Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55956 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 6 (mGluR6) | ||||
| Synonyms |
MGLUR6; GPRC1F
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | GRM6 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
NBQX
Click to Show/Hide
|
Phase 1 | Compound Info | ||
| Synonyms |
nbqx; 118876-58-7; FG 9202; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline; 6-Nitro-7-sulfamoylbenzo(f)quinoxaline-2,3-dione; CHEMBL222519; CHEBI:31073; SBB066176; 6-nitro-2,3-dioxo-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide; 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxobenzo(f)quinoxaline-8-sulfonamide; 6-Nitro-7-sulphamoylbenzo[f]quinoxaline-2,3-dione; 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-Dione; 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[1] | |||
| Compound Name |
SIB-1757
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
LY-379268
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
LY 379268; LY-379268; CHEMBL275079; LY379268; 191471-52-0; SCHEMBL2454646; GTPL1394; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; CTK8F0567; DTXSID90436637; ZINC3952369; BDBM50074749; FCH888149; AKOS006306876; API0003234; NCGC00159572-01; LS-98795; RT-013615; LY-379,268; B7061; J-012378; 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
SIB-1893
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SIB 1893; SIB-1893; 2-methyl-6-(2-phenylethenyl)pyridine; 6266-99-5; SIB1893; 2-methyl-6-[(E)-2-phenylethenyl]pyridine; 7370-21-0; CHEMBL88612; MLS002607995; (E)-2-methyl-6-styrylpyridine; [E]-2-Methyl-6-[2-phenylethenyl]pyridine; (E)-2-Methyl-6-[2-phenylethenyl]pyridine; SR-01000076143; Lopac0_001171; Pyridine,2-methyl-6-(2-phenylethenyl)-; AC1NSKMI; AC1Q4VO3; GTPL1432; CHEBI:93178; BDBM86715; MolPort-003-959-634; HMS3263L03; ZINC3941522; 2-[(E)-Styryl]-6-methylpyridine; NSC36665; SIB 1893, >99%, solid; Tox21_501171
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid; (2R,4R)-APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid; 169209-63-6; 2R,4R-APDC; CHEMBL40086; CHEBI:40139; EN300-88063; 2R, 4R-APDC monohydrate; 52A; 4-amino-2,4-pyrrolidinedicarboxylic acid; AC1NSJRT; AC1Q4UAD; SCHEMBL158843; 2R, 4R-APDC; (2R,3R)-APDC; GTPL1392; CTK0E5090; DTXSID10415500; MolPort-003-982-102; BDBM50052398; ZINC32628523; SBB067830; MFCD16875409; AKOS015916056; AKOS015854214; RTC-065564; FCH3884669; NCGC00025040-02; LY314593; AJ-85443; SC-48823; TC-065564; B6634
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[2] | |||
| Compound Name |
Ethyl 4-methyl-2-(morpholinodiazenyl)-5-phenylthiophene-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566754; BDBM50299483
Click to Show/Hide
|
||||
| Activity |
IC50 = 54000 nM
|
[1] | |||
| Compound Name |
2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315268; (S)-Homo-AMPA; NCGC00024946-01; Tocris-1026; SCHEMBL12506417; BDBM50060719; (s)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid; (S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid; 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid(S-homo-AMPA)
Click to Show/Hide
|
||||
| Activity |
Ki = 58000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093081; BDBM50255290
Click to Show/Hide
|
||||
| Activity |
EC50 = 68400 nM
|
[4] | |||
| Compound Name |
2-Amino-4-methyl-5-phenyl-3-thiophenecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Amino-4-methyl-5-phenylthiophene-3-carbonitrile; UNII-4IIO6GJS6V; NSC209020; 4IIO6GJS6V; CHEMBL565502; NSC 209020; Maybridge3_001212; Cambridge id 5175071; 2-Amino-4-methyl-5-phenyl-thiophene-3-carbonitrile; 3-Thiophenecarbonitrile, 2-amino-4-methyl-5-phenyl-; SCHEMBL10710844; CTK4I5787; DTXSID20194990; HMS1434H02; ZINC190705; BDBM50299479; CCG-45588; AKOS000511411; MCULE-5554450813; NSC-209020; IDI1_012599; DS-012926; 2-Amino-3-cyano-4-methyl-5-phenylthiophene; SR-01000635343-1; BRD-K17497947-001-01-8
