Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84631 | Target Info | |||
| Target Name | Coagulation factor Xa (F10) | ||||
| Synonyms |
Fxa; Factor Xa; F10; Activated coagulation factor X
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| Target Type | Successful Target | ||||
| Gene Name | F10 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 259 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Argatroban
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|
Approved | Compound Info | ||
| Synonyms |
Acova; Argatrobanum; MMTQAP; MPQA; Novastan; Argatrobanum [Latin]; MITSUBISHI INHIBITOR; MCI 9038; MD 805; MD805; Argatroban (anhydrous); Argatroban [INN:JAN]; GN-1600; MCI-9038; MD-805; MQI-ARG-MCP; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-1-[5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid; (2R,4R)-4-Methyl-1-((S)-N(sup 2)-(((RS)-1,2,3,4-tetrahydro-3-methyl-8-quinolyl)sulfonyl)arginyl)pipecolic acid; (2R,4R)-4-Methyl-1[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl)]-2-piperadinecarboxylic acid; (2r,4r)-4-methyl-1-[n2-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-l-arginyl]-2-piperidinecarboxylic acid; 21R-Argatroban; 4-methyl-1-(N(2)-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl)-2-piperidinecarboxylic acid
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
Hexamethylene amiloride
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Preclinical | Compound Info | ||
| Synonyms |
5-(N,N-Hexamethylene)amiloride; 5-HMA; BIDD; BSPBio_003443; C12H18ClN7O; DivK1c_006875; HMA; HMA-5; Hexamethyleneamiloride; KBioGR_001206; KBioSS_002076; Lopac-A-9561; Lopac0_000104; MLS002153208; N,N-HEXAMETHYLENEAMILORIDE; SPECTRUM1504215; SpecPlus_000779; Spectrum2_001669; Spectrum3_001662; Spectrum4_000623; Spectrum5_001388; Spectrum_001596
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
PF-429242
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Investigative | Compound Info | ||
| Synonyms |
947303-87-9; PF-429242; (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide; UNII-49WB3OA7VN; 49WB3OA7VN; PF 429242; PF429242; CHEMBL233611; J-502224; C25H35N3O2; 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide; (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benz amide; (-)-PF-429242; SCHEMBL2742702; CTK8B5018; DTXSID00635376; EX-A1409; ANW-47048; ZINC28823615; BDBM50216181; AKOS015998619; RL05965; Benzamide, 4-((diethylamino)methyl)-N-(2-(
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
Chembl4217043
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Investigative | Compound Info | ||
| Synonyms |
3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide; BDBM50459059; 30I
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
8-Methoxy-2-oxo-N-phenylchromene-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
8-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide; Oprea1_190668; Oprea1_689234; SCHEMBL981812; CHEMBL493603; IFLab1_000844; BDBM23550; 8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid phenylamide; HMS1414G08; ZINC208754; 3-Carboxamide-coumarin deriv., 40; AKOS000421085; MCULE-6503315868; (8-methoxy-2-oxochromen-3-yl)-N-benzamide; ST50102332; SR-01000520069; SR-01000520069-1; F0249-0129
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 43
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521526; BDBM23566; 6,8-dichloro-N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 46
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL495155; BDBM23568; 8-bromo-6-chloro-N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Phenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL13357; NSC716525; SCHEMBL14642286; BDBM23563; CTK6H6599; 3-Carboxylate-coumarin deriv., 3; NSC-716525; NCI60_040286; 2-Oxo-6-chloromethyl-2H-1-benzopyran-3-carboxylic acid phenyl ester
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2R)-2-[[(2R)-2-[[2-[[2-[[2-[[(2S)-2-[[(1R,7S,10S,13S,16S,22S,25S,28S,40R,43S,46S,49S,52S,58S,61S)-40-Acetamido-43,52-bis(2-amino-2-oxoethyl)-13-(carboxymethyl)-46-[(1R)-1-hydroxyethyl]-10,49,61-tris(1H-indol-3-ylmethyl)-16-methyl-25-(2-methylpropyl)-2,8,11,14,17,23,26,41,44,47,50,53,59,62-tetradecaoxo-30,38,65-trithia-3,9,12,15,18,24,27,42,45,48,51,54,60,63-tetradecazahexacyclo[32.29.3.132,36.03,7.018,22.054,58]heptahexaconta-32,34,36(67)-triene-28-carbonyl]amino]propanoyl]-methylamino]acetyl]-methylamino]acetyl]-methylamino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059991; BDBM50256261
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4208878
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Investigative | Compound Info | ||
| Synonyms |
BDBM50459529
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(7R,10S,13S,21S,24S,27S,30S,33S,36S,39S,42S,45R)-7-Acetamido-36-(3-amino-3-oxopropyl)-13-benzyl-24-(4-carbamimidamidobutyl)-39-(carboxymethyl)-10-(hydroxymethyl)-21-[(4-hydroxyphenyl)methyl]-33-(1H-imidazol-5-ylmethyl)-30-methyl-42-(2-methylpropyl)-8,11,14,19,22,25,28,34,37,40,43-undecaoxo-5,47,52-trithia-9,12,15,20,23,26,29,32,35,38,41,44-dodecazatetracyclo[25.23.3.13,49.015,18]tetrapentaconta-1,3(54),49-triene-45-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094403; BDBM50256260
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-Oxo-N-phenyl-3H-benzo[f]chromene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
Oprea1_332334; Oprea1_401977; CHEMBL495038; 3-Oxo-3H-benzo[f]chromene-2-carboxylic acid phenylamide; BDBM23551; 3-Carboxamide-coumarin deriv., 48; STK042072; ZINC12062408; AKOS000511888; CCG-311417; MCULE-4505918310; EU-0036469; SR-01000416840; SR-01000416840-1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Carboxamide-coumarin deriv., 4
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Investigative | Compound Info | ||
| Synonyms |
NSC716527; CHEMBL274376; BDBM23544; NSC-716527; NCI60_040288; 6-(chloromethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide; 6-Chloromethyl-N-phenyl-2-oxo-2H-1-benzopyran-3-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Chembl4207715
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Investigative | Compound Info | ||
| Synonyms |
BDBM50459055
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
3-[(1R,3As,8bS)-1-(5-amino-5-iminopentyl)-2-oxo-3-(5-phenylpentyl)-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrol-7-yl]-N,N-diethylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL296972; BDBM50078547
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
7-Hydroxy-2-oxo-N-phenyl-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
7-hydroxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide; EINECS 302-422-3; 7-hydroxy-2-oxo-N-phenylchromene-3-carboxamide; Oprea1_567475; Oprea1_613532; CHEMBL508427; SCHEMBL10980649; BDBM23552; CTK5H5054; DTXSID10240591; ZINC193181; 3-Carboxamide-coumarin deriv., 37; STK057369; AKOS000511885; MCULE-8391530313; NCGC00343225-01; EU-0034812; AB00124768-02; SR-01000400262; SR-01000400262-1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4213248; 50I; BDBM50459054
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
7-Methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_813820; CHEMBL447503; BDBM23553; ZINC192815; 3-Carboxamide-coumarin deriv., 38; STL376493; AKOS000415407; MCULE-1646989031; ST066313; (7-methoxy-2-oxochromen-3-yl)-N-benzamide; SR-01000399886; SR-01000399886-1
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Ethyl 3-[2-(4-Carbamimidoylbenzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-ylamino]-3-oxo-2-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461191; BDBM50253717
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| Activity |
Ki = 50300 nM
|
[8] | |||
| Compound Name |
2-[6-(3-Carbamimidoylphenoxy)-3,5-difluoro-4-[[(2R)-4-phenylbutan-2-yl]amino]pyridin-2-yl]oxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL193709; BDBM50172233
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| Activity |
IC50 = 51000 nM
|
[9] | |||
| Compound Name |
3-[[4-(Diaminomethylideneamino)phenyl]methylamino]-N-(2-hydroxyethyl)imidazo[1,2-a]pyridine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740904; BDBM50499919
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| Activity |
IC50 = 51580 nM
|
[10] | |||
| Compound Name |
1-(4-Chlorobenzoyl)-6-methoxy-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084611; BDBM50259081
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| Activity |
IC50 = 52000 nM
|
[11] | |||
| Compound Name |
(2S)-N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL338788; BDBM50060747
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| Activity |
Ki = 52000 nM
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[12] | |||
| Compound Name |
2-(5-Carbamimidoyl-benzofuran-2-yl)-3-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL279367; BDBM50041230; 4-[[(3S)-Pyrrolidin-3beta-yl]oxy]-alpha-(5-amidinobenzofuran-2-yl)benzenepropionic acid ethyl ester
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| Activity |
IC50 = 52000 nM
|
[13] | |||
| Compound Name |
N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-2,2-dichloroacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330474; SCHEMBL17267446; BDBM50024370
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| Activity |
IC50 = 52690 nM
|
[14] | |||
| Compound Name |
4-[[(2-Methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL39760; BDBM50141558
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| Activity |
Ki = 53000 nM
|
[15] | |||
| Compound Name |
(2S)-2-[[2-(4-Chlorophenyl)acetyl]amino]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040985; BDBM50386273
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| Activity |
IC50 = 54000 nM
|
[16] | |||
| Compound Name |
(2S)-N-[[3-[3-(4-Amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-2-hydroxyphenyl]phenyl]methyl]-2-hydroxy-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL212401; BDBM50189937
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| Activity |
Ki = 54000 nM
|
[17] | |||
| Compound Name |
(2R)-N-[(2S)-4-(Benzylamino)-3,4-dioxo-1-piperidin-4-ylbutan-2-yl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL283570; BDBM50076953
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| Activity |
IC50 = 54000 nM
|
[18] | |||
| Compound Name |
Acetic acid;1-[4-[(5S)-5-[[(4-carbamimidoylphenyl)methylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391198
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| Activity |
Ki = 54100 nM
|
