Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83813 | Target Info | |||
| Target Name | 5-HT 2C receptor (HTR2C) | ||||
| Synonyms |
Serotonin receptor 2C; HTR1C; 5HT-1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-HT2C receptor; 5-HT2C; 5-HT1C; 5-HT-2C; 5-HT-1C
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| Target Type | Successful Target | ||||
| Gene Name | HTR2C | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 60 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CGS-12066B
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|
Terminated | Compound Info | ||
| Synonyms |
CGS 12066B; UNII-5TB4SXQ7HG; CGS 12066B-parent; Cgs 12066; CGS12066; 5TB4SXQ7HG; 109028-09-3; 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline; CHEMBL27403; CGS-12066B; CHEBI:64055; CGS-12066A; CGS-12066; CGS-12066A maleate salt; Pyrrolo[1,2-a]quinoxaline, 4-(4-methyl-1-piperazinyl)-7-(trifluoromethyl)-; Pyrrolo(1,2-a)quinoxaline, 4-(4-methyl-1-piperazinyl)-7-(trifluoromethyl)-; NCGC00024701-01; Tocris-0638; 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo-[1,2-a]quinoxaline maleate salt
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| Activity |
IC50 = 97723.72 nM
|
[1] | |||
| Compound Name |
Schembl21373237
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633656; BDBM50133682
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| Activity |
IC50 = 51286.14 nM
|
[2] | |||
| Compound Name |
Pindolol
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Investigative | Compound Info | ||
| Synonyms |
Visken; Prinodolol; Betapindol; Carvisken; Durapindol; Pinbetol; Calvisken; Decreten; Pectobloc; Pynastin; Blocklin L; LB-46; Pindololum; Glauco-visken; Blockin L; LB 46; Blocklin-L; 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole; l-Pindolol; 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol; 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole; 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-; Glauco-Viskin; NCGC00015786-11; (+-)-Pindolol; DSSTox_CID_3476; DL-Pindolol; Pindololum [INN-Latin]; (-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol; DSSTox_RID_77043; DSSTox_GSID_23476; Blocklin; Carvisken (TN); SMR000059120; Blocklin-L (TN); Visken (TN); CCRIS 9215; HSDB 6539; SR-01000000027; EINECS 236-867-9; EINECS 244-623-8; BRN 1536506; DL-LB 46; Prestwick_397; Pindolol [USAN:USP:INN:BAN:JAN]; Spectrum_001109; (.+/-.)-Pindolol; Prestwick0_000090; Prestwick1_000090; Prestwick2_000090; Prestwick3_000090; Spectrum2_001285; Spectrum3_000547; Spectrum4_000479; Spectrum5_001266; (R,S)-PINDOLOL; CHEMBL500; GTPL91; PINDOLOL,(-); P 0778; P-6820; SCHEMBL5219; Lopac0_000955; Oprea1_770884; BSPBio_000020; BSPBio_002193; KBioGR_000958; KBioSS_001589; 5-21-03-00017 (Beilstein Handbook Reference); DL-4-[2-Hydroxy-3-(isopropylamino)propoxy]indole; MLS000069496; MLS002548891; DivK1c_000837; SPECTRUM1500488; Pindolol (JP17/USP/INN); SPBio_001289; SPBio_001959; BPBio1_000022; DTXSID8023476; CTK8G2432; HMS502J19; KBio1_000837; KBio2_001589; KBio2_004157; KBio2_006725; KBio3_001693; NINDS_000837; HMS1568A22; HMS1920H16; HMS2089I21; HMS2091P20; HMS2095A22; HMS3259I07; HMS3262P12; HMS3267K17; HMS3369E14; HMS3414J03; HMS3678H21; HMS3712A22; HMS3742C07; HMS3885N04; Pharmakon1600-01500488; HY-B0982; Pindolol, >=98% (TLC), powder; Tox21_110221; Tox21_500955; BDBM50019443; CCG-39223; MFCD00010530; NSC757276; PDSP1_000771; PDSP1_000772; PDSP2_000759; PDSP2_000760; (+/-)-Pindolol-d7(iso-propyl-d7); AKOS015969756; Tox21_110221_1; CS-4473; DB00960; LP00955; MCULE-7764948919; NC00467; NSC-757276; SDCCGSBI-0050929.P005; IDI1_000837; NCGC00015786-06; NCGC00015786-07; NCGC00015786-08; NCGC00015786-09; NCGC00015786-10; NCGC00015786-13; NCGC00015786-14; NCGC00015786-16; NCGC00015786-20; NCGC00015786-22; NCGC00024925-03; NCGC00024925-04; NCGC00024925-05; NCGC00024925-06; NCGC00024925-07; NCGC00261640-01; SC-25688; SBI-0050929.P004; AB00052072; EU-0100955; FT-0673907; ST50319990; SW196641-3; Z3376; C07445; D00513; AB00052072-11; AB00052072_12; AB00052072_13; 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol; 523P869; L000006; Q418101; 3-indol-4-yloxy-1-[(methylethyl)amino]propan-2-ol; SR-01000000027-2; SR-01000000027-4; SR-01000000027-5; SR-01000000027-7; 1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol; BRD-A97701745-001-05-3; BRD-A97701745-001-09-5
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| Activity |
Ki = 54000 nM
|
[3] | |||
| Compound Name |
N-[(2S)-6-[(Dimethylamino)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216821; BDBM50241095
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| Activity |
IC50 = 55000 nM
|
[4] | |||
| Compound Name |
(S)-5-(4-Chlorophenyl)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylpicolinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215278; BDBM50198501
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| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
