Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50089 | Target Info | |||
| Target Name | Sphingosine-1-phosphate receptor 5 (S1PR5) | ||||
| Synonyms |
Sphingosine 1-phosphate receptor Edg-8; S1PR5; S1P5; S1P receptor Edg-8; S1P receptor 5; Endothelial differentiation G-protein-coupled receptor 8
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | S1PR5 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885034; BDBM50209058
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883521; BDBM50209040
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884740; BDBM50209048
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883502; BDBM50209063
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883420; BDBM50209065
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[7-(6-Methoxynaphthalen-2-yl)-1-benzothiophen-2-yl]methylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885357; BDBM50209054
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884941; BDBM50209047
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-3-[[4-(2-ethylphenyl)-1-benzothiophen-2-yl]methylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884862; BDBM50209049
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884517; BDBM50209076
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885187; BDBM50209021
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884270; BDBM50209066
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methyl]azetidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885035; BDBM50209032
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]-2-methylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883549; BDBM50209075
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[3-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883399; BDBM50209039
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885499; BDBM50209038
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A benzo[b]thiophene-based selective type 4 S1P receptor agonist. Bioorg Med Chem Lett. 2017 Jan 1;27(1):1-5. | ||||
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