Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79724 | Target Info | |||
| Target Name | Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) | ||||
| Synonyms |
PPPK; HPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
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| Target Type | Literature-reported Target | ||||
| Gene Name | Bact folK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-8-{[2-(3-Methylphenyl)-2-Oxoethyl]sulfanyl}-1,9-Dihydro-6h-Purin-6-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233208; BDBM50497029; Q27467738; 2-Amino-8-[2-(3-methylphenyl)-2-oxoethylthio]-9H-purine-6(1H)-one
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
2-Amino-8-{[2-(4-Methylphenyl)-2-Oxoethyl]sulfanyl}-1,7-Dihydro-6h-Purin-6-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233203; Oprea1_847137; BDBM50497030; Q27467743; 2-Amino-8-[2-(4-methylphenyl)-2-oxoethylthio]-9H-purine-6(1H)-one
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| Activity |
IC50 = 64000 nM
|
[1] | |||
| Compound Name |
2-Amino-8-[2-(4-fluorophenyl)-2-oxoethylthio]-9H-purine-6(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233205; Oprea1_306397; ZINC4396837; BDBM50497023; AKOS003262411
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| Activity |
IC50 = 79000 nM
|
[1] | |||
| Compound Name |
2-Amino-8-[2-(4-hydroxyphenyl)-2-oxoethylthio]-9H-purine-6(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233204; BDBM50497024
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| Activity |
IC50 = 82000 nM
|
[1] | |||
| Compound Name |
4-[2-(2-Amino-6-oxo-1,6-dihydro-9H-purine-8-ylthio)acetyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233206; BDBM50497025
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| Activity |
IC50 = 88000 nM
|
[1] | |||
| Compound Name |
5'-S-[1-(2-{[(2-Amino-4-Oxo-3,4-Dihydropteridin-6-Yl)methyl]amino}ethyl)piperidin-4-Yl]-5'-Thioadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928284; BDBM50484526; Q27461621; J1A
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Amino-8-[(2-Oxo-2-Phenylethyl)sulfanyl]-1,9-Dihydro-6h-Purin-6-One
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233201; Oprea1_012105; ZINC4639531; BDBM50031523; Q27467735
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| Activity |
IC50 = 139000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-8-{[2-(2-Methylphenyl)-2-Oxoethyl]sulfanyl}-1,7-Dihydro-6h-Purin-6-One
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233209; BDBM50497026; Q27467736; 2-Amino-8-[2-(2-methylphenyl)-2-oxoethylthio]-9H-purine-6(1H)-one
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| Activity |
IC50 = 243000 nM
|
[1] | |||
| Compound Name |
4-{[(2-Amino-6-Oxo-6,9-Dihydro-1h-Purin-8-Yl)sulfanyl]methyl}benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233202; Oprea1_352224; SCHEMBL12820932; ZINC4639554; BDBM50031533; Q27467740
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| Activity |
IC50 = 254000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Bioorg Med Chem. 2014 Apr 1;22(7):2157-65. | ||||
| REF 2 | Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties. Bioorg Med Chem. 2012 Jan 1;20(1):47-57. | ||||
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