Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T41141 | Target Info | |||
| Target Name | Cathepsin L (CTSL) | ||||
| Synonyms |
Major excreted protein; MEP; Cathepsin L1; CTSL1
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CTSL | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 158 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Nitro-2-(4-phenylmethoxyanilino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042453; BDBM50385983
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478737
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-Methoxy-2-(3-nitro-4-phenylmethoxyanilino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042455; BDBM50385985
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Anilino-3-methoxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042456; SCHEMBL11541393; BDBM50385986
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-((4-Methoxyphenyl)amino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-[(4-methoxyphenyl)amino]benzoic acid; 2-(4-Methoxyanilino)benzoic acid; N-p-Anisylanthranilic acid; Anthranilic acid, N-p-anisyl-; N-(4-Metenyl)anthranilic acid; Anthranilic acid, N-(4-methoxyphenyl)-; N-(4-Methoxyphenyl)anthranilic acid; 2-(4-Methoxyphenylamino)Benzoic Acid; Benzoic acid,2-[(4-methoxyphenyl)amino]-; MLS000775662; SMR000370544; BRN 0654162; 2-(4-METHOXY-PHENYLAMINO)-BENZOICACID; Cambridge id 5482951; 2-(p-anisidino)benzoic acid; Oprea1_042911; 3-14-00-00911 (Beilstein Handbook Reference); SCHEMBL355486; cid_202918; CHEMBL1596993; BDBM69369; CTK4B9608; DTXSID40159203; HMS2663N15; ZINC241322; 2-(4-Methoxyanilino)benzoic acid #; 6263AA; ANW-63980; MFCD00477471; N-(p-methoxyphenyl) anthranilic acid; AKOS001047469; MCULE-8579305485; NE24349; VZ23399; NCGC00246065-01; 2-[(4-Methoxyphenyl)amino]-benzoic acid; DA-17888; 4'-Methoxy-diphenylamine-2-carboxylic acid; FT-0753846; UNM000011032801; 2-(4-METHOXY-PHENYLAMINO)BENZOIC ACID; EN300-40218; AB00086706-01; SR-01000393543; J-006631; SR-01000393543-1; Z56903876
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Ethyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205320; SCHEMBL5357938; BDBM19636; Heterocyclic arylaminoethyl amide, 13h
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
Aryl-morpholino-containing analogue, 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200301; SCHEMBL6185946; BDBM19858; N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-morpholin-4-ylbenzamide; N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-(morpholin-4-yl)benzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 50000 nM
|
[4] | |||
| Compound Name |
3-Methoxy-2-(3-methoxy-4-phenylmethoxyanilino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042462; BDBM50385963
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(5,6-dihydro-4H-cyclopenta[d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071096; SCHEMBL8112869; BDBM50390401
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50118.72 nM
|
[5] | |||
| Compound Name |
(3S)-2-[(2S)-2-[[(2S)-2-Cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]hexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184035; BDBM50152751
Click to Show/Hide
|
||||
| Activity |
Ki = 51000 nM
|
[6] | |||
| Compound Name |
(2S)-N-[(2S)-1-Amino-4-methylsulfanyl-1-oxobutan-2-yl]-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401176; SCHEMBL3814800; BDBM50214539
Click to Show/Hide
|
||||
| Activity |
IC50 = 55728 nM
|
[7] | |||
| Compound Name |
(E)-1-(4-Fluorophenyl)-3-(4-pyrrolidin-1-ylphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382118; BDBM50491481
Click to Show/Hide
|
||||
| Activity |
IC50 = 56510 nM
|
[8] | |||
| Compound Name |
4-[[(2R)-5-(Diaminomethylideneamino)-1-[[3-(4-hydroxyphenyl)-1-oxo-1-(2-phenylethylamino)propan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxo-3-[[2-(4-phenylphenyl)acetyl]amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162208
Click to Show/Hide
|
||||
| Activity |
Ki = 57500 nM
|
[9] | |||
| Compound Name |
Methyl (E)-4-[[2-[(3R)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-5-(4-methoxyphenyl)-2-oxo-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171634; BDBM50322344
Click to Show/Hide
|
||||
| Activity |
Ki = 59900 nM
|
[10] | |||
| Compound Name |
Gold trichloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Gold(III) chloride; trichlorogold; Gold chloride (AuCl3); Auric trichloride; Gold(III)chloride; MFCD00014172; auricchloride; Goldchlorid; Aurochloric acid; AuCl3; EINECS 236-623-1; gold(III)-chloride; gold(3+) chloride; Gold (III) chloride; [AuCl3]; DSSTox_CID_24379; DSSTox_RID_80183; DSSTox_GSID_44379; Gold(III) chloride, 99%; KSC491S9R; ACMC-1C068; CHEMBL182062; DTXSID4044379; CTK3J1998; Tox21_302116; BDBM50153290; Gold(III) chloride (64.4% Au); AKOS024437575; SC10710; NCGC00255972-01; CS-0077823; FT-0626802; 453G071; Q174129; Gold(III) chloride, >=99.99% trace metals basis; Gold(III) chloride, SAJ special grade (dihydrate), >=98.5%
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[11] | |||
| Compound Name |
Chembl4249139
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50463231
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-oxo-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210315; BDBM50410972
