Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64591 | Target Info | |||
| Target Name | 5-HT 3A receptor (HTR3A) | ||||
| Synonyms |
Serotonin-gated ion channel receptor; Serotonin receptor 3A; HTR3; 5HT3R; 5-hydroxytryptamine receptor 3A; 5-HT3RA; 5-HT3A; 5-HT3-A; 5-HT 3A
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| Target Type | Successful Target | ||||
| Gene Name | HTR3A | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 44 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
TD-8954
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|
Phase 2 | Compound Info | ||
| Synonyms |
TD-8954; UNII-35F0Y2W16Q; CHEMBL2402904; 35F0Y2W16Q; 916075-84-8; compound 18 [PMID 23756062]; SCHEMBL390795; GTPL8426; BDBM50436989; SB17471; DB12725; 1-Piperidinecarboxylic acid, 4-((4-((((2-(1-methylethyl)-1H-benzimidazol-7-yl)carbonyl)amino)methyl)-1-piperidinyl)methyl)-, methyl ester; methyl 4-[[4-[[(2-propan-2-yl1H-benzimidazole-4-carbonyl)amino]methyl]piperidin-1-yl]methyl]piperidine-1-carboxylate
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
linalool
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Investigative | Compound Info | ||
| Synonyms |
Linalool; 78-70-6; 3,7-Dimethylocta-1,6-dien-3-ol; Linalol; 3,7-Dimethyl-1,6-octadien-3-ol; beta-Linalool; allo-Ocimenol; LINALYL ALCOHOL; 1,6-Octadien-3-ol, 3,7-dimethyl-; p-Linalool; (+-)-Linalool; Linanool; 2,6-Dimethyl-2,7-octadien-6-ol; 2,6-Dimethylocta-2,7-dien-6-ol; .beta.-Linalool; Linalool (natural); 2,6-Dimethyl-2,7-octadiene-6-ol; Caswell No. 526A; Linolool; FEMA Number 2635; NSC 3789; FEMA No. 2635; CCRIS 3726; CCRIS 6557; HSDB 645; Linalool, 97%; EINECS 201-134-4; EINECS 245-083-6; 3,7-dimethyl-octa-1,6-dien-3-ol; EPA Pest
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| Activity |
IC50 = 141253.75 nM
|
[2] | |||
| Compound Name |
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
GSK137647A; GSK 137647; GSK-137647A; N-mesityl-4-methoxybenzenesulfonamide; CHEMBL3311308; MFCD02007969; 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide; CBMicro_012617; Oprea1_349531; Oprea1_545891; SCHEMBL19357604; KS-00000TIW; AOB2991; ZINC184126; BCP17136; EX-A1097; GSK 137647A; SMSF0014079; BDBM50044849; STK899558; AKOS003261220; CB15818; CS-5549; GSK-137647; MCULE-5583867808; N-mesityl-4-methoxy-1-benzenesulfonamide; NCGC00387253-02; NCGC00387253-05; AK240703; AS-16737; HY-19995; BIM-0012523.P001; FFA4 (GPR120) agonist GSK137647A; B7793; EU-0076636; FT-0700296; S0001; ST50719559; GSK137647A, >=98% (HPLC); A14542; AJ-292/14925630; SR-01000478738; J-690285; SR-01000478738-1; [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine; 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide; 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
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| Activity |
EC50 ~ 50118.72 nM
|
[3] | |||
| Compound Name |
N-[[1-[2-Hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]piperidin-4-yl]methyl]-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402887; BDBM50437006
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| Activity |
Ki = 50118.72 nM
|
[1] | |||
| Compound Name |
2-Cyclopropyl-N-[[1-[2-hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]piperidin-4-yl]methyl]-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402892; BDBM50437001
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| Activity |
Ki = 50118.72 nM
|
[1] | |||
| Compound Name |
Methyl N-[2-hydroxy-3-[4-[[(2-propan-2-yl-1H-benzimidazole-4-carbonyl)amino]methyl]piperidin-1-yl]propyl]-N-methylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402901; BDBM50436992
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| Activity |
Ki = 50118.72 nM
|
[1] | |||
| Compound Name |
(3R,5S)-5-[2-(2,3-Dihydro-1-benzofuran-5-yl)ethynyl]-1-methyl-3-(piperidin-1-ylmethyl)pyrrolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503427
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| Activity |
IC50 = 50118.72 nM
|
[4] | |||
| Compound Name |
3-(4-Fluorophenyl)-N-(2-morpholinoethyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374351; KKHT-10103; BDBM50295837
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| Activity |
IC50 = 57000 nM
|
[5] | |||
| Compound Name |
N-Pyridin-4-ylspiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892238; BDBM50211098
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| Activity |
IC50 = 58000 nM
|
[6] | |||
| Compound Name |
