Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63505 | Target Info | |||
| Target Name | Tyrosine-protein kinase ABL1 (ABL) | ||||
| Synonyms |
p150; Proto-oncogene tyrosine-protein kinase ABL1; Proto-oncogene c-Abl; JTK7; C-ABL; Abl; Abelson tyrosine-protein kinase 1; Abelson murine leukemia viral oncogene homolog 1
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| Target Type | Successful Target | ||||
| Gene Name | ABL1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 149 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Imatinib
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Approved | Compound Info | ||
| Synonyms |
Cgp 57148; Glamox; Glamox (TN); Gleevec (TN); Glivec (TN); Imatinib (INN); Imatinib (STI571); Imatinib Methansulfonate; Imatinib [INN:BAN]; 112GI019; 152459-95-5; BKJ8M8G5HI; CCRIS 9076; CGP-57148; CHEMBL941; Imatinib free base; STI; UNII-BKJ8M8G5HI
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| Activity |
IC50 = 74000 nM
|
[1] | |||
| Compound Name |
Vorinostat
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Approved | Compound Info | ||
| Synonyms |
NHNPODA; SAHA; SHH; Zolinza; Merck brand of Vorinostat; OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE; SAHA cpd; Suberanilohydroxamic acid; Suberoylanilide hydroxamic acid; Vorinostat MSD; Vorinostat [USAN]; M344; MK0683; SKI390; WIN64652; MK-0683; SAHA, Suberoylanilide hydroxamic acid; SW-064652; Zolinza (TN); Vorinostat (JAN/USAN); N1-hydroxy-N8-phenyloctanediamide; Zolinza, MK-0683, SAHA; N'-hydroxy-N-phenyloctanediamide; N-Hydroxy-N'-phenyl octanediamide; N-Hyrdroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide; Vorinostat (HDAC inhibitor)
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Niclosamide
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Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
R-roscovitine
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Phase 2 | Compound Info | ||
| Synonyms |
Seliciclib; roscovitine; 186692-46-6; R-Roscovitine; (R)-roscovitine; CYC202; CYC-202; CYC 202; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; UNII-0ES1C2KQ94; Roscovitine (Seliciclib,CYC202); NSC 701554; AL-39256; Roscovitine; CHEMBL14762; 0ES1C2KQ94; CHEBI:45307; NSC701554; NSC-701554; (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol; (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; RRC; Rosco; M02443; BMK1-E12; CYC202, Seliciclib, R-roscovitine, Roscovitine; (2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol; 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-(R)-1-butanol; 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
PMID28460551-Compound-2
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Patented | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
oxindole i; CHEMBL86755; 3-(1H-Pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one; oxindole 1; AC1NZGXV; K00027; (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one; Indolinone based inhibitor, 1; SCHEMBL1162655; SCHEMBL13819612; BDBM17015; MolPort-023-197-743; SEZFNTZQMWJIAI-FLIBITNWSA-N; ZINC3874586; HSCI1_000049; NCGC00343760-01; BRD-K51816706-001-01-7; (3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; 3-[(1H-Pyrrole-2-yl)methylene]-1H-indole-2(3H)-one; Z-(1H-Pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one; Oxindole I
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
SU 6656
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Investigative | Compound Info | ||
| Synonyms |
su6656; 330161-87-0; SU-6656; SU6656; CHEMBL605003; (3z)-N,N-Dimethyl-2-Oxo-3-(4,5,6,7-Tetrahydro-1h-Indol-2-Ylmethylidene)-2,3-Dihydro-1h-Indole-5-Sulfonamide; (3Z)-N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indole-5-sulfonamide; SR-01000076237; 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide; AC1NSM2X; Lopac-S-9692; Lopac0_000979; MLS002153475; GTPL6044; EX-A584; MolPort-003-959-609; HMS3229I04; HMS2232C04
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
NSC-73306
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(E)-3-(4-hydroxybenzylidene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL103307; (E)-3-(4-hydroxybenzylidene)indolin-2-one; 3-(4-Hydroxybenzylidenyl)indolin-2-one; SCHEMBL16442341; BDBM50131995; ZINC12568108; AKOS001309473; 3-(4-hydroxybenzylidene)indolin-2-one; NCGC00343741-01; ACM293302144; AB00756566-01
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
4-[(3-Methyl-4-oxo-1-phenyl-5H-pyrazolo[3,4-d]pyrimidin-6-yl)methylamino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809669; BDBM50174976
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b]thiophene-5-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2437351; CHEMBL1241684; 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b] thiophene-5-carbaldehyde; 2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1-benzothiophene-5-carbaldehyde
