Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63966 | Target Info | |||
| Target Name | Vascular endothelial growth factor receptor 1 (FLT-1) | ||||
| Synonyms |
Vascular permeability factor receptor; VEGFR1; VEGFR-1; VEGF-1 receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-like tyrosine kinase 1; FRT; FLT
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| Target Type | Successful Target | ||||
| Gene Name | FLT1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 90 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Saracatinib
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|
Phase 2 | Compound Info | ||
| Synonyms |
H8H; AZD-0530; Saracatinib, AZD-0530, AZD0530; N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-((5-(6-((4-Methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-(2-(trifluoromethyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215417; BDBM50188768
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(3,4,5-trimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL514014; BDBM50292735
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(3r)-1-{2-[4-(4-Acetylphenyl)piperazin-1-Yl]-2-Oxoethyl}-N-(3-Chloro-4-Hydroxyphenyl)pyrrolidine-3-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3356117; SCHEMBL7878839; BDBM50030881; Q27453793
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095761; BDBM50318174
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335376; BDBM50429675
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499344; BDBM50271906; 6-benzyl-N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-(2-Chlorophenyl)-3-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL209922; BDBM50188742
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095464; BDBM50318182
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(4-phenylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956887; BDBM50366080
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395080; BDBM50218700
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2R,3S)-8-[(2S,4R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335722; BDBM50428820
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(3,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956886; BDBM50366078
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[(3S,6S,9S,12R,17R,20S,23S,26S,29S,32S,35S,38S)-12-Amino-9-(3-amino-3-oxopropyl)-20,29-bis[(2S)-butan-2-yl]-26,32-bis(2-carboxyethyl)-35-(carboxymethyl)-17-[[(2S)-1,6-diamino-1-oxohexan-2-yl]carbamoyl]-3,23-bis[(4-hydroxyphenyl)methyl]-2,5,8,11,19,22,25,28,31,34,37-undecaoxo-14,15-dithia-1,4,7,10,18,21,24,27,30,33,36-undecazabicyclo[36.3.0]hentetracontan-6-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062433; BDBM50257258
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| Activity |
IC50 = 50400 nM
|
[8] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-(naphthalen-2-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956896; BDBM50366083
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| Activity |
IC50 = 50800 nM
|
[3] | |||
| Compound Name |
(4S,6E,12E)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668418; BDBM50336459
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| Activity |
IC50 = 51000 nM
|
[9] | |||
| Compound Name |
3-[(3S,6S,9S,12R,17R,20S,23S,26S,29S,32S,35S,38S)-12-Amino-17-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]-26,32-bis(2-carboxyethyl)-9,35-bis(hydroxymethyl)-3-[(4-hydroxyphenyl)methyl]-23-(1H-imidazol-5-ylmethyl)-20-(2-methylsulfanylethyl)-2,5,8,11,19,22,25,28,31,34,37-undecaoxo-29-propan-2-yl-14,15-dithia-1,4,7,10,18,21,24,27,30,33,36-undecazabicyclo[36.3.0]hentetracontan-6-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077087; BDBM50257253
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| Activity |
IC50 = 56000 nM
|
[8] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]pent-4-enoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]pentanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684366; BDBM50338752
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| Activity |
IC50 = 61200 nM
|
[10] | |||
| Compound Name |
N-(4-Chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)cinnolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL150825; 4-anilinocinnoline deriv. 19; BDBM4636; SCHEMBL6098105; 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline; N-(2-Fluoro-4-chlorophenyl)-6-methoxy-7-(2-methoxyethoxy)cinnoline-4-amine
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| Activity |
IC50 = 63000 nM
|
[11] | |||
| Compound Name |
Geranin B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499587; BDBM50428819
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| Activity |
IC50 = 65000 nM
|
[7] | |||
| Compound Name |
5-[(E)-2-(2-Chloropyrimidin-4-yl)vinyl]-6-phenylimidazo[2,1-b][1,3]thiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL501444; SCHEMBL4770215; BDBM50272074; (E/Z)-5-(2-(2-chloropyrimidin-4-yl)vinyl)-6-phenylimidazo[2,1-b]thiazole; 5-[(E)-2-(2-chloropyrimidin-4-yl)ethenyl]-6-phenylimidazo[2,1-b][1,3]thiazole