CID 72710014
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928032; SCHEMBL17238981; BDBM50206252
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| Activity |
IC50 = 61000 nM
|
[7] | |||
| Compound Name |
N-[1-[2-Hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]piperidin-4-yl]-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402889; BDBM50437004
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| Activity |
Ki = 63095.73 nM
|
[1] | |||
| Compound Name |
N-[[1-[3-[Acetyl(methyl)amino]-2-hydroxypropyl]piperidin-4-yl]methyl]-2-propan-2-yl-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402902; BDBM50436991
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|
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| Activity |
Ki = 63095.73 nM
|
[1] | |||
| Compound Name |
CID 72709767
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932288; SCHEMBL15546992; BDBM50211222
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| Activity |
IC50 = 64000 nM
|
[6] | |||
| Compound Name |
(3R)-N-(7-Methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3907100; SCHEMBL10222353; BDBM50206245
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| Activity |
IC50 = 71000 nM
|
[7] | |||
| Compound Name |
N-[[1-[2-Hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]piperidin-4-yl]methyl]-2-propan-2-yl-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402891; BDBM50437002
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| Activity |
Ki = 79432.82 nM
|
[1] | |||
| Compound Name |
N-[[1-[2-Hydroxy-3-[methyl(methylsulfonyl)amino]propyl]piperidin-4-yl]methyl]-2-propan-2-yl-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402900; BDBM50436993
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| Activity |
Ki = 79432.82 nM
|
[1] | |||
| Compound Name |
Methyl 4-[2-[4-[[(2-propan-2-yl-1H-benzimidazole-4-carbonyl)amino]methyl]piperidin-1-yl]ethyl]piperazine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402898; BDBM50436995
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| Activity |
Ki = 79432.82 nM
|
[1] | |||
| Compound Name |
2-Ethyl-N-[[1-[2-hydroxy-3-(4-methylsulfonylpiperazin-1-yl)propyl]piperidin-4-yl]methyl]-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402890; BDBM50437003
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|
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| Activity |
Ki = 79432.82 nM
|
[1] | |||
| Compound Name |
(3R)-N-(7-Methylpyrrolo[2,3-d]pyrimidin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891441; BDBM50206268
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|
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| Activity |
IC50 = 86000 nM
|
[7] | |||
| Compound Name |
(3S)-N-(7-Chloropyrrolo[2,1-f][1,2,4]triazin-4-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919130; BDBM50206246
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|
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| Activity |
IC50 = 87000 nM
|
[7] | |||
| Compound Name |
(3S)-N-(6-Methoxy-1,3-benzothiazol-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3969801; BDBM50211192
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| Activity |
IC50 ~ 97000 nM
|
[6] | |||
| Compound Name |
5-[2-(1-Benzofuran-5-yl)ethynyl]-1-methyl-3-(piperidin-1-ylmethyl)pyrrolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459900; SCHEMBL1459633; BDBM50413331
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|
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
2-[(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-31-(2-Acetyloxyethyl)-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaen-15-yl]ethyl acetate;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395960
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| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
Methyl (1S,2R,7R,9S,10S,12S,19S)-12-ethyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadecane-10-carboxylate;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216651
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-Isopropyl-1H-benzoimidazole-4-carboxylic acid [1-(1-methanesulfonylpiperidin-4-ylmethyl)piperidin-4-ylmethyl]amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402903; SCHEMBL828848; BDBM50436990
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
[20-[[Dimethyl-[(4-nitrophenyl)methyl]azaniumyl]methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl-dimethyl-[(4-nitrophenyl)methyl]azanium;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229999
