Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T48873 | Target Info | |||
| Target Name | Synaptic vesicle amine transporter (SLC18A2) | ||||
| Synonyms |
Vesicular amine transporter; Vesicular Monoamine Transporter; VMAT; VAT; Solute carrier family 18 member 2; SLC18A2; Monoamine transporter
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| Target Type | Successful Target | ||||
| Gene Name | SLC18A2 | ||||
| Biochemical Class | Major facilitator superfamily | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SEROTONIN
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Investigative | Compound Info | ||
| Synonyms |
serotonin; 5-HYDROXYTRYPTAMINE; 3-(2-Aminoethyl)-1H-indol-5-ol; 50-67-9; Enteramine; 5-HT; Serotonine; Thrombotonin; Thrombocytin; Antemovis; Ds substance; Hippophain; Antemoqua; Substance DS; Substanz DS; 1H-Indol-5-ol, 3-(2-aminoethyl)-; 5-Hta; Tryptamine, 5-hydroxy-; 3-(2-Aminoethyl)indol-5-ol; Enteramin; UNII-333DO1RDJY; Indol-5-ol, 3-(2-aminoethyl)-; 5-Hydroxy-3-(beta-aminoethyl)indole; 3-(beta-Aminoethyl)-5-hydroxyindole; EINECS 200-058-9; 3-(2-Amino-ethyl)-1H-indol-5-ol; BRN 0143524; 333DO1RDJY; CHEBI:28790
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| Activity |
Ki = 640000 nM
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[1] | |||
| Compound Name |
DL-Methamphetamine
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Investigative | Compound Info | ||
| Synonyms |
N-methyl-1-phenylpropan-2-amine; dl-Desoxyephedrine; Anadrex; Pervertin; dl-Methamphetamin; Ephedrine, deoxy-; Deoxyephedrine; (2-Methylaminopropyl)benzene; Desoxyephedrine; (+/-)-Methamphetamine; Benzeneethanamine, N,alpha-dimethyl-; Desoxyn; rac-Methamphetamine; (+-)-N,alpha-Dimethylphenethylamine; (+-)-Desoxyephedrine; (+-)-Methamphetamine; 1-Phenyl-2-methylamino-propan; (+-)-N-Methylamphetamine; N-Methyl-beta-phenylisopropylamin; N,alpha-Dimethylphenethylamine; N,alpha-Dimethylbenzeneethanamine; N-Methyl-1-phenyl-2-propylamine; alpha-Phenyl-beta-methylaminopropane; d,l-Methamphetamine; EINECS 231-559-0; Methamphetamine, DL-; (+-)-N,alpha-Dimethylbenzeneethanamine; PHENETHYLAMINE, N,alpha-DIMETHYL-; BRN 1072499; Benzeneethanamine, N,.alpha.-dimethyl-, (R)-; Benzeneethanamine, N,.alpha.-dimethyl-, (S)-; (+/-)-Deoxyephedrine; Phenethylamine, N,.alpha.-dimethyl-, (S)-(+)-; (.+-.)-Deoxyephedrine; Racemic methyl amphetamine; NCGC00247330-02; CHEMBL508; METHAMPHETAMINE (+); METHAMPHETAMINE (-); (+/-)-N-Methylamphetamine; SCHEMBL42178; 1-Phenyl-2-methylaminopropan; DivK1c_000988; GTPL4803; DTXSID3043861; NIOSH/SH4911000; CTK4G2699; KBio1_000988; 2-(Methylamino)-1-phenylpropane; dl-1-Phenyl-2-methylaminopropane; N-Methyl-1-phenyl-isopropylamine; NINDS_000988; alpha-phenyl-beta-methlaminopropane; Benzeneethanamine,dimethyl- (9CI); BDBM50009057; NSC403767; Phenethylamine, N,.alpha.-dimethyl-; (+/-)-N,alpha-Dimethylphenethylamine; AKOS008901219; Benzeneethanamine, N,.alpha.-dimethyl-; NSC 403767; NSC-403767; IDI1_000988; (+/-)-N,alpha-Dimethylbenzeneethanamine; Methyl-(1-methyl-2-phenyl-ethyl)-amine; NCGC00247330-01; Phenethylamine, N,.alpha.-dimethyl-, D-; Phenethylamine, N,alpha-dimethyl- (8CI); rac-Methamphetamine 0.1 mg/ml in Methanol; rac-Methamphetamine 1.0 mg/ml in Methanol; Phenethylamine, N,alpha-dimethyl-, (+-)-; (R)Methyl-(1-methyl-2-phenyl-ethyl)-amine; SH49110000; (-)-2-[METHYLAMINO]-1-PHENYLPROPANE; Phenethylamine,.alpha.-dimethyl-, (.+-.)-; Benzeneethanamine,.alpha.-dimethyl-, (.+-.)-; 4-12-00-02589 (Beilstein Handbook Reference); J-523644; Q44909815; Methyl-(1-methyl-2-phenyl-ethyl)-amine(methamphetamine)
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| Activity |
Ki = 346000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem. 2018 Oct 25;61(20):9121-31. | ||||
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