[19] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391038
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| Activity |
Ki = 54400 nM
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[19] | |||
| Compound Name |
(S)-3-{[2-(4-Carbamimidoyl-benzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl]-amino}-3-phenyl-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL511597; CHEMBL191912; BDBM50165961; BDBM50253682
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| Activity |
Ki = 54600 nM
|
[8] | |||
| Compound Name |
3-Hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64654; BDBM50115894
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| Activity |
Ki = 55000 nM
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[20] | |||
| Compound Name |
US8569313, Inhibitor 35
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466585; SCHEMBL8201046; SCHEMBL19309576; BDBM104920; BDBM50254024
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| Activity |
Ki = 55000 nM
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[21] | |||
| Compound Name |
Ethyl 1-[(4-carbamimidoylphenyl)methyl]indole-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL420070; SCHEMBL6436953
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| Activity |
Ki = 55000 nM
|
[22] | |||
| Compound Name |
2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-methyl-3-phenyl-propylamino)-pyridin-2-yloxy]-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364066; BDBM50172230
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-3-methyl-2-oxopiperidine-3-carboxylate;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391186
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| Activity |
Ki = 55600 nM
|
[19] | |||
| Compound Name |
(3S)-2-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040959; BDBM50386249
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| Activity |
IC50 = 56000 nM
|
[16] | |||
| Compound Name |
3-[(2S)-3-[4-(3-Carbamimidamidopropanoyl)piperazin-1-yl]-2-(naphthalene-2-sulfonamido)-3-oxopropyl]benzene-1-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL212271; BDBM23880; 3-amidinophenylalanine deriv., 24
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| Activity |
Ki = 56000 nM
|
[23] | |||
| Compound Name |
1-Carbamimidoyl-N-(3-(4-fluorobenzyloxy)phenyl)piperidine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL490892; BDBM50292885
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| Activity |
Ki = 57000 nM
|
[24] | |||
| Compound Name |
1-Ethanimidoyl-N-[3-[(4-fluorophenyl)methoxy]phenyl]piperidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441065; BDBM50442102
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| Activity |
Ki = 57300 nM
|
[25] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[(2-amino-5,6,7,8-tetrahydroquinazolin-6-yl)methyl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL164239; BDBM50124084
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| Activity |
Ki = 57600 nM
|
[26] | |||
| Compound Name |
1-[4-[(5R)-5-[[(3-Amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391202; BDBM50435608
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| Activity |
Ki = 57700 nM
|
[19] | |||
| Compound Name |
Methyl 2-benzyl-3-(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-ylamino)-3-oxopropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466529; BDBM50261624
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| Activity |
Ki = 58700 nM
|
[27] | |||
| Compound Name |
(2S)-N-[[4-[(Z)-C-Aminocarbonohydrazonoyl]thiophen-2-yl]methyl]-1-[(2R)-2-(methanesulfonamido)-3,3-diphenylpropanoyl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414606; BDBM50111112
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| Activity |
Ki = 59000 nM
|
[28] | |||
| Compound Name |
2-[6-(3-Carbamimidoylphenoxy)-3,5-difluoro-4-(4-phenylbutan-2-ylamino)pyridin-2-yl]oxy-5-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194618
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[9] | |||
| Compound Name |
5-Chloro-thiophene-2-carboxylic acid {(R)-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-ethyl}-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184686; SCHEMBL4026975; BDBM50155613; ZINC28385502; 5-chloro-N-[(2R)-1-oxo-1-[4-(3-oxomorpholin-4-yl)anilino]propan-2-yl]thiophene-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[29] | |||
| Compound Name |
{(S)-1-[(S)-2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidine-1-carbonyl]-4-guanidino-butyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40765; BDBM50084008
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[30] | |||
| Compound Name |
2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168471; SCHEMBL3913553; BDBM50124010; ZINC13493521
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[31] | |||
| Compound Name |
(2,2-Difluoro-2-piperidin-2-yl-ethyl)-[2-(2-[1,2,4]triazol-1-yl-benzyl)-benzooxazol-4-yl]-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372108; SCHEMBL6924216; BDBM50172840
Click to Show/Hide
|
||||
| Activity |
Ki = 60000 nM
|
[32] | |||
| Compound Name |
N-{3-[(S)-2-[4-(2-Amino-ethyl)-piperidin-1-yl]-1-(3-carbamimidoyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-3-hydroxy-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513339; SCHEMBL12998769; BDBM50254220; US8569313, 68
Click to Show/Hide
|
||||
| Activity |
Ki = 61000 nM
|
[21] | |||
| Compound Name |
N-[2-(5,6-Dimethyl-1h-Benzimidazol-2-Yl)ethyl]-4-(4h-1,2,4-Triazol-4-Yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423033; AKOS030471270; Q27454772; 4K6
Click to Show/Hide
|
||||
| Activity |
Ki ~ 62500 nM
|
[33] | |||
| Compound Name |
4-Cyano-2-fluoro-N-(10-hydroxy-2,7-dimethyl-3,4-dihydro-1H-pyrido[1,2-b]indazol-2-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3423046; BDBM50083228
Click to Show/Hide
|
||||
| Activity |
Ki ~ 62500 nM
|
[33] | |||
| Compound Name |
Acetic acid;1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391197
Click to Show/Hide
|
||||
| Activity |
Ki = 62900 nM
|
[19] | |||
| Compound Name |
1-(4-Aminophenyl)-N-[3-[(4-fluorophenyl)methoxy]phenyl]piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441059; BDBM50442097
Click to Show/Hide
|
||||
| Activity |
Ki = 63500 nM
|
[25] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-((S)-2-methyl-cyclohexyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293892; 1o5c; 1o5f; BDBM50115869
Click to Show/Hide
|
||||
| Activity |
Ki = 65000 nM
|
[34] | |||
| Compound Name |
Benzyl (R)-1-((S)-1-(1-(diphenoxyphosphoryl)-4-guanidinobutylamino)-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL311067; BDBM50145688
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[35] | |||
| Compound Name |
4-{4-[5-(2,6-Dimethyl-piperidin-1-yl)-pentyl]-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl}-N-hydroxy-benzamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130967; BDBM50093321
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[36] | |||
| Compound Name |
5-Chloro-thiophene-2-carboxylic acid {(R)-2-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-propyl}-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360856; SCHEMBL4032250; BDBM50155625; ZINC28455293
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[29] | |||
| Compound Name |
4-[[(Naphthalen-2-ylsulfonylamino)-(piperidine-1-carbonyl)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41220; BDBM50141560
Click to Show/Hide
|
||||
| Activity |
Ki = 66000 nM
|
[15] | |||
| Compound Name |
3-[(2S)-3-[4-(3-Aminopropyl)piperidin-1-yl]-2-(naphthalene-2-sulfonamido)-3-oxopropyl]benzene-1-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210815; BDBM23906; 3-amidinophenylalanine deriv., 49
Click to Show/Hide
|
||||
| Activity |
Ki = 66000 nM
|
[23] | |||
| Compound Name |
3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59936; BDBM50115899
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[20] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(2-chloro-4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111468; SCHEMBL4417768; SCHEMBL13885759; BDBM50147490
Click to Show/Hide
|
||||
| Activity |
Ki = 69000 nM
|
[37] | |||
| Compound Name |
(3R)-1-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040989; BDBM50386276
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[16] | |||
| Compound Name |
4-[[Azepane-1-carbonyl-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288862; SCHEMBL14289382; BDBM50141565
Click to Show/Hide
|
||||
| Activity |
Ki = 69000 nM
|
[15] | |||
| Compound Name |
2-(1H-Benzo[d]imidazol-2-yl)-1H-benzo[d]imidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202010; BDBM50176244
Click to Show/Hide
|
||||
| Activity |
Ki = 72000 nM
|
[38] | |||
| Compound Name |
2-[2-(Benzenesulfonyl)-4-(benzyloxy)-5-methoxyphenyl]-N-benzyl-2-[(4-carbamimidoylphenyl)amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
phenylglycine amide compound 8; CHEMBL180104; BDBM13582
Click to Show/Hide
|
||||
| Activity |
Ki ~ 74000 nM
|
[39] | |||
| Compound Name |
Ethyl 4-{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-ylamino}-4-oxobutanoate acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494715; BDBM50253312
Click to Show/Hide
|
||||
| Activity |
Ki = 74700 nM
|
[8] | |||
| Compound Name |
2-[3-(2-Chloro-4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109546; SCHEMBL4424824; BDBM50147486
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[37] | |||
| Compound Name |
4-[[[(6-Methoxynaphthalen-2-yl)sulfonylamino]-(4-methylpiperidine-1-carbonyl)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291101; BDBM50141570
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
N'-Hydroxy-4-[[(2-methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL37857; BDBM50141571
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
N'-Hydroxy-4-[[[(6-methoxynaphthalen-2-yl)sulfonylamino]-(4-methylpiperidine-1-carbonyl)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39590; BDBM50141569
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
N'-Hydroxy-4-[[(4-methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39911; BDBM50141567
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
6-Hydroxy-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127407; BDBM50106242; 6-Hydroxy-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[40] | |||
| Compound Name |
CID 10117543
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL38491; SCHEMBL5109223; BDBM50141561
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