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| Activity |
IC50 = 66000 nM
|
[12] | |||
| Compound Name |
4-[(E)-2-(4-Phenyl-1H-imidazol-5-yl)vinyl]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL502279; SCHEMBL4775402; BDBM50272215; (E/Z)-4-(2-(4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine; 4-[(E)-2-(4-phenyl-1H-imidazol-5-yl)ethenyl]pyrimidin-2-amine
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| Activity |
IC50 = 68000 nM
|
[12] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095130; BDBM50318175; N4-(2-Fluoro-4-chlorophenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 = 70900 nM
|
[13] | |||
| Compound Name |
3-[(3S,6S,9S,12S,21S,24S,27S,30S,33S,36S,39S,42S)-12-Acetamido-9-(3-amino-3-oxopropyl)-24,33-bis[(2S)-butan-2-yl]-30,36-bis(2-carboxyethyl)-39-(carboxymethyl)-21-[[(2S)-1,6-diamino-1-oxohexan-2-yl]carbamoyl]-3,27-bis[(4-hydroxyphenyl)methyl]-2,5,8,11,18,23,26,29,32,35,38,41-dodecaoxo-1,4,7,10,17,22,25,28,31,34,37,40-dodecazabicyclo[40.3.0]pentatetracontan-6-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071072; BDBM50257257
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| Activity |
IC50 = 75100 nM
|
[8] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamidopent-4-enoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxopent-4-en-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]pentanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684376; BDBM50338748
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| Activity |
IC50 = 76800 nM
|
[10] | |||
| Compound Name |
N-Methyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL497290; SCHEMBL4767191; BDBM50272590; (E/Z)-N-methyl-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine; N-methyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine
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| Activity |
IC50 = 77000 nM
|
[12] | |||
| Compound Name |
4-[(E)-2-(2-Phenylimidazo[1,2-a]pyridin-3-yl)vinyl]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL525065; SCHEMBL4769246; BDBM50272163; 4-[(E)-2-(2-phenylimidazo[1,2-a]pyridin-3-yl)ethenyl]pyrimidin-2-amine; (E/Z)-4-(2-(2-phenylH-imidazo[1,2-a]pyridin-3-yl)vinyl)pyrimidin-2-amine
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| Activity |
IC50 = 79000 nM
|
[12] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956891; BDBM50366090
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| Activity |
IC50 = 79900 nM
|
[3] | |||
| Compound Name |
N-(1-Phenylethyl)-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL502803; SCHEMBL4769687; SCHEMBL4769691; BDBM50272070; N-(1-phenylethyl)-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine; N-(1-phenylethyl)-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine
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| Activity |
IC50 = 84000 nM
|
[12] | |||
| Compound Name |
(3S,6S,9S,14S,17S,23S,26S,29S)-9-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-3-(4-aminobutyl)-N-[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-17,23-bis(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-26-(1H-imidazol-5-ylmethyl)-2,5,8,12,16,19,22,25,28-nonaoxo-1,4,7,11,15,18,21,24,27-nonazabicyclo[27.3.0]dotriacontane-14-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2367589
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| Activity |
IC50 = 87600 nM
|
[14] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]pent-4-enoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]pentanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684370; BDBM50338751
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| Activity |
IC50 = 90300 nM
|
[10] | |||
| Compound Name |
(3R,6S,9S,14S,17S,23S,26S)-9-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-3-(4-aminobutyl)-N-[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-17-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-23-(1H-imidazol-5-ylmethyl)-2,5,8,16,19,22,25-heptaoxo-1,4,7,15,18,21,24-heptazabicyclo[24.3.0]nonacosane-14-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684372; BDBM50338750
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| Activity |
IC50 = 91600 nM
|
[10] | |||
| Compound Name |
Cyclo[FYDEPLEbtA]-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399914; BDBM50221333
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| Activity |
IC50 = 93000 nM
|
[15] | |||
| Compound Name |
4-N-(3-Bromo-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335377; BDBM50429674
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| Activity |
IC50 = 93600 nM
|
[5] | |||
| Compound Name |
(E/Z)-N-(4-(2-(6-Phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-yl)pivalamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL524708; SCHEMBL4767546; BDBM50272073; 2,2-dimethyl-N-{4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-yl}propanamide
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| Activity |
IC50 = 96000 nM
|
[12] | |||
| Compound Name |
