Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44818 | Target Info | |||
| Target Name | Tryptophan 2,3-dioxygenase (TDO) | ||||
| Synonyms |
Tryptophanase; Tryptophan pyrrolase; Tryptophan oxygenase; Tryptamin 2,3-dioxygenase; TRPO; TO
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| Target Type | Clinical trial Target | ||||
| Gene Name | TDO2 | ||||
| Biochemical Class | Oxygenase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 53 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PF-06840003
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|
Phase 1 | Compound Info | ||
| Synonyms |
3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione; 198474-05-4; PF06840003; 2,5-Pyrrolidinedione, 3-(5-fluoro-1H-indol-3-yl)-; 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione; SCHEMBL5463464; GTPL9565; CTK0A0183; DTXSID00630149; MXKLDYKORJEOPR-UHFFFAOYSA-N; KS-000008MY; EX-A1186; EOS200271; AKOS027252536; CS-6186; AS-51973; HY-101111; 3-(5-Fluoro-1H-indol-3-yl)-pyrrolidine-2,5-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
amg-1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3342402; N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide; BAS 06591295; AC1LLIU7; GTPL8227; SCHEMBL20313457; MolPort-000-220-791; ZINC801901; STL305655; BDBM50030791; AKOS000657540; MCULE-5294683561; ST50049773; Z56882059; N-(2H-1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide; 496023-55-3; N-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)-2-[5-(4-methylphenyl)(1,3-thiazolino[3,2- d]1,2,4-triazol-3-ylthio)]acetamide
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| Activity |
IC50 ~ 62500 nM
|
[1] | |||
| Compound Name |
5-phenyl-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
1680-44-0; 5-phenyl-1H-1,2,3-triazole; 4-Phenyl-1H-1,2,3-triazole; 4-Phenyl-1H-[1,2,3]triazole; 4-Phenyl-1,2,3-triazole; 1H-1,2,3-Triazole, 4-phenyl-; 4-phenyl-2H-triazole; v-Triazole, 4-phenyl-; 4-phenyl-2H-[1,2,3]triazole; LUEYUHCBBXWTQT-UHFFFAOYSA-N; 4-phenyl-1h-1,2,3,-triazole; 5-Phenyl-1H-[1,2,3]triazole; 112614-96-7; phenyltriazole; 4-phenyltriazole; NSC83125; SCHEMBL9868; AC1L3A0F; 5-phenyl-1,2,3-triazole; SCHEMBL8221447; CHEMBL193664; 1,2,3-triazole analogue, 4; 1,2,3-Triazole, 4-phenyl-; ZINC27320; BDBM17448; CTK4D2851
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
7-Chloro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812527; BDBM50350281; ZINC72106256
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-Methyl-N'-(2-oxoindol-3-yl)benzenesulfonohydrazide
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Investigative | Compound Info | ||
| Synonyms |
ST50183111; 4-methyl-N'-[(3E)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzenesulfonohydrazide; NSC39529; Isatin-3-tosylhydrazone; MLS000068551; CHEMBL1399597; CHEMBL4290305; SCHEMBL11546068; DTXSID30417980; HMS2379I14; isatin-3-p-toluenesulfonylhydrazone; NSC-39529; STK391818; ZINC13130177; AKOS000534630; AKOS002939706; AKOS030747205; MCULE-9003849960; SMR000122930; BRD-K02440007-001-07-9; Z49616730; 4-Methyl-N'-(2-oxoindolin-3-ylidene)benzene-1-sulfonohydrazide; 3-({[(4-methylphenyl)sulfonyl]amino}azamethylene)-1H-benzo[d]azolidin-2-one; 4-methyl-N'-(2-oxo-2,3-dihydro-1H-indol-3-ylidene)benzene-1-sulfonohydrazide
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| Activity |
IC50 = 52900 nM
|
[4] | |||
| Compound Name |
3-[2-(4-Chlorophenyl)hydrazinyl]indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1652343; SCHEMBL11764907; ZINC6345070
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| Activity |
IC50 = 53380 nM
|
[4] | |||
| Compound Name |
Chembl4160797
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Investigative | Compound Info | ||
| Synonyms |
BDBM50287566
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| Activity |
IC50 = 54400 nM
|
[5] | |||
| Compound Name |
Chembl4290045
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Investigative | Compound Info | ||
| Activity |