2-(2-Hydroxy-3-ethoxyphenyl)-6-chloro-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62378; BDBM50115862; 6-Chloro-2-(3-ethoxy-2-hydroxy-phenyl)-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[34] | |||
| Compound Name |
6-Methyl-2-(2-hydroxy-3-biphenylyl)-1H-indole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127278; BDBM50106243; 2-(2-Hydroxy-biphenyl-3-yl)-6-methyl-1H-indole-5-carboxamidine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[40] | |||
| Compound Name |
N'-Hydroxy-4-[[(naphthalen-2-ylsulfonylamino)-(piperidine-1-carbonyl)amino]methyl]benzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36960; BDBM50141556
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
CID 10228506
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39078; SCHEMBL5115446; BDBM50141562
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
4-[[Azepane-1-carbonyl-(naphthalen-2-ylsulfonylamino)amino]methyl]-N'-hydroxybenzenecarboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39587; BDBM50141564
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75000 nM
|
[15] | |||
| Compound Name |
(S)-1-((R)-3-Cyclohexyl-2-phenylmethanesulfonylamino-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-5,6,7,8-tetrahydro-quinazolin-6-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165006; SCHEMBL6094266; BDBM50124082
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164915; SCHEMBL6096030; BDBM50124076
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3-(3,4-dichlorophenyl)propanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423266; SCHEMBL6181640; BDBM50124075
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
((R)-1-(3,4-Dichloro-benzyl)-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL166536; BDBM50124077
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
(S)-1-((R)-3-Cyclohexyl-2-phenylmethanesulfonylamino-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168071; SCHEMBL6094898; BDBM50124079
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3-(3,4-dichlorophenyl)propanoyl]-N-[(2-amino-5,6,7,8-tetrahydroquinazolin-6-yl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348735; SCHEMBL6181089; BDBM50124080
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
[(R)-2-{(S)-2-[(2-Amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-(3,4-dichloro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164221; BDBM50124081
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-yl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL167782; SCHEMBL6093332; BDBM50124078
Click to Show/Hide
|
||||
| Activity |
Ki ~ 75400 nM
|
[26] | |||
| Compound Name |
3-[(2S)-3-[4-(2-Aminoethyl)piperidin-1-yl]-2-(naphthalene-2-sulfonamido)-3-oxopropyl]benzene-1-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211939; SCHEMBL12960532; BDBM23901; 3-amidinophenylalanine deriv., 45
Click to Show/Hide
|
||||
| Activity |
Ki = 76000 nM
|
[23] | |||
| Compound Name |
N-[3-[(4-Fluorophenyl)methoxy]phenyl]-1-pyridin-2-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441061; BDBM50442098
Click to Show/Hide
|
||||
| Activity |
Ki = 78000 nM
|
[25] | |||
| Compound Name |
3-Hydroxy-4-methoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294509; BDBM50115905
Click to Show/Hide
|
||||
| Activity |
Ki ~ 78000 nM
|
[20] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082857
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[41] | |||
| Compound Name |
Diphenyl 1-[(N-benzoyloxycarbonyl-D-seryl)-L-alanyl]amino-2-(4-guanidinophenyl)ethanephosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL80844; BDBM50145689
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[35] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-(6-methyl-2-oxo-3-p-tolylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111160; BDBM50147487
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[37] | |||
| Compound Name |
2-Chlorobenzenesulfonic acid 3-methyl-5-(1-amidinopiperidine-4-ylmethoxy)phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41876; SCHEMBL7446067; BDBM50070597; 2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-4-ylmethoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[42] | |||
| Compound Name |
2-[(E)-1-[3-(Benzenesulfonamido)-5-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]ethylideneamino]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644912; BDBM50333192
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[43] | |||
| Compound Name |
3-Amidinophenylalanine deriv., 28
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL211549; BDBM23884
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[23] | |||
| Compound Name |
(2S)-N-[5-(Diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(2R)-2-phenylpropanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320098; 1-(2-Phenyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide; BDBM50046353
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[44] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[6-methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109217; SCHEMBL4422054; SCHEMBL13885838; BDBM50147478
Click to Show/Hide
|
||||
| Activity |
Ki = 81000 nM
|
[37] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL442980; SCHEMBL6179483; BDBM50124073
Click to Show/Hide
|
||||
| Activity |
Ki = 82100 nM
|
[26] | |||
| Compound Name |
Ethyl 1-[4-[(5R)-5-[[(3-amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391200; BDBM50435610
Click to Show/Hide
|
||||
| Activity |
Ki = 82300 nM
|
[19] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-((S)-2-methyl-4,4-dimethyl-cyclopentyloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61442; BDBM50115872
Click to Show/Hide
|
||||
| Activity |
Ki = 83000 nM
|
[34] | |||
| Compound Name |
(S)-5-Guanidino-N-((S)-1-((S)-5-guanidino-1-(3-guanidinopropylamino)-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-2-(2-phenylacetamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL569280; BDBM50303777
Click to Show/Hide
|
||||
| Activity |
Ki = 83000 nM
|
[45] | |||
| Compound Name |
((R)-1-Cyclohexylmethyl-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethylamino)-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164985; BDBM50124071
Click to Show/Hide
|
||||
| Activity |
Ki = 84800 nM
|
[26] | |||
| Compound Name |
alpha-Ketothiazole analogue 16
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384603; BDBM12956
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[46] | |||
| Compound Name |
(3S)-N-Methyl-2-[2-(4-nitrophenyl)acetyl]-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040966; BDBM50386256
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[16] | |||
| Compound Name |
((R)-1-Benzhydryl-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352605; BDBM50124083
Click to Show/Hide
|
||||
| Activity |
Ki = 85200 nM
|
[26] | |||
| Compound Name |
N-[(2R)-3-(3-Aminopropylsulfanyl)-1-[4-(2-fluoroethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907778; BDBM50366643
Click to Show/Hide
|
||||
| Activity |
Ki = 87000 nM
|
[47] | |||
| Compound Name |
N-[(2R)-3-(3-Aminopropylsulfanyl)-1-[4-(2-hydroxyethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1907779; BDBM50366642
Click to Show/Hide
|
||||
| Activity |
Ki = 87000 nM
|
[47] | |||
| Compound Name |
N-(2-Amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321895; SCHEMBL4427616; SCHEMBL8368342; BDBM50132528
Click to Show/Hide
|
||||
| Activity |
Ki = 87300 nM
|
[48] | |||
| Compound Name |
3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63216; BDBM50115896
Click to Show/Hide
|
||||
| Activity |
Ki = 88000 nM
|
[20] | |||
| Compound Name |
1-[4-[(5R)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391041
Click to Show/Hide
|
||||
| Activity |
Ki = 88200 nM
|
[19] | |||
| Compound Name |
1-[4-[(5S)-5-[[[4-Chloro-3-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391203; BDBM50435607
Click to Show/Hide
|
||||
| Activity |
Ki = 89700 nM
|
[19] | |||
| Compound Name |
Chembl4203384
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL7394984; 2-(2-fluorophenyl)-4h-pyrido[3,4-d][1,3]oxazin-4-one; BDBM50457935; 2-(2-fluorophenyl)pyrido[3,4-d][1,3]oxazin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[49] | |||
| Compound Name |
2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-5-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108458; SCHEMBL4420214; BDBM50132524
Click to Show/Hide
|
||||
| Activity |
Ki = 90200 nM
|
[48] | |||
| Compound Name |
N-[3-[(4-Fluorophenyl)methoxy]phenyl]-1-pyrimidin-2-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441062; BDBM50442099
Click to Show/Hide
|
||||
| Activity |
Ki = 91600 nM
|
[25] | |||
| Compound Name |
3-Amino-N-{3-[(S)-2-[4-(2-amino-ethyl)-piperidin-1-yl]-1-(3-aminomethyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459525; SCHEMBL8197411; BDBM50253954; US8569313, 61
Click to Show/Hide
|
||||
| Activity |
Ki = 92000 nM
|
[21] | |||
| Compound Name |
N-[3-(1,3-Benzothiazol-2-yl)-1-(4-ethylpiperidin-1-yl)-1-oxopropan-2-yl]-3,3-dimethyl-2,4-dihydro-1H-quinoline-8-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL39375; BDBM50090231
Click to Show/Hide
|
||||
| Activity |
Ki = 92000 nM
|
[47] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydrobenzothiazole-6-yl)-2-oxo-3-(benzylsulfonylamino)-6-methyl-1,2-dihydropyridine-1-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327136; SCHEMBL4420061; BDBM50147483
Click to Show/Hide
|
||||
| Activity |
Ki = 92000 nM
|
[37] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-1,3-benzothiazol-5-yl)-2-[3-(benzylsulfonylamino)-6-methyl-2-oxopyridin-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320542; BDBM50132526
Click to Show/Hide
|
||||
| Activity |
Ki = 92000 nM
|
[48] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-3-yloxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61791; BDBM50115863
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[34] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[(6-aminopyridin-3-yl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96486; BDBM50060751
Click to Show/Hide
|
||||
| Activity |
Ki = 94000 nM
|
[12] | |||
| Compound Name |
1-[4-[(5R)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methylamino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391191; BDBM50435620
Click to Show/Hide
|
||||
| Activity |
Ki = 94800 nM
|
[19] | |||
| Compound Name |
1-(2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289395; BDBM50057826
Click to Show/Hide
|
||||
| Activity |
Ki = 95000 nM
|
