Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74977 | Target Info | |||
| Target Name | Dual specificity protein kinase TTK (MPS1) | ||||
| Synonyms |
Tyrosine threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; MPS1L1
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TTK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 13 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Inamrinone Lactate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Amrinone; inamrinone; 60719-84-8; Wincoram; Inocor; Cordemcura; Cartonic; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Amrinonum [INN-Latin]; Amrinonum; Amrinona; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Amcoral; 5-Amino-(3,4'-bipyridin)-6(1H)-one; WIN 40680; AWD 08-250; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; UNII-JUT23379TN; CCRIS 3794; Amrinone lactate; MLS000069829; EINECS 262-390-0; 5-amino-3,4'-bipyridin-6(1H)-one; BRN 0744819; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; Amrinone Lactate
Click to Show/Hide
|
||||
| Activity |
Ki = 80800 nM
|
[1] | |||
| Compound Name |
Milrinone
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(2,6-Diethylphenyl)-1-methyl-1-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330261; BDBM50053333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[3-(4-Chloro-1H-indazol-3-yl)phenyl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330242; BDBM50053314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Methoxy-5-(pyridine-4-yl)pyridine-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
[3,4'-Bipyridin]-5-amine, 6-methoxy-; CHEMBL4291350; ACMC-20ltv1; SCHEMBL2684595; CTK3G5501; DTXSID10552969; BDBM50465483; 6-Methoxy[3,4'-bipyridin]-5-amine; 6-Methoxy-[3,4'-bipyridin]-5-amine; 2-methoxy-5-pyridin-4-ylpyridin-3-amine; 2-METHOXY-5-(PYRIDIN-4-YL)PYRIDIN-3-AMINE; A1-32524
Click to Show/Hide
|
||||
| Activity |
Ki = 91200 nM
|
[1] | |||
| Compound Name |
3-Amino-5-(1-Methyl-1h-Pyrazol-4-Yl)pyridin-2(1h)-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4288628; BDBM50465482; Q27453719; 3D7
Click to Show/Hide
|
||||
| Activity |
Ki = 94700 nM
|
[1] | |||
| Compound Name |
5-Amino-[3,3'-bipyridin]-6(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1201292; 3-amino-5-pyridin-3-yl-1H-pyridin-2-one; [3,3'-Bipyridin]-6(1H)-one, 5-amino-; SCHEMBL11368332; CTK8C3782; DTXSID30276216; 2437AC; ANW-70535; BDBM50465489; ZINC31391078; 3-Amino-5-(pyridin-3-yl)pyridin-2-ol
Click to Show/Hide
|
||||
| Activity |
Ki = 98100 nM
|
[1] | |||
| Compound Name |
[3,4'-Bipyridin]-6(1H)-one, 5-amino-2-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302219; SCHEMBL11235286; BDBM50226223; 5-Amino-2-methyl-3,4'-bipyridin-6(1H)-one; 3-amino-6-methyl-5-pyridin-4-yl-1H-pyridin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(6-Oxo-1,6-dihydro-[3,4']bipyridinyl-5-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4278218; SCHEMBL5240813; BDBM50465495; N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)benzenesulfonamide; N-(6-Oxo-1,6-dihydro-[3,4]bipyridinyl-5-yl)-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4281678
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465493
