Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T51408 | Target Info | |||
| Target Name | Adrenergic receptor beta-3 (ADRB3) | ||||
| Synonyms |
Beta3AR; Beta3-AR; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; Beta-3 adrenergic receptor; B3AR; ADRB3R
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| Target Type | Successful Target | ||||
| Gene Name | ADRB3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(R,R)-(+)-{4-[2-{[2-(3-Bromoisoxazol-5-yl)-2-hydroxyethyl]-amino}propyl]phenoxy}acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL226293; BDBM50205508
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-phenoxymethyl)-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41948; BDBM50289569
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| Activity |
Ki = 55300 nM
|
[2] | |||
| Compound Name |
4-(3,4,5-Trimethoxybenzyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73917; BDBM50472299; L018936
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| Activity |
Ki = 67608.3 nM
|
[3] | |||
| Compound Name |
6-[beta,4-Dihydroxy-3-(methylsulfonylamino)phenethylamino]-7-phenylheptanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL318830; SCHEMBL7037494; BDBM50106792; 6-[[2-hydroxy-2-[4-hydroxy-3-(methanesulfonamido)phenyl]ethyl]amino]-7-phenylheptanoic acid; 6-[2-Hydroxy-2-(4-hydroxy-3-methanesulfonylamino-phenyl)-ethylamino]-7-phenyl-heptanoic acid
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| Activity |
Ki = 87000 nM
|
[4] | |||
| Compound Name |
(+/-)-N-[5-(2-Bromo-1-hydroxyethyl)isoxazol-3-yl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL226292; BDBM50205505
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-[4-(methanesulfonamido)phenoxy]propyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511552; BDBM50259164; (S)-4''-(2-{[2-Hydroxy-3-(4-methylsulfonamidophenoxy)-propyl]amino}ethyl)-2-(2-pyridyl)acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466519; BDBM50259167; (S)-4''-(2-{[2-Hydroxy-3-(indol-4-yloxy)propyl]amino}-ethyl)-2-(2-pyridyl)acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-pyridin-3-yloxypropyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466713; BDBM50259166; (S)-4''-(2-{[2-Hydroxy-3-(2-benzimidazolon-4-yloxy)-propyl]amino}ethyl)-2-(2-pyridyl)-acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[2-[[(2S)-3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466923; BDBM50259205
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-(1H-indol-4-yloxy)propyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466704; BDBM50259124
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-2-pyridin-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466515; BDBM50259165; (S)-4''-(2-{[2-Hydroxy-3-phenoxypropyl]amino}ethyl)-2-(2-pyridyl)acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-2-(1-phenylimidazol-2-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467082; BDBM50259254; (S)-4''-{2-[(2-Hydroxy-3-phenoxypropyl)amino]ethyl}-2-(1-phenylimidazol-2-yl)-acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(1-Benzylbenzimidazol-2-yl)-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467298; BDBM50259320; (S)-4''-(2-{[2-Hydroxy-3-phenoxypropyl]amino}ethyl)-2-(1-benzyl-benzimidazol-2-yl)-acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(1-Benzylimidazol-2-yl)-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-N-propylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467117; BDBM50259469; (S)-N-Propyl-4''-{2-[(2-hydroxy-3-phenoxypropyl)-amino]ethyl}-2-(1-benzylimidazol-2-yl)acetanilide
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(1-Benzylimidazol-2-yl)-N-[4-[2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]-N-methylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467116; BDBM50259468; (S)-N-Methyl-4''-{2-[(2-hydroxy-3-phenoxypropyl)-amino]ethyl}-2-(1-benzylimidazol-2-yl)acetanilide
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(R)-N-(3-(2-Amino-1-hydroxyethyl)-2-fluoro-6-hydroxyphenyl)methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251166; BDBM50214229
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|
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| Activity |
Ki = 120000 nM
|
[6] | |||
| Compound Name |
N-[4-[2-[[(2S)-2-Hydroxy-3-phenoxypropyl]amino]ethyl]phenyl]benzamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203997
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|
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| Activity |
EC50 = 130000 nM
|
[7] | |||
| Compound Name |
3-(2-{(R)-2-[2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-thiazol-5-yl)-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72060; SCHEMBL9305019; BDBM50287797; 3-[2-[(2R)-2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-thiazol-5-yl]propanoic acid
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| Activity |
Ki = 146000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[2-oxo-3-(3-oxo-3-pyrrolidin-1-yl-propyl)-imidazolidin-1-yl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79915; BDBM50075909
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| Activity |
EC50 = 7762471.17 nM
|
