Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62431 | Target Info | |||
| Target Name | Tyrosine-protein kinase SYK (SYK) | ||||
| Synonyms |
p72-Syk; Spleen tyrosine kinase
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| Target Type | Successful Target | ||||
| Gene Name | SYK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 28 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
BMS-509744
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|
Investigative | Compound Info | ||
| Synonyms |
BMS-509744; 439575-02-7; BMS 509744; CHEMBL209148; N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide; GTPL9994; SCHEMBL14460651; KS-00001CVA; CHEBI:91404; MolPort-039-101-283; C32H41N5O4S2; BMS509744; BDBM50186460; 3499AH; compound 3 [PMID:16682193]; AKOS025142036; NCGC00229512-02; NCGC00229512-01
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Myricetin
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Investigative | Compound Info | ||
| Synonyms |
myricetin; 529-44-2; Cannabiscetin; Myricetol; Myricitin; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; 3,3',4',5,5',7-Hexahydroxyflavone; 3,5,7,3',4',5'-Hexahydroxyflavone; UNII-76XC01FTOJ; NSC 407290; CCRIS 5838; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one; EINECS 208-463-2; NSC407290; CHEMBL164; NSC-407290; BRN 0332331; 76XC01FTOJ
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| Activity |
EC50 = 54000 nM
|
[2] | |||
| Compound Name |
2-methoxy-4-(2-nitrovinyl)phenol
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Investigative | Compound Info | ||
| Synonyms |
2-methoxy-4-(2-nitrovinyl)phenol; 6178-42-3; 2-Methoxy-4-[(E)-2-nitroethenyl]phenol; 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE; (E)-2-methoxy-4-(2-nitrovinyl)phenol; trans-4-Hydroxy-3-methoxy-beta-nitrostyrene; 2-methoxy-4-[(E)-2-nitrovinyl]phenol; CHEMBL309016; 22568-51-0; AF-467/00017042; 2-methoxy-4-(2-nitroethenyl)phenol; 2-Methoxy-4-(2-nitro-vinyl)-phenol; 4-((1E)-2-nitrovinyl)-2-methoxyphenol; 4-{2-nitrovinyl}-2-methoxyphenol; 4-Hydroxy-3-methoxy-beta-nitrostyrene; AC1LCWDN; PubChem19447; AC1Q1WR9; MLS000574924
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| Activity |
IC50 = 76000 nM
|
[3] | |||
| Compound Name |
p38 MAP Kinase Inhibitor IX
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259922; Kinome_3519; SCHEMBL16576573; CTK8G2239; BDBM50376226; 4-methyl-N-(1,2-oxazol-3-yl)-3-[(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-Tert-butyl-2-(6-chloro-1-methylindazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348853; SCHEMBL14737096; BDBM50431390; N-tert-butyl-2-(6-chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
N-Dodecyl-5-(2,5-dihydroxybenzylamino)-2-hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL138340; BDBM50102420; 5-(2,5-Dihydroxy-benzylamino)-N-dodecyl-2-hydroxy-benzamide
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
5-(2,5-Dihydroxy-benzylamino)-2-hydroxy-N-[2-(4-methoxy-phenyl)-ethyl]-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440529; BDBM50102424; N-(4-Methoxyphenethyl)-5-(2,5-dihydroxybenzylamino)-2-hydroxybenzamide
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
BMS-605541; CHEMBL377734; BMS 605541; SCHEMBL2861987; BDBM50189603; AKOS034831603
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290746; SCHEMBL14097139; BDBM50331629
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
7-(3,4-Dimethoxyphenyl)-3-methyl-5-[[(2R)-3,3,3-trifluoro-2-hydroxypropyl]amino]pyrido[4,3-d]pyrimidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1235595; CHEMBL3701594; BDBM121878; US8722692, 317
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
6-(2-Aminoethoxy)-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237567; SCHEMBL15649801; BDBM50007188; 6-(2-aminoethoxy)-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide
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| Activity |
IC50 ~ 50118.72 nM
|
[12] | |||
| Compound Name |
4-Chloro-3-(pyridin-2-ylmethoxy)aniline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4293043; SCHEMBL17601189; BDBM50467666; AKOS013325159
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| Activity |
IC50 = 50118.72 nM
|
[13] | |||
| Compound Name |
Chembl4283270
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467639
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| Activity |
IC50 ~ 50118.72 nM
|
[13] | |||
| Compound Name |
(4E)-4-{[5-(2-Chlorophenyl)furan-2-yl]methylidene}-1-phenylpyrazolidine-3,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112617; BDBM50446911; STK062393; ZINC13897078; AKOS005133277; BIM-0038764.P001
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| Activity |
IC50 = 57000 nM
|
[14] | |||
| Compound Name |
(4S)-4-[[(2S)-2-[[2-[[4-[3-[[2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]acetyl]amino]prop-1-ynyl]benzoyl]amino]acetyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-5-[[(2S,3R)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1793843; BDBM50366881