Click to Show/Hide
|
||||
| Activity |
Ki = 63000 nM
|
[13] | |||
| Compound Name |
N-{(1S)-2,2,2-Trifluoro-1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucylglycinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401175; SCHEMBL4205509; BDBM50214537
Click to Show/Hide
|
||||
| Activity |
IC50 = 63060 nM
|
[7] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381996; BDBM50491296
Click to Show/Hide
|
||||
| Activity |
Ki = 64000 nM
|
[14] | |||
| Compound Name |
4-Cyclohexanesulfonylamino-N-[1-(2S-ethyl-4-oxotetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482191; SCHEMBL8264964; BDBM50255131
Click to Show/Hide
|
||||
| Activity |
Ki = 64000 nM
|
[15] | |||
| Compound Name |
Methyl (E)-4-[[2-[(3R)-3-(1-adamantylcarbamoyloxymethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171802; BDBM50322349
Click to Show/Hide
|
||||
| Activity |
Ki = 65000 nM
|
[10] | |||
| Compound Name |
Succinamide peptidomimetic, 34
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238948; SCHEMBL3027680; BDBM19668
Click to Show/Hide
|
||||
| Activity |
Ki ~ 65000 nM
|
[16] | |||
| Compound Name |
(E)-3-(3-Bromo-4-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382055; BDBM50491482
Click to Show/Hide
|
||||
| Activity |
IC50 = 67510 nM
|
[8] | |||
| Compound Name |
(R)-3,3-Dimethyl-1-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)butan-2-yl(S)-1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188400; BDBM50169482
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[17] | |||
| Compound Name |
(3S)-3-[(2S)-2-[(6-Chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380538; SCHEMBL5353469; BDBM19635; Heterocyclic arylaminoethyl amide, 13g
Click to Show/Hide
|
||||
| Activity |
Ki ~ 70000 nM
|
[3] | |||
| Compound Name |
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-methylpiperazin-1-yl)sulfonylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199488; SCHEMBL6181947; BDBM50410597
Click to Show/Hide
|
||||
| Activity |
Ki = 71000 nM
|
[4] | |||
| Compound Name |
(E)-1-(4-Fluorophenyl)-3-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382112; BDBM50491469
Click to Show/Hide
|
||||
| Activity |
IC50 = 73220 nM
|
[8] | |||
| Compound Name |
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(2-morpholin-4-yl-1,3-thiazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199358; SCHEMBL6183543; BDBM19857; aryl-morpholino-containing analogue, 12; N-[1-[(Cyanomethyl)carbamoyl]cyclohexyl]-4-(2-morpholino-4-thiazolyl)benzamide; N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(morpholin-4-yl)-1,3-thiazol-4-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 74000 nM
|
[4] | |||
| Compound Name |
(2R)-N-[(2S)-1-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(2S)-3-hydroxy-2-[[2-(4-phenylphenyl)acetyl]amino]propanoyl]amino]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143392
Click to Show/Hide
|
||||
| Activity |
Ki = 74000 nM
|
[18] | |||
| Compound Name |
Methyl (E)-4-[[2-[(3R)-3-(cyclohexylcarbamoyloxymethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171094; BDBM50322348
Click to Show/Hide
|
||||
| Activity |
Ki = 76500 nM
|
[10] | |||
| Compound Name |
Arylaminoethyl amide, 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL198438; BDBM19572
Click to Show/Hide
|
||||
| Activity |
Ki ~ 79000 nM
|
[19] | |||
| Compound Name |
Benzyl N-[(1S)-2-(cyanomethylamino)-2-oxo-1-phenylethyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200775; BDBM50410586
Click to Show/Hide
|
||||
| Activity |
Ki = 88000 nM
|
[4] | |||
| Compound Name |
Disodium aurothiomalate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
disodium [2-(sulfanyl-kappaS)butanedioato(3-)]aurate(2-); aurothiomalate dianion; CHEMBL182346; BDBM50153289
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[11] | |||
| Compound Name |
(E)-3-(4-Fluorophenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382115; BDBM50491479
Click to Show/Hide
|
||||
| Activity |
IC50 = 91170 nM
|
[8] | |||
| Compound Name |
Benzyl 1-((cyanomethyl)carbamoyl)cyclohexylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200151; Benzyl N-[1-(cyanomethylcarbamoyl)cyclohexyl]carbamate; SCHEMBL6184084; BDBM50410608
Click to Show/Hide
|
||||
| Activity |
Ki = 95000 nM
|
[4] | |||
| Compound Name |
(E)-3-(4-Fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148111; ZINC4279051; BDBM50491466; STK788253; AKOS002164039; MCULE-6619799912; VU0488971-1; F1190-0598; 3-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one; (2E)-3-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one; (E)-3-(4-fluorophenyl)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 98680 nM
|
[8] | |||
| Compound Name |
Arylaminoethyl carbamate, 17
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214431; SCHEMBL3019335; BDBM19686
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(E)-3-(3-Bromo-4-methoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382059; BDBM50491475
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070938; SCHEMBL8123486; BDBM50390390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Benzyl (3S)-3-[(2S)-4-cyclohexyl-2-[(3-methoxyphenyl)formamido]butanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
arylaminoethyl amide, 8p; CHEMBL203857; SCHEMBL4798570; BDBM19608