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-[6-(Anilinomethyl)-3-methyl-4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl]acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809087; BDBM50174979
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095626; SCHEMBL3984085; BDBM50316252; methyl 4-[6-(4-aminophenyl)-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
2-(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2433152; CHEMBL1241583; 2-[3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]acetonitrile
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
4-[4-(2-Dimethylaminomethyl-acryloyl)-phenoxysulfonyl]-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL80030; BDBM50031651; 4-[[4-[2-Methylene-3-(dimethylamino)propionyl]phenoxy]sulfonyl]benzoic acid
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| Activity |
IC50 = 50000 nM
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[14] | |||
| Compound Name |
2-[6-(Chloromethyl)-3-methyl-4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl]acetonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808531; BDBM50174744
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
4-[[4-[2-Methylene-3-(dimethylamino)propionyl]phenoxy]sulfonyl]salicylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL310580; BDBM50031659; 4-[4-(2-Dimethylaminomethyl-acryloyl)-phenoxysulfonyl]-2-hydroxy-benzoic acid
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| Activity |
IC50 ~ 50000 nM
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[14] | |||
| Compound Name |
6-(Ethoxymethyl)-3-methyl-1-phenyl-5H-pyrazolo[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809431; BDBM50174748
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
5-(2-Ethoxy-5-pyrrolidin-1-ylsulfonylphenyl)-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261391; BDBM50066001
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
4-[3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxyphenyl]sulfonylmorpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261389; BDBM50065998
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
4-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241862
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| Activity |
IC50 = 50000 nM
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[9] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
1,3-Dimethyl-N-(4-pyrrolidin-1-ylsulfonylphenyl)pyrazolo[4,3-e][1,2,4]triazin-5-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233061; BDBM50004351
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
3-Methyl-6-(morpholin-4-ylmethyl)-1-phenyl-5H-pyrazolo[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809950; BDBM50174983
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
CID 49806721
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
(3Z)-5-Amino-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL18053; SCHEMBL18054; Indolinone based inhibitor, 3g; CHEMBL232144; BDBM17035; (3Z)-5-amino-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
6-[(4-Hydroxyanilino)methyl]-3,5-dimethyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808883; BDBM50174978
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| Activity |
IC50 ~ 50000 nM
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[8] | |||
| Compound Name |
2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
PIK-294; PIK294; PIK 294; C28H23N7O2; cc-610; MLS006010993; SCHEMBL1952680; CHEMBL1241767; BDBM36411; AOB6611; DTXSID20648004; SYN1098; HMS3244E13; HMS3244E14; HMS3244F13; HMS3655P12; BCP01970; EX-A2568; s2227; ZINC62260316; AKOS026750411; CCG-269607; CS-3528; CID24905149; NCGC00346614-01; NCGC00346614-02; NCGC00346614-07; AC-32796; AK176035; AS-16244; HY-10303; QC-11467; SMR004702793; PIK-294, >=98% (HPLC); FT-0699808; SW220212-1; X7436; Z-3176; J-505227
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| Activity |
IC50 ~ 50000 nM
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[9] | |||
| Compound Name |
4-[(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)amino]-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237856; BDBM50004343
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| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
2-[(Dimethylamino)methyl]-1-(4-phenylmethoxyphenyl)-3-phenylsulfanylpropan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540292
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
[4-(4-Chloro-phenyl)-pyrimidin-2-yl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57581; SCHEMBL8837820; BDBM50290425; 4-(4-chlorophenyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine; N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-(4-chloro-phenyl)-2-pyrimidineamine
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| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
2-[(Dimethylamino)methyl]-1-(3-hydroxy-4-phenylmethoxyphenyl)prop-2-en-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542887