[50] | |||
| Compound Name |
2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(2-methyl-4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316820; SCHEMBL4425042; BDBM50132529
Click to Show/Hide
|
||||
| Activity |
Ki = 95000 nM
|
[48] | |||
| Compound Name |
2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105980; SCHEMBL4427640; BDBM50132527
Click to Show/Hide
|
||||
| Activity |
Ki = 99000 nM
|
[48] | |||
| Compound Name |
N-(4-Carbamimidoyl-phenyl)-2-hydroxy-5-nitro-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62736; BDBM50115879
Click to Show/Hide
|
||||
| Activity |
Ki = 99000 nM
|
[20] | |||
| Compound Name |
(2R)-1-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]piperidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040988; BDBM50386275
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[16] | |||
| Compound Name |
N-[1-(3-Amino-5-methyl-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069648
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-3-hydroxy-2-(3,4,5-triisopropyl-benzenesulfonylamino)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157131; BDBM50110026
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[51] | |||
| Compound Name |
(S)-Benzyl 1-(5-(4-((2,3-dihydro-1H-inden-2-yl)carbamoyl)benzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213927; BDBM50187158
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[52] | |||
| Compound Name |
Diphenyl 1-(benzyloxycarbonylamino)-2-(4-guanidinophenyl)-ethanephosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239535; SCHEMBL17126273; BDBM50228410; benzyl N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]carbamate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[53] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-pyrimidin-5-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101793; SCHEMBL17188153
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121661; BDBM50060753
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[[(2S,4S)-1-(1-Carbamimidoylpiperidine-4-carbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3889796; SCHEMBL15534247; BDBM238251; US9394250, 9
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
4-[[(2S,4S)-1-[4-(Aminomethyl)cyclohexanecarbonyl]-4-(4-cyclopropylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926756; SCHEMBL15534112; SCHEMBL16755132; BDBM238256; US9394250, 55
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
2-Chloro-N-[3-methyl-1-(4-methyl-2-nitrophenyl)pyrrolidin-3-yl]-4-(1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
3-Amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carbamoyl}methyl)-3-chloro-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyrazin-2-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77076; Pyrazinone Analog 34; SCHEMBL14542855; BDBM14593
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
N-(2-(3-(4-(Aminomethyl)phenyl)propylamino)ethyl)-1-chloronaphthalene-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL208638; BDBM50184499
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
CID 90295622
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330481; SCHEMBL15893706; BDBM50024528
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1-methyl-5-oxo-1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069082; SCHEMBL17188042
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-dicyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420334; BDBM50060742
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
4-[[(2S,4R)-1-(3-Chloro-4-fluoro-1-methylindole-5-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidine-2-carbonyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946619; SCHEMBL16755154; BDBM238264; US9394250, 93
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
Methyl N-[4-[2-[(2S,4R)-1-(4-carbamimidoylbenzoyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953111; SCHEMBL16781416; BDBM238260; US9394250, 73
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
3-((S)-2-(((Benzyloxy)carbonyl)amino)-3-methylbutanamido)-5-fluoro-4-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MX1013; Z-VAL-DL-ASP-FLUOROMETHYLKETONE; CHEMBL23226; Z-Val-Asp-fmk; CASPASE INHIBITOR IX; Z-Val-Asp-Fluoromethyl Ketone; SCHEMBL4466395; EX-A500; BDBM50140543; BP-22470-B; AS-35053; BP-22470; 3-(CBz-Val-amido)-5-fluoro-4-oxo-pentanoic acid; J-690326
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[56] | |||
| Compound Name |
1-[4-[(5S)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]methylamino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391190; BDBM50435621
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
NC1=NOC2=C(C=CC=C12)N1CCC(C1)NC(=O)C1=C(Cl)C=C(C=C1)N1C=NN=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085322; SCHEMBL17188104
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
(1R,3As,8bS)-1-(5-amino-5-iminopentyl)-7-[3-(diethylcarbamoyl)phenyl]-N-ethyl-2-oxo-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45032; BDBM50078546
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-3-hydroxyphenyl)methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230031; BDBM50215421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
[4-(3-Aminomethylphenyl)-piperidin-1-yl]-[5-(2-fluorophenylethynyl)-furan-2-yl]-methanone trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944727; SCHEMBL6804030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[58] | |||
| Compound Name |
7-({[1-(3-Chloro-benzoyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243368; BDBM50209910
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
4-[[(2S,4S)-1-[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-morpholin-4-ylpyrrolidine-2-carbonyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3982298; SCHEMBL15547388; SCHEMBL15559826; BDBM238253; US9394250, 37
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
2-(2-Carbamimidoylbenzo[b]thiophen-4-yloxy)propionic AcidMethyl Ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589526; SCHEMBL13709776; BDBM50307282
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[60] | |||
| Compound Name |
Methyl N-[4-[5-chloro-2-[(2S,4R)-1-[4-(diaminomethylideneamino)benzoyl]-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956330; SCHEMBL15607631; BDBM238261; US9394250, 79
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
7-{[Methanesulfonyl-(1-methanesulfonyl-piperidin-4-yl)-amino]-methyl}-naphthalene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241910; BDBM50209907
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-2-(2-chloroethylsulfanyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330473; SCHEMBL17267462; BDBM50024369
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
4-[[(2S,4S)-1-(4-Carbamimidoylbenzoyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912373; SCHEMBL15533470; BDBM238252; US9394250, 20
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-fluoro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098387; SCHEMBL17188127
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
1-[4-[(5R)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391189; BDBM50435622
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[(2-amino-1,3-thiazol-4-yl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122432; BDBM50060749
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S,4S)-1-[(E)-3-[5-Chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-[(3S)-3-methyl-4-sulfamoylpiperazin-1-yl]-N-phenylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898718; SCHEMBL15560511; SCHEMBL15560512; BDBM238257; US9394250, 57
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
US10336741, Example 96
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934208; SCHEMBL16781418; SCHEMBL16781628; SCHEMBL19113035; BDBM238266; BDBM406677; US9394250, 96
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
US9585881, Example 86
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947788; SCHEMBL16781676; BDBM238262; BDBM294104; US9394250, 86
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
Pyrazinone Analog 29f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77490; BDBM14543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
7-({Methanesulfonyl-[1-(toluene-4-sulfonyl)-piperidin-4-yl]-amino}-methyl)-naphthalene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242501; BDBM50209906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
5-[(1R,3As,8bS)-2-oxo-3-(5-phenylpentyl)-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrol-1-yl]pentanimidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46923; BDBM50078558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S,4S)-4-[4-(Benzenesulfonyl)piperazin-1-yl]-1-[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-N-phenylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965746; SCHEMBL15546069; SCHEMBL15546071; BDBM238254; US9394250, 39
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
Methyl N-[4-[2-[(2S,4R)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964787; SCHEMBL16781420; BDBM238259; SB18995; US9394250, 71
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
N-{[4-(N-Aminocarbamimidoyl)phenyl]methyl}-2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243108; BDBM50215435
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
7-[(Methanesulfonyl-piperidin-4-yl-amino)-methyl]-naphthalene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396028; BDBM50209902
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
1-[4-[(5S)-2-Oxo-5-[[[4-(5-oxo-4H-1,2,4-oxadiazol-3-yl)benzoyl]amino]methyl]-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391188; BDBM50435623
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
NC1=NOC2=C(N=CC=C12)N1CCC(C1)NC(=O)C1=C(Cl)C=C(C=C1)N1C=NN=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060976; SCHEMBL17188189
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[1-(3-Amino-5-chloro-1,2-benzoxazol-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090664; SCHEMBL17188060
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(3-methyl-1,2,4-triazol-1-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065316; SCHEMBL17188076
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421494; SCHEMBL7979435; BDBM50129971; 1-[3-[(4-carbamimidoylphenyl)methyl]-1-methyl-2-oxoquinoxalin-6-yl]cyclopropane-1-carboxylic acid; 4-{[6-(1-carboxy-cyclopropyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
Acetic acid;ethyl 1-[4-[(5S)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391192
