hexanamide
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|
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| Activity |
Ki = 91000 nM
|
[3] | |||
| Compound Name |
Ethyl 5-(methanesulfonamido)-1H-indole-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939861; SCHEMBL8408444; BDBM50361619
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|
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| Activity |
IC50 = 97000 nM
|
[11] | |||
| Compound Name |
3-Acetoxy-5-(biphenyl-4-yl)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574445; SCHEMBL5694346; BDBM50300477; 3-acetyloxy-5-(4-phenylphenyl)pentanoic acid
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|
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| Activity |
IC50 ~ 98000 nM
|
[2] | |||
| Compound Name |
5-(4''-(Benzyloxy)biphenyl-4-yl)-3-hydroxypentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572926; BDBM50300466
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|
||||
| Activity |
IC50 ~ 98000 nM
|
[2] | |||
| Compound Name |
4-Phenoxy-N-[(1R,2S)-2-sulfanylcyclopentyl]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380391; BDBM50433876
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|
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| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(N-Methyl-N-phenylamino)-N-((5-chloro-8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL473841; SCHEMBL1817784; BDBM50256700; N-[(5-chloro-8-hydroxyquinolin-7-yl)-(3-nitrophenyl)methyl]-2-(N-methylanilino)acetamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(4-cyclohexylbutyl)thiourea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437163; BDBM50441574
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|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Thiadiazole derivative, 34
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401435; SCHEMBL4354162; BDBM24008; 1'-benzyl-5-(4-methoxyphenyl)-5'-methylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R)-6-Cyclohexyl-N-hydroxy-3-(3-{[(phenylsulfonyl)amino]carbonyl}-1,2,4-oxadiazol-5-yl)hexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439012; SCHEMBL6178395; BDBM50216817
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|
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| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
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|
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Thiadiazole derivative, 35
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237366; SCHEMBL4983250; BDBM24009; 5-(4-methoxyphenyl)-5'-methyl-1'-(2-methylphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
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|
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260886; BDBM50359901
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-(Carboxymethyl)-N-(3-Phenylpropyl)glycyl-N-Methyl-L-Histidinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235416; SCHEMBL12198648; BDBM50005641; Q27463133
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|
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-[[4-Oxo-6-(3-phenylpropa-1,2-dienyl)quinazolin-3-yl]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272188; SCHEMBL6297946; BDBM50372651; 4-[4-oxo-6-(3-phenyl-propa-1,2-dienyl)-4h-quinazolin-3-ylmethyl]-benzoic acid
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|
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| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
4-(Benzyloxy)-N-(4-pyridinylmethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1703805; MLS001001031; ZINC4841066; BDBM50418817; AKOS003370326; MCULE-7657311868; SMR000498738
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
[2-Methyl-1-[[4-(5-methylthiophen-2-yl)phenyl]sulfonylamino]propyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752826; BDBM50500715
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|
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[[1-[2-[2-[2-[2-[4-[[[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-(4-methoxyphenyl)sulfonylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064553; BDBM50389105
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|
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| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(5E)-2-(1,2-Benzothiazol-3-ylimino)-5-[(2-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3398610; BDBM50063579
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
[1-[[4-[5-(Methoxymethyl)thiophen-2-yl]phenyl]sulfonylamino]-2-methylpropyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754314; BDBM50500719
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|
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Thiadiazole derivative, 33
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237149; SCHEMBL4356155; BDBM24007; 1'-benzyl-5-(4-methoxyphenyl)spiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one; 1-benzyl-5''-(4-methoxyphenyl)-1,2-dihydro-3''H-spiro[indole-3,2''-[1,3,4]thiadiazole]-2-one
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|
