Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T46482 | Target Info | |||
| Target Name | Toll-like receptor 7 (TLR7) | ||||
| Synonyms |
Toll-like receptor 7
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|
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| Target Type | Successful Target | ||||
| Gene Name | TLR7 | ||||
| Biochemical Class | Toll-like receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 93 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4282327
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19385120; BDBM50467797
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|
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
2-Methyl-1-(2-nonylimidazo[4,5-c]quinolin-3-yl)propan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795705; BDBM50346932; ZINC72175410
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|
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| Activity |
IC50 = 52940 nM
|
[2] | |||
| Compound Name |
Chembl4287549
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19385098; BDBM50467769
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|
||||
| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
1-[2-(Ethylaminomethyl)imidazo[4,5-c]quinolin-3-yl]-2-methylpropan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1187626; CHEMBL512499; BDBM50278696
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|
||||
| Activity |
IC50 = 56310 nM
|
[2] | |||
| Compound Name |
N-[[3-[(4-Methoxyphenyl)methyl]imidazo[4,5-c]quinolin-2-yl]methyl]ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795691; BDBM50346938; ZINC72177067
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| Activity |
IC50 = 59640 nM
|
[2] | |||
| Compound Name |
Chembl4207057
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457682
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|
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| Activity |
IC50 = 60000 nM
|
[3] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC(=C1)C)CN
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895772; SCHEMBL18041321; BDBM254776; US9475775, 43
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|
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| Activity |
EC50 = 61000 nM
|
[4] | |||
| Compound Name |
4-(Aminomethyl)-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084216; BDBM50252290
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|
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| Activity |
IC50 = 66170 nM
|
[5] | |||
| Compound Name |
3-Methyl-2-nonyl-imidazo[4,5-c]quinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795709; BDBM50346936; ZINC72175511
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|
||||
| Activity |
IC50 = 68800 nM
|
[2] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=NC=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915422; SCHEMBL18041325; BDBM254736; US9475775, 3
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|
||||
| Activity |
EC50 = 70100 nM
|
[4] | |||
| Compound Name |
2-Amino-N4,N4-dipropyl-N8-(3-pyridyl)-3H-1-benzazepine-4,8-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971249; SCHEMBL18041290; BDBM254734; US9475775, 1
Click to Show/Hide
|
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| Activity |
EC50 = 80800 nM
|
[4] | |||
| Compound Name |
4-Amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
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|
Investigative | Compound Info | ||
| Synonyms |
R 842; UNII-T8NPD94NTJ; T8NPD94NTJ; CHEMBL195276; 1-(4-aminoimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol; 2-Hydroxy Imiquimod; 4-amino-alpha,alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; R-842; SCHEMBL189202; CTK8G5878; DTXSID80150133; 4-Amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinolin-1-ethanol; BDBM50403024; DS-020086; 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-; A-dimethyl-; 4-amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinoline; 4-amino-alpha,alpha,-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; 4-amino-alpha,alphadimethyl-1H-imidazo [4,5-c]quinoline-1-ethanol; 1H-Imidazo(4,5-c)quinoline-1-ethanol, 4-amino-alpha,alpha-dimethyl-
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|
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| Activity |
EC50 = 95000 nM
|
[6] | |||
| Compound Name |
CU-CPT17e
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|
Investigative | Compound Info | ||
| Synonyms |
CU-CPT-17e; CHEMBL4074408; BCP29395; HY-101929; CS-0022184
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|
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| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)occcccn
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984631; SCHEMBL18041330; BDBM254779; US9475775, 46
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4284645
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760756; BDBM50467918
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)cccn
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963744; SCHEMBL18041370; BDBM254783; US9475775, 50
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4288029
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761875; BDBM50467910
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=C(C=C1)cccn
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923648; SCHEMBL18041335; BDBM254794; US9475775, 61
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccco)C=CC(=C2)C(=O)NC=1C=NC=CC=1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900503; SCHEMBL18041393; BDBM254772; US9475775, 39
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Amino-N8-[3-(5-aminopentyl)phenyl]-N4,N4-dipropyl-3H-1-benzazepine-4,8-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914070; SCHEMBL18041314; BDBM254790; US9475775, 57
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccccccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947170; SCHEMBL18041288; BDBM254807; US9475775, 74
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)OC
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949289; SCHEMBL18041368; BDBM254763; US9475775, 30
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=C(C=C1)cccccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892090; SCHEMBL18041409; BDBM254791; US9475775, 58
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1SC=CN=1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3962164; SCHEMBL18041291; BDBM254744; US9475775, 11