(4S)-5-[[(2S)-1-Amino-1-oxopent-4-yn-2-yl]amino]-4-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-azido-2-phenylacetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372113
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| Activity |
IC50 = 96000 nM
|
[15] | |||
| Compound Name |
7-Benzyl-4-N-(3-bromophenyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956888; BDBM50366088
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| Activity |
IC50 = 99300 nM
|
[3] | |||
| Compound Name |
(E/Z)-N-(4-(2-(6-Phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503074; SCHEMBL4776133; BDBM50272072; N-[4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-yl]acetamide; N-{4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-yl}acetamide
Click to Show/Hide
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| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
N-(5-Chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
Benzodioxole deriv. 19; BDBM6210; CHEMBL369360; N-(5-chloro-2H-1,3-benzodioxol-4-yl)-6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-yl)cyclopropyl)pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL526880; BDBM50272308
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-Amino-N-(1-methyl-4-phenyl-1H-imidazol-5-yl)pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL525048; BDBM50272268
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(4S,6R)-6-Bromo-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668415; BDBM50336458
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(3-Chloro-4-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
Gefitinib Impurity 10; CHEMBL301018; Anilinoquinazoline deriv. 9; BDBM4626; SCHEMBL2099106; ZINC16978; AKOS002350953; MCULE-5998118475; DS-015821; N-(3-Chloro-4-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(E/Z)-4-(2-(3-Phenylthiophen-2-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500930; BDBM50272162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(E/Z)-N-Phenyl-4-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL526932; SCHEMBL4775072; BDBM50272071; N-phenyl-4-[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine; N-Phenyl-4[(E)-2-(6-phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-{(E)-2-[4-Phenyl-1-(2-pyrrolidin-1-ylethyl)-1H-imidazol-5-yl]vinyl}pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500153; SCHEMBL4774678; BDBM50272264; 4-[(E)-2-[5-phenyl-3-(2-pyrrolidin-1-ylethyl)imidazol-4-yl]ethenyl]pyrimidin-2-amine; (E/Z)-4-(2-(4-phenyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-N-(3-Methyl-5-phenylimidazol-4-yl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL525047; BDBM50272266; (E/Z)-N4-(1-methyl-4-phenyl-1H-imidazol-5-yl)pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(2-Aminopyrimidin-4-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500152; BDBM50272267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(5-Chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Chlorobenzodioxole deriv. 27; AZD0530 analogue 34; BDBM6218; CHEMBL170984; SCHEMBL3186214
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Anilinoquinazoline deriv. 31
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4648; CHEMBL151948; N-[4-(4-Chloro-2-fluoroanilino)-6-methoxy-7-quinazolinyl]-2-methoxyacetamide hydrochloride; N-{4-[(4-chloro-2-fluorophenyl)amino]-6-methoxyquinazolin-7-yl}-2-methoxyacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(2-(1-Methyl-4-phenyl-1H-imidazol-5-ylamino)ethyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499863; BDBM50272307
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(E/Z)-4-(2-(2-Phenylthiophen-3-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499883; BDBM50272214
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(5-Chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Chlorobenzodioxole deriv. 28; BMCL182776 Compound 1; BDBM6219; CHEMBL169186; SCHEMBL3210014; DB07249; KX2-328; Q27096474
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[(E)-2-(6-Methylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444654; BDBM50272588; (E/Z)-4-(2-(6-methylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(4S,6Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651523; SCHEMBL15764588; BDBM50335376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL527110; BDBM50272158; (E/Z)-2-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N4-((1-Methyl-4-phenyl-1H-imidazol-5-yl)methyl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450886; BDBM50272269
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[(E)-2-(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)ethenyl]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL507202; BDBM50272589; (E/Z)-4-(2-(6-chloroimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[(E)-2-(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)vinyl]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505610; SCHEMBL4769544; BDBM50272101; (E/Z)-6-phenyl-5-(2-(pyrimidin-4-yl)vinyl)imidazo[2,1-b]thiazole; 6-phenyl-5-[(E)-2-pyrimidin-4-ylethenyl]imidazo[2,1-b][1,3]thiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[(E)-2-(1-Methyl-5-phenylimidazol-4-yl)ethenyl]pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453195; BDBM50272216; (E/Z)-4-(2-(1-methyl-5-phenyl-1H-imidazol-4-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(E/Z)-4-(2-(4-Phenyl-1H-pyrazol-5-yl)vinyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500929; BDBM50272161