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
1-(5,7-Dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-3-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-1-propanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3352910; BDBM50032240; 1-(5,7-dihydroxy-2,2-dimethyl-chroman-6-yl)-3-(2,2-dimethylchroman-6-yl)propan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354497; BDBM50042854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[5-(2-cyanopropan-2-yl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070948; BDBM50390397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(1R,2R)-N-[(1R)-1-Cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164679; BDBM50395223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070943; BDBM50390393
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Succinamide peptidomimetic, 6
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240617; SCHEMBL3024590; BDBM19640; (3R)-3-(cyclohexylmethyl)-N-[2-(4-fluoroanilino)ethyl]-4-morpholin-4-yl-4-oxobutanamide; (3R)-3-(cyclohexylmethyl)-N-{2-[(4-fluorophenyl)amino]ethyl}-4-(morpholin-4-yl)-4-oxobutanamide; 3-(R)-Cyclohexylmethyl-N-[2-(4-fluoro-phenylamino)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397973; SCHEMBL3958229; BDBM50201707; 5-[(2,3-dimethylphenoxy)methyl]-3-methyl-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Arylaminoethyl carbamate, 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213712; SCHEMBL3010786; BDBM19690
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
2-(2,3,4,5,6-Pentafluorophenyl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503392; BDBM50244754
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230479; SCHEMBL3961271; BDBM50201706; trans-4-(2,3-dimethylphenoxy)-3-hydroxypiperidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(1r,2r)-N-(1-Cyanocyclopropyl)-2-{[4-(4-Fluorophenyl)piperazin-1-Yl]carbonyl}cyclohexanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070936; SCHEMBL8115758; BDBM50390404; Q27451185
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Arylaminoethyl carbamate, 26
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424904; SCHEMBL3021491; BDBM19692
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Succinamide peptidomimetic, 36
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239369; SCHEMBL3022642; BDBM19670
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(6-Bromopyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459683; BDBM50244704
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
4,5-Dimethyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512758; BDBM50244752
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
4-Fluoro-2',4'-dihydroxychalcone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928752; BDBM50491467; (e)-1-(2,4-dihydroxyphenyl)-3-(4-fluorophenyl)prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070949; SCHEMBL8108208; BDBM50390398
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Arylaminoethyl carbamate, 27
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444645; SCHEMBL3021814; BDBM19693
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Succinamide peptidomimetic, 35
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239368; SCHEMBL3021841; BDBM19669
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(2,3,5,6-Tetrafluoropyridin-4-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461945; BDBM50244751; 2-(2,3,5,6-Tetrafluoro-4-pyridyl)-4,5,6,7-tetrahydro-1,2-benzoisothiazole-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Arylaminoethyl carbamate, 15
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386382; BDBM19684
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354496; BDBM50042855
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
Diethylcyanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N,N-Diethylcyanamide; CYANAMIDE, DIETHYL-; N-Cyanodiethylamine; Diethylkyanamid; USAF EK-6326; Diethyl-cyanamide; MFCD00001769; CHEMBL274120; aminodiethylcarbonitrile; Diethylcyanamide, 99+%; Diethylkyanamid [Czech]; cyanodiethylamine; (Diethylamino)carbonitrile; NSC 7768; EINECS 210-532-7; BRN 1741595; NSC7768; Diethylcyanamide, 99%; cyanamide, N,N-diethyl-; ACMC-1B2S1; 4-04-00-00381 (Beilstein Handbook Reference); WLN: NCN2&2; CTK2F3540; DTXSID20210705; ALBB-025897; NSC-7768; ZINC1688361; BDBM50095484; SBB060416; AKOS015915817; MCULE-5340167535; AS-56776; D4965; R1024; ST45029069; J-802191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2E)-3-(3-Bromo-4-methoxyphenyl)-1-(4-fluorophenyl)prop-2-EN-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382057; ZINC7058678; BDBM50491471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Arylaminoethyl carbamate, 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425079; SCHEMBL3022810; BDBM19695
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354493; BDBM50042858
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[23] | |||
| Compound Name |
N-[(1R)-7-(Azepan-1-ylmethylideneamino)-1,2,3,4-tetrahydronaphthalen-1-yl]-4-bromobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3342550; BDBM50030816
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Arylaminoethyl carbamate, 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386640; SCHEMBL3024950; BDBM19678