7-(4-Benzylpiperazin-1-yl)-10-methyl-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL54246; SCHEMBL8564666; BDBM50408161
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| Activity |
IC50 = 57543.99 nM
|
[1] | |||
| Compound Name |
8-Piperidin-1-yl-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63114; BDBM50407759
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| Activity |
IC50 = 57543.99 nM
|
[5] | |||
| Compound Name |
Ethyl 2-[4-(3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)piperazin-1-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293879; BDBM50407766
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| Activity |
IC50 = 61659.5 nM
|
[5] | |||
| Compound Name |
8-[4-(4-Fluorophenyl)piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63905; SCHEMBL7296725; BDBM50407771
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| Activity |
IC50 = 72443.6 nM
|
[5] | |||
| Compound Name |
N-(2,6-Dimethoxybenzyl)-4-bromo-2,5-dimethoxybenzeneethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589594; BDBM50097689
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| Activity |
EC50 = 87096.36 nM
|
[6] | |||
| Compound Name |
N-Methyl-4-oxo-N-phenyl-5-(4-(piperidin-1-ylmethyl)phenethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL385340; BDBM50200746
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
5-(4-((Diethylamino)methyl)phenethyl)-N-(4-fluorophenyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217861; BDBM50200738
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
2-(((8-((6-(4-Chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)methyl)quinolin-3-yl)methyl)(methyl)amino)-N,N-dimethylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215635; BDBM50191755
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-((3-((4-(methylsulfonyl)piperazin-1-yl)methyl)quinolin-8-yl)methyl)thieno[3,2-d]pyrimidin-4(3H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384302; BDBM50191759
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[(2S)-6-[[[2-(Dimethylamino)-2-oxoethyl]-methylamino]methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)-N-methylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214432; BDBM50198500
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5-[4-(4-Fluorobenzyl)-1-piperazinyl]pyrrolo[1,2-a]thieno[2,3-e]pyrazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL52772; BDBM50407789
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-7-chloropyrrolo[1,2-a]quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL416662; SCHEMBL8566070; BDBM50408166
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-(4-Phenylpiperazin-1-yl)-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL51225; SCHEMBL8564159; BDBM50408172
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Fluoro-phenyl)-N-(3-morpholin-4-ylmethyl-quinolin-8-ylmethyl)-nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215131; BDBM50191757
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-[4-[(2,4-Dichlorophenyl)methyl]piperazin-1-yl]-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50456; SCHEMBL8879665; BDBM50408158
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-N-(6-((4-Acetylpiperazin-1-yl)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-5-(4-fluorophenyl)-N-methylpicolinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213771; BDBM50198487
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-[[(6S)-6-[[4-(4-Fluorophenyl)benzoyl]-methylamino]-5,6,7,8-tetrahydronaphthalen-2-yl]methyl]piperazine-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL437728; BDBM50241096
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Propyl-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331806; SCHEMBL10436744; SCHEMBL10436745; BDBM50428897
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| Activity |
Ki = 100000 nM
|
[9] | |||
| Compound Name |
4-(4-Fluorophenyl)-N-methyl-N-[(2S)-6-[(3-oxopiperazin-1-yl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214178; BDBM50198504
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-(4-Benzylpiperazin-1-yl)-12-methoxy-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL300725; SCHEMBL8565028; BDBM50408174
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-((3-((4-hydroxypiperidin-1-yl)methyl)quinolin-8-yl)methyl)thieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL384548; BDBM50191752
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-((3-(pyrrolidin-1-ylmethyl)quinolin-8-yl)methyl)thieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL384156; BDBM50191768
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
8-(3,6-Dihydro-2H-pyridin-1-yl)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65212; SCHEMBL7302550; BDBM50407757
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(S)-6-(4-Fluorophenyl)-N-methyl-N-(6-((3-oxopiperazin-1-yl)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216429; BDBM50198497
