Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47768 | Target Info | |||
| Target Name | Opioid receptor mu (MOP) | ||||
| Synonyms |
hMOP; Mu-type opioid receptor; Mu opioid receptor; Mu opiate receptor; MOR1A; MOR1; MOR-1; M-OR-1
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|
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| Target Type | Successful Target | ||||
| Gene Name | OPRM1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 48 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Asimadoline
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|
Phase 3 | Compound Info | ||
| Synonyms |
Asimadoline [INN]; EMD 61753; N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide
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|
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| Activity |
EC50 = 60000 nM
|
[1] | |||
| Compound Name |
PMID28870136-Compound-38
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|
Patented | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468176; BDBM50261729
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Ethoxyanilino)-N,N-diethyl-1-(3-methylbutyl)benzimidazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079520; SCHEMBL5881810; BDBM50244285; 2-(4-Ethoxyanilino)-N,N-diethyl-1-isopentyl-1H-benzimidazole-5-carboxamide
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|
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| Activity |
Ki = 50118.72 nM
|
[4] | |||
| Compound Name |
4-N-[2-(1H-Indol-3-yl)ethyl]-1-N,1-N-dimethyl-1-phenylcyclohexane-1,4-diamine;dihydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3326222; SCHEMBL5165408
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|
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| Activity |
EC50 = 51000 nM
|
[5] | |||
| Compound Name |
4-Chloro-N-[3-(2-pyrrolidin-1-ylethyl)imidazo[4,5-b]pyridin-2-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394007; BDBM50061381
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|
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| Activity |
EC50 = 52500 nM
|
[1] | |||
| Compound Name |
3-Oxo-4-[1-(1-propylcyclooctyl)piperidin-4-yl]quinoxaline-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL853205; CHEMBL3698894; BDBM15351; US8846929, 239
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|
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| Activity |
Ki = 57791 nM
|
[6] | |||
| Compound Name |
Methyl 2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228736; BDBM50210381
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|
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| Activity |
Ki = 59810 nM
|
[7] | |||
| Compound Name |
8-(Diphenylmethyl)-1-phenyl-3-(prop-2-en-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
spiropiperidine analogue, 19; CHEMBL514965; BDBM26898
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|
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| Activity |
Ki = 63020 nM
|
[8] | |||
| Compound Name |
(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178724; BDBM50398709
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|
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| Activity |
Ki = 74000 nM
|
[9] | |||
| Compound Name |
[(2R,3R)-Tmt1]dpdpe
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL134652; BDBM50133261
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|
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| Activity |
IC50 = 77000 nM
|
[10] | |||
| Compound Name |
N-(2-Methoxyethyl)-2-thiophen-3-yl-1,2,3,4-tetrahydronaphthalen-1-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450500; BDBM50276363
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
3-Chloro-N-(2-methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]thiophene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460631; BDBM50276495
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
3,4-Dichloro-N-(2-methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460832; BDBM50276412
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|
||||
| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenoxy)-N-[2-(dimethylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-(2-methoxyethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461257; BDBM50276497
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-(2-methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459784; BDBM50276446
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
N-(2-Methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]furan-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460623; BDBM50276411
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
N-(2-Methoxyethyl)-2-phenylmethoxy-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459573; BDBM50276444
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
N-(2-Methoxyethyl)-2-(3-methoxyphenyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459783; BDBM50276445
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
3,4-Dichloro-N-[2-(dimethylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-(2-methoxyethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461258; BDBM50276498
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-[2-(dimethylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-(2-methoxyethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459387; BDBM50276566
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|
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| Activity |
EC50 ~ 90000 nM
|
[11] | |||
| Compound Name |
(7S,12Bs)-9-methoxy-7-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956767; BDBM209003
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|
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| Activity |
EC50 = 97381 nM
|
[12] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(6-chloro-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319086; BDBM50497850
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|
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| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
Tyr-Gly-Pro-Phe-Leu-Nle-Arg-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369371; CHEMBL304684; BDBM50128082
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|
||||
| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
3,6,6-Trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
