Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T40474 | Target Info | |||
| Target Name | Proto-oncogene c-Met (MET) | ||||
| Synonyms |
Tyrosine-protein kinase Met; Scatter factor receptor; SF receptor; Met proto-oncogene tyrosine kinase; Hepatocyte growth factor receptor; HGF/SF receptor; HGF-SF receptor; HGF receptor; C-met; C-Met receptor tyrosine kinase
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| Target Type | Successful Target | ||||
| Gene Name | MET | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 58 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-benzyl-2-(1H-indol-3-yl)-2-oxoacetamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-{5-[(3,4-Difluorophenyl)methyl]-1,3-thiazol-2-yl}-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125863; BDBM50449315; ZINC12913829; AKOS034027971; MCULE-9320206927; Z278071350
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-(3-((4-Hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092754; SCHEMBL4385411; BDBM50314344
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Chembl4173469
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276849
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|
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
7-((4-Methylpiperazin-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213743; BDBM50188266
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|
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
8-[2-(Diethylamino)ethoxy]-3-ethoxy-6,6-dimethylnaphtho[3,2-b][1]benzofuran-11-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779097; SCHEMBL898429; BDBM50344644; 8-(2-(diethylamino)ethoxy)-3-ethoxy-6,6-dimethylbenzo[d]naphtho[2,3-b]furan-11(6H)-one
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
Chembl4163204
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276856
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[3-Fluoro-4-[[3-(3-morpholin-4-ylpropyl)-2-oxo-1H-imidazo[4,5-h][1,6]naphthyridin-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360674; BDBM50042191
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|
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477817; SCHEMBL5520662; SCHEMBL5520668; BDBM50263132
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|
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
1-[4-(4-Amino-6-methylthieno[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
Thienopyrimidine deriv. 28; BDBM8846; CHEMBL381207; SCHEMBL4466103
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
Eucalyptin A
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171206; BDBM50397046
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|
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
1-Benzyl-5-[(5-chloro-2-hydroxyanilino)methylidene]-4-methyl-2,6-dioxopyridine-3-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL473533; SCHEMBL1050262; SCHEMBL1050264; SCHEMBL12386694; BDBM50292726; ZINC16693864; AKOS000427809; MCULE-1185498497; ST50991920
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
7-((1H-Imidazol-1-yl)methyl)-3-(thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL212084; SCHEMBL4817151; BDBM50188272; 7-(imidazol-1-ylmethyl)-3-thiophen-3-yl-1,4-dihydroindeno[1,2-c]pyrazole
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|
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
GDP366; CHEMBL196363; Thienopyrimidine deriv. 76; Kinome_417; KDR Kinase Inhibitor, 1; SCHEMBL232042; BDBM8826; Biochemistry 469551 Compound 3; BCP30719; EX-A3218; HY-U00177; CS-7241; 3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea; N-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N -(3-methylphenyl)urea; n-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-n'-(3-methylphenyl)urea
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
Chembl4167104
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276842
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
2-{[(5-{[(Oxolan-2-yl)methyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-6-phenyl-3H,4H-thieno[2,3-d]pyrimidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125862; BDBM50449314; AKOS033393124; MCULE-1152611879; Z151832316
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Methylpiperazin-1-yl)-8-phenylquinoxaline-6-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459078; BDBM50266328
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|
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| Activity |
IC50 = 60200 nM
|
[18] | |||
| Compound Name |
N'-[1H-Indol-3-yl(oxo)acetyl]-4-nitrobenzohydrazide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796172; ZINC2251508; BDBM50346844; STK536234; AKOS005467227; MCULE-2202306145
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| Activity |
IC50 = 69000 nM
|
[1] | |||
| Compound Name |
Calicoferol E
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456936; (8S)-3-hydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one; BDBM50358246; LMST03020157
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| Activity |
IC50 = 71500 nM
|
[19] | |||
| Compound Name |
Astrogorgiadiol B
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|
Investigative | Compound Info | ||
| Synonyms |
ASTROGORGIADIOL; (8S,9R)-9,10-seco-1,3,5(10)-cholestatriene-3,9-diol; LMST03020242; CHEMBL517956; SCHEMBL4865385; BDBM50358247
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| Activity |
IC50 = 78000 nM
|
[19] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzohydrazide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796186; BDBM50346833
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|
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| Activity |
IC50 = 95000 nM
|
[1] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]-4-methylbenzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796178; BDBM50346842