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4,5-dimethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070939; BDBM50390388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070951; BDBM50390405
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2E)-2-[(E)-1-Phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180339; BDBM50400187
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
1-(5,7-Dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-3-(1,1,4a-trimethyl-1,2,3,4,4a,9a-hexahydro-9H-xanthene-7-yl)-1-propanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3352912; BDBM50032159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Succinamide peptidomimetic, 33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238748; SCHEMBL3016710; BDBM19667
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(6-Chloropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513281; BDBM50244703; 2-(6-Chloro-2-pyridyl)-4,5,6,7-tetrahydro-1,2-benzoisothiazole-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Arylaminoethyl amide deriv. 32
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386797; BDBM19718
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[30] | |||
| Compound Name |
(1R,2R)-2-[4-(4-Tert-butyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070942; BDBM50390392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Succinamide peptidomimetic, 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239579; BDBM19641; (3S)-3-(cyclohexylmethyl)-N-{2-[(4-fluorophenyl)amino]ethyl}-4-(morpholin-4-yl)-4-oxobutanamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2069324; BDBM50390406
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1,1-Dioxo-2-pyridin-4-yl-4,5,6,7-tetrahydro-1,2-benzothiazol-3-one;perchloric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512569
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(E)-3-(3-Bromo-4-methoxyphenyl)-1-thiophen-2-ylprop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2382058; BDBM50491470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-cyclopropyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070941; SCHEMBL8099073; BDBM50390387
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354499; BDBM50042851
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[5-methyl-4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070944; SCHEMBL8108160; BDBM50390394
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
S-Tert-Butyl Phenylmethanesulfinothioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1224242; Benzenemethanesulfinothioic acid, S-(1,1-dimethylethyl) ester; ACMC-20ln61; CTK2J4574; DTXSID30525579; BDBM50325652
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
Succinamide peptidomimetic, 41
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394207; BDBM19675
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Arylaminoethyl carbamate, 16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217136; SCHEMBL3020642; BDBM19685
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(1R,2R)-N-[(1S)-1-Cyano-2,2-dimethylpropyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164681; BDBM50395231
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
5-Methyl-4-phenyl-2-(2,3,5,6-tetrafluoropyridin-4-yl)-isothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461946; BDBM50244753
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Arylaminoethyl carbamate, 25
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214626; SCHEMBL3006645; BDBM19691
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441907; SCHEMBL3959125; BDBM50201704; (3S,4R)-4-(2,3-Dimethylphenoxy)-3-piperidinol; UNII-LHH887104B component ZHFIAFNZGWCLHU-WCQYABFASA-N
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354492; BDBM50042850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(1R,2R)-N-(Cyanomethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164676; BDBM50395226
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
Succinamide peptidomimetic, 39
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394206; SCHEMBL3015580; BDBM19673
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210712; BDBM50410977
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[13] | |||
| Compound Name |
(2E)-3-(4-Fluorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8102; (E)-3-(4-fluorophenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one; 4-fluoro-4'-hydroxychalcone; SCHEMBL3004968; ZINC5094118; BDBM50491480; AKOS001032442; JS-2988; NCGC00331493-01; ST45113617; AB01325492-02; AB01325492-03; SR-01000227962; SR-01000227962-1; (E)-1-(4-Hydroxyphenyl)-3-(4-fluorophenyl)-2-propene-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Arylaminoethyl carbamate, 33
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215198; SCHEMBL3021674; BDBM19699
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(2E)-2-[(E)-1-Phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-5-propan-2-yl-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180342; BDBM50400185
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
Succinamide peptidomimetic, 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240616; BDBM19639; (2S)-2-(cyclohexylmethyl)-N-{2-[(4-fluorophenyl)amino]ethyl}-4-(morpholin-4-yl)-4-oxobutanamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070950; BDBM50390399