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|
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| Activity |
IC50 = 62000 nM
|
[15] | |||
| Compound Name |
2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-sulfamoyl]-vinyl}-phenylcarbamoyl)-cyclohexyl]-malonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141597; CHEMBL142237; BDBM50107900; BDBM50107902
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|
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| Activity |
IC50 = 63000 nM
|
[16] | |||
| Compound Name |
2-[4-(4-{2-[(5-Carboxy-pentyl)-(5-methyl-hexyl)-sulfamoyl]-vinyl}-phenylcarbamoyl)-cyclohex-1-enyl]-malonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL145228; BDBM50107898
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|
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| Activity |
IC50 = 71000 nM
|
[16] | |||
| Compound Name |
6-Fluoro-2-isopropyl-4-(5-methyl-1H-pyrazol-3-ylamino)phthalazin-1(2H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL475779; SCHEMBL4061646; BDBM50249455; 6-fluoro-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-propan-2-ylphthalazin-1-one
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|
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| Activity |
IC50 = 87500 nM
|
[3] | |||
| Compound Name |
(4R)-4-[(1S)-1-[(7-Phenyl-1,6-naphthyridin-5-yl)oxy]ethyl]pyrrolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696057; SCHEMBL10196746; BDBM144572; US8969568, 125
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|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
3-(2,5-Dihydroxy-benzylamino)-N-phenethyl-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138698; BDBM50102419; N-Phenethyl-3-(2,5-dihydroxybenzylamino)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
9H-Imidazo(4,5-H)isoquinolin-9-one, 2-((2,6-dichlorophenyl)amino)-1,8-dihydro-6,7-dimethyl-
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Investigative | Compound Info | ||
| Synonyms |
BIRA-0596; UNII-0U6QL95YQD; 0U6QL95YQD; CHEMBL27085; SCHEMBL676660; SCHEMBL4960262; BDBM50116391; Q27237262; 2-(2,6-dichloroanilino)-6,7-dimethyl-3,8-dihydroimidazo[4,5-h]isoquinolin-9-one
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| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(2-Methoxy-4-morpholinophenyl)-N'-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076767; SCHEMBL17731732; BDBM50264841; J3.639.761F
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|
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| Activity |
IC50 = 153000 nM
|
[21] | |||
| Compound Name |
1-(2-Chlorobenzyl)-3-(5-oxo-2-thioxotetrahydro-4H-imidazol-4-yliden)-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115319; Oprea1_039085; ZINC6222379; BDBM50446914; STK824031; AKOS002942872; MCULE-5026087455; (3Z)-1-(2-chlorobenzyl)-3-(5-oxo-2-thioxoimidazolidin-4-ylidene)-1,3-dihydro-2H-indol-2-one
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| Activity |
IC50 = 168000 nM
|
[14] | |||
| Compound Name |
(S)-4-{(S)-2-[(S)-2-Acetylamino-3-(4-phosphonooxy-phenyl)-propionylamino]-4-carboxy-butyrylamino}-4-((1S,2S)-1-carbamoyl-2-methyl-butylcarbamoyl)-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL311937; Ac-pY-E-E-I-NH2; Ac-pTyr-Glu-Glu-Ile-amide; Ac-pTyr-Glu-Glu-Ile-NH(2); acetyl-Tyr(P)-Glu-Glu-Ile-amide; BDBM50080177
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| Activity |
IC50 = 171000 nM
|
[22] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 70 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MORIN
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Investigative | Compound Info | ||
| Synonyms |
morin; 480-16-0; Aurantica; Calico Yellow; Al-Morin; Toxylon Pomiferum; Morin hydrate; 2',3,4',5,7-Pentahydroxyflavone; 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one; Bois d,Arc; Osage Orange; Osage Orange Extract; Bois d'arc; C.I. Natural Yellow 11; C.I. Natural Yellow 8; Osage Orange Crystals; 3,5,7,2',4'-Pentahydroxyflavone; 3,5,7,2',4'-Pentahydroxyflavonol; 2'-Hydroxypelargidenolon 1522; 2',4',3,5,7-Pentahydroxyflavone; C.I. 75660; Zlut prirodni 11; 2',4',5,7-Tetrahydroxyflavan-3-ol; Bois d'arc [French]
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| Activity |
EC50 > 300000 nM
|
[2] | |||
| Compound Name |
1,3-DIPHENYLUREA
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Investigative | Compound Info | ||
| Synonyms |
1,3-Diphenylurea; 102-07-8; N,N'-Diphenylurea; CARBANILIDE; Diphenylurea; Diphenylcarbamide; Urea, N,N'-diphenyl-; s-Diphenylurea; sym-Diphenylurea; Acardite I; Acardite; N-Phenyl-N'-phenylurea; 1,3-Diphenylcarbamide; Karbanilid; N,N'-Difenylmocovina; USAF EK-534; Urea, 1,3-diphenyl-; Karbanilid [Czech]; 1,3-diphenyl-urea; AD 30; UNII-94YD8RMX5B; NSC 227401; N,N'-Difenylmocovina [Czech]; CCRIS 4634; HSDB 2757; Urea-based compound, 7; EINECS 203-003-7; BRN 0782650; 94YD8RMX5B; AI3-52320; CHEBI:41320; GWEHVDNNLFDJLR-UHFFFAOYSA-N