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-3,6-dichloro-1-benzothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330472; SCHEMBL17267436; BDBM50024368
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Methyl N-[4-[2-[(2S,4S)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959704; SCHEMBL15607675; BDBM238268; US9394250, 98
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
N-Butyl-3-[[4-(diaminomethylideneamino)phenyl]methylamino]imidazo[1,2-a]pyridine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740183; BDBM50499900
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-dicyclohexylpropanoyl]-N-[(2-amino-1,3-thiazol-4-yl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331181; BDBM50060740
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
CID 90295617
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330480; SCHEMBL15893701; BDBM50024527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(2-Amino-1,3-thiazol-4-yl)methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435012; BDBM50060761
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Methyl N-[4-[2-[(2S,4R)-1-(4-carbamimidoylpiperazine-1-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977040; SCHEMBL16781646; BDBM238263; US9394250, 88
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
[(1-{1-[3-(4-Carbamimidoyl-benzyl)-1-methyl-2-oxo-1,2-dihydro-quinoxalin-6-yl]-cyclopropanecarbonyl}-pyrrolidine-2-carbonyl)-amino]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL76068; BDBM50129978
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[62] | |||
| Compound Name |
(2S,4S)-N-(2H-Benzotriazol-5-yl)-1-[(E)-3-[5-chloro-2-(tetrazol-1-yl)phenyl]prop-2-enoyl]-4-morpholin-4-ylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3939406; SCHEMBL15547306; SCHEMBL15547308; BDBM238255; US9394250, 43
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
2-[6-(3-Aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoyl-2,5,6-trifluoro-3-hydroxyphenyl)methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230661; BDBM50215426
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[3-(difluoromethyl)-1,2,4-triazol-4-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085239; SCHEMBL17188037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Acetic acid;ethyl 1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391193
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-[4-(2-hydroxyethyl)imidazol-1-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092982; SCHEMBL17188151
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
3-[1-(5-Phenylethynyl-furan-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944726; SCHEMBL1381804
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[58] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-5-methyl-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-(1,2,4-triazol-4-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083789
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-2-chloro-4-pyrimidin-2-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-5-fluoro-4-oxo-pentanoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23453; BDBM50140548; methyl 3-([N-[(benzyloxy)carbonyl]-l-valyl]amino)-5-fluoro-4-oxopentanoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[56] | |||
| Compound Name |
N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-7-chloro-1-benzothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330468; SCHEMBL17267454; BDBM50024364
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Anabaenopeptin C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3577334; BDBM50089686
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
Anabaenopeptin B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL368684; BDBM50089688
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
Methyl N-[4-[2-[(2S,4S)-1-(4-carbamimidoylcyclohexanecarbonyl)-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidin-2-yl]-5-chloro-1H-imidazol-4-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961710; BDBM238267; US9394250, 99
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
N-[[(3S,3As)-1-oxo-7-(3-oxomorpholin-4-yl)-3a,4-dihydro-3H-[1,3]oxazolo[4,3-c][1,4]benzoxazin-3-yl]methyl]-4-chloro-1-benzothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330471; SCHEMBL17267427; BDBM50024367
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Methyl N-[4-[2-[(2S,4R)-1-(1-carbamimidoylpiperidine-4-carbonyl)-4-(1-methylsulfonylpiperidin-4-yl)pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985511; SCHEMBL16781638; BDBM238258; US9394250, 69
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
(2S)-N-[[5-(Aminomethyl)thiophen-3-yl]methyl]-1-[(2R)-2-(methanesulfonamido)-3,3-diphenylpropanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8079; BDBM50111123
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[28] | |||
| Compound Name |
7-({[1-(3-Cyano-benzoyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243370; BDBM50209898
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
(2S)-N-[(5-Aminothiophen-3-yl)methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331179; BDBM50060744
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
Benzyl N-[1-bis(4-acetamidophenoxy)phosphoryl-2-[4-(diaminomethylideneamino)phenyl]ethyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391968; SCHEMBL2242610; BDBM50228420; di-(4-acetamidophenyl) 1-(benzyloxycarbonylamino)-2-[(4-guanidino)phenyl]ethanephosphonate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[53] | |||
| Compound Name |
N-[(3R)-1-(3-Amino-4-chloro-[1,2]oxazolo[5,4-c]pyridin-7-yl)pyrrolidin-3-yl]-4-(benzimidazol-1-yl)-2-chlorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087720; SCHEMBL17188072
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
7-({[1-(2,6-Dichloro-benzenesulfonyl)-piperidin-4-yl]-methanesulfonyl-amino}-methyl)-naphthalene-2-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243591; BDBM50209913
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
CID 10230007
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289331; SCHEMBL5111583; BDBM50141563
Click to Show/Hide
|
||||
| Activity |
Ki = 103000 nM
|
[15] | |||
| Compound Name |
2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110440; SCHEMBL4430767; BDBM50132525
Click to Show/Hide
|
||||
| Activity |
Ki = 103000 nM
|
[37] | |||
| Compound Name |
(3S)-2-[3-[5-(4-Chlorophenyl)-1,3-oxazol-2-yl]propanoyl]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040971; BDBM50386281
Click to Show/Hide
|
||||
| Activity |
IC50 = 103000 nM
|
[16] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303335; BDBM50115883; N-(4-Guanidinophenyl)-2-hydroxybenzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 104000 nM
|
[20] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-ylmethyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110565; SCHEMBL4427676; BDBM50132523
Click to Show/Hide
|
||||
| Activity |
Ki = 106000 nM
|
[48] | |||
| Compound Name |
(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350657; BDBM50110013; Boc-L-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[51] | |||
| Compound Name |
2-Chlorobenzenesulfonic acid 3-methyl-5-(4-guanidinobutoxy)phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287807; BDBM50070599; 2-Chloro-benzenesulfonic acid 3-(4-guanidino-butoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 110000 nM
|
[64] | |||
| Compound Name |
CID 10165173
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41359; SCHEMBL5108146; BDBM50141572
Click to Show/Hide
|
||||
| Activity |
Ki = 111000 nM
|
[15] | |||
| Compound Name |
(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(5,6,7,8-tetrahydroquinazolin-6-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165196; BDBM50124070
Click to Show/Hide
|
||||
| Activity |
Ki = 111000 nM
|
[26] | |||
| Compound Name |
Ethyl 1-[4-[(5R)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391040
Click to Show/Hide
|
||||
| Activity |
Ki = 111000 nM
|
[19] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460144; BDBM50253817
Click to Show/Hide
|
||||
| Activity |
Ki = 112000 nM
|
[65] | |||
| Compound Name |
3-[2-(4-Carbamimidoylbenzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460567; BDBM50253779
Click to Show/Hide
|
||||
| Activity |
Ki = 112000 nM
|
[8] | |||
| Compound Name |
Chembl4213790
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL914066; BDBM50457931; 2-(2,6-difluorophenyl)-7-nitro-3,1-benzoxazin-4-one; 2-(2,6-Difluorophenyl)-7-nitro-4H-3,1-benzoxazine-4-one; 2-(2,6-difluoro-phenyl)-7-nitro-benzo[d][1,3]oxazin-4-one; 7-Nitro-2-(2,6-difluoro-phenyl)-benzo[d][1,3]oxazin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[49] | |||
| Compound Name |
6-Methoxy-1-(4-methoxybenzoyl)-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091746; BDBM50259084
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[11] | |||
| Compound Name |
n-(4-Carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62897; N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide; BDBM14159; APC-11421; DB06857; Q27095762; N-(3-Chloro-4-amidinophenyl)-2-hydroxy-3-iodo-5-methylbenzamide; N-{4-[amino(imino)methyl]-3-chlorophenyl}-2-hydroxy-3-iodo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 115000 nM
|
[20] | |||
| Compound Name |
2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287910; BDBM50070595
Click to Show/Hide
|
||||
| Activity |
Ki = 120000 nM
|
[42] | |||
| Compound Name |
(S)-N-((1-Carbamimidoylpiperidin-4-yl)methyl)-5-guanidino-2-((S)-2-((S)-5-guanidino-2-(2-phenylacetamido)pentanamido)-3-methylbutanamido)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568067; BDBM50303778
Click to Show/Hide
|
||||
| Activity |
Ki = 123000 nM
|
[45] | |||
| Compound Name |
2-Phenyl-1H-benzimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96917; SCHEMBL14599542; BDBM50100891; ZINC12354847; 2-Phenyl-1H-benzoimidazole-5-carboxamidine; 2-Phenyl-3H-benzoimidazole-5-carboxamidine; 2-phenyl-3H-benzimidazole-5-carboximidamide
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[66] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(piperidin-3-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303978; BDBM50115854
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[34] | |||
| Compound Name |
[2'-Hydroxy-3'-(1H-pyrrolo[3,2-c]pyridin-2-yl)-biphenyl-3-ylmethyl]-urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-azaindole analog 2; CHEMBL209022; BDBM14864; {[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}phenyl)phenyl]methyl}urea; DB07247; Q27096472; 1-{[2'-hydroxy-3'-(1H-pyrrolo[3,2-c]pyridin-2-yl)biphenyl-3-yl]methyl}urea