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(1R,2R)-2-[4-[5-Chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]-N-(1-cyanocyclopropyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070945; SCHEMBL8106390; BDBM50390395
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Arylaminoethyl carbamate, 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214327; SCHEMBL3018612; BDBM19680
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Arylaminoethyl carbamate, 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424891; SCHEMBL8290919; BDBM19697
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Arylaminoethyl carbamate, 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424894; BDBM19687
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(7,7-dimethyl-4,6-dihydropyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071098; BDBM50390403
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-4-amino-4-oxobutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147223; BDBM50121296
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
Succinamide peptidomimetic, 38
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239781; BDBM19672
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
Succinamide peptidomimetic, 40
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240444; SCHEMBL3013785; BDBM19674
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354498; BDBM50042852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2E)-5-Ethyl-2-[(E)-1-phenoxypropan-2-ylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180341; BDBM50400186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
1,1-Dioxo-2-(2,3,5,6-tetrafluoropyridin-4-yl)-1,2-benzothiazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518500; ChemDiv1_000783; Oprea1_064109; SCHEMBL7439955; CTK7C2784; HMS589D13; ZINC33357; BDBM50244756; STK711607; AKOS001739893; MCULE-5573114341; ST047481; 2-(2,3,5,6-Tetrafluoro-4-pyridinyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; 2-(2,3,5,6-Tetrafluoro-4-pyridinyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide #; 2-(2,3,5,6-tetrafluoro-4-pyridyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; 2-(2,3,5,6-tetrafluoro-4-pyridyl)-1H-1,2-benzisothiazole-1,1,3(2H)-trione; 2-(2,3,5,6-tetrafluoro-4-pyridyl)-2-hydrobenzo[d]isothiazole-1,1,3-trione; 2-(2,3,5,6-Tetrafluoropyridin-4-yl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; 2-(2,3,5,6-tetrafluoropyridin-4-yl)-1,2-benzothiazol-3(2H)-one 1,1-dioxide; Benzisothiazol-3(2H)-one, 2-(2,3,5,6-tetrafluoro-4-pyridyl)-, 1,1-dioxide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071095; SCHEMBL8109493; BDBM50390400
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-ethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070940; BDBM50390389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Succinamide peptidomimetic, 24
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238963; SCHEMBL3839931; BDBM19658
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071097; SCHEMBL8122264; BDBM50390402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Arylaminoethyl carbamate, 32
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386488; SCHEMBL3027669; BDBM19698
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxohexan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272375; BDBM50374299
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[32] | |||
| Compound Name |
(1R,2R)-N-(Cyanomethyl)-2-(piperidine-1-carbonyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164672; BDBM50395229
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
Succinamide peptidomimetic, 23
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238962; SCHEMBL3835679; BDBM19657
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
(1R,2R)-N-(Cyanomethyl)-2-(3,6-dihydro-2H-pyridine-1-carbonyl)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164673; BDBM50395232
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
Tert-butyl (3S)-3-[(2S)-2-[(6-chloro-1,3-benzoxazol-2-yl)amino]-3-cyclohexylpropanamido]-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407941; SCHEMBL5357612; BDBM19637; Heterocyclic arylaminoethyl amide, 13i
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521636; BDBM50250153; 3-acetyl-2-(4-tert-butylanilino)-8-chloro-6-nitro-1H-quinolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
2-(3,5-Difluoropyridin-2-yl)-4,5,6,7-tetrahydro-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459684; BDBM50244705
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Arylaminoethyl carbamate, 28
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214757; SCHEMBL3011651; BDBM19694
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
Arylaminoethyl carbamate, 30
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385719; SCHEMBL3014813; BDBM19696
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[20] | |||
| Compound Name |
S-Cyclohexyl cyclohexane-1-sulfinothioate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1224169; BDBM50325649; S-cyclohexyl cyclohexanesulfinothioate; Cyclohexanethiosulfinic acid S-cyclohexyl ester
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