3,6,6-trimethyl-6,7-dihydro-1H-indazol-4(5H)-one; 3,6,6-trimethyl-5,7-dihydro-2H-indazol-4-one; CHEMBL594957; MLS-0007281.0001; 3,6,6-trimethyl-1H-5,6,7-trihydroindazol-4-one; Cambridge id 5220184; MLS000104294; SCHEMBL460286; BDBM45980; cid_1878753; CTK4D1450; DTXSID20365441; HMS1579O09; HMS2291A09; ZINC5125997; BDBM50055974; MFCD00474387; SBB038310; STL361540; AKOS000268210; MCULE-9060395362; SMR000054229; DB-027718; FT-0741375; ST50115154; W-9869; SR-01000435736; SR-01000435736-1; 3,6,6-trimethyl-6,7-dihydro-1H-indazol-4(5H)-on; 4-oxo-3,6,6-trimethyl-4,5,6,7-tetrahydroindazole; 3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-4-one; 3,6,6-Trimethyl-4,5,6,7-tetrahydro-1H-indazole-4-one; 3,6,6-Trimethyl-4,5,6,7-tetrahydro-2H-indazole-4-one; 3,6,6-Trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazole
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
GSK137647A; GSK 137647; GSK-137647A; N-mesityl-4-methoxybenzenesulfonamide; CHEMBL3311308; MFCD02007969; 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide; CBMicro_012617; Oprea1_349531; Oprea1_545891; SCHEMBL19357604; KS-00000TIW; AOB2991; ZINC184126; BCP17136; EX-A1097; GSK 137647A; SMSF0014079; BDBM50044849; STK899558; AKOS003261220; CB15818; CS-5549; GSK-137647; MCULE-5583867808; N-mesityl-4-methoxy-1-benzenesulfonamide; NCGC00387253-02; NCGC00387253-05; AK240703; AS-16737; HY-19995; BIM-0012523.P001; FFA4 (GPR120) agonist GSK137647A; B7793; EU-0076636; FT-0700296; S0001; ST50719559; GSK137647A, >=98% (HPLC); A14542; AJ-292/14925630; SR-01000478738; J-690285; SR-01000478738-1; [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine; 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide; 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(5-fluoro-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319083; BDBM50497856
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|
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| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
Chembl4176316
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50281628
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|
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| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178732; BDBM50398701
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|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178725
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3-Chlorophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325698; SCHEMBL6771820; BDBM50055991
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|
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| Activity |
EC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R)-2-Acetamido-6-amino-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178728
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(2R)-2-Acetamido-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178730
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
3,6,6-Trimethyl-1-phenyl-6,7-dihydro-1H-indazol-4(5H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3325697; SBB038309; 3,6,6-trimethyl-1-phenyl-1H-5,6,7-trihydroindazol-4-one; Cambridge id 6748101; 3,6,6-trimethyl-1-phenyl-5,7-dihydroindazol-4-one; SCHEMBL6166305; CTK8D3885; DTXSID40387781; ZINC4008780; BDBM50055970; AKOS000268197; MCULE-6392859419; EU-0078098; ST50072144; SR-01000492263; SR-01000492263-1; 3,6,6-Trimethyl-1-phenyl-6,7-dihydro-1H-indazole-4(5H)-one
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R)-2-Acetamido-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178729
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|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(7-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319082; BDBM50497849
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178726
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Chembl4164452
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50340645
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
(2R)-2-Acetamido-6-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2178727
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|
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-2-[[(2R)-2-Acetamido-3-(5-chloro-2-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3319090; BDBM50497853
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[13] | |||
| Compound Name |
Chembl4172330
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Investigative | Compound Info | ||
| Synonyms |
BDBM50340647
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
Chembl4172964
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50281843; ZINC52469366; AKOS034504603; CCG-300638; MCULE-2977172516; Z646344534; 6-chloro-N4-{1-[(2-fluorophenyl)methyl]piperidin-4-yl}pyrimidine-2,4-diamine
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[17] | |||
| Compound Name |
Chembl4159127
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Investigative | Compound Info | ||
| Synonyms |
BDBM50340646
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[1-(2-Pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1,3-benzothiazole-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393999; BDBM50061373
Click to Show/Hide
|
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| Activity |
EC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-Methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393993; BDBM50061375
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-[(7R)-7-(Cyclopropylmethylamino)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-5-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3264442; BDBM50012155
Click to Show/Hide
|
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| Activity |
EC50 = 130000 nM
|
[19] | |||
| Compound Name |
Zilpaterol hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Zilpaterol HCl; SCHEMBL135498; CHEMBL513390; AKOS015967220; X5887; 520Z068; J-501696; Q27277408; UNII-EX8IEP25JU component GIEFXLLRTJNFGT-LOCPCMAASA-N
Click to Show/Hide
|
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| Activity |
Ki = 130000 nM
|
[20] | |||
| Compound Name |
Zilmax
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470585; MFCD09033213; UNII-EX8IEP25JU component GIEFXLLRTJNFGT-JZKFLRDJSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 21 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-12-(2,2-dimethylpropyl)-4,10-dihydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961125; SCHEMBL15842765; BDBM236861; US9388162, 68
Click to Show/Hide
|
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| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970877; SCHEMBL15842548; BDBM236843; US9388162, 28