Click to Show/Hide
|
||||
| Activity |
Ki = 125000 nM
|
[67] | |||
| Compound Name |
N-[3-[(3,5-Dimethoxyphenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441036; BDBM50442074
Click to Show/Hide
|
||||
| Activity |
Ki = 126000 nM
|
[25] | |||
| Compound Name |
N-(4-(Biphenyl-4-ylmethoxy)phenyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491673; BDBM50292888
Click to Show/Hide
|
||||
| Activity |
Ki = 126000 nM
|
[24] | |||
| Compound Name |
Methyl (2S)-1-[(2S)-2-[[3-(3-aminopropanoylamino)phenyl]sulfonylamino]-3-(3-carbamimidoylphenyl)propanoyl]piperidine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492334; BDBM50257762
Click to Show/Hide
|
||||
| Activity |
Ki = 127000 nM
|
[68] | |||
| Compound Name |
2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]guanidine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213434
Click to Show/Hide
|
||||
| Activity |
IC50 = 129000 nM
|
[69] | |||
| Compound Name |
5-Chloro-N-[(2S)-4-methyl-1-oxo-1-[4-(3-oxomorpholin-4-yl)anilino]pentan-2-yl]thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184653; SCHEMBL4030113; BDBM50155627; ZINC28378171
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[29] | |||
| Compound Name |
3-Amidinophenylalanine deriv., 27
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209334; BDBM23883
Click to Show/Hide
|
||||
| Activity |
Ki = 130000 nM
|
[23] | |||
| Compound Name |
2-[[(2R)-1-[[1-[(4-Carbamimidoylphenyl)methylamino]-1-oxo-4-piperidin-4-ylbutan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115894; BDBM50447517
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 130000 nM
|
[70] | |||
| Compound Name |
N-(3-Amino-2-imino-2,3,4,5,6,7-hexahydro-benzothiazol-6-yl)-2-[3-(4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109999; BDBM50147480
Click to Show/Hide
|
||||
| Activity |
Ki = 131000 nM
|
[37] | |||
| Compound Name |
3-(Benzyl(2-(4-carbamimidoylbenzyl)-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)amino)-3-oxopropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468143; BDBM50261591
Click to Show/Hide
|
||||
| Activity |
Ki = 139000 nM
|
[27] | |||
| Compound Name |
(1-{[(4-Carbamimidoyl-benzylcarbamoyl)-methyl]-carbamoyl}-2-hydroxy-ethyl)-carbamic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422533; BDBM50110005; Cbz-D-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[51] | |||
| Compound Name |
Ethyl {(1S)-5-amino-1-[(5-{4-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]benzyl}-1,2,4-oxadiazol-3-YL)carbonyl]pentyl}carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214368; CRA23; BDBM14312; Q27458643
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[52] | |||
| Compound Name |
Boc-D-Ser-Gly-(4-Amidinobenzyl)NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440919; BDBM50110004
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[51] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-diphenylpropanoyl]-N-[1-(diaminomethylideneamino)-5,8-dioxo-8-piperidin-1-yloctan-4-yl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202120
Click to Show/Hide
|
||||
| Activity |
Ki = 149000 nM
|
[71] | |||
| Compound Name |
2-[3-(1H-1,3-Benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
benzimidazole 3; CHEMBL382387; BDBM13779; 2-[3-(1,3-dihydrobenzimidazol-2-ylidene)-5-(3-nitrophenyl)-4-oxocyclohexa-1,5-dien-1-yl]acetic acid
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[72] | |||
| Compound Name |
N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536972
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[73] | |||
| Compound Name |
2-(3-{5-Amino-1H-imidazo[4,5-b]pyridin-2-yl}-4-hydroxy-5-(3-nitrophenyl)phenyl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
imidazopyridine analog 4; CHEMBL426676; BDBM13780
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[72] | |||
| Compound Name |
2-(2-Pyridylmethyl)-6-amidino-1H-benzoimidazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204126; APD-5; SCHEMBL6162109; BDBM16307; 2-(pyridin-2-ylmethyl)-1H-benzimidazole-6-carboximidamide; 2-(pyridin-2-ylmethyl)-3H-benzimidazole-5-carboximidamide; 2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carboximidamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 150000 nM
|
[38] | |||
| Compound Name |
3-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64578; BDBM50115893; N-(4-Guanidinophenyl)-2-hydroxy-3-bromo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 151000 nM
|
[20] | |||
| Compound Name |
(3S)-2-[(4-Chlorophenyl)methylsulfonyl]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040852; BDBM50386282
Click to Show/Hide
|
||||
| Activity |
IC50 = 151000 nM
|
[16] | |||
| Compound Name |
((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337923; BDBM50060755
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[12] | |||
| Compound Name |
(2S)-1-[(2R)-2-Amino-3,3-dicyclohexylpropanoyl]-N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL123942; BDBM50060752
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[12] | |||
| Compound Name |
2-Chlorophenyl[3-[2-[methyl(4-pyridyl)amino]ethoxy]-5-methylphenoxy] sulfone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL289951; SCHEMBL8545290; BDBM50064653; [3-methyl-5-[2-[methyl(pyridin-4-yl)amino]ethoxy]phenyl] 2-chlorobenzenesulfonate; 2-Chloro-benzenesulfonic acid 3-methyl-5-[2-(methyl-pyridin-4-yl-amino)-ethoxy]-phenyl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[42] | |||
| Compound Name |
6-Fluoro-2-[2-hydroxy-3-(pyrrolidin-2-ylmethoxy)-phenyl]-1H-benzoimidazole-5-carboxamidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62397; BDBM50115859
Click to Show/Hide
|
||||
| Activity |
Ki = 167000 nM
|
[34] | |||
| Compound Name |
Chembl4208864
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL915758; BDBM50457930; 2-(2,6-difluorophenyl)-7-(trifluoromethyl)-3,1-benzoxazin-4-one; 2-(2,6-Difluorophenyl)-7-(trifluoromethyl)-4H-3,1-benzoxazine-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 174000 nM
|
[49] | |||
| Compound Name |
2-[2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]guanidine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215750
Click to Show/Hide
|
||||
| Activity |
IC50 = 175400 nM
|
[69] | |||
| Compound Name |
N-((S)-2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419023; BDBM50147491
Click to Show/Hide
|
||||
| Activity |
Ki = 176400 nM
|
[37] | |||
| Compound Name |
1-(5-Chlorothiophene-2-carbonyl)-6-methoxy-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102953; BDBM50259083
Click to Show/Hide
|
||||
| Activity |
IC50 = 179000 nM
|
[11] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(butane-1-sulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322542; SCHEMBL4431600; BDBM50147481
Click to Show/Hide
|
||||
| Activity |
Ki = 179000 nM
|
[37] | |||
| Compound Name |
N-(4-Amidinophenyl)-2-hydroxy-3-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292300; BDBM50115906; 2-Hydroxy-biphenyl-3-carboxylic acid (4-carbamimidoyl-phenyl)-amide
Click to Show/Hide
|
||||
| Activity |
Ki = 188000 nM
|
[20] | |||
| Compound Name |
(3S)-2-[3-(4-Methoxyphenyl)propanoyl]-N-methyl-N-[4-(3-oxomorpholin-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040975; BDBM50386263
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[16] | |||
| Compound Name |
{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320407; BDBM50046369
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[44] | |||
| Compound Name |
Sodium;[2-[(2-benzyl-3-ethoxycarbonyl-6-methoxy-1-benzofuran-5-yl)oxymethyl]-3-ethoxycarbonyl-1H-indol-5-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359902
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[74] | |||
| Compound Name |
(3S)-2-(4-Chlorobenzoyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040960; BDBM50386250
Click to Show/Hide
|
||||
| Activity |
IC50 = 197000 nM
|
[16] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[6-methyl-2-oxo-3-(propane-1-sulfonylamino)-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111013; BDBM50147482
Click to Show/Hide
|
||||
| Activity |
Ki = 200000 nM
|
[37] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 103 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Chloro-benzenesulfonic acid 3-(3-guanidino-propoxy)-5-methyl-phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291062; BDBM50070598
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[42] | |||
| Compound Name |
Chembl4209404
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL7393864; BDBM50457938; 2-(2,6-difluorophenyl)pyrido[3,4-d][1,3]oxazin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[49] | |||
| Compound Name |
5-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]carbamoyl]-2-[2-[(3-carbamoylphenyl)carbamoyl]-4-(methylamino)phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388161; BDBM50197325
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[75] | |||
| Compound Name |
N-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384180; BDBM50192103
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[69] | |||
| Compound Name |
Chembl4216440
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZINC7984087; BDBM50459510; AKOS001216084; MCULE-4021787042; Z76818846
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
Chembl4211470
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZINC9670559; BDBM50459513; AKOS001221230; MCULE-9165584447
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
3alpha-(4-Amidinobutyl)-1,2,3,3aalpha,8,8abeta-hexahydroindeno[2,1-b]pyrrole-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46649; BDBM50078559; 5-((3R,3aS,8aS)-2-Oxo-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-3-yl)-pentanamidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
(12E)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,12,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883423; BDBM50210074
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[76] | |||
| Compound Name |
20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883788; BDBM50210075
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[76] | |||
| Compound Name |
N-(3-Amino-2-imino-2,3,4,5,6,7-hexahydro-benzothiazol-6-yl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111122; BDBM50147477
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[37] | |||
| Compound Name |