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(CC#C)Ccc)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935496; SCHEMBL18041446; BDBM254774; US9475775, 41
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Cco)cccc)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945379; SCHEMBL18041312; BDBM254798; US9475775, 65
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4278564
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761205; BDBM50467913
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=C(C=C1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899088; SCHEMBL18041396; BDBM254761; US9475775, 28
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccc1=CC=C(C=C1)OC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932895; SCHEMBL18041315; BDBM254803; US9475775, 70
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=C(C=C1)F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920750; SCHEMBL18041440; BDBM254746; US9475775, 13
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)cccccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938389; SCHEMBL18041281; BDBM254805; US9475775, 72
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957004; SCHEMBL18041296; BDBM254809; US9475775, 76
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)cccoccoccn)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930709; SCHEMBL18041447; BDBM254782; US9475775, 49
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC(=CC=1)CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908864; SCHEMBL18041329; BDBM254738; US9475775, 5
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
C(C1=CC=CC=C1)OC(Ncc=1C=NC=C(C=1)NC(=O)C1=CC2=C(C=C(CC(=N2)N)C(N(ccc)ccc)=O)C=C1)=O
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967094; SCHEMBL18041421; BDBM254800; US9475775, 67
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4290288
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760565; BDBM50467914
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccco)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922406; SCHEMBL18041401; BDBM254759; US9475775, 26
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=C(C=C1)F)ccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891617; SCHEMBL18041438; BDBM254796; US9475775, 63
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccc1=CC=CC=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972397; SCHEMBL18041362; BDBM254802; US9475775, 69
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(CCC)CCC)C=CC(=C2)C(=O)NC1=CC=C(C=C1)Cl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970076; SCHEMBL18041430; BDBM254743; US9475775, 10
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)C#ccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935182; SCHEMBL18041287; BDBM254781; US9475775, 48
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951961; SCHEMBL18041375; BDBM254752; US9475775, 19
Click to Show/Hide
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4286476
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761270; BDBM50467916
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4277080
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761531; BDBM50467915
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)occoccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906274; SCHEMBL18041324; BDBM254778; US9475775, 45
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccc1=CC(=CC=C1)OC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922874; SCHEMBL18041305; BDBM254806; US9475775, 73
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=C(C=C1)ccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931979; SCHEMBL18041380; BDBM254758; US9475775, 25
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)CO
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956859; SCHEMBL18041400; BDBM254739; US9475775, 6
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908120; SCHEMBL18041345; BDBM254769; US9475775, 36
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC(=CC=1)CO
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3907895; SCHEMBL18041387; BDBM254740; US9475775, 7
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=CC=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943393; SCHEMBL18041279; BDBM254737; US9475775, 4
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4293700
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760937; BDBM50467912
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)CC(C)C)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896793; SCHEMBL18041322; BDBM254788; US9475775, 55
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)occn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3918347; SCHEMBL18041297; BDBM254799; US9475775, 66
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CN=CS1
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946092; SCHEMBL18041411; BDBM254742; US9475775, 9
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965526; SCHEMBL18041289; BDBM254747; US9475775, 14
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC(=C1)C)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958421; SCHEMBL18041354; BDBM254756; US9475775, 23
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccc1=CC=C(C=C1)CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910450; SCHEMBL18041352; BDBM254804; US9475775, 71
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(CCC)CCC)C=CC(=C2)C(=O)NC1=CC(=CC=C1)Cl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930313; SCHEMBL18041319; BDBM254765; US9475775, 32
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1N(C=NC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913371; SCHEMBL18041309; BDBM254745; US9475775, 12
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC=C(C=C1)CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961755; SCHEMBL18041407; BDBM254757; US9475775, 24
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)CN(C)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930119; SCHEMBL18041427; BDBM254811; US9475775, 78
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC(=CC=1)ccccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3954257; SCHEMBL18041334; BDBM254810; US9475775, 77
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)C(=O)N1cccc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973387; SCHEMBL18041459; BDBM254748; US9475775, 15
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C(=NC=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953150; SCHEMBL18041332; BDBM254754; US9475775, 21