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-Benzo[1,3]dioxol-5-yl-4-[4-(3-methoxy-benzyl)-piperazin-1-yl]-cyclohexanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100086; SCHEMBL9035305; BDBM50122411; 1-(1,3-Benzodioxole-5-yl)-4beta-[4-(3-methoxybenzyl)piperazino]cyclohexane-1alpha-ol
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
CID 20026449
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331793; BDBM50428892; 3-ethoxy-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepine
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| Activity |
Ki = 100000 nM
|
[9] | |||
| Compound Name |
(S)-N-(6-((Dimethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-4-(pyridin-2-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL267320; BDBM50198498
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-(4-Chlorophenyl)-3-((3-((4-methylpiperazin-1-yl)methyl)quinolin-8-yl)methyl)thieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL386507; BDBM50191753
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-(4-Benzylpiperazin-1-yl)-12-phenylmethoxy-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL51675; SCHEMBL8563543; BDBM50408153
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
12-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-6,11,17-triazatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2(7),3,5,8,11,13,15-octaene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL52867; BDBM50408163
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 4-(3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL63289; SCHEMBL7295524; BDBM50407761
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-7-methylpyrrolo[1,2-a]quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL300692; SCHEMBL8567127; BDBM50408159
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(2S)-6-[(4-Acetylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL261964; BDBM50198494
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7,12-Bis(4-benzylpiperazin-1-yl)-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53195; SCHEMBL8570453; BDBM50408169
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Ethyl 4-(2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaen-7-yl)piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL52007; SCHEMBL8566903; BDBM50408160; 4-[4-(Ethoxycarbonyl)piperazine-1-yl]-5,9,9b-triaza-9bH-benzo[e]indene
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
8-(4-Phenylpiperidin-1-yl)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63588; SCHEMBL7297168; BDBM50407778
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(4-Fluorophenyl)-N-methyl-4-oxo-5-(4-(piperidin-1-ylmethyl)phenethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217140; BDBM50200749
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S)-1-[[(6S)-6-[[4-(4-Fluorophenyl)benzoyl]-methylamino]-5,6,7,8-tetrahydronaphthalen-2-yl]methyl]-N,N-dimethylpyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL424895; BDBM50198491
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Fluorophenyl)-1-oxo-2-(4-(piperidin-1-ylmethyl)phenethyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217351; BDBM50200747
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| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
(S)-N-(6-((Dimethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-4-(pyridin-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216187; BDBM50198503
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[(2S)-6-[(1,1-Dioxo-1,4-thiazinan-4-yl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)-N-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217860; BDBM50198492
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-Fluorophenyl)-4-oxo-5-(4-(piperidin-1-ylmethyl)phenethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408198; BDBM50200744
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[7] | |||
| Compound Name |
8-(4-Phenylpiperazin-1-yl)-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302104; SCHEMBL7297117; BDBM50407793
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(S)-N-(6-((Dimethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-4-(pyridin-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216050; BDBM50198488
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-12-methoxy-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(9),3,5,7,10,12-hexaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL52800; SCHEMBL8565934; BDBM50408156
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-Chloro-4-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]pyrrolo[1,2-a]quinoxaline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL410531; SCHEMBL8571686; BDBM50408175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-10-methyl-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL298649; SCHEMBL8570048; BDBM50408176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(4-Fluorophenyl)-[4-(3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaen-8-yl)piperazin-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417570; BDBM50407764