[2-[(3,5-Dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-phenylacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1883669; MLS001161429; SCHEMBL20037216; HMS3010I19; BDBM50459509; AKOS001192799; MCULE-6355232739; SMR000707769
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(S)-3-{[2-(4-Carbamimidoyl-benzyloxy)-4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl]-amino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462037; CHEMBL444873; SCHEMBL6475289; BDBM50165953; BDBM50253716
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[8] | |||
| Compound Name |
((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122488; BDBM50060759
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[12] | |||
| Compound Name |
alpha-Ketothiazole analogue 27
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216110; BDBM12967
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[46] | |||
| Compound Name |
Chembl4204525
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL916150; BDBM50457939; 1-methyl-6-(2-methylphenyl)pyrazolo[3,4-d][1,3]oxazin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[49] | |||
| Compound Name |
5-[[(2S)-1-Amino-4-methyl-1-oxopentan-2-yl]carbamoyl]-2-[2-[[4-(aminomethyl)phenyl]carbamoyl]-4-(methylamino)phenyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426187; BDBM50197324
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[75] | |||
| Compound Name |
Chembl4218188
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL914839; BDBM50457937; 4H-Pyrimido[4,5-d][1,3]oxazin-4-one,7-(ethylthio)-2-(2-fluorophenyl)-; 7-ethylsulfanyl-2-(2-fluorophenyl)pyrimido[4,5-d][1,3]oxazin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[49] | |||
| Compound Name |
2-[2-[(3-Carbamoylphenyl)carbamoyl]-4-(methylamino)phenyl]-5-[[(1S)-1-carboxy-3-methylbutyl]carbamoyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376806; BDBM50197327
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[75] | |||
| Compound Name |
alpha-Ketothiazole analogue 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265598; BDBM12961
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[46] | |||
| Compound Name |
Methyl 2-[(1R,3aS,8bS)-1-(5-amino-5-iminopentyl)-2-oxo-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrol-3-yl]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295211; BDBM50078550
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
Chembl4211986
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZINC9463364; BDBM50459536; AKOS001219290; MCULE-4052888396
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(13Z)-20-Amino-22-methyl-6-(pyrazol-1-ylmethyl)-9,17-dioxa-1,21,25,29-tetrazatetracyclo[25.2.1.03,8.018,23]triaconta-3(8),4,6,13,18,20,22,27(30),28-nonaen-26-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883461; BDBM50210073
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[76] | |||
| Compound Name |
CGH-1484A free base
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-620VW8H64Y; CHEMBL263806; 620VW8H64Y; BDBM50090238; Q27263411
Click to Show/Hide
|
||||
| Activity |
Ki >= 200000 nM
|
[77] | |||
| Compound Name |
2-[2-[(3-Carbamoylphenyl)carbamoyl]-4-(methylamino)phenyl]-5-(2-methylpropylcarbamoyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375051; BDBM50197326; 2''-(3-carbamoyl-phenylcarbamoyl)-4-isobutylcarbamoyl-4''-methylamino-biphenyl-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[75] | |||
| Compound Name |
Chembl4212332
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL20037270; BDBM50459511; ZINC10622021; AKOS008062054; MCULE-9531505500; [2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-(2-methylindol-1-yl)acetate
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]-N-(pyridin-4-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331908; BDBM50060750
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[12] | |||
| Compound Name |
alpha-Ketothiazole analogue 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219462; BDBM12958
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[46] | |||
| Compound Name |
(8e)-3-Amino-1-Methyl-15-[(1h-Pyrazol-1-Yl)methyl]-7,10,11,12,24,25-Hexahydro-6h,18h,23h-19,22-(Metheno)pyrido[4,3-J][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884851; BDBM50210127; GBT
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[76] | |||
| Compound Name |
(3S)-N-Methyl-2-(4-methylbenzoyl)-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040961; BDBM50386251
Click to Show/Hide
|
||||
| Activity |
IC50 = 209000 nM
|
[16] | |||
| Compound Name |
1-[5-(Diaminomethyl-amino)-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL177078; BDBM50091037
Click to Show/Hide
|
||||
| Activity |
Ki = 210000 nM
|
[78] | |||
| Compound Name |
2-(3,4-Dihydroxyphenyl)-5-[[4-[[2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4-oxochromen-5-yl]oxymethyl]phenyl]methoxy]-3,7-dihydroxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069227; BDBM50260050
Click to Show/Hide
|
||||
| Activity |
IC50 = 212000 nM
|
[79] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-dicyclohexylpropanoyl)pyrrolidine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555333
Click to Show/Hide
|
||||
| Activity |
Ki = 220000 nM
|
[80] | |||
| Compound Name |
Tert-butyl (3S)-3-[methyl-[4-(2-oxopiperidin-1-yl)phenyl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040957; BDBM50386280
Click to Show/Hide
|
||||
| Activity |
IC50 = 221000 nM
|
[16] | |||
| Compound Name |
N-((R)-2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109696; BDBM50147489
Click to Show/Hide
|
||||
| Activity |
Ki = 225200 nM
|
[37] | |||
| Compound Name |
2-(6-Methyl-2-oxo-3-p-tolylmethanesulfonylamino-2H-pyridin-1-yl)-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324859; BDBM50147485
Click to Show/Hide
|
||||
| Activity |
Ki = 228000 nM
|
[37] | |||
| Compound Name |
Sodium;[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-2-methyl-1H-indol-5-yl)oxymethyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-5-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359903
Click to Show/Hide
|
||||
| Activity |
IC50 = 229000 nM
|
[74] | |||
| Compound Name |
(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-(3,4-dichlorophenyl)propanoyl]-N-(pyridin-3-ylmethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124408; BDBM50060757
Click to Show/Hide
|
||||
| Activity |
Ki = 230000 nM
|
[12] | |||
| Compound Name |
4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (6-guanidino-pyridin-3-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64653; BDBM50115889
Click to Show/Hide
|
||||
| Activity |
Ki = 235000 nM
|
[20] | |||
| Compound Name |
3-Hydroxy-4-isopropoxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304219; BDBM50115902
Click to Show/Hide
|
||||
| Activity |
Ki = 240000 nM
|
[20] | |||
| Compound Name |
(2S)-N-[(6-Amino-2,4-dimethylpyridin-3-yl)methyl]-1-[(2R)-2-amino-3,3-diphenylpropanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122601; BDBM50060748
Click to Show/Hide
|
||||
| Activity |
Ki = 240000 nM
|
[12] | |||
| Compound Name |
1-(3-Chlorobenzoyl)-6-methoxy-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062061; BDBM50259082
Click to Show/Hide
|
||||
| Activity |
IC50 = 243000 nM
|
[11] | |||
| Compound Name |
(3S)-2-[2-(3,4-Dimethoxyphenyl)acetyl]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040968; BDBM50386257
Click to Show/Hide
|
||||
| Activity |
IC50 = 246000 nM
|
[16] | |||
| Compound Name |
N-[3-[(4-Fluorophenyl)methoxy]phenyl]-1-propan-2-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441063; BDBM50442101
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[25] | |||
| Compound Name |
N-[2-[(3-Fluorophenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441026; BDBM50442063
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[25] | |||
| Compound Name |
3-Carbamimidoylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269203; SCHEMBL2850803; BDBM50328732; ZINC39063507
Click to Show/Hide
|
||||
| Activity |
Ki = 250000 nM
|
[81] | |||
| Compound Name |
[1-[(Benzyloxycarbonyl)amino]-4-aminobutyl]phosphonic acid diphenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9971041; CHEMBL1179439
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[82] | |||
| Compound Name |
N-[3-[(3-Fluorophenoxy)methyl]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441031; BDBM50442077
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[25] | |||
| Compound Name |
2-[4-[2-Diphenoxyphosphoryl-2-(methanesulfonamido)ethyl]phenyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238493; BDBM50228421; diphenyl 1-(methylsulfonylamino)-2-(4-guanidinophenyl)-ethanephosphonate
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[53] | |||
| Compound Name |
Diphenyl 1-(benzoylamino)-2-(4-guanidinophenyl)-ethanephosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393592; BDBM50228424; N-[2-[4-(diaminomethylideneamino)phenyl]-1-diphenoxyphosphorylethyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[53] | |||
| Compound Name |
N-[3-[(3-Chlorophenyl)methoxy]phenyl]-1-pyridin-4-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2441053; BDBM50442093
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[25] | |||
| Compound Name |
2-[6-Methyl-2-oxo-3-(3-trifluoromethyl-phenylmethanesulfonylamino)-2H-pyridin-1-yl]-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111703; BDBM50147479
Click to Show/Hide
|
||||
| Activity |
Ki = 252000 nM
|
[37] | |||
| Compound Name |
N-{3-[(4-Fluorobenzyl)oxy]-phenyl}piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL489114; BDBM50292883
Click to Show/Hide
|
||||
| Activity |
Ki = 260000 nM
|
[24] | |||
| Compound Name |
N-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110201; BDBM50147488
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[37] | |||
| Compound Name |
Sodium;[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1812010
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[83] | |||
| Compound Name |
3-[3-(3-Benzyl-1H-indol-2-yl)-5-bromo-4-hydroxy-phenyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL297031; BDBM50101886; 3-(3-Benzyl-1H-indole-2-yl)-4-hydroxy-5-bromobenzenepropionic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[84] | |||
| Compound Name |
N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(Aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927307; BDBM50359552
Click to Show/Hide
|
||||
| Activity |
Ki = 310000 nM
|
[85] | |||
| Compound Name |
(3R)-N-Methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-2-[2-[4-(trifluoromethyl)phenyl]acetyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040980; BDBM50386268