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methylsulfonylphenyl)methyl]phosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094636; SCHEMBL8232961; BDBM50255293
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methyl-3-nitrophenyl)methyl]phosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101241; SCHEMBL13774889; BDBM50255403
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-morpholin-4-yl-3-nitrophenyl)methyl]phosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082270; SCHEMBL4103522; BDBM50255333
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]-hydroxymethyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061539; SCHEMBL4101257; BDBM50255400
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-4-[[amino-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]-hydroxyphosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082769; SCHEMBL346142; BDBM50255393
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082813; BDBM50255391
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-4-[[(2-amino-1,3-thiazol-5-yl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101796; BDBM50255436
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(1R,2S)-1-Amino-2-(phosphonomethyl)cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34880; BDBM50089516; (1R,2S)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 111000 nM
|
[5] | |||
| Compound Name |
L-2-Aminoadipic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-2-aminohexanedioic acid; L-alpha-Aminoadipic acid; (2S)-2-aminohexanedioic acid; L-alpha-Aminoadipate; L-2-Aminoadipate; L-Homoglutamic acid; l-2-amino adipic acid; homoglutamic acid; (S)-2-Aminoadipic acid; UNII-88ZH74L7SR; hexanedioic acid, 2-amino-, (2S)-; h-2-aad-oh; l-a-aminoadipic acid; h-l-2-aad-oh; MFCD00002636; L-2-Aminohexanedioate; CHEMBL88804; 88ZH74L7SR; L-2-Aminoadipic acid, 98%; A-aminoadipic acid; Adipic acid, 2-amino-; alpha-Aminoadipate, L-; 2-Aminoadipic acid, L-; L-alpha-Aminoadipatic acid; Hexanedioic acid, 2-amino-, (S)-; l-a-aminohexanoic acid; (S)-Aminoadipic Acid; L-2-amino-adipic acid; aminoadipic acid, l-2-; l-alpha-amino-adipic acid; L -alpha-aminoadipic acid; (2S)-2-aminoadipic acid; l-alpha-aminohexanedioic acid; Lopac0_000091; SCHEMBL97323; KSC493I2B; (S)-2-amino-hexanedioic acid; (2S)-2-Amino-hexanedioic Acid; CTK3J3420; DTXSID801017096; HMS3260C04; KS-00000YV4; ZINC1532798; Tox21_500091; ANW-43725; BDBM50052553; AKOS015920301; CCG-204186; LP00091; SDCCGSBI-0050079.P002; L-2-Aminoadipic acid, >=98% (TLC); NCGC00093593-01; NCGC00093593-02; NCGC00093593-03; NCGC00093593-04; NCGC00260776-01; AS-13597; BR-25294; SC-10038; AB0013911; EU-0100091; A 7275; C00956; M-3010; 118A907; SR-01000075684; J-002657; SR-01000075684-1; Q27104392; Aad; (S)-2-Aminohexanedioic acid; L-Homoglutamic acid; 9EF7020B-8995-4D0E-BE44-34D8F18766DF; UNII-1K7B1OED4N component OYIFNHCXNCRBQI-BYPYZUCNSA-N
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 23 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Glutamic Acid
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 270000 nM
|
[1] | |||
| Compound Name |
(S)-AMPA
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-AMPA; 83643-88-3; (S)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; UNII-9280SC28GD; CHEMBL276815; 9280SC28GD; (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid; AMPA, L-; AMQ; glutamate-AMPA; 1ftm; Tocris-0254; Tocris-0169; Tocris-1074; S-AMPA; 1p1q; L-AMPA; Lopac-G-017; AC1L4JUQ; Biomol-NT_000216; (S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; SCHEMBL667915; BPBio1_001304; CTK7I3476; BDBM17662; BDBM85214; UUDAMDVQRQNNHZ-YFKPBYRVSA-N; MolPort-003-940-001; MolPort-003-983-512; HMS3266E09
Click to Show/Hide
|
||||
| Activity |
EC50 = 220000 nM
|
[6] | |||
| Compound Name |