IC50 = 54690 nM
|
[4] | |||
| Compound Name |
Chembl4294515
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|
Investigative | Compound Info | ||
| Activity |
IC50 = 56120 nM
|
[4] | |||
| Compound Name |
Chembl4286924
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|
Investigative | Compound Info | ||
| Synonyms |
AKOS027643775
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| Activity |
IC50 = 58330 nM
|
[4] | |||
| Compound Name |
beta-3-Oxindolylalanine
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Investigative | Compound Info | ||
| Synonyms |
(2S)-2-amino-3-(2-oxo-1,3-dihydroindol-3-yl)propanoic acid; 2,3-dihydro-2-oxo-tryptophan; SCHEMBL1226606; CHEMBL4283109; CTK4D0320; (2S)-2-Amino-3-(2-oxoindolin-3-yl)propanoic acid
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| Activity |
IC50 = 60220 nM
|
[4] | |||
| Compound Name |
4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
INCB024360; INCB024360 analogue; IDO5L; INCB 024360-analog; CHEMBL584991; UNII-2HR315841W; INCB14943; 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboxamidine; 2HR315841W; (4E)-4-[(3-chloro-4-fluoroanilino)-nitrosomethylidene]-1,2,5-oxadiazol-3-amine; 914471-09-3 (INCB14943); IDO inhibitor 5l; INCB-024360 analog; SCHEMBL149779; SCHEMBL16933189; SCHEMBL17679343; SCHEMBL19654569; SCHEMBL19808082; AOB6408; BDBM347045; HMS3653H15; BCP08453; EX-A2076; ABP001121; BDBM50235921; BDBM50300305; MFCD18633286; s7587; US10202388, Ref. B; ZINC45319649; AKOS005266714; AKOS026750581; AKOS027470329; AKOS030228677; AKOS032947263; ZINC135817512; ZINC198540724; CCG-267172; CS-1495; SB18974; NCGC00386366-01; AC-33015; AK173147; AS-35126; AS-35229; DA-33529; HY-15683; QC-11856; SC-93943; C3011; FT-0700504; SW219363-1; J3.435.401D; A13004; W-6138; indoleamine-2,3-dioxygenase inhibitor INCB024360; Q27254756; (4Z)-4-[(3-chloro-4-fluoroanilino)-nitrosomethylidene]-1,2,5-oxadiazol-3-amine
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| Activity |
IC50 = 70000 nM
|
[2] | |||
| Compound Name |
Diethyl 2-(2-oxo-1H-indol-3-ylidene)propanedioate
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Investigative | Compound Info | ||
| Synonyms |
NSC351698; CHEMBL4293426; DTXSID70319914; AKOS004119146; NSC-351698; (2-Oxoindoline-3-ylidene)malonic acid diethyl ester
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| Activity |
IC50 = 71010 nM
|
[4] | |||
| Compound Name |
Chembl4279220
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Investigative | Compound Info | ||
| Activity |
IC50 = 83470 nM
|
[4] | |||
| Compound Name |
Chembl4165309
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50287567
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| Activity |
IC50 = 84000 nM
|
[5] | |||
| Compound Name |
3-(2H-1,2,3-Triazol-4-yl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
3-(2H-triazol-4-yl)benzonitrile; 3-(1H-1,2,3-triazol-4-yl)benzonitrile; CHEMBL2147990; Benzonitrile, 3-(1H-1,2,3-triazol-4-yl)-; SCHEMBL5206170; 2C9H6N4; DTXSID90460811; BDBM50391365; MFCD08275073; ZINC85210733; AKOS016010298; AKOS024015906; DS-2806; FS-3754; MP-1614; AK116365; 3-(1H-1,2,3-Triazole-4-yl)benzonitrile; AB0020069; CS-0045389; V0804; 3-(1H-(1,2,3)Triazol-4-yl)-benzonitrile; J3.574.418E; KS-00000139; 3-(1H-1,2,3-TRIAZOL-4-YL)BENZONITRILEAND3-(2H-1,2,3-TRIAZOL-4-YL)BENZONITRILE
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4281233
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50469076
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-(3-Nitrophenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147993; SCHEMBL4585369; 5-nitrophenyl-1,2,3-triazole; BDBM50391375; ZINC16399933; AKOS024385323; MCULE-7957048708; 4-(3-Nitrophenyl)-2H-1,2,3-triazole; ST51035988; J3.574.416I; J3.659.433K
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(3-Chlorophenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
4-(3-chlorophenyl)-2H-triazole; CHEMBL2147989; 4-(3-chlorophenyl)-1h-1,2,3-triazole; SCHEMBL1336095; ZINC85654; BDBM50391358; MCULE-3638426506; DA-38704; FT-0735951; 4-(3-CHLOROPHENYL)-2H-1,2,3-TRIAZOLE