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N-(2-morpholin-4-ylethyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261394; BDBM50066004
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-(Anilinomethyl)-3,5-dimethyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808991; BDBM50174977
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(2-Aminoethylsulfanylmethyl)-3-(dimethylamino)-1-(4-phenylmethoxyphenyl)propan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL543361
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
6-(Chloromethyl)-3,5-dimethyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808469; BDBM50174743
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2465891; CHEMBL1241772; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile
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| Activity |
IC50 = 50000 nM
|
[9] | |||
| Compound Name |
N-Cyclohexyl-1-[(E)-styryl]pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824215; SCHEMBL10034089; BDBM50186219; N-Cyclohexyl-1-[2-phenylethenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[19] | |||
| Compound Name |
N-(2-Aminoethyl)-3-(1,3-dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261393; BDBM50066003; N-(2-Aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine-5-yl)-4-ethoxybenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-[6-[(4-Hydroxyanilino)methyl]-3-methyl-4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl]acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809223; BDBM50174980
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propylpyrazolo[4,3-e][1,2,4]triazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356722; BDBM50065990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-(Methoxymethyl)-3-methyl-1-phenyl-5H-pyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810382; BDBM50174747; 6-methoxymethyl-3-methyl-1-phenyl-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
1,3-Dimethyl-N-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]pyrazolo[4,3-e][1,2,4]triazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237848; BDBM50004346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095627; SCHEMBL3991434; BDBM50316253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N,N-diethylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357169; BDBM50066005
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N-(2-hydroxyethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261395; BDBM50066006
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Methyl-1-phenyl-6-(piperidin-1-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808770; BDBM50174982; 3-methyl-1-phenyl-6-piperidin-1-ylmethyl-1,5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602472; BDBM50306684; CH-5234152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[20] | |||
| Compound Name |
6-(Diethylaminomethyl)-3-methyl-1-phenyl-5H-pyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809625; BDBM50174981
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261387; BDBM50065991
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(3Z)-5-Amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597181; SCHEMBL19978; BDBM50307137; Q27467425; (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one; (Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-(2-Ethoxy-5-piperazin-1-ylsulfonylphenyl)-1,3-dimethylpyrazolo[4,3-e][1,2,4]triazine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261388; BDBM50065994
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-((4-(Dimethylamino)naphthalen-1-yl)methylene)-4-methylindolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597960; BDBM50307129
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438610; BAS-0321734; Oprea1_483753; Oprea1_802964; ZINC1244403; BDBM50187567; STK385953; STK563487; AKOS000542284; AKOS005489054; MCULE-7390335201; ST50868704; (phenylamino)-N-[5-benzyl(1,3,4-thiadiazol-2-yl)]carboxamide; 1-[(2Z)-5-benzyl-1,3,4-thiadiazol-2(3H)-ylidene]-3-phenylurea
Click to Show/Hide
|
||||
| Activity |
Ki = 58000 nM
|
[21] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2435077; CHEMBL1242032; 4-(4-amino-1-isopropyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[9] | |||
| Compound Name |
(E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(tert-butyl)phenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559628; BDBM50294005
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[22] | |||
| Compound Name |
3-[(E)-2-[6-(Cyclopropylamino)purin-9-yl]ethenyl]-4-methyl-N-(3-propan-2-ylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559702; SCHEMBL4133117; SCHEMBL4133124; BDBM50294006; (E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(3-(iso-propyl)phenyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[22] | |||
| Compound Name |
2-Amino-6-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-4-(3-thienyl)pyridine-3,5-dicarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172147; BDBM50321739; 2-amino-6-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-4-thiophen-3-ylpyridine-3,5-dicarbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[23] | |||
