Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76685 | Target Info | |||
| Target Name | Cannabinoid receptor 1 (CB1) | ||||
| Synonyms |
Cannabinoid CB1 receptor; CNR; CB-R; CANN6
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|
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| Target Type | Successful Target | ||||
| Gene Name | CNR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 59 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID27215781-Compound-27
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|
Patented | Compound Info | ||
| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
(2S)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-1-(4-cyanophenyl)-5-oxopyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353883; SCHEMBL9892011; BDBM50042702
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-(5-Tert-butyl-1,3,4-thiadiazol-2-yl)-1-(oxan-4-yl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353871; SCHEMBL9892167; BDBM50042661
Click to Show/Hide
|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Benzenesulfonamide, N-[(2Z)-5-(1,1-dimethylethyl)-3,4-dimethyl-2(3H)-thiazolylidene]-
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235747; BDBM5035; SCHEMBL13989991; thiazolidenebenzenesulfonamide deriv. 10r; (NZ)-N-(5-tert-butyl-3,4-dimethyl-thiazol-2-ylidene)benzenesulfonamide; N-[(2Z)-5-tert-butyl-3,4-dimethyl-2,3-dihydro-1,3-thiazol-2-ylidene]benzenesulfonamide
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-1-(4-chlorophenyl)-5-oxopyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353880; SCHEMBL9892005; BDBM50042699
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,4S)-9-(4-Oxidopyrazin-4-ium-2-yl)-N-(1-pyridin-2-ylcyclobutyl)-8,9-diazatricyclo[4.3.0.02,4]non-7-ene-7-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235055; BDBM50006450
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|
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[3-(2-Hydroxy-1,1-dimethyl-ethyl)-isoxazol-5-yl]-2-methyl-2-(tetrahydro-pyran-4-sulfonyl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3234702; SCHEMBL1691162; BDBM50006447; N-[3-(1-hydroxy-2-methylpropan-2-yl)-1,2-oxazol-5-yl]-2-methyl-2-(oxan-4-ylsulfonyl)propanamide
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|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-1-(4-methylsulfonylphenyl)-5-oxopyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353884; SCHEMBL9892013; BDBM50042703
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|
||||
| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,4R)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-4-hydroxy-1-(oxan-4-ylmethyl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353877; SCHEMBL9892042; BDBM50042696
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[3-(1-Hydroxy-2-methylpropan-2-yl)-1,2-oxazol-5-yl]-2-methyl-2-[methyl(oxan-4-yl)amino]propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3234704; SCHEMBL12566255; BDBM50006237
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353881; SCHEMBL9892136; BDBM50042700
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,4S)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-4-hydroxy-1-(oxan-4-ylmethyl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353876; SCHEMBL9892135; BDBM50042695
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-(3-Tert-butyl-1,2-oxazol-5-yl)-1-(4-fluorophenyl)-5-oxopyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353882; SCHEMBL9892023; BDBM50042701
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|
||||
| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-(6-Chloro-1H-benzimidazol-2-yl)-1-(oxan-4-yl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353875; SCHEMBL9892139; BDBM50042694
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|
||||
| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-[(2-Nitrophenyl)methylsulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353812; SCHEMBL14811873; BDBM50040891
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|
||||
| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
2-[[5-[(2-Nitrophenyl)methyl]-[1,2,4]triazino[5,6-b]indol-3-yl]sulfanylmethyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353835; SCHEMBL14823665; BDBM50040936
Click to Show/Hide
|
||||
| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
Methyl 4-[3-[(2-cyanophenyl)methylsulfanyl]-[1,2,4]triazino[5,6-b]indol-5-yl]-4-oxobutanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354396; SCHEMBL14813029; BDBM50040945
Click to Show/Hide
|
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| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
2-[[5-(Cyclohexanecarbonyl)-[1,2,4]triazino[5,6-b]indol-3-yl]sulfanylmethyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354395; SCHEMBL14812560; BDBM50040944
Click to Show/Hide
|
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| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
2-[[5-[4-(Trifluoromethoxy)benzoyl]-[1,2,4]triazino[5,6-b]indol-3-yl]sulfanylmethyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354403; SCHEMBL14812921; BDBM50040952
Click to Show/Hide
|
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| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
[3-[(2-Nitrophenyl)methylsulfanyl]-[1,2,4]triazino[5,6-b]indol-5-yl]-phenylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354399; SCHEMBL14812813; BDBM50040948
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|
||||
| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
2-[(5H-[1,2,4]Triazino[5,6-b]indol-3-ylsulfanyl)methyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353802; Oprea1_027842; Oprea1_521844; SCHEMBL14812044; ZINC80459; HMS1620I06; BDBM50040880; STK730572; AKOS001748994; MCULE-2832189916
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|
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| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