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2H-Triazol-4-yl)aniline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147999; SCHEMBL1822947; BDBM50391370; ZINC95558762; 2-(1H-1,2,3-triazol-4-yl)aniline; 2-(1h-1,2,3-triazol-5-yl)aniline
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Chloro-4-(1H-1,2,3-triazol-4-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2146496; BDBM50391374
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1H-1,2,3-Triazole, 5-(2-ethylphenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148001; SCHEMBL11194759; BDBM50391371
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Phenol, 2-(1H-1,2,3-triazol-5-yl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147998; 2-triazolylphenol; SCHEMBL207829; BDBM50391359; ZINC34027363; 2-(1H-1,2,3-triazol4-yl)-phenol; 2-(1H-1,2,3-triazol-4-yl)-phenol; DA-28824; 6-(1,2-dihydrotriazol-5-ylidene)cyclohexa-2,4-dien-1-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4288429
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Investigative | Compound Info | ||
| Synonyms |
BDBM50469072
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-(2,3-Dichlorophenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148077; SCHEMBL5791176; BDBM50391364
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(3-Methylphenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL194853; 4-(m-tolyl)-1H-1,2,3-triazole; 4-(3-methylphenyl)-2H-triazole; 5-(3-methylphenyl)-1H-1,2,3-triazole; SCHEMBL670668; SCHEMBL13993856; 1,2,3-triazole analogue, 18; BDBM17462; ZINC13671886; DA-37075; FT-0769503; 15291-EP2270001A1; 15291-EP2284157A1; 15291-EP2287165A2; 15291-EP2287166A2; 15291-EP2289876A1; 15291-EP2292601A1; 15291-EP2292620A2; 15291-EP2295416A2; 15291-EP2295437A1; 15291-EP2298748A2; 15291-EP2298775A1; 15291-EP2299510A1; 15291-EP2299785A1; 15291-EP2301932A1; 15291-EP2305642A2; 15291-EP2306788A1; 15291-EP2306789A1; 15291-EP2308874A1; 15291-EP2316832A1; 15291-EP2316833A1; 15291-EP2374792A1; Q27464823
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4292907
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Investigative | Compound Info | ||
| Synonyms |
BDBM50469057
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1H-1,2,3-Triazole, 5-(3-ethylphenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147992; BDBM50391372
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(5-Chloro-2-methylphenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148075; BDBM50391369
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2,5-Dichlorophenyl)-1H-1,2,3-triazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148076; BDBM50391373
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Bromo-4-(2H-triazol-4-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147995; SCHEMBL15825152; BDBM50391360; DB-104331; 2-bromo-4-(1H-1,2,3-triazol-4-yl)pyridine
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(1H-1,2,3-Triazol-4-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
3-(2H-triazol-4-yl)phenol; 3-(1H-1,2,3-triazol-5-yl)phenol; CHEMBL198937; SCHEMBL4831837; ZINC9120; 1,2,3-triazole analogue, 19; BDBM17463; 3-(2H-1,2,3-Triazole-4-yl)phenol; 3-(1H-1,2,3-triazol-4-yl)-phenol; DA-25488; FT-0719849; J3.659.425J
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1H-1,2,3-Triazole, 5-(3-fluorophenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147994; SCHEMBL13896466; 4-(3-fluorophenyl)-2H-triazole; BDBM50391367
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2-Methoxyphenyl)-1h-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
4-(2-methoxyphenyl)-2H-triazole; 5-(2-methoxyphenyl)-1H-1,2,3-triazole; 1,2,3-triazole analogue, 9; CHEMBL372363; SCHEMBL5020204; BDBM17453; ZINC13671871; AKOS027406025; DA-38767; FT-0721169; J3.574.417G; 1H-1,2,3-Triazole,4-(2-methoxyphenyl)-(9CI)