(3S)-N-[1-[[(2R)-Butan-2-yl]amino]-1,2-dioxohexan-3-yl]-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184715; BDBM50152748
Click to Show/Hide
|
||||
| Activity |
Ki = 107000 nM
|
[6] | |||
| Compound Name |
2-Methyl-5-nitroquinoline-8-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-methyl-5-nitroquinolin-8-ol; CHEMBL4229176; SCHEMBL8381316; DTXSID10876218; 8-Quinolinol, 2-methyl-5-nitro-; BDBM50460480
Click to Show/Hide
|
||||
| Activity |
Ki = 122000 nM
|
[34] | |||
| Compound Name |
Chembl365415
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371797; BDBM50152752
Click to Show/Hide
|
||||
| Activity |
Ki = 123000 nM
|
[6] | |||
| Compound Name |
7-(Cyanomethylaminomethyl)-5-nitro-8-quinolinol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312216; MDK7677; 2-{[(8-Hydroxy-5-nitroquinoline-7- yl)methyl]amino}-acetonitrile; BDBM50425030; 2-[[(8-hydroxy-5-nitroquinolin-7-yl)methyl]amino]acetonitrile
Click to Show/Hide
|
||||
| Activity |
Ki = 124000 nM
|
[35] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[5-[4-(dimethylamino)phenyl]-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210523; BDBM50410974
Click to Show/Hide
|
||||
| Activity |
Ki = 130000 nM
|
[13] | |||
| Compound Name |
[(S)-1-(Pyridin-3-ylmethyl)-aminooxalyl]-pentyl)-carbamic acid (R)-1-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylmethyl]-2,2-dimethyl-propyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189417; SCHEMBL8370404; BDBM50169484
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[17] | |||
| Compound Name |
(3S,3As,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
VX-950, Telaprevir; CHEMBL443336; CYC142; SCHEMBL1709083; SCHEMBL16556602; CTK5A5985; DTXSID00389004; AKOS015896277; AC-5241; AB01566825_01
Click to Show/Hide
|
||||
| Activity |
Ki = 134000 nM
|
[6] | |||
| Compound Name |
Acetic acid (2S,3S)-3-[(1-benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-4-oxo-azetidin-2-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62453; BDBM50129077; (3S)-3beta-[1-(Benzyloxycarbonylamino)cyclopentylcarbonylamino]-4alpha-acetoxyazetidine-2-one
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[36] | |||
| Compound Name |
Chembl184525
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371796; BDBM50152755
Click to Show/Hide
|
||||
| Activity |
Ki = 146000 nM
|
[6] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378780; BDBM50410969
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[13] | |||
| Compound Name |
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-methylpiperazine-1-carbonyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199487; SCHEMBL6185586; BDBM50410601
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
Benzyl N-[(2R)-1-(cyanomethylamino)-4-methyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200511; BDBM50410573
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
N-[(2S)-1-[5-(Furan-2-yl)-1,3,4-oxadiazol-2-yl]-1-oxopentan-2-yl]-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209294; BDBM50410970
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[13] | |||
| Compound Name |
N-(Cyanomethyl)-1-(3-phenylpropanoylamino)cyclohexane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372139; SCHEMBL6183662; BDBM50410610
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
Methyl (E,4S)-4-[[2-[(3R)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]-6-methylhept-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171803; BDBM50322341
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[10] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-oxo-1-(5-propan-2-yl-1,3,4-oxadiazol-2-yl)pentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209766; BDBM50410975
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[13] | |||
| Compound Name |
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-2-pyridin-4-yl-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371771; BDBM50410579
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
2-((2S,3S)-2-Acetoxy-4-oxo-azetidin-3-ylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL411932; BDBM50129078
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[36] | |||
| Compound Name |
Benzyl 1-((cyanomethyl)carbamoyl)cyclopropylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200776; SCHEMBL6181261; Benzyl N-[1-(cyanomethylcarbamoyl)cyclopropyl]carbamate; BDBM50410599
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
Acetic acid (2S,3S)-3-{[(R)-2-((S)-benzyloxycarbonylamino)-cyclopentanecarbonyl]-amino}-4-oxo-azetidin-2-yl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65990; BDBM50129076
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[36] | |||
| Compound Name |
Benzyl N-[(2S)-1-(cyanomethylamino)-3,3-dimethyl-1-oxobutan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199483; BDBM50410581
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
2-((2S,3S)-2-Acetoxy-4-oxo-azetidin-3-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62923; BDBM50129074
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[36] | |||
| Compound Name |
N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-[2-[4-(oxan-4-yl)piperazin-1-yl]-1,3-thiazol-4-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200543; BDBM50410590