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[(1S,2S)-2-Hydroxycyclopentyl]-4-phenoxybenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380397; BDBM50433870
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|
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| Activity |
Ki = 100000 nM
|
[16] | |||
| Compound Name |
(R)-2-(N-Benzyl-4-(2-fluoroethoxy)phenylsulphonamido)-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237177; BDBM50225408
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-(2-Phenylethoxy)-N-(pyridin-4-ylmethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796290; BDBM50418816
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(R)-2-(4-Fluorophenylsulphonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393793; BDBM50225398
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(5Z)-2-(1,2-Benzothiazol-3-ylimino)-5-[(3-chlorophenyl)methylidene]-1,3-thiazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412064; BDBM50359898
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
US9187406, Curcumin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892642; SCHEMBL10077702; BDBM191763
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|
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| Activity |
IC50 = 110000 nM
|
[25] | |||
| Compound Name |
(E)-2-(5-((5-(4-Methoxyphenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927186; ZINC2698193; BDBM50359724; STK711873; AKOS002386597; ST50326453; AB00674549-01; F1542-0089
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|
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| Activity |
IC50 = 120000 nM
|
[14] | |||
| Compound Name |
(2Z,NE)-N-benzylidene-4-(3,4-dimethoxyphenyl)-2-(phenylimino)thiazol-3(2H)-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927187; BDBM50359725; STL264510; AKOS002238584; ST50113618; F0807-0342; (2Z)-4-(3,4-dimethoxyphenyl)-2-(phenylimino)-N-[(E)-phenylmethylidene]-1,3-thiazol-3(2H)-amine; 4-[3-((1E)-2-phenyl-1-azavinyl)-2-(phenylazamethylene)(1,3-thiazolin-4-yl)]-1, 2-dimethoxybenzene
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|
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| Activity |
IC50 = 140000 nM
|
[14] | |||
| Compound Name |
3-(1-Phenyl-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)-2H-chromen-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000583508; CHEMBL1352521; SMR000206694; Oprea1_153798; Oprea1_327986; BDBM63209; cid_3380837; 3-(3-phenyl-2-sulfanylidene-1H-imidazol-5-yl)chromen-2-one; HMS2546H23; ZINC5646879; AKOS002096713; MCULE-8333834154; 3-(1-phenyl-2-thioxo-4-imidazolin-4-yl)coumarin; SR-01000555381; SR-01000555381-1; 3-(3-phenyl-2-sulfanylidene-1H-imidazol-5-yl)-1-benzopyran-2-one
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|
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| Activity |
IC50 = 177000 nM
|
[14] | |||
| Compound Name |
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-trifluoromethoxy-phenylsulfanyl)-propyl]-phosphinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323885; BDBM50138686
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|
||||
| Activity |
Ki = 200000 nM
|
[26] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(2S)-3-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-oxo-2-[2-(trifluoromethoxy)phenyl]sulfanylpropyl]-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153738; BDBM50393207
Click to Show/Hide
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||||
| Activity |
Ki > 200000 nM
|
[27] | |||
| Compound Name |
N-((5-Chloro-8-hydroxyquinolin-7-yl)(3-nitrophenyl)methyl)-2-phenoxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480567; SCHEMBL1814553; BDBM50256102; N-[(3-nitrophenyl)(5-chloro-8-hydroxyquinolin-7-yl)methyl]-2-phenoxyacetamide; N-[(5-chloro-8-hydroxyquinolin-7-yl)-(3-nitrophenyl)methyl]-2-phenoxyacetamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
N-[(3S,4S)-1-(6-Aminohexanoyl)-4-hydroxypyrrolidin-3-yl]-4-phenoxybenzenesulfonamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2380404
Click to Show/Hide
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| Activity |
Ki > 200000 nM
|
[16] | |||
| Compound Name |
2-(4-Methoxyphenoxy)-N-((5-chloro-8-hydroxyquinolin-7-yl)(4-methoxyphenyl)methyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472144; BDBM50256313; N-[(5-chloro-8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]-2-(4-methoxyphenoxy)acetamide
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
N-[2-(4,5-Dihydro-1,3-oxazol-2-yl)-1H-indol-5-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939866; BDBM50361624
Click to Show/Hide
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||||
| Activity |
IC50 = 220000 nM
|
[11] | |||
| Compound Name |
(1E,6E)-1-[4-[(Dimethylamino)methyl]phenyl]-7-(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963341; US9187406, Compound 4; BDBM191768
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[25] | |||
| Compound Name |
Ethyl 3-[5-(2-oxochromen-3-yl)-2-sulfanylidene-1H-imidazol-3-yl]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927203; BDBM50359727
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[14] | |||
| Compound Name |
