Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53510 | Target Info | |||
| Target Name | Glutathione S-transferase A2 (GSTA2) | ||||
| Synonyms |
GTH2; GSTA2-2; GST2; GST-gamma; GST class-alpha member 2; GST HA subunit 2
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| Target Type | Literature-reported Target | ||||
| Gene Name | GSTA2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-4-[1-(carboxymethyl-carbamoyl)-2-(1-isopropyl-3-oxo-butylsulfanyl)-ethylcarbamoyl]-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174957; BDBM50088975
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|
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| Activity |
IC50 = 66000 nM
|
[1] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-2,3-dimethoxy-2,3-dimethyl-5-oxo-8-[(4-phenylphenyl)methoxy]-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938639; BDBM50361798
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| Activity |
IC50 = 66300 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-2,3-dimethoxy-2,3-dimethyl-8-(naphthalen-2-ylmethoxy)-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938634; BDBM50361793
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| Activity |
IC50 = 77600 nM
|
[2] | |||
| Compound Name |
2-Amino-4-[1-(carboxymethyl-carbamoyl)-2-(1-methyl-3-oxo-pentylsulfanyl)-ethylcarbamoyl]-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426936; BDBM50088968
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| Activity |
IC50 = 90000 nM
|
[1] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-8-hexoxy-2,3-dimethoxy-2,3-dimethyl-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938636; BDBM50361795
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|
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| Activity |
IC50 = 93000 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-2,3-dimethoxy-2,3-dimethyl-5-oxo-8-[(E)-3-phenylprop-2-enoxy]-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938638; BDBM50361797
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|
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| Activity |
IC50 = 94200 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-2,3-dimethoxy-2,3-dimethyl-8-(3-methylbut-2-enoxy)-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938635; BDBM50361794
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|
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| Activity |
IC50 = 96300 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8R,8aS)-2,3,8-trimethoxy-2,3-dimethyl-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938627; BDBM50361809
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8R,8aS)-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938626; BDBM50361808
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(6Ar,8R,9R,10aS,10bR)-8,9-dimethoxy-2,2,8,9-tetramethyl-4,6a,10a,10b-tetrahydro-[1,4]dioxino[2,3-h][1,3]benzodioxin-6-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938621; BDBM50361804
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-2,3-dimethoxy-2,3-dimethyl-5-oxo-8-phenylmethoxy-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938633; BDBM50361792
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
[(2R,3R,4Ar,8R,8aS)-8-hydroxy-2,3-dimethoxy-2,3-dimethyl-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-7-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938623; BDBM50361805
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Amino-5-[[1-(carboxymethylamino)-3-(1,4-dioxo-1,4-dipropoxybutan-2-yl)sulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL176946; BDBM50088970
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|
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| Activity |
IC50 = 143300 nM
|
[1] | |||
| Compound Name |
[(2R,3R,4Ar,8S,8aS)-8-[(2E)-3,7-dimethylocta-2,6-dienoxy]-2,3-dimethoxy-2,3-dimethyl-5-oxo-8,8a-dihydro-4aH-1,4-benzodioxin-6-yl]methyl acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938637; BDBM50361796
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|
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| Activity |
IC50 = 178600 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-4-[1-(carboxymethyl-carbamoyl)-2-(3-oxo-cyclohexylsulfanyl)-ethylcarbamoyl]-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175098; BDBM50088973
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|
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| Activity |
IC50 = 220000 nM
|
[1] | |||
| Compound Name |
2-[2-(4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-succinic acid dimethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL174379; SCHEMBL1360127; BDBM50088972
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|
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| Activity |
IC50 > 250000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Beta-carbonyl substituted glutathione conjugates as inhibitors Of O. volvulus GST2. Bioorg Med Chem Lett. 2000 May 1;10(9):979-81. | ||||
| REF 2 | Inhibition of glutathione S-transferase M1 by new gabosine analogues is essential for overcoming cisplatin resistance in lung cancer cells. J Med Chem. 2011 Dec 22;54(24):8574-81. | ||||
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