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(2-Fluorophenyl)-1h-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148000; 4-(2-fluorophenyl)-2H-triazole; SCHEMBL2820801; BDBM50391362; ZINC34027365; AKOS027406023; J3.529.201B; 4-(2-FLUOROPHENYL)-2H-1,2,3-TRIAZOLE
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(4-Fluorophenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909735; 4-(4-fluorophenyl)-2H-triazole; 4-fluorophenyl-triazole; 1H-1,2,3-Triazole, 4-(4-fluorophenyl)-; SCHEMBL104083; BDBM50355867; ZINC16429384; AKOS024385321; AB23651; MCULE-2170106079; 4-(4-fluoro-phenyl)-1H-[1,2,3]triazole; ST51035985
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[2-(Trifluoromethyl)phenyl]-2H-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148002; SCHEMBL21690275; BDBM50391376
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(3-Bromophenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
4-(3-bromo-phenyl)-1H-[1,2,3]triazole; 4-(3-bromophenyl)-2H-triazole; SCHEMBL481943; 3-[3-(2-bromo-4-tert-butylphenoxy)propyl]pyridine; CHEMBL382312; 1,2,3-triazole analogue, 23; BDBM17467; ZINC13671894; AKOS023565809; AB23655; MCULE-3923678552; 5-(3-bromophenyl)-1H-1,2,3-Triazole; DA-06524; 5-(3-bromophenyl)-1H-[1,2,3]triazole; FT-0739906; ST51035989; pyridine, 3-[3-[2-bromo-4-(1,1-dimethylethyl)phenoxy]propyl]-
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4250771
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463915
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Fluoro-4-(1H-1,2,3-triazol-4-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147996; BDBM50391361
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4248088
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463903
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4239450
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463908
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4291850
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Investigative | Compound Info | ||
| Synonyms |
BDBM50469071
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(1H-1,2,3-Triazol-5-yl)aniline
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Investigative | Compound Info | ||
| Synonyms |
3-(2H-1,2,3-triazol-4-yl)aniline; Benzenamine, 3-(1H-1,2,3-triazol-5-yl)-; 3-(2H-triazol-4-yl)aniline; CHEMBL198194; SCHEMBL4313886; 1,2,3-triazole analogue, 20; BDBM17464; ZINC13671888; AKOS004122931; MCULE-4995165434; 3-(1H-1,2,3-Triazole-4-yl)aniline; DA-25489; 3-(2H-[1,2,3]Triazol-4-yl)phenylamine; FT-0704272
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-(3-(Trifluoromethyl)phenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147991; 4-[3-(trifluoromethyl)phenyl]-2H-triazole; SCHEMBL5020244; BDBM50391366
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-(2-Bromophenyl)-1H-1,2,3-triazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909733; 4-(2-bromophenyl)-2H-triazole; 1H-1,2,3-Triazole, 5-(2-bromophenyl)-; SCHEMBL5020238; BDBM50355861; 4-(2-Bromophenyl)-2H-1,2,3-triazole; J3.579.365H
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-Chloro-2-(1H-1,2,3-triazol-4-yl)phenol
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Investigative | Compound Info | ||
| Synonyms |
MMG-0358; CHEMBL2148074; 4-Chloro-2-(1H-1,2,3-triazol-5-yl)phenol; 4-chloranyl-2-(2~{H}-1,2,3-triazol-4-yl)phenol; EX-A986; BDBM50391363; MFCD24730415; ZINC95561226; AKOS027201161; J3.550.623C; 2-(1H-1,2,3-Triazole-5-yl)-4-chlorophenol; Z2327039962
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Chembl4285062
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Investigative | Compound Info | ||
| Synonyms |
BDBM50469070
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
Chembl4277781
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Investigative | Compound Info | ||
| Synonyms |
BDBM50469073
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| Activity |
IC50 ~ 100000 nM
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[6] | |||
| Compound Name |
Chembl4237632