[3H]quisqualate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Quisqualic acid; QUISQUALIC ACID; Quisqualate; L-Quisqualic acid; 52809-07-1; (+)-Quisqualic acid; UNII-8OC22C1B99; C5H7N3O5; CHEBI:8734; CHEMBL279956; 8OC22C1B99; (2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid; 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine; 2jbk; 1,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-; (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID; 2or4; AC1ODZB5; (S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid; QUS; SR-01000075471; QUISQUALATE
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[2] | |||
| Compound Name |
D-aspartic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-Aspartic acid; 1783-96-6; (R)-2-aminosuccinic acid; D-Aspartate; H-D-Asp-OH; (-)-Aspartic acid; (R)-Aspartic acid; Aspartic acid D-form; (2R)-2-aminobutanedioic acid; Aspartic acid, D-; D-(-)-Aspartic acid; (R)-(-)-Aminosuccinic acid; D-Asp; D-Aminosuccinic acid; NSC 97922; D-Asparaginsaeure; UNII-4SR0Q8YD1X; BRN 1723529; Tocris-0213; EINECS 217-234-6; 4SR0Q8YD1X; (R)-2-aminobutanedioic acid; CHEMBL29757; CHEBI:17364; CKLJMWTZIZZHCS-UWTATZPHSA-N; MFCD00063081; NCGC00024498-02; (R)-2-Aminobutanedioate; D(-)-Aspartic acid, 99+%; D-aspartate; [3H]D-aspartic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
D-glutamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-glutamate; D-Glu
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
L-aspartic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
L-Asp; L-aspartate; Aspatofort
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
Kainic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Digenin; Digenic acid; Helminal; Kainate; L-alpha-Kainic acid; alpha-Kainic acid; Digensaeure; Kainsaeure; Acidum kainicum; Acide kainique; Acido kainico; C10H15NO4; UNII-SIV03811UC; alpha- Kainic acid; CHEMBL275040; SIV03811UC; NSC136038; NCGC00024504-05; NSC 136038; DSSTox_CID_20526; DSSTox_RID_79503; DSSTox_GSID_40526; Kainic acid [INN:JAN]; 3-(Carboxymethyl)-4-isopropenylproline; Acide kainique [INN-French]; Acido kainico [INN-Spanish]; Acidum kainicum [INN-Latin]; 2-Carboxy-4-isopropenyl-3-pyrrolidineacetic acid; SR-01000075454; BRN 0086660; Kainic acid (synthetic); Biomol-NT_000217; UPCMLD-DP146; Lopac0_000656; SCHEMBL15777; 4-22-00-01523 (Beilstein Handbook Reference); MLS001074661; BPBio1_001306; (-)-(.alpha.)-Kainic Acid; DTXSID7040526; UPCMLD-DP146:001; UPCMLD-DP146:002; CTK1D6000; HMS2233K05; HMS3262C13; HMS3266C11; HMS3411A21; HMS3675A21; HY-N2309; ZINC3995575; Tox21_110905; Tox21_500656; BDBM50002369; Kainic Acid - CAS 487-79-6; AKOS024456995; Tox21_110905_1; CCG-204742; LP00656; MB00564; NSC-136038; SDCCGSBI-0050635.P002; NCGC00024504-02; NCGC00024504-03; NCGC00024504-04; NCGC00024504-06; NCGC00024504-07; NCGC00024504-08; NCGC00024504-09; NCGC00024504-15; NCGC00261341-01; SC-19815; SMR000471885; B6226; CS-0020451; EU-0100656; C12819; K 0250; Q390239; SR-01000597728; SR-01000075454-1; SR-01000075454-5; SR-01000075454-6; SR-01000075454-7; SR-01000597728-1
Click to Show/Hide
|
||||
| Activity |
EC50 = 299000 nM
|
[1] | |||
| Compound Name |
(2S,3S)-3-(Carboxymethyl)azetidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S,3S)-trans-3-(Carboxymethyl)-azetidine-2-acetic Acid; CHEMBL314690; CTK8F0661; ZINC4262470; BDBM50288204; ST50824727; J-011895; (2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[7] | |||
| Compound Name |
2-Amino-5-(3-hydroxy-5-methyl-isoxazol-4-yl)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324686; BDBM50052555
Click to Show/Hide
|
||||
| Activity |
EC50 = 410000 nM
|
[6] | |||
| Compound Name |
(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46527; BDBM50064246; (1R,4R)-2beta-Aminobicyclo[2.1.1]hexane-2,5beta-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 800000 nM
|
[8] | |||
| Compound Name |