N-[3-(Dimethylamino)propyl]-4-(4-methylphenoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796286; BDBM50418819
Click to Show/Hide
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||||
| Activity |
IC50 > 398107.17 nM
|
[6] | |||
| Compound Name |
4-(3-Methoxy-4-nitrophenoxy)-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796292; BDBM50418828
Click to Show/Hide
|
||||
| Activity |
IC50 > 398107.17 nM
|
[6] | |||
| Compound Name |
4-(2-Cyanophenoxy)-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796293; BDBM50418818
Click to Show/Hide
|
||||
| Activity |
IC50 > 398107.17 nM
|
[6] | |||
| Compound Name |
N-Benzyl-4-(4-methylphenoxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796280; BDBM50418820; AKOS003061839
Click to Show/Hide
|
||||
| Activity |
IC50 > 398107.17 nM
|
[6] | |||
| Compound Name |
4-(4-Methylphenoxy)-N-(2-pyridin-4-ylethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796283; BDBM50418823
Click to Show/Hide
|
||||
| Activity |
IC50 > 398107.17 nM
|
[6] | |||
| Compound Name |
2-N-Ethyl-1H-indole-2,5-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939864; BDBM50361622
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
Ethyl 5-pyridin-2-yl-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939868; BDBM50361626
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
2-Butanoyl-1H-indole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939863; BDBM50361621
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
Ethyl 5-phenyl-1H-indole-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1939867; 5-phenyl-2-carbethoxyindole; SCHEMBL419130; CTK1H9732; DTXSID30496679; BDBM50361625; 5-Phenyl-1H-indole-2-carboxylic Acid Ethyl Ester; 1H-Indole-2-carboxylic acid, 5-phenyl-, ethyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[11] | |||
| Compound Name |
4-Methoxy-N-(pyridin-4-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796288; Oprea1_081502; Oprea1_576873; SCHEMBL8325247; CTK2A8254; DTXSID50354702; ZINC272121; BDBM50418821; STK189953; AKOS000373669; MCULE-9515847684; N-(4-Pyridinylmethyl)-4-methoxybenzamide; ST51018654; Benzamide, 4-methoxy-N-(4-pyridinylmethyl)-; (4-methoxyphenyl)-N-(4-pyridylmethyl)carboxamide; SR-01000206366; SR-01000206366-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9206139B2, Aggrecanase inhibitors | ||||
| REF 2 | The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. | ||||
| REF 3 | Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. | ||||
| REF 4 | Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5321-4. | ||||
| REF 5 | Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT). J Med Chem. 2012 Aug 23;55(16):7061-79. | ||||
| REF 6 | Selective non zinc binding inhibitors of MMP13. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4215-9. | ||||
| REF 7 | Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. | ||||
| REF 8 | Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic mat... J Med Chem. 2008 Mar 13;51(5):1406-14. | ||||
| REF 9 | Evaluation of the anti-inflammatory/chondroprotective activity of aldose reductase inhibitors in human chondrocyte cultures. Medchemcomm. 2015;6:823-30. | ||||
| REF 10 | 2-Benzisothiazolylimino-5-benzylidene-4-thiazolidinones as protective agents against cartilage destruction. Bioorg Med Chem. 2015 Apr 1;23(7):1551-6. | ||||
| REF 11 | Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87. | ||||
| REF 12 | Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem. 2009 Sep 10;52(17):5408-19. | ||||
| REF 13 | Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. J Med Chem. 2008 Feb 28;51(4):835-41. | ||||
| REF 14 | Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization. Eur J Med Chem. 2012 Jan;47(1):143-52. | ||||
| REF 15 | N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett. 2008 Dec 15;18(24):6454-7. | ||||
| REF 16 | Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13;56(11):4357-73. | ||||
| REF 17 | Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group. Eur J Med Chem. 2013 Nov;69:244-61. | ||||
| REF 18 | Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J Med Chem. 2007 Jul 26;50(15):3442-56. | ||||
| REF 19 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 20 | 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2). Bioorg Med Chem Lett. 2007 Oct 15;17(20):5630-3. | ||||
| REF 21 | Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis. Eur J Med Chem. 2014 May 22;79:184-93. | ||||
| REF 22 | Fluorinated matrix metalloproteinases inhibitors--Phosphonate based potential probes for positron emission tomography. Bioorg Med Chem. 2016 Feb 15;24(4):902-9. | ||||
| REF 23 | A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem. 2012 May 24;55(10):4714-27. | ||||
| REF 24 | Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64. | ||||
| REF 25 | US patent application no. 9187406B2, Curcumin analogues as zinc chelators and their uses | ||||
| REF 26 | Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem. 2004 Jan 15;47(2):325-36. | ||||
| REF 27 | Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J Med Chem. 2011 Sep 8;54(17):5955-80. | ||||
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