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
c[YYDEALEE]-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1086296; BDBM50319609
Click to Show/Hide
|
||||
| Activity |
IC50 = 101000 nM
|
[18] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684365; BDBM50338753
Click to Show/Hide
|
||||
| Activity |
IC50 = 102700 nM
|
[14] | |||
| Compound Name |
4-N-(3-Ethynylphenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335379; BDBM50429678
Click to Show/Hide
|
||||
| Activity |
IC50 = 103100 nM
|
[5] | |||
| Compound Name |
5-(Phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093099; SCHEMBL1994777; BDBM50314076; 5-phenylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 118100 nM
|
[19] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(3,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956894; BDBM50366085
Click to Show/Hide
|
||||
| Activity |
IC50 = 118600 nM
|
[3] | |||
| Compound Name |
Cyclo[GHQMFYYbtA]-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249743; BDBM50221336
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[15] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956890; BDBM50366087
Click to Show/Hide
|
||||
| Activity |
IC50 = 126300 nM
|
[3] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956889; BDBM50366089
Click to Show/Hide
|
||||
| Activity |
IC50 = 129300 nM
|
[3] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094423; BDBM50318162
Click to Show/Hide
|
||||
| Activity |
IC50 = 129400 nM
|
[20] | |||
| Compound Name |
(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-1-Acetylpyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-amino-5-oxopentanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083044; BDBM50257259
Click to Show/Hide
|
||||
| Activity |
IC50 = 129500 nM
|
[8] | |||
| Compound Name |
2,2-Dimethyl-N-[6-(2-pyridin-2-ylethyl)-4-[3-(trifluoromethyl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335018; BDBM50429669
Click to Show/Hide
|
||||
| Activity |
IC50 = 129600 nM
|
[5] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956893; BDBM50366086
Click to Show/Hide
|
||||
| Activity |
IC50 = 138100 nM
|
[3] | |||
| Compound Name |
N-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096972; BDBM50318163
Click to Show/Hide
|
||||
| Activity |
IC50 = 142300 nM
|
[20] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-(naphthalen-1-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956895; BDBM50366084
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[3] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094783; BDBM50318186
Click to Show/Hide
|
||||
| Activity |
IC50 = 150900 nM
|
[13] | |||
| Compound Name |
(4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-Amino-2-azidohexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S)-1-amino-1-oxopent-4-yn-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372116
Click to Show/Hide
|
||||
| Activity |
IC50 = 151000 nM
|
[15] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095445; BDBM50318177; N4-(3-Trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 156100 nM
|
[13] | |||
| Compound Name |
N-[4-(3-Ethynylanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335017; BDBM50429677
Click to Show/Hide
|
||||
| Activity |
IC50 = 156300 nM
|
[5] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(3,4,5-trimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956898; BDBM50366081
Click to Show/Hide
|
||||
| Activity |
IC50 = 156500 nM
|
[3] | |||
| Compound Name |
N4-(4-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095463; BDBM50318180
Click to Show/Hide
|
||||
| Activity |
IC50 = 157000 nM
|
[13] | |||
| Compound Name |
3-[(3S,6S,9S,12S,15R,20R,23S,26S,29S,32S,35S,38S,41S)-15-Amino-9-(3-amino-3-oxopropyl)-12-benzyl-23,32-bis[(2S)-butan-2-yl]-29,35-bis(2-carboxyethyl)-38-(carboxymethyl)-20-[[(2S)-1,6-diamino-1-oxohexan-2-yl]carbamoyl]-3,26-bis[(4-hydroxyphenyl)methyl]-2,5,8,11,14,22,25,28,31,34,37,40-dodecaoxo-17,18-dithia-1,4,7,10,13,21,24,27,30,33,36,39-dodecazabicyclo[39.3.0]tetratetracontan-6-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090414; BDBM50257261
Click to Show/Hide
|
||||
| Activity |
IC50 = 157400 nM
|
[8] | |||
| Compound Name |
5-[(4-Methylphenyl)thio]-9h-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG311; CHEMBL1093100; SCHEMBL1997367; BDBM50314077; 5-(p-tolylthio)-9H-pyrimido[4,5-b]indole-2,4-diamine; 5-(4-methylphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 160100 nM
|
[19] | |||
| Compound Name |
Cyclo[KYDEPLEbtA]-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399245; BDBM50221334
Click to Show/Hide
|
||||
| Activity |
IC50 = 162000 nM
|