2-[[5-(Cyclopentanecarbonyl)-[1,2,4]triazino[5,6-b]indol-3-yl]sulfanylmethyl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353842; SCHEMBL14812667; BDBM50040943
Click to Show/Hide
|
||||
| Activity |
Ki ~ 60000 nM
|
[1] | |||
| Compound Name |
1-((S)-1-{4-[4-Methoxy-2-(4-methoxy-benzenesulfonyl)-benzenesulfonyl]-phenyl}-ethyl)-3-propyl-urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361218; BDBM50160437
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|
||||
| Activity |
Ki = 72089 nM
|
[5] | |||
| Compound Name |
N-[2-(Cyclobutylmethylcarbamoyl)-6-(2-hydroxyethoxy)pyridin-3-yl]quinoline-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316388; BDBM50424458
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[6] | |||
| Compound Name |
N-(Cyclobutylmethyl)-3-[[4-(pyrrol-1-ylmethyl)naphthalene-1-carbonyl]amino]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316408; SCHEMBL5273721; BDBM50424462
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[6] | |||
| Compound Name |
(2S)-N-(5-Tert-butyl-1,2-oxazol-3-yl)-1-cyclobutylpyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353866; SCHEMBL9892098; BDBM50042600
Click to Show/Hide
|
||||
| Activity |
EC50 = 98005 nM
|
[2] | |||
| Compound Name |
2-Methyl-6-(4-methyl-1-piperazinyl)-8-(2-chlorophenyl)-9-[(3S)-tetrahydrofuran-3beta-yl]-9H-purine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057804; SCHEMBL12012426; BDBM50387885
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
8-(2-Chlorophenyl)-9-cyclopropyl-2-methyl-6-(4-methylpiperazin-1-yl)purine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092897
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-Methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)-8-[2-(trifluoromethyl)phenyl]purine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092903; SCHEMBL3340200; BDBM50494511
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-(2-Chlorophenyl)-6-(4-ethylpiperazin-1-yl)-2-methyl-9-(oxan-4-ylmethyl)purine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092900; SCHEMBL2485239; BDBM50494513
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethyl]pyrrolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057805; SCHEMBL12283645; BDBM50387886
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-[(3R)-oxolan-3-yl]purine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092899
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-(4-Methyl-1-piperazinyl)-8-(2-chlorophenyl)-9-[(3R)-tetrahydrofuran-3-yl]-2-methyl-9H-purine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057803; SCHEMBL12012483; BDBM50387884
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357339; SCHEMBL2508145; BDBM50039495
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
8-(2-Chlorophenyl)-9-cyclopropyl-2-methyl-6-(4-methylpiperazin-1-yl)purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057800; SCHEMBL14672381; BDBM50387882
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethyl]pyrrolidin-2-one;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092895; SCHEMBL14320856
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-Methyl-4-(4-methyl-1-piperidinyl)-6-phenylthieno[2,3-d]pyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057796; Oprea1_472358; ZINC390194; BDBM50387879; AKOS001136364; MCULE-3060004099
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
8-(2-Chlorophenyl)-6-[4-(2-fluoroethyl)piperazin-1-yl]-9-(2-methoxyethyl)-2-methylpurine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092891; SCHEMBL2513140; BDBM50494505
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-(2-Ethylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092889; SCHEMBL3342784; BDBM50494504
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4161451
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50450101
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4159535
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50450100
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3234686; SCHEMBL2511735; BDBM50006249
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Methyl-6-(4-ethyl-1-piperazinyl)-8-(2-chlorophenyl)-9-(2-methoxyethyl)-9H-purine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3139138; SCHEMBL12197618; BDBM50039497
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Chembl4167940
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50450099
Click to Show/Hide
|
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| Activity |
IC50 = 100000 nM
|
[10] | |||
| Compound Name |
8-(2-Chlorophenyl)-6-(4-ethylpiperazin-1-yl)-9-(2-methoxyethyl)-2-methylpurine;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2511696; CHEMBL3092908
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-(2-Chlorophenyl)-9-(1,3-dimethoxypropan-2-yl)-6-(4-ethylpiperazin-1-yl)-2-methylpurine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357338; SCHEMBL12197640; BDBM50039496
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-Methyl-8-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092888; SCHEMBL2485844; BDBM50494509
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Methyl N-[2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057802; SCHEMBL2552939; BDBM50387876
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(4-{2-Methyl-6-phenylthieno[2,3-d]pyrimidin-4-yl}piperazin-1-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057797; HMS1716A01; ZINC2622402; BDBM50387880; AKOS034154722; CCG-291126; MCULE-9974673600; AB00725774-01; Z31212661
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-((S)-1-{4-[4-Methoxy-2-(4-methoxy-benzenesulfonyl)-benzenesulfonyl]-phenyl}-ethyl)-3-p-tolyl-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426962; BDBM50160424
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[5] | |||
| Compound Name |
8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-[(3S)-oxolan-3-yl]purine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092898