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|
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| Activity |
IC50 = 95000 nM
|
[1] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]-4-methoxybenzohydrazide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796179; BDBM50346846
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|
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| Activity |
IC50 = 96000 nM
|
[1] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-Fluoro-N'-[2-(1H-indol-3-yl)-2-oxoacetyl]benzohydrazide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796184; BDBM50346831
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N'-Phenyl-2-(1H-indole-3-yl)-2-oxoacetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72505; BDBM50066940; (1H-Indol-3-yl)-oxo-acetic acid N''-phenyl-hydrazide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109402; BDBM50446565
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Tert-butyl N-[2-[[4-(3-bromoanilino)quinazolin-6-yl]amino]-2-oxoethyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071058; BDBM50237553
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-[2-(3-Chlorophenyl)ethyl]-2-(1H-indol-3-yl)-2-oxoacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796176; BDBM50346825
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N'-(4-Chlorophenyl)-2-(1H-indole-3-yl)-2-oxoacetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124871; BDBM50066943; (1H-Indol-3-yl)-oxo-acetic acid N''-(4-chloro-phenyl)-hydrazide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]benzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796177; BDBM50346826
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[3-(Dimethylcarbamoyl)phenyl]-2-phenylmethoxy-4-(3-pyrrolidin-1-ylpropoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824599; BDBM50419092
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL281957; SCHEMBL6621670; BDBM50126732
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| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[2-(4-Chlorophenyl)ethyl]-2-(1H-indol-3-yl)-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL71184; MLS001198399; HMS2885H18; ZINC2873929; BDBM50000767; STK734898; AKOS003356295; MCULE-8231753624; SMR000559268; ST4081619; SR-01000293292; SR-01000293292-1; N-[2-(4-chlorophenyl)ethyl]-2-indol-3-yl-2-oxoacetamide; N~1~-(4-chlorophenethyl)-2-(1H-indol-3-yl)-2-oxoacetamide; 2-(1H-Indol-3-yl)-2-oxo-N-[2-(4-chlorophenyl)ethyl]acetamide; Acetamide, N-[2-(4-chlorophenyl)ethyl]-2-(1H-indol-3-yl)-2-oxo-; N-[2-(4-Chloro-phenyl)-ethyl]-2-(1H-indol-3-yl)-2-oxo-acetamide
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N'-(4-Bromophenyl)-2-(1H-indol-3-yl)-2-oxoacetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796173; BDBM50346840
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N'-(4-iodophenyl)-2-oxoacetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796174; BDBM50346841
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Calicoferol C
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-(4-Chlorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73288; MLS000674387; HMS2608G07; ZINC4268552; BDBM50055241; STK710824; AKOS000346802; MCULE-8563552712; SMR000297338; ST4127583; N-[(4-chlorophenyl)methyl]-2-indol-3-yl-2-oxoacetamide; N-(4-Chloro-benzyl)-2-(1H-indol-3-yl)-2-oxo-acetamide; 1H-Indole-3-acetamide, N-[(4-chlorophenyl)methyl]-.alpha.-oxo-
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-(1H-indol-3-yl)-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL71999; N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(1H-indol-3-yl)-2-oxo-acetamide; N-(3,4-dimethoxyphenethyl)-2-(1H-indol-3-yl)-2-oxoacetamide; N-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-2-INDOL-3-YL-2-OXOETHANAMIDE; NSC377714; MLS001211757; CTK6J7761; HMS2831M21; ZINC1590445; BDBM50000761; MFCD00245698; STK710823; AKOS001695117; MCULE-6186184263; MS-7224; NSC-377714; KS-0000290Q; SMR000518987; ST058888; N-[2-(3,4-dimethoxyphenyl)ethyl]-2-indol-3-yl-2-oxoacetamide; 2-(1H-Indol-3-yl)-2-oxo-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide; Acetamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(1H-indol-3-yl)-2-oxo-
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Calicoferol B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092491; BDBM50237567
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-(4-methylbenzyl)-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220737; ZINC4163156; BDBM50346845; AKOS000423609; MCULE-4050371716; NCGC00294126-01; AB01258772-02; F0675-0091
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Chloro-benzyl)-2-(1H-indol-3-yl)-2-oxo-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL358147; BDBM50055248
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-[2-(4-methylphenyl)ethyl]-2-oxoacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796175; BDBM50346824
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
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| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N'-[2-(1H-Indol-3-yl)-2-oxoacetyl]-4-(6-methylpyrazin-2-yl)oxybenzohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1796187; BDBM50346834
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Norlichexanthone
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Investigative | Compound Info | ||
| Synonyms |
1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one; 9H-xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; CHEMBL466154; 1,3,6-trihydroxy-8-methylxanthen-9-one; 1,3,6-trihydroxy-8-methyl-xanthen-9-one; 3,6,8-Trihydroxy-1-methylxanthone; Fusarindin; AC1NQYTV; Xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; C10087; ACon0_000599; ACon1_001113; CTK4E4931; DTXSID20174777; 1,3,6-trihydroxy-8-methylxanthone; ZINC5765089; BDBM50350423; AKOS000365318; MCULE-8777096541; NCGC00169665-01; W2650; 1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one #; BRD-K97951054-001-01-6; Q27107546; NCGC00169665-03!1,3,6-trihydroxy-8-methylxanthen-9-one