Click to Show/Hide
|
||||
| Activity |
IC50 = 311000 nM
|
[16] | |||
| Compound Name |
2-[3-(4-Fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-N-(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110415; BDBM50147476
Click to Show/Hide
|
||||
| Activity |
Ki = 314000 nM
|
[37] | |||
| Compound Name |
(3S)-N-Methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]-2-[2-[4-(trifluoromethyl)phenyl]acetyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040967; BDBM50386236
Click to Show/Hide
|
||||
| Activity |
IC50 = 335000 nM
|
[16] | |||
| Compound Name |
Sodium;[3-ethoxycarbonyl-2-[[3-ethoxycarbonyl-2-[(3-ethoxycarbonyl-6-methoxy-2-methyl-1-benzofuran-5-yl)oxymethyl]-6-methoxy-1-benzofuran-5-yl]oxymethyl]-1H-indol-5-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359904
Click to Show/Hide
|
||||
| Activity |
IC50 = 344000 nM
|
[74] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-3-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL59690; BDBM50115900
Click to Show/Hide
|
||||
| Activity |
Ki = 350000 nM
|
[20] | |||
| Compound Name |
Sodium;[2-[[6-methoxy-3-[(2-methylpropan-2-yl)oxycarbonyl]-1-benzofuran-5-yl]oxymethyl]-1,3-benzothiazol-6-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359897
Click to Show/Hide
|
||||
| Activity |
IC50 = 352000 nM
|
[74] | |||
| Compound Name |
6-Methoxy-1-(3-methoxybenzoyl)-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090100; BDBM50259117
Click to Show/Hide
|
||||
| Activity |
IC50 = 354000 nM
|
[11] | |||
| Compound Name |
(2S)-1-(5-Chlorothiophene-2-carbonyl)-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]piperidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040987; BDBM50386274
Click to Show/Hide
|
||||
| Activity |
IC50 = 358000 nM
|
[16] | |||
| Compound Name |
6-Amino-N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927450; BDBM50359553
Click to Show/Hide
|
||||
| Activity |
Ki = 360000 nM
|
[85] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-2-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332870
Click to Show/Hide
|
||||
| Activity |
Ki = 370000 nM
|
[80] | |||
| Compound Name |
N-((S)-2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109345; BDBM50147492
Click to Show/Hide
|
||||
| Activity |
Ki = 370600 nM
|
[37] | |||
| Compound Name |
(3S)-1-[2-(4-Chlorophenyl)acetyl]-N-methyl-N-[4-(2-oxopiperidin-1-yl)phenyl]piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040986; BDBM50386237
Click to Show/Hide
|
||||
| Activity |
IC50 = 371000 nM
|
[16] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3-phenyl-3-pyridin-4-ylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431675
Click to Show/Hide
|
||||
| Activity |
Ki = 400000 nM
|
[80] | |||
| Compound Name |
(2S)-2-Acetamido-N-[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797523; BDBM50347169
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[86] | |||
| Compound Name |
{(R)-2-[(S)-2-(4-Amino-benzylcarbamoyl)-pyrrolidin-1-yl]-1-benzyl-2-oxo-ethyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL331160; BDBM50060758
Click to Show/Hide
|
||||
| Activity |
Ki = 420000 nM
|
[12] | |||
| Compound Name |
3-Amino-N-{3-[(S)-2-[4-(2-amino-ethyl)-piperidin-1-yl]-1-(4-aminomethyl-benzyl)-2-oxo-ethylsulfamoyl]-phenyl}-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462253; BDBM50253981
Click to Show/Hide
|
||||
| Activity |
Ki = 430000 nM
|
[21] | |||
| Compound Name |
Benzyl N-[(2R)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797527; BDBM50347173
Click to Show/Hide
|
||||
| Activity |
IC50 = 440000 nM
|
[86] | |||
| Compound Name |
3-Hydroxy-4-iodo-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60478; BDBM50115877
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64563; BDBM50115904
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-4-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64308; BDBM50115884
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
4-Bromo-3-hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63050; BDBM50115880
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
4-Chloro-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL292488; BDBM50115881
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
5-Bromo-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62414; BDBM50115882
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
4-Ethoxy-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63038; BDBM50115887
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
3-Hydroxy-anthracene-2-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64740; BDBM50115891
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64164; BDBM50115888; N-(4-Guanidinophenyl)-2-hydroxy-3-iodo-5-methylbenzamide
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
3-Chloro-N-(4-guanidino-phenyl)-2-hydroxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294776; BDBM50115892
Click to Show/Hide
|
||||
| Activity |
Ki = 470000 nM
|
[20] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-methyl-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64841; BDBM50115897; Benzamide,N-[4-[(aminoiminomethyl)amino]phenyl]-2-hydroxy-5-methyl-
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
2-Hydroxy-biphenyl-3-carboxylic acid (4-guanidino-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291622; BDBM50115890
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
N-(4-Guanidino-phenyl)-2-hydroxy-5-nitro-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64463; BDBM50115885
Click to Show/Hide
|
||||
| Activity |
Ki > 470000 nM
|
[20] | |||
| Compound Name |
(3S)-2-[3-(2,4-Dimethoxyphenyl)propanoyl]-N-methyl-N-[4-(3-oxomorpholin-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040977; BDBM50386265
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
Benzyl (3S)-3-[(4-piperidin-1-ylphenyl)carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040954; BDBM50386245
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
(3S)-2-[4-(4-Bromophenyl)thiophene-2-carbonyl]-N-methyl-N-[4-(3-oxomorpholin-4-yl)phenyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040976; BDBM50386264
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
Benzyl (3S)-3-[[4-(4-acetylpiperazin-1-yl)phenyl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040955; BDBM50386246
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
Benzyl (3S)-3-[[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040956; BDBM50386247
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
Benzyl (3S)-3-[(4-chlorophenyl)carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040953; BDBM50386244; ZINC84723666
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
N-((R)-2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-yl)-2-[3-(4-fluoro-phenylmethanesulfonylamino)-6-methyl-2-oxo-2H-pyridin-1-yl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419008; BDBM50147475
Click to Show/Hide
|
||||
| Activity |
Ki > 500000 nM
|
[37] | |||
| Compound Name |
Octasodium;[2-(3,4-disulfonatooxyphenyl)-5-[[4-[[2-(3,4-disulfonatooxyphenyl)-4-oxo-3,7-disulfonatooxychromen-5-yl]oxymethyl]phenyl]methoxy]-4-oxo-3-sulfonatooxychromen-7-yl] sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084933; BDBM50260048
Click to Show/Hide
|
||||
| Activity |
IC50 = 505000 nM
|
[79] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797526; BDBM50347172
Click to Show/Hide
|
||||
| Activity |
IC50 = 508000 nM
|
[86] | |||
| Compound Name |
1-Benzoyl-6-methoxy-3-[4-(2-oxopiperidin-1-yl)phenyl]-2H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065217; BDBM50259085
Click to Show/Hide
|
||||
| Activity |
IC50 = 546000 nM
|
[11] | |||
| Compound Name |
(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797521; BDBM50347167
Click to Show/Hide
|
||||
| Activity |
IC50 > 580000 nM
|
[86] | |||
| Compound Name |
(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797524; BDBM50347170
Click to Show/Hide
|
||||
| Activity |
IC50 > 590000 nM
|
[86] | |||
| Compound Name |
(2S)-2-[[(2R)-2-(Benzylsulfonylamino)-3-phenylpropanoyl]amino]-N-[(3S)-7-(diaminomethylideneamino)-2-oxo-1-phenylheptan-3-yl]-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1797525; BDBM50347171
Click to Show/Hide
|
||||
| Activity |
IC50 > 640000 nM
|
[86] | |||
| Compound Name |
5-Chloro-N-[2-oxo-2-[4-(3-oxomorpholin-4-yl)anilino]ethyl]thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183969; SCHEMBL4028227; BDBM50155611; ZINC28382396; 5-Chloro-thiophene-2-carboxylic acid {[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-methyl}-amide
Click to Show/Hide
|
||||
| Activity |
IC50 = 700000 nM
|
[29] | |||
| Compound Name |
[(2S,3R,4S,5R,6R)-2-[9-Oxo-6-[(2S,3R,4S,5R,6R)-3,4,5-trisulfooxy-6-(sulfooxymethyl)oxan-2-yl]oxyxanthen-3-yl]oxy-3,5-disulfooxy-6-(sulfooxymethyl)oxan-4-yl] hydrogen sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158198; BDBM50393527
Click to Show/Hide
|
||||
| Activity |
IC50 = 740000 nM
|
[87] | |||
| Compound Name |
Mangiferin heptasulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158201; BDBM50393526
Click to Show/Hide
|
||||
| Activity |
IC50 = 970000 nM
|
[87] | |||
| Compound Name |
(2S)-N-[(4-Aminocyclohexyl)methyl]-1-(3,3-diphenylpropanoyl)pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL122894
Click to Show/Hide
|
||||
| Activity |
Ki = 980000 nM
|
[80] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 23 | Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26. | ||||
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| REF 53 | Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem. 2007 Dec 27;50(26):6638-46. | ||||
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| REF 56 | Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1269-72. | ||||
| REF 57 | Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4568-74. | ||||
| REF 58 | Structure-based library design and the discovery of a potent and selective mast cell -tryptase inhibitor as an oral therapeutic agent. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1049-54. | ||||
| REF 59 | Prodrug-based design, synthesis, and biological evaluation of N-benzenesulfonylpiperidine derivatives as novel, orally active factor Xa inhibitors. Bioorg Med Chem. 2007 Jun 15;15(12):4175-92. | ||||
| REF 60 | Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem. 2010 Feb 25;53(4):1473-82. | ||||
| REF 61 | Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2319-25. | ||||
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