Click to Show/Hide
|
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| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(1R,9R,10S,12S)-12-Butyl-17-(cyclopropylmethyl)-4,10-dihydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110924; SCHEMBL15843185; BDBM236860; US9388162, 67
Click to Show/Hide
|
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| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(1R,9R,10S,12S)-12-(Cyclohexylmethyl)-17-(cyclopropylmethyl)-4,10-dihydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111704; SCHEMBL15842547; BDBM236863; US9388162, 70
Click to Show/Hide
|
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| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]ethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4115022; SCHEMBL15842648; BDBM236854; US9388162, 42
Click to Show/Hide
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||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4109574; SCHEMBL15843341; BDBM236855; US9388162, 43
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(1R,9R,10S,12E)-17-(Cyclopropylmethyl)-10-hydroxy-4-methoxy-12-(3-methylbutylidene)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111757; SCHEMBL15842603; BDBM236856; US9388162, 62
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]cyclopentanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4113094; SCHEMBL15842924; BDBM236850; US9388162, 35
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(2S)-1-[2-[(1R,9R,10S,12R)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110715; SCHEMBL15843342; BDBM236825; US9388162, 17
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928981; SCHEMBL15842683; BDBM236842; US9388162, 27
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112403; SCHEMBL15842744; BDBM236844; US9388162, 29
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
2-[(1R,9R,10S)-12-(Carboxymethyl)-17-(cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107030; SCHEMBL15842580; BDBM236821; US9388162, 12
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-12-(2-methylpropyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940268; SCHEMBL15842817; BDBM236862; US9388162, 69
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952294; SCHEMBL15842392; BDBM236849; US9388162, 34
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-12-(2-methylbutyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4114481; SCHEMBL15842668; BDBM236859; US9388162, 66
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
2-[(1R,9R,10S,12R)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890527; SCHEMBL15842497; BDBM236819; US9388162, 9
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-12-(3-methylbutyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4108710; SCHEMBL15842579; BDBM236857; US9388162, 64
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(S)-(1,2,3,5,6,8a-Hexahydroindolizin-8-yl)(2-methoxy-6-methylphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1080152; BDBM50313164
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[22] | |||
| Compound Name |
(1R,9R,10S,12S)-12-(Cyclopentylmethyl)-17-(cyclopropylmethyl)-4,10-dihydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111028; SCHEMBL15842468; BDBM236858; US9388162, 65
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
(2S)-N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]-2-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4109056; SCHEMBL15842285; BDBM236852; US9388162, 37
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-[(1R,9R,10S,12S)-17-(Cyclopropylmethyl)-4,10-dihydroxy-13-oxo-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924605; SCHEMBL15842874; BDBM236848; US9388162, 33
Click to Show/Hide
|
||||
| Activity |
EC50 > 200000 nM
|
[21] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists. Bioorg Med Chem Lett. 2015 Feb 15;25(4):887-92. | ||||
| REF 2 | Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6736-9. | ||||
| REF 3 | Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4267-74. | ||||
| REF 4 | Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles. J Med Chem. 2018 Feb 22;61(4):1646-1663. | ||||
| REF 5 | Discovery of Spiro[cyclohexane-dihydropyrano[3,4-b]indole]-amines as Potent NOP and Opioid Receptor Agonists. ACS Med Chem Lett. 2014 Jun 24;5(8):851-6. | ||||
| REF 6 | US patent application no. 8846929B2, Substituted-quinoxaline-type piperidine compounds and the uses thereof | ||||
| REF 7 | Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. | ||||
| REF 8 | Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1164-7. | ||||
| REF 9 | Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus. J Med Chem. 2012 Nov 26;55(22):10292-6. | ||||
| REF 10 | Peptide science: exploring the use of chemical principles and interdisciplinary collaboration for understanding life processes. J Med Chem. 2003 Sep 25;46(20):4215-31. | ||||
| REF 11 | Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1228-32. | ||||
| REF 12 | US patent application no. 9233167B2, Oligomer-opioid agonist conjugates | ||||
| REF 13 | Synthesis of tripeptides containing D-Trp substituted at the indole ring, assessment of opioid receptor binding and in vivo central antinociception. J Med Chem. 2014 Aug 14;57(15):6861-6. | ||||
| REF 14 | Structure-activity relationships of dynorphin a analogues modified in the address sequence. J Med Chem. 2003 May 22;46(11):2104-9. | ||||
| REF 15 | Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists. Bioorg Med Chem. 2014 Sep 1;22(17):4694-703. | ||||
| REF 16 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. | ||||
| REF 17 | Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets. J Med Chem. 2018 Aug 9;61(15):6830-6845. | ||||
| REF 18 | Constraining Endomorphin-1 by ,alpha-Hybrid Dipeptide/Heterocycle Scaffolds: Identification of a Novel -Opioid Receptor Selective Partial Agonist. J Med Chem. 2018 Jul 12;61(13):5751-5757. | ||||
| REF 19 | Antagonists of the kappa opioid receptor. Bioorg Med Chem Lett. 2014 May 1;24(9):2021-32. | ||||
| REF 20 | Synthesis and pharmacological characterization of beta2-adrenergic agonist enantiomers: zilpaterol. J Med Chem. 2009 Mar 26;52(6):1773-7. | ||||
| REF 21 | US patent application no. 9388162B2, Substituted morphinans and the use thereof | ||||
| REF 22 | Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1601-3. | ||||
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