| Compound Name |
[3-(5-Chlorothiophen-3-yl)-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151546; Indenopyrazole 24j; BDBM5650; SCHEMBL4025497; BDBM50528240; [3-(5-chlorothiophen-3-yl)-4-oxo-2H,4H-indeno[1,2-c]pyrazol-5-yl]urea; 3-(5-Chlorothien-3-yl)-5-(carbamoylamino)indeno[1,2-c]pyrazol-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[24] | |||
| Compound Name |
(3-Nitro-phenyl)-(4-pyridin-4-yl-pyrimidin-2-yl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55683; SCHEMBL1144; BDBM50290426; VCC792768; N-(3-nitrophenyl)-4-pyridin-4-ylpyrimidin-2-amine; 4-(4-Pyridinyl)-N-(3-nitrophenyl)pyrimidin-2-amine; N-(3-nitrophenyl)-4-(4-pyridyl)-2-pyrimidine-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[18] | |||
| Compound Name |
(E)-1-(3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559069; SCHEMBL4129293; SCHEMBL4129297; BDBM50294002
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[22] | |||
| Compound Name |
2-Bromo-N-[2-(1H-pyrrol-2-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3712794; CHEMBL3347621; BDBM104262; US8580815, ND-0037
Click to Show/Hide
|
||||
| Activity |
IC50 = 63330 nM
|
[25] | |||
| Compound Name |
2-[4-Amino-3-(3-ethoxy-4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242753
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[9] | |||
| Compound Name |
Tert-butyl 6-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-4-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242033
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[9] | |||
| Compound Name |
4-Chloro-N'-(4-oxo-1,5-diphenylpyrazolo[3,4-d]pyrimidin-6-yl)benzohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967164; BDBM50206300
Click to Show/Hide
|
||||
| Activity |
IC50 = 65600 nM
|
[26] | |||
| Compound Name |
[4-[2-[(Dimethylamino)methyl]prop-2-enoyl]phenyl] 4-(dimethylcarbamoyl)benzenesulfonate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552634
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[14] | |||
| Compound Name |
N-Benzyl-7-[(4-fluorophenyl)methyl]-2-methylsulfanylpyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091022; BDBM50230317
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[27] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-3-methyl-1-oxo-1-[[(2S)-1-oxo-1-(2-phenylethylamino)propan-2-yl]amino]butan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343050; BDBM50067659
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[28] | |||
| Compound Name |
2-(Benzylsulfanyl)-4-(thiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171912; Oprea1_137625; Oprea1_693278; SCHEMBL1177162; ZINC2273180; BDBM50321746; STK860425; AKOS000551106; CCG-255739; MCULE-3674597469; ST50250074; 2-(benzylthio)-4-(thiophen-2-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile; 2-(phenylmethylthio)-4-(2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[23] | |||
| Compound Name |
(E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-[3-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553695; BDBM50294013
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[22] | |||
| Compound Name |
2-(4-Fluorobenzylsulfanyl)-4-(2-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172697; Oprea1_383135; Oprea1_778929; C21H17FN2S2; ZINC2259037; BDBM50321745; STK748819; AKOS000675276; MCULE-9199921795; ST009943; EU-0050760; SR-01000423380; SR-01000423380-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[23] | |||
| Compound Name |
(E)-N-(4-Methyl-3-(2-(6-(cyclopropylamino)-9H-purin-9-yl)vinyl)-phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564575; SCHEMBL10277503; SCHEMBL10277508; BDBM50293994; N-[3-[(E)-2-[6-(cyclopropylamino)purin-9-yl]ethenyl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[22] | |||
| Compound Name |
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201511; SCHEMBL1155440; BDBM47167; CTK3C7420; DTXSID40468140; US8957103, Z1; 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-; 3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[29] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[[(2S)-1-(dioctylamino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137653; BDBM50067656
Click to Show/Hide
|
||||
| Activity |
IC50 = 95900 nM
|
[28] | |||
| Compound Name |
N-(4-Methyl-3-(2-(6-(methylamino)-9H-purin-9-yl)ethyl)phenyl)-3-(trifluoromethyl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550623; SCHEMBL4131786; BDBM50294015; N-[4-methyl-3-[2-[6-(methylamino)purin-9-yl]ethyl]phenyl]-3-(trifluoromethyl)benzamide; N-(4-Methyl-3-(2-(6-(methylamino)-9H-purin-9-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[22] | |||
| Compound Name |
Ethyl 1-[3-oxo-3-(4-phenylmethoxyphenyl)propyl]piperidine-4-carboxylate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-(Dimethylamino)-1-(3-hydroxy-4-phenylmethoxyphenyl)propan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552860