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
Benzyl 1-((cyanomethyl)carbamoyl)cyclopentylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372140; SCHEMBL6183581; Benzyl N-[1-(cyanomethylcarbamoyl)cyclopentyl]carbamate; BDBM50410577
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
Methyl (E)-4-[[2-[(3R)-5-(4-bromophenyl)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-2-oxo-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171633; BDBM50322343
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[10] | |||
| Compound Name |
Benzyl N-[(2S)-1-(cyanomethylamino)-2,4-dimethyl-1-oxopentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200545; BDBM50410604
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[4] | |||
| Compound Name |
(3S,3As,6aR)-N-[1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-2-[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(pyrazine-2-carbonylamino)butanoyl]amino]butanoyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315390; SCHEMBL13091808; BDBM50137739
Click to Show/Hide
|
||||
| Activity |
Ki = 154000 nM
|
[6] | |||
| Compound Name |
5-Nitro-8-(4-methylpiperidino)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312204; MDK0734; 8-(4-methylpiperidin-1-yl)-5-nitroquinoline; BDBM50425024
Click to Show/Hide
|
||||
| Activity |
Ki = 155000 nM
|
[35] | |||
| Compound Name |
Chembl4228126
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460481
Click to Show/Hide
|
||||
| Activity |
Ki = 155000 nM
|
[34] | |||
| Compound Name |
(1R)-2,2-Dimethyl-1-({5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-YL}methyl)propyl (1S)-1-{oxo[(2-oxo-1,3-oxazolidin-3-YL)amino]acetyl}pentylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365822; SCHEMBL8369275; BDBM50169488; Q27453776
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[17] | |||
| Compound Name |
2-Bromo-4-nitronaphthalen-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Bromo-4-nitro-1-naphthalenamine; 2-Bromo-4-nitro-naphthalen-1-ylamine; 2-Bromo-4-nitro-1-naphthylamine; CHEMBL2312203; MFCD00085870; 2-bromo-4-nitro-1-aminonaphthalene; SCHEMBL3609722; CTK2A9597; DTXSID70629368; 1-Amino-2-Bromo-4-nitronaphthalene; 1606AJ; BDBM50425017; ZINC95595255; 1-Naphthalenamine, 2-bromo-4-nitro-; ACN-047841; SB38041; AS-62816; SY129737; CS-0103519; W-3987
Click to Show/Hide
|
||||
| Activity |
Ki = 182000 nM
|
[35] | |||
| Compound Name |
(1r)-2,2-Dimethyl-1-({5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}methyl)propyl(1S)-1-(oxo{[(1r)-1-phenylethyl]amino}acetyl)pentylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363773; SCHEMBL8370419; BDBM50169492
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[17] | |||
| Compound Name |
Chembl4228576
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460502
Click to Show/Hide
|
||||
| Activity |
Ki = 195000 nM
|
[34] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ethyl (2R,3R)-3-[[(1-acetylpyrrolidine-2-carbonyl)amino]-(2-amino-2-oxoethyl)carbamoyl]oxirane-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111487; BDBM228616; US9345789, LI-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[37] | |||
| Compound Name |
[(S)-1-(Pyridin-2-ylaminooxalyl)-pentyl]-carbamic acid (S)-2,2-dimethyl-1-[3-(4-trifluoromethyl-phenyl)-pyrazol-1-ylmethyl]-propyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188929; SCHEMBL8371501; BDBM50169485
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[17] | |||
| Compound Name |
Pyrrolidine, 1-(4-nitro-1-naphthalenyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570897; 1-(4-nitronaphthalen-1-yl)pyrrolidine; ACMC-20mc9g; (4-nitronaphthyl)pyrrolidine; Oprea1_221230; SCHEMBL3603749; CTK0D5811; DTXSID10403220; 1-(4-nitro-1-naphthyl)pyrrolidine; ZINC4126409; BDBM50415097; AKOS001483561; MCULE-7970978795; EU-0066932; ST50993708; SR-01000390159; SR-01000390159-1
Click to Show/Hide
|
||||
| Activity |
Ki = 245000 nM
|
[35] | |||
| Compound Name |
Ridaura
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AURANOFIN; Triethylphosphine gold; SK&F-39162; SK-39162; 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold; Auranofina; Auranofine; Auranofinum; Auroafen; CHEMBL1366; GTPL6306; BDBM50153291; DB00995; (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold2,3,4,6-tetraacetate
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[11] | |||
| Compound Name |
2-(2-{2-Cyclohexyl-2-[(pyrazine-2-carbonyl)-amino]-acetylamino}-3,3-dimethyl-butyryl)-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid (1-cyclopropylaminooxalyl-3,3-difluoro-propyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL414805; BDBM50152750
Click to Show/Hide
|
||||
| Activity |
Ki = 760000 nM
|
[6] | |||
| Compound Name |
Chembl4244085
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50463145
Click to Show/Hide
|
||||
| Activity |
Ki = 780000 nM
|
[38] | |||
| Compound Name |
Chembl4128058
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50271687
Click to Show/Hide
|
||||
| Activity |
IC50 = 816000 nM
|
[39] | |||
| Compound Name |
[(2S)-3,3-Dimethyl-1-[3-[4-(trifluoromethyl)phenyl]pyrazol-1-yl]butan-2-yl] N-[(3S)-1-(1,2-oxazol-5-ylmethylamino)-1,2-dioxoheptan-3-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365049; BDBM50169489