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(4-Fluorophenyl)-N-[[3-[(4-methylsulfonylpiperidin-1-yl)methyl]quinolin-8-yl]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214916; BDBM50191767
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[(2S)-6-[(1,1-Dioxo-1,4-thiazinan-4-yl)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methyl-4-pyridin-2-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217501; BDBM50198496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(S)-N-(6-((4-Acetylpiperazin-1-yl)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-4-(pyridin-2-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268848; BDBM50198489
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
8-(4-Benzylpiperazino)pyrido[2,3-h]pyrrolo[1,2-a]quinoxaline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50740; BDBM50408154
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-7-methoxypyrrolo[1,2-a]quinoxaline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53662; SCHEMBL8565546; BDBM50408152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
8-[4-(4-Chlorophenyl)piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66310; SCHEMBL7303793; BDBM50407781
Click to Show/Hide
|
||||
| Activity |
IC50 = 102329.3 nM
|
[5] | |||
| Compound Name |
8-(4-Benzylpiperazin-1-yl)-4,5-dimethyl-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62612; BDBM50407751
Click to Show/Hide
|
||||
| Activity |
IC50 = 154881.66 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 30 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Schembl21373240
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633663; BDBM50133685
Click to Show/Hide
|
||||
| Activity |
IC50 = 208929.61 nM
|
[2] | |||
| Compound Name |
2-[Methyl-(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-phenyl-1H-indol-3-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633650; SCHEMBL21373244; BDBM50133676; ZINC57473783; AKOS027324569; Z90240217; 2-{methyl[2-(morpholin-4-yl)-2-oxoethyl]amino}-1-(2-phenyl-1H-indol-3-yl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 213796.21 nM
|
[2] | |||
| Compound Name |
4-Phenyl-8-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293219; SCHEMBL7296823; BDBM50407775
Click to Show/Hide
|
||||
| Activity |
IC50 = 213796.21 nM
|
[5] | |||
| Compound Name |
Schembl21373245
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3633665; BDBM50133679
Click to Show/Hide
|
||||
| Activity |
IC50 = 269000 nM
|
[2] | |||
| Compound Name |
8-[4-[(4-Chlorophenyl)-phenylmethyl]piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66307; SCHEMBL7296930; BDBM50407776
Click to Show/Hide
|
||||
| Activity |
IC50 = 281838.29 nM
|
[5] | |||
| Compound Name |
4h-Isoxazolo[4,5-d]azepine,5,6,7,8-tetrahydro-3-methoxy-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331792; ZINC11259; BDBM50428893; 3-methoxy-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepine
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[9] | |||
| Compound Name |
3-Methoxy-6-methyl-4,5,7,8-tetrahydro-[1,2]oxazolo[4,5-d]azepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331795; BDBM50428901
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[9] | |||
| Compound Name |
2-Ethyl-6-methyl-4,5,7,8-tetrahydro-[1,2]oxazolo[4,5-d]azepin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331791; SCHEMBL10436564; SCHEMBL10436565; BDBM50428894
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[9] | |||
| Compound Name |
CID 14515722
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331804; BDBM50428899; 2-methyl-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepin-3-one
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[9] | |||
| Compound Name |
3-Ethoxy-6-methyl-4,5,7,8-tetrahydro-[1,2]oxazolo[4,5-d]azepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331796; BDBM50428900
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[9] | |||
| Compound Name |
2-Ethyl-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331805; SCHEMBL10436608; SCHEMBL10576605; BDBM50428898
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[9] | |||
| Compound Name |
5,6,7,8-Tetrahydro-4H-isoxazolo(4,5-d)azepin-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309689; 5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepin-3-one; 5,6,7,8-tetrahydro-4H-isoxazolo-[4,5-d]azepin-3-ol; SCHEMBL7412843; DTXSID00201893; 5,6,7,8-Tetrahydro-2H-isoxazolo(4,5-d)azepin-3(4H)-one; BDBM50224808; ZINC13859296; AKOS023622247; 5,6,7,8-tetrahydro-4h-isoxazolo-[ 4,5-d]azepin-3-ol; 2H-Isoxazolo(4,5-d)azepin-3(4H)-one, 5,6,7,8-tetrahydro-; 5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-d]azepin-6-ium-3-olate
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[9] | |||