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(Ethylcarbamoylamino)-N-pyridin-4-yl-3H-benzimidazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2347708; BDBM50490909
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
1-Propan-2-yl-3-[2-[3-(trifluoromethyl)phenyl]ethynyl]pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735380; BDBM50499301
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Phenylmethoxyphenyl)-3-piperidin-1-ylpropan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545006; DTXSID80669831; NSC25590; NSC-25590; 1-[4-(Benzyloxy)phenyl]-3-(piperidin-1-yl)propan-1-one--hydrogen chloride (1/1)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[1-(4-Methylpiperazin-1-yl)-3-phenylpropan-2-yl] N-(3-bromophenyl)-N-[6-methylsulfanyl-1-(2-phenylpropyl)pyrazolo[3,4-d]pyrimidin-4-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060917
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
1-Methyl-3-(quinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242756
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-2-yl]-3-ethylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318024; SCHEMBL1932174; BDBM50050850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(2S)-2-[[(2S,3S)-2-[[(2S)-4-Carboxy-2-[[(2S)-4-carboxy-2-[[2-phenyl-3-(4-phosphonooxyphenyl)propanoyl]amino]butanoyl]amino]butanoyl]amino]-3-methylpentanoyl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2092743; BDBM50403558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-(2-phenylethyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318030; SCHEMBL1933387; BDBM50050852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
3-(1,3-Dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxy-N-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401464; BDBM50065993
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[(Dimethylamino)methyl]-3-(3,4-dimethylphenyl)sulfanyl-1-(4-phenylmethoxyphenyl)propan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538507
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Cyclapolin 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin-9; CHEMBL476124; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide; 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide; SCHEMBL5055142; CTK8I6133; AOB5979; ZINC2577648; BDBM50263697; AKOS024457436; HY-15159; CS-0003792; 7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide; 2-(aminocarbonyl)-7-nitro-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-3-olate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221633; BDBM50324796
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
1-(3-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-[(Dimethylamino)methyl]-1-(4-phenylmethoxyphenyl)prop-2-en-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552859
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
6-(Ethoxymethyl)-3,5-dimethyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3810117; BDBM50174840
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
[[2-[(Dimethylamino)methyl]-3-oxo-3-(4-phenylmethoxyphenyl)propyl]amino]urea;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541307
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Methyl 5-[(2-fluoro-6-methoxybenzoyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3715510; CHEMBL3347624; BDBM104261; US8580815, ND-0047
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[(2-Bromobenzoyl)amino]-N-[3-(dimethylamino)propyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3713370; CHEMBL3347647; BDBM104263; US8580815, ND-0009
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
4-Pyridin-4-yl-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55662; SCHEMBL1269; BDBM50290420; 4-(4-Pyridinyl)-N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]pyrimidin-2-amine; N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4(4-pyridyl)-2-pyrimidineamine; N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-(4-pyridyl)-2-pyrimidine-amine; (4-Pyridin-4-yl-pyrimidin-2-yl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318025; SCHEMBL1932951; BDBM50050849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
2-Cyano-2-(3,4-dihydroxy-benzyl)-thioacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78249; TRYPHOSTIN; BDBM50031654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-Propen-1-one, 2-((dimethylamino)methyl)-1-phenyl-, hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CCRIS 8957; CHEMBL468975; 1-Phenyl-2-dimethylaminomethyl-2-propen-1-one hydrochloride; 2-((Dimethylamino)methyl)-1-phenyl-2-propen-1-one hydrochloride; SCHEMBL4799828; DTXSID50143416; NSC382011; NSC-382011; 2-((DIMETHYLAMINO)METHYL)-1-PHENYL-2-PROPEN-1-ONE HYDROCLORIDE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(1,3-Dihydroxy-2-methylpropan-2-yl)-3-(1,3-dimethylpyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3401463; BDBM50065992
