Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55398 | Target Info | |||
| Target Name | Renal carcinoma antigen NY-REN-64 (IRAK-4) | ||||
| Synonyms |
Interleukin-1 receptor-associated kinase 4; IRAK-4
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| Target Type | Clinical trial Target | ||||
| Gene Name | IRAK4 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Tert-Butyl-N-[2-Methyl-3-(6-{[4-(Morpholin-4-Ylcarbonyl)phenyl]amino}-7h-Purin-2-Yl)phenyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263640; BDBM50012060; Q27453164; 4-t-butyl-N-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide; 4-tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Isopropoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
2-[(Propan-2-Yl)oxy]benzamide; Maybridge3_005104; 2-propan-2-yloxybenzamide; 2-Isopropoxy-benzamide; 2-(propan-2-yloxy)benzamide; SCHEMBL2103513; CHEMBL4093989; ZINC83593; HMS1445H22; AKOS003510905; MCULE-2735240047; IDI1_016491
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| Activity |
IC50 = 55000 nM
|
[2] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CID 73670173
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403448; SCHEMBL17184191; BDBM50068474
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| Activity |
IC50 = 228000 nM
|
[5] | |||
| Compound Name |
CID 73670172
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403449; SCHEMBL16481605; BDBM50068476
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| Activity |
IC50 = 333000 nM
|
[5] | |||
| Compound Name |
Schembl21106727
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403450; BDBM50068483
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| Activity |
IC50 = 403000 nM
|
[5] | |||
| Compound Name |
CID 73670344
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403452; SCHEMBL16481522; BDBM50068535
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| Activity |
IC50 = 1081000 nM
|
[5] | |||
| Compound Name |
(1r,2s,3r,5r)-3-{[5-(1,3-Benzothiazol-2-Yl)-2-(Propylamino)pyrimidin-4-Yl]amino}-5-(Hydroxymethyl)cyclopentane-1,2-Diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403447; SCHEMBL21105799; BDBM50068472; Q27454921; 4S1
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| Activity |
IC50 = 1193000 nM
|
[5] | |||
| Compound Name |
CID 73670345
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3403451; SCHEMBL16481523; BDBM50068534
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| Activity |
IC50 = 3012000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases. Bioorg Med Chem Lett. 2014 May 1;24(9):2206-11. | ||||
| REF 2 | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13;60(13):5521-5542. | ||||
| REF 3 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 4 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 5 | Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4. Bioorg Med Chem Lett. 2015 May 1;25(9):1836-41. | ||||
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