[15] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095131; BDBM50318176; N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo-[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 162900 nM
|
[13] | |||
| Compound Name |
N4-(2-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095776; BDBM50318181
Click to Show/Hide
|
||||
| Activity |
IC50 = 163100 nM
|
[13] | |||
| Compound Name |
N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096415; BDBM50318166
Click to Show/Hide
|
||||
| Activity |
IC50 = 164300 nM
|
[20] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929556; BDBM50360178
Click to Show/Hide
|
||||
| Activity |
IC50 = 185600 nM
|
[21] | |||
| Compound Name |
N-[4-[4-Fluoro-3-(trifluoromethyl)anilino]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335019; BDBM50429668
Click to Show/Hide
|
||||
| Activity |
IC50 = 189600 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 36 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-N-(4-Chlorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929553; BDBM50360175
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[21] | |||
| Compound Name |
N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096737; BDBM50318165; N-(3-bromo-4-flurophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-phenylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956897; BDBM50366082
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
N-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096416; BDBM50318167
Click to Show/Hide
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| Activity |
IC50 > 200000 nM
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[20] | |||
| Compound Name |
N4-(3-Chloro-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL504416; BDBM50271804
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| Activity |
IC50 > 200000 nM
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[22] | |||
| Compound Name |
6-(2-Phenylethyl)-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097743; BDBM50318164
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| Activity |
IC50 > 200000 nM
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[20] | |||
| Compound Name |
N4-(3-Ethynylphenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520803; BDBM50271849; N4-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
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| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929554; BDBM50360176
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| Activity |
IC50 > 200000 nM
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[21] | |||
| Compound Name |
N-[4-(3-Chloro-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335016; BDBM50429670
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2,5-dimethoxyphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956892; BDBM50366091
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| Activity |
IC50 > 200000 nM
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[3] | |||
| Compound Name |
6-(2-Pyridin-2-ylethyl)-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335013; BDBM50429672
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
N-[4-(3-Bromo-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335015; BDBM50429676
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
N4-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499067; BDBM50271905; N4-(1H-indol-5-yl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335014; BDBM50429671
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
6-Phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483312; BDBM50271848; N4-(3-Trifluromethylphenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
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| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N4-(4-Fluoro-3-(trifluoromethyl)phenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482715; BDBM50271852; N4-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
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| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N4-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483313; BDBM50271850; N4-(4-chloro-2-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-N-(3-Chloro-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335378; BDBM50429673
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL519147; BDBM50271851; N4-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
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| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
N4-(3-Bromo-4-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483108; BDBM50271803; N4-(3-bromo-4-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 > 200000 nM
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[20] | |||
| Compound Name |
N-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097368; BDBM50318168
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| Activity |
IC50 = 223800 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090834; BDBM50257260
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| Activity |