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| Activity |
IC50 > 660000 nM
|
[23] | |||
| Compound Name |
RU78191
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Investigative | Compound Info | ||
| Synonyms |
Phenylmalonic acid; 2613-89-0; 2-Phenylmalonic acid; 2-phenylpropanedioic acid; Propanedioic acid, phenyl-; Phenylmalonicacid; Phenylpropanedioc acid; Malonic acid, phenyl-; RU78191; Propanedioic acid, 2-phenyl-; phenylpropanedioic acid; CHEMBL78794; .alpha.-Carboxyphenylacetic acid; WWYDYZMNFQIYPT-UHFFFAOYSA-N; Toluene-.alpha.,.alpha.-dicarboxylic acid; phenylmalonate; alpha-Carboxyphenylacetic acid; EINECS 220-044-6; Toluene-alpha,alpha-dicarboxylic acid; NSC 41697; NSC 27164; 2-Phenyl-malonic acid; 1o4p; AC1L2PIV
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| Activity |
IC50 = 12000000 nM
|
[16] | |||
| Compound Name |
{4-Amino-2-[(4-ethoxyphenyl)amino]-1,3-thiazol-5-yl}(3-methoxyphenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115324; ZINC1125825; BDBM50446909; STK843373; AKOS003680468; MCULE-3712794100; ST071560; SR-01000282989; SR-01000282989-1; 4-amino-2-[(4-ethoxyphenyl)amino](1,3-thiazol-5-yl) 3-methoxyphenyl ketone
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| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 13c
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Investigative | Compound Info | ||
| Synonyms |
BDBM5103; CHEMBL336949
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| Activity |
IC50 = 250000 nM
|
[22] | |||
| Compound Name |
(6Ar,10aS)-4-Methoxy-7,9-dimethyl-4,6,6a,7,8,10a-hexahydro-indolo[4,3-fg]quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL435240; 1-methoxy-5R,10S-agroclavine; BDBM50069242
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| Activity |
IC50 = 285000 nM
|
[24] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 13b
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Investigative | Compound Info | ||
| Synonyms |
BDBM5102; CHEMBL407143
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| Activity |
IC50 = 288000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 14e
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Investigative | Compound Info | ||
| Synonyms |
BDBM5090; CHEMBL336864
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| Activity |
IC50 = 302000 nM
|
[22] | |||
| Compound Name |
[5-[[(1S)-1-[3-[(3,4-Dichlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]ethyl]carbamoylamino]naphthalen-2-yl] dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319179; BDBM50082326
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| Activity |
IC50 = 310000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 15a
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Investigative | Compound Info | ||
| Synonyms |
BDBM5104; CHEMBL337737
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| Activity |
IC50 = 318000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 13a
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5101; CHEMBL337253
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| Activity |
IC50 = 323000 nM
|
[22] | |||
| Compound Name |
2-(4-{4-[2-(5-Carboxy-pentylsulfamoyl)-vinyl]-phenylcarbamoyl}-cyclohexyl)-malonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423737; CHEMBL2368111; BDBM50107895; 6-[4-[[(1beta)-4-(Dicarboxymethyl)cyclohexyl]carbonylamino]styrylsulfonylamino]hexanoic acid
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| Activity |
IC50 = 350000 nM
|
[16] | |||
| Compound Name |
(3S)-3-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336957
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|
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| Activity |
IC50 = 389000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 14c
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5088; CHEMBL134004
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|
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| Activity |
IC50 = 397000 nM
|
[22] | |||
| Compound Name |
(4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-amino-4-oxobutanoyl]amino]-5-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430059
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|
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| Activity |
IC50 = 420000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 14f
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5091; CHEMBL131229
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|
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| Activity |
IC50 = 433000 nM
|
[22] | |||
| Compound Name |
[2-[[(1S)-1-[3-[(3,4-Dichlorophenyl)methyl]-1,2,4-oxadiazol-5-yl]ethyl]carbamoyl]-1H-indol-5-yl] dihydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706656; BDBM50217232
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|
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| Activity |