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
1'-Methyl-5-[3-(quinolin-6-ylmethyl)triazolo[4,5-d]pyrimidin-5-yl]spiro[1H-indole-3,4'-piperidine]-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950195; BDBM50365174
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| Activity |
IC50 = 140000 nM
|
[27] | |||
| Compound Name |
6-(2,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420911; BDBM50439463; 9-(9H-purin-6-yl)-2,9-diazaspiro[5.5]undecane; Q27451706; 15I
Click to Show/Hide
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| Activity |
IC50 = 183000 nM
|
[28] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ro-0505124
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Investigative | Compound Info | ||
| Synonyms |
RO0505124
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| Activity |
IC50 > 20000000 nM
|
[29] | |||
| Compound Name |
1-N'-[3-Fluoro-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]pyridin-7-yl)oxy]phenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360678; BDBM50042144
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| Activity |
IC50 = 209000 nM
|
[12] | |||
| Compound Name |
1-N-(4-Fluorophenyl)-1-N'-[3-fluoro-4-(1,3,8-triazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraen-6-yloxy)phenyl]cyclopropane-1,1-dicarboxamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360680; BDBM50042055
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| Activity |
IC50 = 260000 nM
|
[12] | |||
| Compound Name |
1'-Methyl-5-[9-(quinolin-6-ylmethyl)purin-2-yl]spiro[1H-indole-3,4'-piperidine]-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950196; BDBM50365175
Click to Show/Hide
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||||
| Activity |
IC50 = 1100000 nM
|
[27] | |||
| Compound Name |
1'-Methyl-6-[3-(quinolin-6-ylmethyl)triazolo[4,5-d]pyrimidin-5-yl]spiro[1H-indole-3,4'-piperidine]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950199; BDBM50365170
Click to Show/Hide
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| Activity |
IC50 = 1200000 nM
|
[27] | |||
| Compound Name |
1'-Methyl-6-[9-(quinolin-6-ylmethyl)purin-2-yl]spiro[1H-indole-3,4'-piperidine]-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950200; BDBM50365171
Click to Show/Hide
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| Activity |
IC50 = 1400000 nM
|
[27] | |||
| Compound Name |
[4-Amino-2-[[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]amino]-5-thiazolyl](3-methoxyphenyl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956069; SCHEMBL5741716; HMS3401E09; BDBM50365217; Ro-0506220; [4-amino-2-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(3-methoxyphenyl)methanone
Click to Show/Hide
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| Activity |
IC50 > 20000000 nM
|
[29] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure. Eur J Med Chem. 2011 Jul;46(7):2759-69. | ||||
| REF 2 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 3 | Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1523-7. | ||||
| REF 4 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 5 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
| REF 6 | Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. | ||||
| REF 7 | Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2321-5. | ||||
| REF 8 | The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6223-7. | ||||
| REF 9 | Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors. Eur J Med Chem. 2017 Sep 29;138:942-951. | ||||
| REF 10 | Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4371-5. | ||||
| REF 11 | Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3788-93. | ||||
| REF 12 | Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization. Bioorg Med Chem Lett. 2015 Feb 1;25(3):708-16. | ||||
| REF 13 | 2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4420-3. | ||||
| REF 14 | Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. J Med Chem. 2005 Sep 22;48(19):6066-83. | ||||
| REF 15 | Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity. J Med Chem. 2012 Sep 27;55(18):8183-7. | ||||
| REF 16 | Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening. J Med Chem. 2009 Feb 26;52(4):943-51. | ||||
| REF 17 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 18 | Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. | ||||
| REF 19 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. | ||||
| REF 20 | Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod. 2014 Feb 28;77(2):218-26. | ||||
| REF 21 | Design, synthesis, and biological evaluation of novel 4-anilinoquinazoline derivatives bearing amino acid moiety as potential EGFR kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:393-405. | ||||
| REF 22 | The discovery of benzanilides as c-Met receptor tyrosine kinase inhibitors by a directed screening approach. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5224-9. | ||||
| REF 23 | Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. J Med Chem. 2003 Apr 10;46(8):1337-49. | ||||
| REF 24 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 25 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 26 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. Bioorg Med Chem. 2011 Aug 1;19(15):4644-51. | ||||
| REF 27 | Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4'-piperidine]-2-ones as potential c-Met inhibitors. Eur J Med Chem. 2012 Apr;50:370-5. | ||||
| REF 28 | Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases. Bioorg Med Chem. 2013 Sep 15;21(18):5707-24. | ||||
| REF 29 | Inhibition of S/G2 phase CDK4 reduces mitotic fidelity. J Biol Chem. 2006 Apr 14;281(15):9987-95. | ||||
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