Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56175 | Target Info | |||
| Target Name | Lanosterol synthase (LSS) | ||||
| Synonyms |
Oxidosqualene--lanosterol cyclase; Oxidosqualene cyclase; OSC; LSS; 2,3-epoxysqualene--lanosterol cyclase
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| Target Type | Literature-reported Target | ||||
| Gene Name | LSS | ||||
| Biochemical Class | Intramolecular transferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[(Dimethylamino)methyl]-N-[[1-(4-methoxyphenyl)-2,5-dimethylpyrrol-3-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258965; BDBM50327307; 4-((dimethylamino)methyl)-N-((1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl)methyl)benzamide
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| Activity |
IC50 = 58800 nM
|
[1] | |||
| Compound Name |
2,2-Dimethyl-3-(3,7,12-trimethyl-hexadeca-3,7,11,15-tetraenyl)-oxirane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL152273; BDBM50062851
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| Activity |
IC50 = 70000 nM
|
[2] | |||
| Compound Name |
(E)-4-[[3-(4-Bromophenyl)-1-benzofuran-6-yl]oxy]-N-methyl-N-prop-2-enylbut-2-en-1-amine;(E)-but-2-enedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL481811
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| Activity |
IC50 = 90000 nM
|
[3] | |||
| Compound Name |
2,2-Dimethyl-3-(3,7,12,20-tetramethyl-16-vinyl-henicosa-3,7,11,19-tetraenyl)-oxirane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL152272; BDBM50062845
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(6Z)-10-Azasqualene-2,3-epoxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL102630; BDBM50406679
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5807-10. | ||||
| REF 2 | 29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase. J Med Chem. 1998 Feb 12;41(4):540-54. | ||||
| REF 3 | Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents. Bioorg Med Chem Lett. 2009 Feb 1;19(3):718-23. | ||||
| REF 4 | 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase. J Med Chem. 1992 Aug 7;35(16):3050-8. | ||||
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