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S)-2-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357340; SCHEMBL19475381; BDBM50039629
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-[8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]-2-methylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357342; SCHEMBL12197626; BDBM50039662
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Chembl4176556
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50450102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
8-(2-Chlorophenyl)-2-Methyl-6-(4-Methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine (hydrochloride)
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3340740; CHEMBL3092901
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-(2-Chloro-phenyl)-2-methyl-6-(4-methyl-piperazin-1-yl)-9-(tetrahydro-pyran-4-yl)-9h-purine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
LY2828360; CHEMBL3139186; UNII-O12H7VFU6P; O12H7VFU6P; SCHEMBL2486504; BCP29625; EX-A2735; BDBM50006250; HY-16642A; SB17392; CS-0067162; LY 2828360; LY-2828360; 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
8-(2-Cyclopropylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092887; SCHEMBL3341163; BDBM50494510
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-(4-Methoxy-2-methylphenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092890; BDBM50494519
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(Benzenesulfonyl)-3-[1-(2-piperidin-1-ylethyl)indol-3-yl]prop-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836187; BDBM50354137
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||||
| Activity |
Ki = 163400 nM
|
[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(3-Tert-butyl-1-methyl-1H-pyrazol-5-yl)-2-(4-chlorophenylsulfonyl)-2-methylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467029; SCHEMBL469410; BDBM50254147; ZINC40395804
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|
||||
| Activity |
EC50 = 223000 nM
|
[12] | |||
| Compound Name |
N-(Cyclobutylmethyl)-3-[[4-(methylsulfonylmethyl)naphthalene-1-carbonyl]amino]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316110; BDBM50424492
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|
||||
| Activity |
IC50 = 240000 nM
|
[6] | |||
| Compound Name |
(4-Fluoronaphthalen-1-yl)-(2-methyl-1-propylindol-3-yl)methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206854; BDBM50401072
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|
||||
| Activity |
EC50 = 268000 nM
|
[13] | |||
| Compound Name |
CID 23555598
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822940; BDBM50353086; N-[2-(4-fluorophenyl)ethyl]-7-methoxy-2-oxo-8-propoxy-1H-quinoline-3-carboxamide
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|
||||
| Activity |
Ki = 336000 nM
|
[14] | |||
| Compound Name |
N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-(4-chlorophenylsulfonyl)-2-methylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466603; BDBM50254104
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|
||||
| Activity |
EC50 = 700000 nM
|
[12] | |||
| Compound Name |
N-[2-(4-Fluorophenyl)ethyl]-8-hydroxy-7-methoxy-1-methyl-2-oxo-6-pentylquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822942; BDBM50353088
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|
||||
| Activity |
Ki = 864000 nM
|
[14] | |||
| Compound Name |
2-[2-Methyl-6-(4-methyl-piperazin-1-yl)-9-(tetrahydro-pyran-4-yl)-9h-purin-8-yl]-benzonitrile hydrochloride salt
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092885; SCHEMBL2490325; BDBM50494517
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[8] | |||
| Compound Name |
N-[2-(4-Fluorophenyl)ethyl]-8-hydroxy-7-methoxy-2-oxo-6-pentyl-1H-quinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822941; BDBM50353087
Click to Show/Hide
|
||||
| Activity |
Ki = 2398000 nM
|
[14] | |||
| Compound Name |
4-[[2-(Oxan-4-ylmethylcarbamoyl)pyridin-3-yl]carbamoyl]naphthalene-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316405; SCHEMBL5233160; BDBM50424480
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists. Bioorg Med Chem. 2015 Jan 1;23(1):241-63. | ||||
| REF 2 | Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds. Bioorg Med Chem Lett. 2015 Feb 1;25(3):581-6. | ||||
| REF 3 | Sulfonamide derivatives as new potent and selective CB2 cannabinoid receptor agonists. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5133-5. | ||||
| REF 4 | Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists. J Med Chem. 2013 Nov 14;56(21):8224-56. | ||||
| REF 5 | Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies. Bioorg Med Chem Lett. 2005 Feb 1;15(3):783-6. | ||||
| REF 6 | Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease. J Med Chem. 2013 Jan 10;56(1):220-40. | ||||
| REF 7 | Discovery and optimization of novel purines as potent and selective CB2 agonists. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4962-6. | ||||
| REF 8 | Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain. J Med Chem. 2013 Jul 25;56(14):5722-33. | ||||
| REF 9 | The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain. Bioorg Med Chem Lett. 2014 Dec 15;24(24):5572-5575. | ||||
| REF 10 | Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB 2 R affinity. Bioorg Med Chem. 2018 Oct 1;26(18):5069-5078. | ||||
| REF 11 | Homology modeling in tandem with 3D-QSAR analyses: a computational approach to depict the agonist binding site of the human CB2 receptor. Eur J Med Chem. 2011 Sep;46(9):4489-505. | ||||
| REF 12 | Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties. Bioorg Med Chem Lett. 2009 Jan 1;19(1):31-5. | ||||
| REF 13 | Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents. Bioorg Med Chem. 2012 Mar 15;20(6):2067-81. | ||||
| REF 14 | Fluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivatives. Bioorg Med Chem. 2011 Sep 15;19(18):5698-707. | ||||
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