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| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
Sodium;(1S,2R,7R,9S,10S,12S,19S)-12-ethyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadecane-10-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL453023
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-piperazin-1-yl]-cyclohexanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100086; SCHEMBL9035305; BDBM50122411; 1-(1,3-Benzodioxole-5-yl)-4beta-[4-(3-methoxybenzyl)piperazino]cyclohexane-1alpha-ol
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Dibenzyl-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396705
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| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
N-[[1-[2-(4-Methylsulfonylpiperazin-1-yl)ethyl]piperidin-4-yl]methyl]-2-propan-2-yl-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402897; BDBM50436996
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
(3R)-N-(5-Phenylpyrazin-2-yl)spiro[1-azabicyclo[2.2.2]octane-3,5'-4H-1,3-oxazole]-2'-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093500; BDBM50232604
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Trimethyl-[[20-[(trimethylazaniumyl)methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl]azanium;diiodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL382243
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| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[20-[(Dimethylamino)methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]-N,N-dimethylmethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL203627; BDBM50220060; (14-dimethylaminomethyl-6H,13H-pyrazino[1,2-a;4,5-a'']diindol-7-ylmethyl)-dimethyl-amine
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| Activity |
Ki ~ 100000 nM
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[8] | |||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,17R,18R,20R,27S,29R,30R,31S)-14,26-Bis[(3,4-dimethoxyphenyl)methyl]-19-phenyl-21-oxa-8,19-diaza-14,26-diazoniadecacyclo[24.5.2.211,14.01,27.02,7.08,31.010,18.013,17.020,30.024,29]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethanol;dichloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388049
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| Activity |
Ki = 100000 nM
|
[8] | |||
| Compound Name |
[20-[[Dimethyl(prop-2-enyl)azaniumyl]methyl]-3,13-diazapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(20),4,6,8,10,14,16,18-octaen-10-yl]methyl-dimethyl-prop-2-enylazanium;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL206666
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| Activity |
Ki ~ 100000 nM
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[8] | |||
| Compound Name |
CID 90022612
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959798; SCHEMBL15545397; SCHEMBL15545399; BDBM50211191
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Bis[(4-nitrophenyl)methyl]-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL229998
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[[1-[(1-Acetylpiperidin-4-yl)methyl]piperidin-4-yl]methyl]-2-propan-2-yl-1H-benzimidazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2401750; BDBM50436988
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-24-Phenyl-15,31-bis(prop-2-enyl)-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL390135
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| Activity |
Ki = 100000 nM
|
[8] | |||
| Compound Name |
(2E)-2-[(9Z,11S,13S,17S,25Z,27S,33S,35S,36S,38E)-38-(2-Hydroxyethylidene)-14,30-dimethyl-8,24-diaza-14,30-diazoniaundecacyclo[25.5.2.211,14.11,26.110,17.02,7.013,17.018,23.030,33.08,35.024,36]octatriaconta-2,4,6,9,18,20,22,25-octaen-28-ylidene]ethanol;dichloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL231047
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,14R,17S,25Z,27S,33S,35S,36S,38E)-38-(2-Hydroxyethylidene)-14,30-bis(prop-2-enyl)-8,24-diaza-14,30-diazoniaundecacyclo[25.5.2.211,14.11,26.110,17.02,7.013,17.018,23.030,33.08,35.024,36]octatriaconta-2,4,6,9,18,20,22,25-octaen-28-ylidene]ethanol
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Investigative | Compound Info | ||
| Synonyms |
Alcuronium; CHEMBL1180293
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| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