| Compound Name |
2,6-Dimethyl-4,5,7,8-tetrahydro-[1,2]oxazolo[4,5-d]azepin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331808; BDBM50428895
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[9] | |||
| Compound Name |
8-(4-Benzylpiperazin-1-yl)-4-phenyl-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66540; SCHEMBL7298138; BDBM50407782
Click to Show/Hide
|
||||
| Activity |
IC50 = 467735.14 nM
|
[5] | |||
| Compound Name |
2-Benzyl-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331801; BDBM50428907
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-Ethyl-4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331797; BDBM50428911
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
8-(4-Benzylpiperazin-1-yl)-4-phenyl-5-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaene
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66408; SCHEMBL7294021; BDBM50407779
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[5] | |||
| Compound Name |
2-Benzyl-5,6,7,8-tetrahydro-4H-[1,2]oxazolo[4,5-c]azepin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331802; BDBM50428906
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-Ethyl-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331800; BDBM50428908
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-Methyl-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331799; BDBM50428909
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
3-Ethoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2331798; BDBM50428910
Click to Show/Hide
|
||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899832; SCHEMBL3163790; BDBM50207400
Click to Show/Hide
|
||||
| Activity |
Ki > 7870000 nM
|
[11] | |||
| Compound Name |
3-[(Dipropylamino)methyl]-5-methoxy-N,N-dipropyl-2,4-dihydrochromen-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416336; BDBM50421374
Click to Show/Hide
|
||||
| Activity |
IC50 = 2.14E+12 nM
|
[12] | |||
| Compound Name |
4'-Benzyl-5-methoxy-1'-propylspiro[2,4-dihydrochromene-3,2'-piperazine]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL275481; BDBM50421375
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.29E+13 nM
|
[12] | |||
| Compound Name |
8-[4-(5-Methoxy-4'-propylspiro[2,4-dihydrochromene-3,3'-piperazine]-1'-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11409; BDBM50421377
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.24E+13 nM
|
[12] | |||
| Compound Name |
5-Methoxy-1',4'-dipropylspiro[2,4-dihydrochromene-3,2'-piperazine]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438755; BDBM50421376
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.31E+13 nM
|
[12] | |||
| Compound Name |
8-[4-[5'-Methoxyspiro[pyrrolidine-2,3'(4'H)-[2H-1]benzopyran]-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11265; BDBM50054143; L009549
Click to Show/Hide
|
||||
| Activity |
IC50 = 9.55E+13 nM
|
[12] | |||
| Compound Name |
8-[4-[(5-Methoxy-3,4-dihydro-2H-chromen-3-yl)methyl-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417608; BDBM50421370
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.16E+14 nM
|
[12] | |||
| Compound Name |
8-[4-(3,4-Dihydro-2H-chromen-3-ylmethylamino)butyl]-8-azaspiro[4.5]decane-7,9-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11425; BDBM50421371
Click to Show/Hide
|
||||
| Activity |
IC50 = 8.13E+14 nM
|
[12] | |||
| Compound Name |
8-[4-[(5-Methoxy-3,4-dihydro-2H-chromen-3-yl)methylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416523; BDBM50421373
Click to Show/Hide
|
||||
| Activity |
IC50 = 5.89E+15 nM
|
[12] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. J Med Chem. 1997 Jun 6;40(12):1808-19. | ||||
| REF 2 | Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. J Med Chem. 2015 Nov 25;58(22):8938-51. | ||||
| REF 3 | Central serotonin receptors as targets for drug research. J Med Chem. 1987 Jan;30(1):1-12. | ||||
| REF 4 | Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG. Bioorg Med Chem Lett. 2007 Feb 1;17(3):814-8. | ||||
| REF 5 | Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. J Med Chem. 1996 May 10;39(10):2068-80. | ||||
| REF 6 | Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. Bioorg Med Chem. 2015 Jul 15;23(14):3933-7. | ||||
| REF 7 | Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists. Bioorg Med Chem Lett. 2007 Feb 1;17(3):657-61. | ||||
| REF 8 | Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5207-11. | ||||
| REF 9 | Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. J Med Chem. 2013 Feb 14;56(3):1211-27. | ||||
| REF 10 | Development of a presynaptic 5-HT1A antagonist. Bioorg Med Chem Lett. 2003 Jan 20;13(2):285-8. | ||||
| REF 11 | Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett. 2017 Jan 15;27(2):323-328. | ||||
| REF 12 | Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives. Bioorg Med Chem Lett. 1996 May 21;6(10):1077-82. | ||||
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