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)\\C=C/CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940695; SCHEMBL18041426; BDBM254785; US9475775, 52
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3968836; SCHEMBL18041434; BDBM254766; US9475775, 33
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)CC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964498; SCHEMBL18041328; BDBM254762; US9475775, 29
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)coccoccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986818; SCHEMBL18041304; BDBM254780; US9475775, 47
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4283103
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761549; BDBM50467911
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)CC1=CC=C(C=C1)CN)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966671; SCHEMBL18041286; BDBM254793; US9475775, 60
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4279629
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20761372; BDBM50467917
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)cccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957505; SCHEMBL18041416; BDBM254792; US9475775, 59
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Cccc)cccc)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922493; SCHEMBL18041327; BDBM254775; US9475775, 42
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)C(F)(F)F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895602; SCHEMBL18041398; BDBM254764; US9475775, 31
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4276704
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760966; BDBM50467919
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4280136
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760850; BDBM50467920
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(CCC)CCC)C=CC(=C2)C(=O)NC1=CC(=CC(=C1)Cl)CCN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980029; SCHEMBL18041378; BDBM254797; US9475775, 64
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)\\C=C\\CN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895819; SCHEMBL18041353; SCHEMBL18041355; BDBM254801; US9475775, 68
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Amino-8-N-[3-(4-aminobutyl)phenyl]-4-N,4-N-dipropyl-3H-1-benzazepine-4,8-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984890; SCHEMBL18057685; BDBM254795; US9475775, 62
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CN=NC=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942748; SCHEMBL18041372; BDBM254767; US9475775, 34
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC1=CC(=CC=C1)ccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3939801; SCHEMBL18041436; BDBM254750; US9475775, 17; US9475775, 54
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC(=CC=1)occ
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3936078; SCHEMBL18041360; BDBM254768; US9475775, 35
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=NC=1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946051; SCHEMBL18041366; BDBM254735; US9475775, 2
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC(=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981903; SCHEMBL18041365; BDBM254755; US9475775, 22
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)C(=O)N1cccc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940440; SCHEMBL18041318; BDBM254749; US9475775, 16
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)ccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917664; SCHEMBL18041320; BDBM254813; US9475775, 80
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)cccocccn)C=CC(=C2)C(=O)NC=1C=C(C=CC=1)C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971469; SCHEMBL18041424; BDBM254789; US9475775, 56
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4285025
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20760753; BDBM50467921
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC(=CC=1)cccn
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929430; SCHEMBL18041356; BDBM254808; US9475775, 75
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NC1=NC2=C(C=C(C1)C(=O)N(Ccc)ccc)C=CC(=C2)C(=O)NC=1C=NC=C(C=1)OC
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963860; SCHEMBL18041299; BDBM254773; US9475775, 40
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-[2-(2-Aminoethoxy)ethyl]-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5111244; CHEMBL3915625; BDBM60954; 1-[2-(2-aminoethoxy)ethyl]-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine; 1-[2-(2aminoethoxy)ethyl]-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine; US9334268, 1-[2-(2-Aminoethoxy)ethyl]-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Chembl4166427
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19196883; BDBM50279616
Click to Show/Hide
|
||||
| Activity |
EC50 = 190000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Methyl 4-amino-1-(2-hydroxy-2-methylpropyl)imidazo[4,5-c]quinoline-7-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2216759; SCHEMBL14758154; BDBM50403023
Click to Show/Hide
|
||||
| Activity |
EC50 > 270000 nM
|
[6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Activity-guided development of potent and selective toll-like receptor 9 antagonists. Eur J Med Chem. 2018 Nov 5;159:187-205. | ||||
| REF 2 | Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorg Med Chem. 2011 Jun 15;19(12):3801-11. | ||||
| REF 3 | Discovery of Novel Small-Molecule Inhibitors of NF-B Signaling with Antiinflammatory and Anticancer Properties. J Med Chem. 2018 Jul 26;61(14):5881-5899. | ||||
| REF 4 | US patent application no. 9475775B2, Benzazepine dicarboxamide compounds | ||||
| REF 5 | Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism. Eur J Med Chem. 2017 Jul 7;134:334-347. | ||||
| REF 6 | Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction. ACS Med Chem Lett. 2012 Jun 14;3(6):501-504. | ||||
| REF 7 | Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities. J Med Chem. 2017 Jun 22;60(12):5029-5044. | ||||
| REF 8 | NLRP3 Modulators for the Treatment of Autoinflammatory Disorders. ACS Med Chem Lett. 2018 Sep 19;9(10):965-966. | ||||
| REF 9 | US patent application no. 9334268B2, 4-amino-imidazoquinoline compounds | ||||
| REF 10 | Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8. ACS Med Chem Lett. 2017 Oct 16;8(11):1148-1152. | ||||
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