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463907
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
5-(2-Methylphenyl)-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
1H-1,2,3-Triazole, 5-(2-methylphenyl)-; 4-(2-methylphenyl)-2H-triazole; ACMC-1CLI8; SCHEMBL20849; 1,2,3-triazole analogue, 8; CHEMBL196408; BDBM17452; CTK1A1855; ZINC27316; AKOS025310722; 4-(2-methylphenyl)-1h-1,2,3-triazole; DA-38762; DB-047572; FT-0703050
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1H-1,2,3-Triazole, 5-(2-chlorophenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1909734; 4-(2-chlorophenyl)-1h-1,2,3-triazole; 4-(2-chlorophenyl)-2H-triazole; SCHEMBL102470; BDBM50355862
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-(2H-Triazol-4-yl)-2-(trifluoromethyl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147997; BDBM50391368
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
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| Compound Name |
L-Tryptophan
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Approved | Compound Info | ||
| Synonyms |
Ardeytropin; Kalma; LTR; Lyphan; Optimax; Pacitron; Sedanoct; Triptofano; Trofan; Trp; Tryptacin; Tryptan; Tryptophane; Tryptophanum; Triptofano [Spanish]; Tryptophane [French]; Tryptophanum [Latin]; EH 121; MT1; T 0254; Alti-Tryptophan; L-TRYPTOPHAN SIGMA GRADE; L-Trp; L-Tryptofan; L-Tryptophane; L-Ttp; TRP NH3+ COOH; TRP-01; Tryptophan (VAN); Tryptophan [USAN:INN]; H-Trp-oh; Indole-3-alanine; L-Tryptophan (9CI); L-Tryptophan (JP15); Tryptophan (H-3); Tryptophan (USP/INN); L-b-3-Indolylalanine; L-beta-3-Indolylalanine; Tryptophan, L-(8CI); Alanine, 3-indol-3-yl; Alpha'-Amino-3-indolepropionic acid; L-(-)-Tryptophan; L-(-)-Tryptophane; L-a-Aminoindole-3-propionic acid; L-alpha-Aminoindole-3-propionic acid; L-alpha-amino-3-indolepropionic acid; Alpha-Amino-beta-(3-indolyl)-propionic acid; Alpha-amino-beta-(3-indolyl)-pr opionic acid; Propionic acid, 2-amino-3-indol-3-yl; S(-)-1-alpha-Aminoindole-3-propionic acid; (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid; (L)-TRYPTOPHAN; (S)-(-)-2-Amino-3-(3-indolyl)propionic Acid; (S)-(-)-Tryptopha n; (S)-(-)-Tryptophan; (S)-2-Amino-3-(1H-indol-3-yl)propanoic acid; (S)-2-Amino-3-(3-indolyl)propionic acid; (S)-Tryptophan; (S)-a-Amino-1H-indole-3-propanoic acid; (S)-a-Amino-b-indolepropionic acid; (S)-a-Aminoindole-3-propionic acid; (S)-alpha-Amino-1H-indole-3-propanoic acid; (S)-alpha-Amino-beta-indolepropionic acid; (S)-alpha-Aminoindole-3-propionic acid; (S)-alpha-amino-beta-(3-indolyl)-propionic acid; 1-beta-3-Indolylalanine; 151A3008-4CFE-40C9-AC0B-467EF0CB50EA; 1H-Indole-3-alanine; 1H-Indole-3-alanine (VAN); 1beta-3-Indolylalanine; 2-Amino-3-(lH-indol-3-yl)-propanoic acid; 2-Amino-3-indolylpropanoic acid; 2-amino-3-indol-3-ylpropionic acid; 3-Indol-3-ylalanine
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| Activity |
Ki = 11500000 nM
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[8] | |||
| References | Top | ||||
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| REF 1 | Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy. Eur J Med Chem. 2018 Jan 1;143:656-669. | ||||
| REF 2 | Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem. 2012 Jun 14;55(11):5270-90. | ||||
| REF 3 | Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles. Eur J Med Chem. 2012 Aug;54:95-102. | ||||
| REF 4 | Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1. Medchemcomm. 2017 Jun 20;8(8):1640-1654. | ||||
| REF 5 | Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold. ACS Med Chem Lett. 2018 Jan 11;9(2):131-136. | ||||
| REF 6 | Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors. Eur J Med Chem. 2018 Sep 5;157:423-436. | ||||
| REF 7 | Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors. Bioorg Med Chem. 2018 Sep 15;26(17):4886-4897. | ||||
| REF 8 | Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J Med Chem. 2011 Aug 11;54(15):5320-34. | ||||
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