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(4-(2-Aminophenylcarbamoyl)benzylamino)methyl nicotinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL514671; BDBM50256975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[6-(Methoxymethyl)-3-methyl-4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl]acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808590; BDBM50174751
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780768
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-(Morpholin-4-ylmethyl)-1-(4-phenylmethoxyphenyl)prop-2-en-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544067
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-(3-Phenylpyrido[3,4-b]pyrazin-8-yl)-3-prop-2-enylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
1-Ethyl-3-[6-(4-methylpiperazine-1-carbonyl)-1H-benzimidazol-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2347707; BDBM50490896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
2-(4-Methylpiperazin-1-yl)ethyl N-(3-bromophenyl)-N-[6-methylsulfanyl-1-(2-phenylpropyl)pyrazolo[3,4-d]pyrimidin-4-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407628; SCHEMBL20356842
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
1-(4-Phenylmethoxyphenyl)-2-(piperazin-1-ylmethyl)prop-2-en-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[4-[(2S)-2-Acetamido-3-[[(2S)-1-[3-cyclohexylpropyl(methyl)amino]-1-oxobutan-2-yl]amino]-3-oxopropyl]phenyl] dihydrogen phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL301845; BDBM50289744
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[37] | |||
| Compound Name |
4-(Dimethylamino)-1-(4-phenylmethoxyphenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL543362
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185140; SCHEMBL21585709; BDBM50324797; 3-(1-(4-chlorobenzyl)-1H-indol-3-yl)-N-(pyridin-4-yl)propanamide; 3-[1-(4-Chloro-benzyl)-1H-indol-3-yl]-N-pyridin-4-yl-propionamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
6-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242117
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-Propanone, 3-(4-morpholinyl)-1-(4-(phenylmethoxy)phenyl)-, hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542893; 3-(4-Morpholinyl)-1-(4-(phenylmethoxy)phenyl)-1-propanone hydrochloride; DTXSID20199344; MCULE-5918920246
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
BrC=1C=C(C=CC=1)N(C(OCCN1CCN(CC1)C)=O)C1=C2C(=NC(=N1)SCCN1CCOCC1)N(N=C2)CC(C1=CC=CC=C1)Cl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087882; SCHEMBL17725976
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
6-(Methoxymethyl)-3,5-dimethyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809128; BDBM50174750
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-Benzyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318029; SCHEMBL1933048; BDBM50050853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin 1; 2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-3-oxide; SCHEMBL5062617; CHEMBL1222044; CTK2H1083; DTXSID10429521; 7-nitro-3-oxido-5-(trifluoromethylsulfanyl)-1,3-benzothiazol-3-ium-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780151
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098682; BDBM50242512
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781566
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
1-(4-Phenylmethoxyphenyl)-2-(piperidin-1-ylmethyl)prop-2-en-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544074
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
1-Propanone, 3-(dimethylamino)-1-(4-(phenylmethoxy)phenyl)-, hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544770; 3-(Dimethylamino)-1-(4-(phenylmethoxy)phenyl)-1-propanone hydrochloride; DTXSID60199343
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Methyl 5-[(2-bromobenzoyl)amino]-1H-pyrrolo[2,3-b]pyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3718671; CHEMBL3347636; BDBM104260; US8580815, ND-0020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318028; SCHEMBL1932302; BDBM50050854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
Methyl 2-[2-[(dimethylamino)methyl]-3-oxo-3-(4-phenylmethoxyphenyl)propyl]sulfanylbenzoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538757
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
eCF309; eCF-309; eCF 309; GTPL9571; CHEMBL3800481; SCHEMBL22773819; BDBM200300; cid_122163152; AKOS030211008; ZINC585672921; compound 12 [Fraser et al., 2016]; J3.595.265I
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
1-(4-Methylpiperazin-1-yl)propan-2-yl N-(3-bromophenyl)-N-[6-methylsulfanyl-1-(2-phenylpropyl)pyrazolo[3,4-d]pyrimidin-4-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084427; SCHEMBL17714367
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[31] | |||
| Compound Name |
2-[6-(Ethoxymethyl)-3-methyl-4-oxo-1-phenylpyrazolo[3,4-d]pyrimidin-5-yl]acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808505; BDBM50174841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318026; SCHEMBL1933008; BDBM50050848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
