Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47306 | Target Info | |||
| Target Name | Glucose-6-phosphate translocase (SLC37A4) | ||||
| Synonyms |
Transformation-related gene 19 protein; TRG19; TRG-19; Solute carrier family 37 member 4; PRO0685; Glucose-6-phosphate exchanger SLC37A4; Glucose-5-phosphate transporter; Glucose 5-phosphate transporter; G6PT1
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| Target Type | Literature-reported Target | ||||
| Gene Name | SLC37A4 | ||||
| Biochemical Class | Major facilitator | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Hydroxy-6-[1-[2-hydroxy-6-(1-methoxyhexyl)phenyl]ethenyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394076; BDBM50476958
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
8-Hydroxy-3-methoxy-9,10-dioxo-1-(phenylsulfanylmethyl)anthracene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL236656; BDBM50476967
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
8-Hydroxy-3-methoxy-1-[(E)-oct-1-enyl]-9,10-dioxoanthracene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235796; SCHEMBL16225767; BDBM50476965
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-Butyl-3,8-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235587; BDBM50476963
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3,8-Dihydroxy-1-(3-methylpentyl)-9,10-dioxoanthracene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396071; BDBM50476970
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| Activity |
IC50 = 200000 nM
|
[1] | |||
| Compound Name |
Aspulvinone E
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Investigative | Compound Info | ||
| Synonyms |
C02006; 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one; CHEMBL2337339; BDBM50453556; ZINC30724298; ZINC136143039; CCG-208773; NCGC00183583-01; NCGC00183583-02; Aspulvinone E - Yellow pigment - Found in Aspergillus; Q27102544; (5Z)-4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one
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| Activity |
IC50 = 200000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
phloretin
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Investigative | Compound Info | ||
| Synonyms |
phloretin; 60-82-2; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Dihydronaringenin; Phloretol; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; UNII-S5J5OE47MK; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; CCRIS 7459; beta-(p-Hydroxyphenyl)phloropropiophenone; 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone; EINECS 200-488-7; NSC407292; S5J5OE47MK; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
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| Activity |
IC50 = 340000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationships of semisynthetic mumbaistatin analogs. Bioorg Med Chem. 2007 Aug 1;15(15):5207-18. | ||||
| REF 2 | Natural product inhibitors of glucose-6-phosphate translocase. Medchemcomm. 2012;3:926-31. | ||||
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