2-Aminooctanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DL-ALPHA-AMINOSUBERIC ACID; Octanedioic acid, 2-amino-; DL-2-Aminosuberic Acid; 2-Amino-octanedioic acid; DL-2-Aminoctanedioic acid; DL-2-Aminooctanedioic Acid; H-D-Asu-OH; CHEMBL320957; (S)-2-Aminooctanedioic acid;L-alpha-Aminosuberic acid; D-alpha-Aminosuberic acid;(R)-2-Aminooctanedioic acid; aminosuberic acid; L-a-Aminosubericacid; alpha-aminosuberic acid; H-DL-Asu-OH.nH2O; DL-2-amino suberic acid; SCHEMBL127239; CTK8B9843; DTXSID60275757; 0126AB; ANW-63286; BDBM50052552; MFCD00063122; AKOS015893070; AS-58788; SC-10114; DB-044930; A1279; FT-0637883; 4,4-methylenebis(2-tert-butyl-6-methylphenol); 054A077; J-018004
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-4-yl)-2-methylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313713; BDBM50089891; 2-Amino-3-(3-hydroxy-5-oxo-[1,2,4]oxadiazol-4-yl)-2-methyl-propionic acid(S-MetQUIS)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[2] | |||
| Compound Name |
(RS)-Apica
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-amino-5-phosphono-2,3-dihydroindene-1-carboxylic acid; CHEMBL277961; (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid; (S)-MPPG (cyclic); 1-Amino-5-phosphono-indan-1-carboxylic acid; 1H-Indene-1-carboxylicacid; SCHEMBL2799885; CTK8F2086; BDBM50089893; AKOS024456371; NCGC00024982-02; SR-01000597477; J-010657; J-013076; SR-01000597477-1; 1-Amino-5-phosphono-indan-1-carboxylic acid(RS-APICA)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[2] | |||
| Compound Name |
D-2-Aminoadipic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(R)-2-Aminohexanedioic acid; (2R)-2-aminohexanedioic acid; D-a-Aminoadipic acid; (R)-2-Aminoadipic acid; D-alpha-aminoadipic acid; A-Aminoadipic acid; Hexanedioic acid, 2-amino-, (2R)-; (R)-2-Amino-hexanedioic acid; Hexanedioic acid, 2-amino-, (-)- and (+)-; D-Homoglutamic acid; D-2-Aminoadipic acid, 98%; MFCD00063118; alpha-Aminoadipate, D-; H-D-2-Aad-OH; d-2-aminoadipate; D-Aad; D-Ho-Glu; 2-Aminohexanedioic acid (-)- and (+)-; Lopac-A-7275; KSC493Q2H; SCHEMBL2022365; CHEMBL1169505; BDBM85356; CTK3J3823; KS-00000JOF; DTXSID90227062; ZINC1678992; ANW-43726; AKOS016842486; CS-W016142; NCGC00015087-01; AC-22381; AS-14204; SC-10039; AB0014153; M-3011; Q27117011; Z2767445962; UNII-1K7B1OED4N component OYIFNHCXNCRBQI-SCSAIBSYSA-N
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297150; BDBM50078596; 4-Amino-2,4-dicarboxy-pyrrolidin-1-yl-ammonium(1-Amino-APDC)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[2] | |||
| Compound Name |
(R)-Ampa
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
D-AMPA; UNII-F45TJ02EL1; CHEMBL14815; F45TJ02EL1; (R)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid; 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo-, (alphaR)-; (2R)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; Ampa, D-; (R)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; (-)-Ampa; Tocris-0253; Biomol-NT_000215; BPBio1_001302; SCHEMBL2458874; SCHEMBL13957590; CTK7I3077; HMS3266E07; ZINC3870314; BDBM50026947; AKOS006272257; SB38934; NCGC00024516-01; NCGC00024516-02; B6237; SR-01000597719; SR-01000597719-1; Q27277614; (R)-?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; (r)-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; UNII-J090588E6X component UUDAMDVQRQNNHZ-RXMQYKEDSA-N; (R)-2-ammonio-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoate; (R)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid; 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid(D-AMPA)
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
2-Aminoheptanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