IC50 = 271100 nM
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[8] | |||
| Compound Name |
N4-(3-Fluoro-4-trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094808; BDBM50318179
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094784; BDBM50318187
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098440; BDBM50318188
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095466; BDBM50318184
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094475; BDBM50318178; N4-(3-Ethynylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
N4-(4-Bromo-2-chlorophenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095762; BDBM50318173; 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N4-(4-bromo-2-chlorophenyl)-6-[(2,4-dichlorophenyl)methyl]-
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094782; BDBM50318185
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| Activity |
IC50 > 300000 nM
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[13] | |||
| Compound Name |
N-[3-[3-[[2-Methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807788; SCHEMBL12077782; BDBM50349021
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Compound Name |
N-[3-[3-[[6-(4-Hydroxypiperidin-1-yl)-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807785; SCHEMBL12077625; BDBM50349018
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Compound Name |
N-[3-[3-[[6-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807786; SCHEMBL12077190; BDBM50349019
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Compound Name |
N-[3-[3-[[6-[2-(Dimethylamino)ethylamino]-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807787; SCHEMBL12091967; BDBM50349020
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Compound Name |
CID 56659825
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807485; SCHEMBL12077735; BDBM50349017
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Compound Name |
CID 56676977
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807484; SCHEMBL12077993; BDBM50349016
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Compound Name |
N-[3-[3-[[2-Methyl-6-(3-morpholin-4-ylpropylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807789; SCHEMBL12077359; BDBM50349022
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
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[23] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem. 2006 Nov 2;49(22):6465-88. | ||||
| REF 2 | 1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4266-71. | ||||
| REF 3 | N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem. 2012 Apr 1;20(7):2444-54. | ||||
| REF 4 | Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase. J Med Chem. 2014 Nov 13;57(21):8817-26. | ||||
| REF 5 | N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. Bioorg Med Chem. 2013 Mar 1;21(5):1312-23. | ||||
| REF 6 | Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem. 2007 Aug 23;50(17):4162-76. | ||||
| REF 7 | Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities. J Nat Prod. 2013 Jan 25;76(1):29-35. | ||||
| REF 8 | Identification of Peptidic Antagonists of Vascular Endothelial Growth Factor Receptor 1 by Scanning the Binding Epitopes of Its Ligands. J Med Chem. 2017 Aug 10;60(15):6598-6606. | ||||
| REF 9 | Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1167-70. | ||||
| REF 10 | Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction. Bioorg Med Chem. 2011 Mar 15;19(6):1978-86. | ||||
| REF 11 | Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J Med Chem. 1999 Dec 30;42(26):5369-89. | ||||
| REF 12 | Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4723-6. | ||||
| REF 13 | Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endo... Bioorg Med Chem. 2010 May 15;18(10):3575-87. | ||||
| REF 14 | Disulfide and amide-bridged cyclic peptide analogues of the VEGF1 81-91 fragment: synthesis, conformational analysis and biological evaluation. Bioorg Med Chem. 2011 Dec 15;19(24):7526-33. | ||||
| REF 15 | On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloa... Bioorg Med Chem Lett. 2007 Oct 15;17(20):5590-4. | ||||
| REF 16 | Discovery of a new class of anilinoquinazoline inhibitors with high affinity and specificity for the tyrosine kinase domain of c-Src. J Med Chem. 2004 Feb 12;47(4):871-87. | ||||
| REF 17 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 18 | Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist. J Med Chem. 2010 Jun 10;53(11):4428-40. | ||||
| REF 19 | Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. J Med Chem. 2010 Feb 25;53(4):1563-78. | ||||
| REF 20 | The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Bioorg Med Chem Lett. 2010 May 15;20(10):3177-81. | ||||
| REF 21 | N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2012 Jan 15;20(2):910-4. | ||||
| REF 22 | Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2008 May 15;16(10):5514-28. | ||||
| REF 23 | Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorg Med Chem. 2011 Jul 15;19(14):4173-82. | ||||
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