Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72702 | Target Info | |||
| Target Name | Tissue factor (F3) | ||||
| Synonyms |
Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen
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| Target Type | Successful Target | ||||
| Gene Name | F3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]carbamoyl]-2-[2-[(3-carbamoylphenyl)carbamoyl]-4-(cyclohexylamino)phenyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376188; BDBM50197328
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| Activity |
IC50 = 91000 nM
|
[1] | |||
| Compound Name |
5-Azaindole analog 27
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL210678; BDBM14889
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| Activity |
Ki = 130000 nM
|
[2] | |||
| Compound Name |
2-[2-[(3-Carbamoylphenyl)carbamoyl]phenyl]-5-[[(2R)-1-hydroxy-4-methylpentan-2-yl]carbamoyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225130; BDBM50197337
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| Activity |
IC50 = 191000 nM
|
[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Valproate
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Approved | Compound Info | ||
| Synonyms |
99-66-1; Dipropylacetic acid; Depakine; Depakene; 2-Propylvaleric acid; Ergenyl; Di-n-propylacetic acid; Mylproin; Pentanoic acid, 2-propyl-; 4-Heptanecarboxylic acid; Propylvaleric acid; n-Dipropylacetic acid; Myproic Acid; Di-n-propylessigsaure; n-DPA; Dipropylacetate; Convulex; Depakin; Vupral; Acido valproico; Acide valproique; Acidum valproicum; Stavzor; Avugane; Baceca; Kyselina 2-propylvalerova; 2-n-Propyl-n-valeric acid; Acetic acid, dipropyl-; Abbott 44090; Valproinsaeure; Savicol; Convulsofin; Deproic; VPA; Depakin chrono; Dipropyl Acetate; Med Valproic; Valproic acid USP; Valproic acid USP24; Acide valproique [INN-French]; Acido valproico [INN-Spanish]; Acidum valproicum [INN-Latin]; Alti-Valproic; Depakote (TM); Dom-Valproic; G2M-777; Kyselina 2-propylvalerova [Czech]; N-DPA; N-Dipropylacetic acid; Novo-Valproic; Nu-Valproic; PMS-Valproic Acid; Penta-Valproic; Valproic acid (USP); Di-n-propylessigsaeure; Di-n-propylessigsaure [German]; Valproic acid [USAN:INN:BAN]; Valproic Acid, SodiumSalt (2:1); 2 PP (base)
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| Activity |
IC50 = 1500000 nM
|
[3] | |||
| Compound Name |
Sodium butyrate
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|
Phase 2 | Compound Info | ||
| Synonyms |
Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA)
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| Activity |
IC50 = 1000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands. Bioorg Med Chem. 2007 Jan 1;15(1):160-73. | ||||
| REF 2 | Novel 5-azaindole factor VIIa inhibitors. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3197-200. | ||||
| REF 3 | Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. J Biol Chem. 2007 Sep 28;282(39):28408-28418. | ||||
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