Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65889 | Target Info | |||
| Target Name | Pyruvate kinase M2 (PKM) | ||||
| Synonyms |
p58; Tumor M2-PK; Thyroid hormone-binding protein 1; THBP1; Pyruvate kinase muscle isozyme; Pyruvate kinase isozymes M1/M2; Pyruvate kinase PKM; Pyruvate kinase 2/3; PKM2; PK3; PK2; Opa-interacting protein 3; OIP3; OIP-3; Cytosolic thyroid hormone-binding protein; CTHBP
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PKM | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SCUTELLAREIN
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Scutellarein; 529-53-3; 6-Hydroxyapigenin; 5,6,7,4'-Tetrahydroxyflavone; SCUTELLARTLN; 4',5,6,7-tetrahydroxyflavone; 4',5,6,7-Tetrahydroxyflavanone; UNII-P460GTI853; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; CHEBI:9062; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; JVXZRQGOGOXCEC-UHFFFAOYSA-N; P460GTI853; 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-; Q-100602; 2-(4-hydroxyphenyl)-5,6,7-tris(oxidanyl)chromen-4-one; AC1NQYX1
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-Nitro-[3,3'-ethylenebis(1H-indole)]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3339205; BDBM50029022
Click to Show/Hide
|
||||
| Activity |
IC50 = 54600 nM
|
[2] | |||
| Compound Name |
8-Methyl-2-[1-(propan-2-ylamino)ethenyl]thieno[3,2-c]chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695458; BDBM138388; US8877791, G1
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[3] | |||
| Compound Name |
2-(1H-1,2,4-Triazol-3-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000095706; ChemDiv2_007918; Oprea1_546842; CHEMBL1601400; BDBM138389; HMS1391H20; HMS2459E22; IDI1_006633; SMR000031254; US8877791, H1; EU-0095547; SR-01000572004; SR-01000572004-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[3] | |||
| Compound Name |
1-[4-(2,5-Dimethylpyrrol-1-yl)phenyl]sulfanylpropan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3695455; BDBM138385; US8877791, A1
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[3] | |||
| Compound Name |
2-Chloro-5-(2,5-dimethyl-pyrrol-1-yl)-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid; 2-chloro-5-(2,5-dimethylpyrrol-1-yl)benzoic acid; 5-(2,5-dimethylpyrrolyl)-2-chlorobenzoic acid; Interchim compound 57; CBMicro_048282; Oprea1_496585; Oprea1_520061; CHEMBL212406; SCHEMBL13430836; BDBM11995; CTK7I6788; ZINC266941; BBL019698; MFCD01125265; SBB004489; STK193011; AKOS000301073; CCG-106256; MCULE-1086422236; BIM-0048142.P001; BB 0217848; ST50004466; T8998; EN300-25540; N-(3-Carboxy-4-chloro)phenyl-2,5-dimethylpyrrole; SR-01000430216; SR-01000430216-1; Z57131671; 2-Chloro-5-(2,5-dimethyl-1H-pyrrol-1 -yl)benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic acid; 5-(2,5-dimethylpyrrol-1-yl)-2-hydroxybenzoic acid; 5-(2,5-Dimethyl-pyrrol-1-yl)-2-hydroxy-benzoicacid; CBMicro_048082; Oprea1_299508; Oprea1_532952; CHEMBL214344; SCHEMBL3504857; BDBM82190; CTK4G7000; KS-00003KJK; DTXSID70354603; ZINC267003; 9943AD; NSC731232; STK199646; Salicylic acid derivative, compound 2; AKOS000323780; CCG-106259; FS-1887; MCULE-7078969949; NSC-731232; BIM-0048145.P001; BB 0253607; CS-0116616; FT-0677051; ST50008695; Z-2129; 5-(2,5-dimethylpyrrolyl)-2-hydroxybenzoic acid; SR-01000430239; N-(3-Carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole; SR-01000430239-1; 5-(2,5-dimethylpyrrol-1-yl)-2-hydroxy-benzoic acid; 2-Hydroxy-5-(2,5-dimethyl-1H-pyrrole-1-yl)benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5404-5408. | ||||
| REF 2 | Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5059-62. | ||||
| REF 3 | US patent application no. 8877791B2, Inhibitors of pyruvate kinase and methods of treating disease | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.