Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T47657 | Target Info | |||
Target Name | Leukocyte receptor tyrosine kinase (LTK) | ||||
Synonyms |
TYK1; Protein tyrosine kinase 1; Leukocyte tyrosine kinase receptor
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Target Type | Literature-reported Target | ||||
Gene Name | LTK | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
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Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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Activity |
IC50 ~ 50000 nM
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[1] | |||
Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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Activity |
IC50 ~ 50000 nM
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[2] | |||
Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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Activity |
IC50 ~ 50000 nM
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[2] | |||
Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
Synonyms |
CHEMBL600795; BDBM50306683
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Activity |
IC50 ~ 50000 nM
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[3] |
References | Top | ||||
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REF 1 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
REF 2 | Angiogenesis inhibitors identified by cell-based high-throughput screening: synthesis, structure-activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation. Bioorg Med Chem. 2012 Feb 15;20(4):1442-60. | ||||
REF 3 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. |
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