IC50 = 434000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12g
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM5085; CHEMBL132006
Click to Show/Hide
|
||||
| Activity |
IC50 = 452000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5m
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5074; CHEMBL336644
Click to Show/Hide
|
||||
| Activity |
IC50 = 464000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5j
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5071; CHEMBL133929
Click to Show/Hide
|
||||
| Activity |
IC50 = 472000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316967; BDBM5098
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 14d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5089; CHEMBL131944
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5n
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5075; CHEMBL340977
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
N-{1-[3-(3,4-Dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-3-(4-phosphonooxy-benzyl)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102765; BDBM50082327
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5066; CHEMBL334891
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5061; CHEMBL341314
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4j
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5094; CHEMBL134243
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5096; CHEMBL335628
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4i
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310313; BDBM5063
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
N-{1-[3-(3,4-Dichloro-benzyl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-ethyl}-3-(4-phosphonooxy-benzyl)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102766; BDBM50082328
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318300; BDBM5095
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5081; CHEMBL134042
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(1S)-4-amino-4-oxo-1-[3-[(4,6,6-trimethylcyclohexa-2,4-dien-1-yl)methyl]-1,2,4-oxadiazol-5-yl]butyl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL134191
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5058; CHEMBL130871
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5065; CHEMBL335284
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 15b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5105; CHEMBL337451
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5067; CHEMBL130106
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4k
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76963; BDBM5064
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
N-[(S)-1-[3-(3,4-Dichlorobenzyl)-1,2,4-oxadiazole-5-yl]ethyl]-4-(phosphonooxy)benzenepropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419353; BDBM50082329
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 14a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5086; CHEMBL130931
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5057; CHEMBL130401
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5084; CHEMBL132007
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 14b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5087; CHEMBL133644
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5k
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5072; CHEMBL424449
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
3-(4-Phosphonooxy-benzyl)-N-{1-[3-(4-trifluoromethyl-benzyl)-[1,2,4]oxadiazol-5-yl]-ethyl}-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419539; BDBM50082330
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5100; CHEMBL334979
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5077; CHEMBL132014
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5078; CHEMBL130751
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5060; CHEMBL423330
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5080; CHEMBL334539
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5i
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5069; CHEMBL339077
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5059; CHEMBL336978
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5l
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5073; CHEMBL131361
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5083; CHEMBL134030
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
[4-[(2S)-2-(Tert-butylsulfonylmethyl)-3-oxo-3-[[(1S)-1-[3-[[4-(trifluoromethyl)phenyl]methyl]-1,2,4-oxadiazol-5-yl]ethyl]amino]propyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320372; BDBM50082331
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5068; CHEMBL133511
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5099; CHEMBL336314
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 12a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5082; CHEMBL133185
