Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38584 | Target Info | |||
| Target Name | Hepatocyte growth factor activator (HGFAC) | ||||
| Synonyms |
Hepatocyte growth factor activator long chain; HGFAC; HGFA; HGF activator
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| Target Type | Literature-reported Target | ||||
| Gene Name | HGFAC | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Benzamidophenylguanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL579653; BDBM50069123
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 6-[[4-(diaminomethylideneamino)phenyl]sulfonylamino]naphthalene-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403526; BDBM50069126
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]-N-(2-phenylethyl)piperazine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403533; BDBM50069113
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Benzyl 4-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402439; BDBM50069106
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[(2S)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N-hexylpiperazine-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3400827; SCHEMBL18049338; BDBM50069112
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2S)-3-[4-(1-Benzothiophene-3-carbonyl)piperazin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402437; SCHEMBL19923043; BDBM50069110
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Benzyl N-[(3R)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperidin-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402438; BDBM50069109
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[4-[(4-Methylphenyl)sulfonylamino]phenyl]guanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403527; BDBM50069125
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Benzyl N-[(3S)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperidin-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403530; BDBM50069116
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(Diaminomethylideneamino)-N-phenylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL535214; SCHEMBL4063687; BDBM50069124
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[3-(1-Benzyl-piperidin-4-yl)-ureido]-benzamidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327254; BDBM50071945
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| Activity |
Ki = 54600 nM
|
[2] | |||
| Compound Name |
3-[[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]methyl]benzenecarboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780277; BDBM50158163
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15;23(10):2328-43. | ||||
| REF 2 | Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation. ACS Med Chem Lett. 2015 Dec 22;7(2):177-81. | ||||
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