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[17] | |||
| Compound Name |
(3S)-3-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-5-(2,6-dimethylbenzoyl)oxy-4-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3954843; BDBM228617; US9345789, LI-0
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[37] | |||
| Compound Name |
[(S)-1-(Thiazol-2-ylaminooxalyl)-pentyl]-carbamic acid (S)-2,2-dimethyl-1-[4-(4-trifluoromethyl-phenyl)-imidazol-1-ylmethyl]-propyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187864; BDBM50169497
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[17] | |||
| Compound Name |
(1r)-1-{[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-2,2-dimethylpropyl(1S)-1-[oxo(1h-pyrazol-5-ylamino)acetyl]pentylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186149; SCHEMBL6616610; BDBM50169491
Click to Show/Hide
|
||||
| Activity |
IC50 = 3800000 nM
|
[17] | |||
| Compound Name |
(1R,21S,24S)-21-Tert-butyl-N-[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,7.06,11]heptacosa-6(11),7,9-triene-24-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599872; SCHEMBL3263999; BDBM50326055
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[40] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V. Eur J Med Chem. 2012 Aug;54:10-21. | ||||
| REF 2 | Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007 Jul 20;282(29):20836-46. | ||||
| REF 3 | Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1975-80. | ||||
| REF 4 | Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem. 2005 Dec 1;48(24):7520-34. | ||||
| REF 5 | Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5563-8. | ||||
| REF 6 | P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors. Bioorg Med Chem Lett. 2004 Oct 4;14(19):5007-11. | ||||
| REF 7 | Primary amides as selective inhibitors of cathepsin K. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4328-32. | ||||
| REF 8 | Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3320-4. | ||||
| REF 9 | Exploring inhibitor binding at the S' subsites of cathepsin L. J Med Chem. 2008 Mar 13;51(5):1361-8. | ||||
| REF 10 | Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):4928-38. | ||||
| REF 11 | Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorg Med Chem Lett. 2004 Oct 18;14(20):5113-6. | ||||
| REF 12 | Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs. Bioorg Med Chem. 2018 Aug 7;26(14):4310-4319. | ||||
| REF 13 | Keto-1,3,4-oxadiazoles as cathepsin K inhibitors. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2909-14. | ||||
| REF 14 | Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors?. Bioorg Med Chem Lett. 2013 May 15;23(10):2968-73. | ||||
| REF 15 | Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity. Bioorg Med Chem. 2009 Feb 1;17(3):1307-24. | ||||
| REF 16 | Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorg Med Chem Lett. 2007 May 15;17(10):2899-903. | ||||
| REF 17 | P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3540-6. | ||||
| REF 18 | Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides. J Med Chem. 2002 Nov 21;45(24):5321-9. | ||||
| REF 19 | Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4979-84. | ||||
| REF 20 | Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5107-11. | ||||
| REF 21 | Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1486-90. | ||||
| REF 22 | Structures and bioactivities of dihydrochalcones from Metrodorea stipularis. J Nat Prod. 2014 Nov 26;77(11):2418-22. | ||||
| REF 23 | Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg Med Chem Lett. 2015 Feb 1;25(3):438-43. | ||||
| REF 24 | (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis. J Med Chem. 2012 Jul 26;55(14):6363-74. | ||||
| REF 25 | Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1254-9. | ||||
| REF 26 | Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides. Bioorg Med Chem. 2008 Sep 1;16(17):8127-35. | ||||
| REF 27 | Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. J Med Chem. 2001 Jan 4;44(1):94-104. | ||||
| REF 28 | Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. ACS Med Chem Lett. 2014 Aug 27;5(10):1138-42. | ||||
| REF 29 | Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice. J Med Chem. 2012 Dec 27;55(24):10918-36. | ||||
| REF 30 | Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5112-7. | ||||
| REF 31 | Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. | ||||
| REF 32 | Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. | ||||
| REF 33 | Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. J Med Chem. 2009 May 14;52(9):3093-7. | ||||
| REF 34 | Cathepsin B inhibitors: Further exploration of the nitroxoline core. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1239-1247. | ||||
| REF 35 | Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem. 2013 Jan 24;56(2):521-33. | ||||
| REF 36 | 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2051-3. | ||||
| REF 37 | US patent application no. 9345789B2, Specific inhibitors and active site probes for legumain | ||||
| REF 38 | Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates. Bioorg Med Chem. 2018 Sep 1;26(16):4624-4634. | ||||
| REF 39 | Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1972-1980. | ||||
| REF 40 | MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.