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5070; CHEMBL129842
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 6
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5076; CHEMBL131768
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5093; CHEMBL337459
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5079; CHEMBL132963
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 15c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5106; CHEMBL336958
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 5f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103838; BDBM5097
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1,2,4-Oxadiazole Analogue 4a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77067; BDBM5092
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[22] | |||
| Compound Name |
Ac-pTyr-Glu-Thr-Leu-NH(2)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1793841; BDBM50366878
Click to Show/Hide
|
||||
| Activity |
IC50 = 570000 nM
|
[15] | |||
| Compound Name |
(4R)-4-[(1R)-1-(1,6-Naphthyridin-5-yloxy)ethyl]pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696059; SCHEMBL10196759; BDBM144574; US8969568, 127
Click to Show/Hide
|
||||
| Activity |
IC50 = 2156000 nM
|
[17] | |||
| Compound Name |
Cyclohexanemalonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-cyclohexylpropanedioic acid; cyclohexylmalonic acid; 2-Cyclohexyl-malonic acid; CHEMBL142870; 2-Cyclohexylmalonic acid; Cyclohexylmalonsaure; cyclohexyl-malonic acid; SCHEMBL431289; ZINC388380; BDBM50107903; NSC408420; NSC-408420; DS-013185
Click to Show/Hide
|
||||
| Activity |
IC50 = 5900000 nM
|
[16] | |||
| Compound Name |
4-Cyclooctenylmalonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357125; 2-Cyclooct-4-enyl-malonic acid; BDBM50107894
Click to Show/Hide
|
||||
| Activity |
IC50 = 7700000 nM
|
[16] | |||
| Compound Name |
6-(2-Phenyl-ethenesulfonylamino)-hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142578; (E)-6-(2-phenylvinylsulfonamido)hexanoic acid; 6-{[((1E)-2-phenylvinyl)sulfonyl]amino}hexanoic acid; MLS000713739; HMS2632C19; ZINC2566582; 6-(Styrylsulfonylamino)hexanoic acid; BDBM50107896; SBB027708; STL079515; AKOS000301768; 6-(2-Phenylvinylsulfonamido)hexanoic acid; SMR000273220; ST50217072; SR-01000357393; SR-01000357393-1; BRD-K91127258-001-08-8; 6-({[(E)-2-phenylethenyl]sulfonyl}amino)hexanoic acid; F0864-0011
Click to Show/Hide
|
||||
| Activity |
IC50 = 8000000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3706-12. | ||||
| REF 2 | Discovery and development of spleen tyrosine kinase (SYK) inhibitors. J Med Chem. 2012 Apr 26;55(8):3614-43. | ||||
| REF 3 | Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1944-9. | ||||
| REF 4 | Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2652-7. | ||||
| REF 5 | Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors. J Med Chem. 2013 Feb 28;56(4):1677-92. | ||||
| REF 6 | Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. | ||||
| REF 7 | Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin ... J Med Chem. 2001 Feb 1;44(3):441-52. | ||||
| REF 8 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 9 | Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. | ||||
| REF 10 | 5-amino-pyrazoles as potent and selective p38alpha inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6886-9. | ||||
| REF 11 | US patent application no. 8722692B2, Compounds and compositions as Syk kinase inhibitors | ||||
| REF 12 | Using ovality to predict nonmutagenic, orally efficacious pyridazine amides as cell specific spleen tyrosine kinase inhibitors. J Med Chem. 2014 Mar 27;57(6):2683-91. | ||||
| REF 13 | Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-62. | ||||
| REF 14 | Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5721-6. | ||||
| REF 15 | Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1241-4. | ||||
| REF 16 | Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening. J Med Chem. 2001 Dec 20;44(26):4737-40. | ||||
| REF 17 | US patent application no. 8969568B2, Substituted naphthyridines and their use as medicaments | ||||
| REF 18 | Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase. J Med Chem. 2002 Aug 1;45(16):3394-405. | ||||
| REF 19 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 20 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 21 | Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer. Bioorg Med Chem. 2017 Apr 1;25(7):2156-2166. | ||||
| REF 22 | Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70. J Med Chem. 1999 Oct 7;42(20):4088-98. | ||||
| REF 23 | Selectivity of kinase inhibitor fragments. J Med Chem. 2011 Jul 28;54(14):5131-43. | ||||
| REF 24 | 1-Methoxy-agroclavine from Penicillium sp. WC75209, a novel inhibitor of the Lck tyrosine kinase. Bioorg Med Chem Lett. 1998 Mar 17;8(6):569-74. | ||||
| REF 25 | Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3009-14. | ||||
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