(1S,9R,18R,19S,21R,22R,23R,25R,32S,34R,35R,36S)-15,31-Bis[(E)-but-2-enyl]-24-phenyl-10,26-dioxa-8,24-diaza-15,31-diazoniaundecacyclo[29.5.2.01,32.02,7.08,36.09,22.013,21.015,19.018,23.025,35.029,34]octatriaconta-2,4,6,12,28-pentaene;dibromide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230952
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| Activity |
IC50 = 100000 nM
|
[8] | |||
| Compound Name |
CID 72709190
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066441; SCHEMBL17239046; BDBM50259926; N-(6-methoxypyrimidin-4-yl)spiro[1,4-dihydroimidazole-5,3'-1-azabicyclo[2.2.2]octane]-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2E)-2-[(1S,9Z,11S,13S,18R,20R,27S,29R,30R,31S)-14,26-Bis[(4-nitrophenyl)methyl]-19-phenyl-21-oxa-8,19-diaza-14,26-diazoniadecacyclo[24.5.2.211,14.01,27.02,7.08,31.010,18.013,17.020,30.024,29]pentatriaconta-2,4,6,9,23-pentaen-35-ylidene]ethanol;dibromide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415570
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| Activity |
Ki = 100000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
eucalyptol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
Eucalyptol; cineole; 1,8-Cineole; 1,8-Cineol; Cajeputol; 470-82-6; 1,8-Epoxy-p-menthane; Eucalyptole; Zineol; Eucapur; Terpan; p-Cineole; 1,8-Oxido-p-menthane; 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane; Eukalyptol; CINEOL; Cucalyptol; Soledum; Eukalyptol [Czech]; Zedoary oil; Eucalyptol (natural); EUCALYPTUS OIL; p-Menthane, 1,8-epoxy-; Cineole (VAN); 2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl-; NCI-C56575; Eucalyptol [USAN]; UNII-RV6J6604TK; FEMA No. 2465; 2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-; NSC 6171
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| Activity |
IC50 = 257039.58 nM
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[2] | |||
| Compound Name |
AF353
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Investigative | Compound Info | ||
| Synonyms |
AF-353; AF 353
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| Activity |
Ki = 100000000 nM
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[13] | |||
| Compound Name |
cis-1-Methyl-5-(phenylethynyl)-3-(piperidin-1-ylmethyl)pyrrolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL454407; SCHEMBL3152748; BDBM50247983; ZINC35823656; (3R,5S)-1-methyl-5-(2-phenylethynyl)-3-(piperidin-1-ylmethyl)pyrrolidin-2-one
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| Activity |
IC50 = 251188.64 nM
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[4] | |||
| Compound Name |
(4As,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1224527; BDBM50325822; trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol
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| Activity |
Ki = 870000 nM
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[14] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4210-5. | ||||
| REF 2 | Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3207-3218. | ||||
| REF 3 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. | ||||
| REF 4 | Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1287-91. | ||||
| REF 5 | Quinazolindione derivatives as potent 5-HT3A receptor antagonists. Bioorg Med Chem. 2009 Jul 1;17(13):4793-6. | ||||
| REF 6 | Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as alpha7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. J Med Chem. 2016 Dec 22;59(24):11171-11181. | ||||
| REF 7 | Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] as alpha7 Nicotinic Receptor Agonists. ACS Med Chem Lett. 2016 Dec 1;8(1):133-137. | ||||
| REF 8 | Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine re... J Med Chem. 2007 Sep 20;50(19):4616-29. | ||||
| REF 9 | Perhydrogenation of tabersonine, ans Aspidiosperma indole alkaloid. J Nat Prod. 1997 Apr;60(4):419-20. | ||||
| REF 10 | Development of a presynaptic 5-HT1A antagonist. Bioorg Med Chem Lett. 2003 Jan 20;13(2):285-8. | ||||
| REF 11 | Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as alpha7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1261-1266. | ||||
| REF 12 | Development of spiroguanidine-derived alpha7 neuronal nicotinic receptor partial agonists. Bioorg Med Chem Lett. 2017 Feb 1;27(3):578-581. | ||||
| REF 13 | Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31. | ||||
| REF 14 | Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorg Med Chem. 2010 Sep 15;18(18):6763-70. | ||||
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