Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T60003 | Target Info | |||
| Target Name | Protein kinase N1 (PKN1) | ||||
| Synonyms |
Serine/threonine-protein kinase N1; Serine-threonine protein kinase N; Protein-kinase C-related kinase 1; Protein kinase PKN-alpha; Protein kinase C-like PKN; Protein kinase C-like 1; Protease-activated kinase 1; PRKCL1; PRK1; PKN; PAK1
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| Target Type | Literature-reported Target | ||||
| Gene Name | PKN1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Norlichexanthone
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Investigative | Compound Info | ||
| Synonyms |
1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one; 9H-xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; CHEMBL466154; 1,3,6-trihydroxy-8-methylxanthen-9-one; 1,3,6-trihydroxy-8-methyl-xanthen-9-one; 3,6,8-Trihydroxy-1-methylxanthone; Fusarindin; AC1NQYTV; Xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; C10087; ACon0_000599; ACon1_001113; CTK4E4931; DTXSID20174777; 1,3,6-trihydroxy-8-methylxanthone; ZINC5765089; BDBM50350423; AKOS000365318; MCULE-8777096541; NCGC00169665-01; W2650; 1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one #; BRD-K97951054-001-01-6; Q27107546; NCGC00169665-03!1,3,6-trihydroxy-8-methylxanthen-9-one
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| Activity |
IC50 = 54900 nM
|
[1] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Calicoferol E
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456936; (8S)-3-hydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one; BDBM50358246; LMST03020157
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109402; BDBM50446565
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Methyl 3-[[(1R,2S,4aR,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-4,5-dihydroxybenzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109404; 18-Hydroxy-5-epi-hyrtiophenol; BDBM50446564
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Calicoferol C
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Calicoferol B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Astrogorgiadiol B
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Investigative | Compound Info | ||
| Synonyms |
ASTROGORGIADIOL; (8S,9R)-9,10-seco-1,3,5(10)-cholestatriene-3,9-diol; LMST03020242; CHEMBL517956; SCHEMBL4865385; BDBM50358247
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Calicoferol A
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Investigative | Compound Info | ||
| Synonyms |
(22E)-(8S)-3-hydroxy-9,10-seco-1,3,5(10),22-cholestatetraen-9-one; LMST03020605; CHEMBL518060; BDBM50358244
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Rel-Astrogorgol F
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922224; BDBM50358243
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
24-Exomethylenecalicoferol E
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922225; BDBM50358245
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. Bioorg Med Chem. 2011 Aug 1;19(15):4644-51. | ||||
| REF 2 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. | ||||
| REF 3 | Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod. 2014 Feb 28;77(2):218-26. | ||||
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