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carboxamide; [3,4'-Bipyridine]-5-carboxamide, 1,6-dihydro-2-methyl-6-oxo-; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carboxamide; Milrinone Related Compound A; UNII-75E39HK2X2; CHEMBL4278538; 75E39HK2X2; (3,4'-Bipyridine)-5-carboxamide, 1,6-dihydro-2-methyl-6-oxo-; MFCD09800601; POTASSIUMBENZENESULFONATE; SCHEMBL10704473; CTK5E7412; DTXSID30510182; KS-000002CI; 9920AE; BDBM50465491; SBB055744; WIN 47338; ZINC15021487; AKOS025116857; DS-3289; Milrinone related compound A [USP-RS]; AK468647; 6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carboxamide; 6-methyl-2-oxo-5-(4-pyridyl)hydropyridine-3-carboxamide; 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carboxamide; 2-Methyl-6-oxo-1,6-dihydro[3,4'-bipyridine]-5-carboxamide; 6-Methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carboxamide; 1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4279867
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL10062845; BDBM50465494
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Amino-5-phenyl-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1605269; SCHEMBL1392973; SCHEMBL21857207; BDBM50465487; NCGC00181388-01
Click to Show/Hide
|
||||
| Activity |
Ki = 128200 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Amino-1-methyl[3,4'-bipyridin]-6(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4282410; 5-amino-1-methyl-[3,4'-bipyridin]-6(1H)-one; SCHEMBL11448759; CTK2B3222; DTXSID30633103; BDBM50465480; 3-amino-1-methyl-5-pyridin-4-ylpyridin-2-one; [3,4'-Bipyridin]-6(1H)-one, 5-amino-1-methyl-; 3-Amino-1-methyl-5-(4-pyridinyl)-2(1H)-pyridinone
Click to Show/Hide
|
||||
| Activity |
Ki = 236400 nM
|
[1] | |||
| Compound Name |
Chembl4295011
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465488
Click to Show/Hide
|
||||
| Activity |
Ki = 269300 nM
|
[1] | |||
| Compound Name |
Chembl4280041
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465490
Click to Show/Hide
|
||||
| Activity |
Ki = 367300 nM
|
[1] | |||
| Compound Name |
3-Amino-2-hydroxypyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Amino-2-pyridinol; 3-aminopyridin-2-ol; 3-aminopyridin-2(1H)-one; 3-amino-1H-pyridin-2-one; 2(1H)-Pyridinone, 3-amino-; 2-Pyridinol, 3-amino-; 3-Amino-2-pyridone; 3-amino-pyridin-2-ol; 2-HYDROXY-3-AMINOPYRIDINE; 3-Amino-2-pyridinone; MFCD03411556; NSC279497; 3-aminohydropyridin-2-one; 3-Amino-2(1H)-pyridinone; CHEMBL4286709; 3-Amino-2-pyridinol, 97%; aminopyridinone; aminopyridone; Aminopyridinol; 2(1H)-Pyridinone,3-amino-; 3-aminopyrid-2-one; NSC 279497; PubChem1263; 3-Aminopyridine-2-ol; ACMC-1AJGZ; 3-amino-2-hydroxy pyridine; 3-amino-2-hydroxy-pyridine; SCHEMBL87697; 3-azanyl-1H-pyridin-2-one; KSC269G4B; Yttrium(III)OxalateNonahydrate; ACMC-209i21; SCHEMBL7834765; 3-Amino-2(1H)-pyridinone #; CTK1G9340; CTK7H0285; DTXSID70187317; Pyridin-2(1H)-one, 3-amino-; 3-amino-1,2-dihydropyridin-2-one; ACN-S003496; ACT01552; ALBB-027684; KS-00000PC2; KS-000010TU; ZINC8698104; AC-074; ANW-27671; ANW-51533; BBL100664; BDBM50465479; SBB051906; STK776258; STL554458; AKOS002670113; AKOS005618212; 3-amino-2-hydroxypyridine, AldrichCPR; CCG-325587; CS-W004662; MCULE-2705834056; NSC-279497; PB30752; PS-3655; VP11025; VP14460; AC-31846; AK-26159; AK-88485; AM807018; BR-26159; SC-03575; SC-51165; ST041905; SY008406; TS-01536; AB0015719; AB0068998; FT-0601494; FT-0649416; C-8187; K-7745; Z-4054; 630A998; A821885; AE-641/00363028; J-505326; J-511548
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorg Med Chem. 2018 Jul 15;26(11):3021-3029. | ||||
| REF 2 | Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides. Bioorg Med Chem. 2014 Sep 1;22(17):4968-97. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.