dl-2-Aminopimelic acid; 2-AMINOPIMELIC ACID; 2-Aminopimelate; dl-alpha-Aminopimelic acid; DL-2-Aminopimelate; DL-2-Aminoheptanedioic acid; alpha-Aminopimelic acid; (+/-)-2-Aminopimelic acid; 2-Amino-heptanedioic acid; (+-)-2-Aminopimelic acid; Heptanedioic acid, 2-amino-; DL-alpha-Aminopimelic acid;H-DL-Apm-OH; CHEMBL111050; DL-Heptyline; D,L-alpha-Aminopimelic acid; heptyline; aminopimelic acid; DL-2-Aminopimelic Acid(alpha-); a-aminopimelic acid; EINECS 211-011-7; NSC 402480; DL-2-AminopimelicAcid; H-DL-Apim(2)-OH; DL-2-amino pimelic acid; 2-Aminoheptanedioic acid #; 2-Aminopimelic acid, DL-; Heptanedioic acid,2-amino-; d,l-2-aminoheptanedioic acid; dl-.alpha.-Aminopimelic acid; SCHEMBL116556; CTK8B9845; DTXSID00978316; (+/-)-2-Aminoheptanedioic acid; 2-Amino-(+-)-Heptanedioic acid; ()-2-Aminopimelic acid; ANW-63293; BDBM50052549; CCG-49889; KM0656; MFCD00053314; NSC402480; AKOS016003609; MCULE-2486712857; NSC-402480; VZ23774; Heptanedioic acid, 2-amino-, (+-)-; KS-0000170J; (+/-)-2-Aminopimelic acid, >=99%; AS-47823; SC-10081; DB-054281; Heptanedioic acid, 2-amino-, (.+/-.)-; A0404; FT-0611264; FT-0658289; 627H769; SR-01000639310-1; W-204236; Q27894420; DB946E0D-C5D0-47E2-A9AA-3E29D190922E
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
(1S,2S,4S,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42148; BDBM50064247; (1S,4S)-2beta-Aminobicyclo[2.1.1]hexane-2,5beta-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[8] | |||
| Compound Name |
alpha-Amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL280585; 2-amino-2-(5-methyl-3-oxo-1,2-oxazol-4-yl)acetic acid; Amaa acid; 2-Amino-3-hydroxy-5-methyl-4-isoxazoleacetic acid; SCHEMBL5290687; CTK5E3723; DTXSID20998293; BDBM50004852; alpha-amino-5-methyl-3-hydroxy-4-isoxazoleacetic acid; Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-acetic acid; Amino(3-hydroxy-5-methyl-1,2-oxazol-4-yl)acetic acid; 4-Isoxazoleacetic acid,a-amino-2,3-dihydro-5-methyl-3-oxo-; 2-Amino-2-(5-methyl-3-oxo-2,3-dihydroisoxazol-4-yl)acetic acid; Amino-(3-hydroxy-5-methyl-isoxazol-4-yl)-acetic acid (D-AMAA); 4-Isoxazoleacetic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo-, (+-)-
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
(1R,2S,4R,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43857; BDBM50064245; (1R,4R)-2beta-Aminobicyclo[2.1.1]hexane-2,5alpha-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[8] | |||
| Compound Name |
2-Amino-2,3-methano-4-phosphonobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287703; (1R,2R)-1-amino-2-(phosphonomethyl)cyclopropane-1-carboxylic acid; (1R,2R)-1-amino-2-(phosphonomethyl)cyclopropanecarboxylic acid; 2-Ampba; DTXSID80928258; BDBM50089518; 1-amino-2-(phosphonomethyl)cyclopropane-1-carboxylic acid; (1R,2R)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid; Cyclopropanecarboxylic acid, 1-amino-2-(phosphonomethyl)-, trans-(+-)-
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[5] | |||
| Compound Name |
2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313394; SCHEMBL13319983; BDBM50089898; (2S,7S)-2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[2] | |||
| Compound Name |
2-Amino-6-(3-hydroxy-5-methylisoxazol-4-yl)hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111441; BDBM50052554; 2-Amino-6-(3-hydroxy-5-methyl-isoxazol-4-yl)-hexanoic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists. Eur J Med Chem. 2010 Jan;45(1):69-77. | ||||
| REF 2 | Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. | ||||
| REF 3 | Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40. | ||||
| REF 4 | Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. | ||||
| REF 5 | Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. J Med Chem. 2007 Jul 26;50(15):3585-95. | ||||
| REF 6 | A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. J Med Chem. 1996 Aug 2;39(16):3188-94. | ||||
| REF 7 | Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA). Bioorg Med Chem Lett. 1996 Nov 5;6(21):2559-64. | ||||
| REF 8 | Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. J Med Chem. 1998 May 7;41(10):1641-50. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.