6-[(4-Hydroxyanilino)methyl]-3-methyl-1-phenyl-5H-pyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3808727; BDBM50174975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(2-Chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418203; Flavopiridol; (+/-)-Flavopiridol; SCHEMBL12445809; BDBM50079331
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[40] | |||
| Compound Name |
6-[(2E)-2-[(4-Fluorophenyl)methylidene]hydrazinyl]-1,5-diphenylpyrazolo[3,4-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3983676; BDBM50206302
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[26] | |||
| Compound Name |
6-(1,9-Diazaspiro[5.5]undecan-9-Yl)-9h-Purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420909; BDBM50439464; 9-(9H-purin-6-yl)-1,9-diazaspiro[5.5]undecane; Q27465376; SIJ
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[41] | |||
| Compound Name |
N-(5-Tert-butyl-2-methylpyrazol-3-yl)-3-[(E)-2-[6-(cyclopropylamino)purin-9-yl]ethenyl]-4-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556670; BDBM50294009
Click to Show/Hide
|
||||
| Activity |
IC50 = 146000 nM
|
[22] | |||
| Compound Name |
12-Anilino-3,8-diphenyl-1,3,4,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-2(6),4,9,11-tetraen-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908573; BDBM50206299
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[26] | |||
| Compound Name |
2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(3-thienyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170563; BDBM50321729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[23] | |||
| Compound Name |
N-[3-[(E)-2-[6-[3-(Dimethylamino)propylamino]purin-9-yl]ethenyl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559068; SCHEMBL4128294; BDBM50294000
Click to Show/Hide
|
||||
| Activity |
IC50 = 157000 nM
|
[22] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(2-fluoro-5-(trifluoromethyl)phenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551838; BDBM50294003
Click to Show/Hide
|
||||
| Activity |
IC50 = 236000 nM
|
[22] | |||
| Compound Name |
(E)-N-(4-Methyl-3-(2-(6-(pyridine-2-yl-amino)-9H-purin-9-yl)vinyl)phenyl)-3-(trifluoromethyl)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551030; SCHEMBL4128265; SCHEMBL4128274; BDBM50293995; N-[4-methyl-3-[(E)-2-[6-(pyridin-2-ylamino)purin-9-yl]ethenyl]phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 243000 nM
|
[22] | |||
| Compound Name |
N-(5-Tert-butyl-1,3-thiazol-2-yl)-3-[(E)-2-[6-(cyclopropylamino)purin-9-yl]ethenyl]-4-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559438; BDBM50294007; (E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl)-4-methyl-N-(5-(tert-butyl)thiazo-2-yl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 267000 nM
|
[22] | |||
| Compound Name |
8-(Trifluoromethyl)-7H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
8-trifluoromethyladenine; 8-Trifluoromethyl-9H-purin-6-ylamine; 8-(TRIFLUOROMETHYL)-9H-PURIN-6-AMINE; SCHEMBL1271207; CHEMBL3105076; DTXSID30394520; BDBM154573; ZINC1573667; NSC327196; AKOS000320412; MCULE-6927560807; NSC-327196; 8-(Trifluoromethyl)-6-amino-9H-purine; 9H-Purin-6-amine, 8-(trifluoromethyl)-; DS-001667; 8-(trifluoromethyl)-9H-purin-6-amine (4); L-3517; 8-(trifluoromethyl)-9H-purin-6-amine, AldrichCPR; F2124-0890
Click to Show/Hide
|
||||
| Activity |
IC50 = 380000 nM
|
[42] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
Click to Show/Hide
|
||||
| Activity |
IC50 = 392000 nM
|
[43] | |||
| Compound Name |
6-Methyl-3-methylsulfanyl-1-(2,4,6-trichlorophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370283; pyrazolo[3,4-d]pyrimidin-4-one deriv. 4w; BDBM5961; SCHEMBL7953100; 1-(2,4,6-Trichlorophenyl)-3-(methylthio)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-one; 3-methylsulfanyl-6-methyl-1-(2,4,6-trichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-ol; 6-methyl-3-(methylsulfanyl)-1-(2,4,6-trichlorophenyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
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| Activity |
IC50 > 500000 nM
|
[40] | |||
| Compound Name |
3-(4-Methoxyphenyl)-1H-indeno[1,2-c]pyrazol-4-one
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Investigative | Compound Info | ||
| Synonyms |
BDBM5728; CHEMBL281470; 3-(4-Methoxyphenyl)-2H-indeno[1,2-c]pyrazol-4-one; 3-(4-methoxyphenyl)-2H,4H-indeno[1,2-c]pyrazol-4-one
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| Activity |
IC50 > 725000 nM
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[44] | |||
| Compound Name |
1-[2-(Furan-2-yl)pyrrolidin-1-yl]prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617729; BDBM50119571
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| Activity |
Ki > 1250000 nM
|
[45] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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