[9] | |||
| Compound Name |
N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(4-octyl-3,5-dioxo-[1,2,4]triazolidin-1-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312364; BDBM50075886
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|
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| Activity |
EC50 = 10000000 nM
|
[9] | |||
| Compound Name |
4-(1-Hexyl-5-oxo-1,5-dihydro-[1,2,4]triazol-4-yl)-N-{4-[2-(2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314893; BDBM50075888
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|
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| Activity |
EC50 = 10000000 nM
|
[9] | |||
| Compound Name |
4-(3-Hexyl-4-methyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[2-((R)-2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312546; BDBM50075883
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|
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| Activity |
EC50 = 12302687.71 nM
|
[9] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(4-methyl-3-octyl-2-oxo-2,3-dihydro-imidazol-1-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79363; BDBM50075885
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| Activity |
EC50 = 16595869.07 nM
|
[9] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[2-oxo-3-(4,4,4-trifluoro-butyl)-imidazolidin-1-yl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79675; BDBM50075915
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|
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| Activity |
EC50 = 54954087.39 nM
|
[9] | |||
| Compound Name |
4-(3-Hexyl-2-oxo-imidazolidin-1-yl)-N-{4-[2-(2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL82296; BDBM50075896; L-760087
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|
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| Activity |
EC50 = 56234132.52 nM
|
[9] | |||
| Compound Name |
N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(1-octyl-5-oxo-[1,2,4]triazolidin-4-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311731; BDBM50130948
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| Activity |
EC50 = 66069344.8 nM
|
[9] | |||
| Compound Name |
4-(3-Hexyl-2-oxo-2,3-dihydro-imidazol-1-yl)-N-{4-[2-(2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL22386; L-764646; BDBM50075889
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| Activity |
EC50 = 70794578.44 nM
|
[9] | |||
| Compound Name |
N-{4-[2-((R)-2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-[2-oxo-3-(4,4,5,5,5-pentafluoro-pentyl)-imidazolidin-1-yl]-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83754; BDBM50075912
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| Activity |
EC50 = 70794578.44 nM
|
[9] | |||
| Compound Name |
4-(4-Hexyl-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl)-N-{4-[2-(2-hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL79806; BDBM50075884
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|
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| Activity |
EC50 = 165958690.7 nM
|
[9] | |||
| Compound Name |
N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(4-octyl-5-oxo-[1,2,4]triazolidin-1-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309628; BDBM50130949
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| Activity |
EC50 = 186208713.7 nM
|
[9] | |||
| Compound Name |
N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(3-octyl-2-oxo-2,3-dihydro-imidazol-1-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83753; BDBM50075892
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| Activity |
EC50 = 295120922.7 nM
|
[9] | |||
| Compound Name |
N-{4-[2-(2-Hydroxy-2-pyridin-3-yl-ethylamino)-ethyl]-phenyl}-4-(3-octyl-2-oxo-imidazolidin-1-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL84190; BDBM50075897
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| Activity |
EC50 = 457088189.6 nM
|
[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes. Bioorg Med Chem. 2007 Apr 1;15(7):2533-43. | ||||
| REF 2 | Carboxyl-promoted enhancement of selectivity for the beta3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-beta3 binding selectivity. Bioorg Med Chem Lett. 1997 Jun 17;7(12):1583-8. | ||||
| REF 3 | 2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists. J Med Chem. 1999 Jun 17;42(12):2287-94. | ||||
| REF 4 | Beta 3 agonists. Part 1: evolution from inception to BMS-194449. Bioorg Med Chem Lett. 2001 Dec 3;11(23):3035-9. | ||||
| REF 5 | Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists. Bioorg Med Chem. 2009 May 1;17(9):3283-94. | ||||
| REF 6 | Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4290-6. | ||||
| REF 7 | Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists. Bioorg Med Chem. 2009 Aug 1;17(15):5510-9. | ||||
| REF 8 | BMS-187257, a potent, selective, and novel heterocyclic beta3 adrenergic receptor agonist. Bioorg Med Chem Lett. 1996 Oct 8;6(19):2253-8. | ||||
| REF 9 | Development of 3D-QSAR models in cyclic ureidobenzenesulfonamides: human beta3-adrenergic receptor agonist. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2481-4. | ||||
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