Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85435 | Target Info | |||
| Target Name | Insulin receptor (INSR) | ||||
| Synonyms |
IR; CD220 antigen; CD220
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| Target Type | Successful Target | ||||
| Gene Name | INSR | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 116 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Erlotinib
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Approved | Compound Info | ||
| Synonyms |
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
HIF-1alpha
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Phase 4 | Compound Info | ||
| Synonyms |
Unii-NA856793UT; 192705-79-6; PD-166866; PD166866; PD 166866; UNII-NA856793UT; CHEMBL299763; NA856793UT; 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea; 1-(2-Amino-6-(3,5-dimethoxyphenyl)-pyrido(2,3-d)pyrimidin-7-yl)-3-tert-butyl urea; Urea,N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-; 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea; 6-arylpyrido[2,3-d]pyrimidine deriv 25; AC1NS3U5; SCHEMBL1248489; BDBM3443; CTK4E1060
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
PD173074
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Phase 2 | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
KENPAULLONE
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Patented | Compound Info | ||
| Synonyms |
kenpaullone; 142273-20-9; 9-Bromopaullone; NSC 664704; 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; NSC-664704; NSC664704; MLS002702152; CHEMBL296586; 9-Bromo-7,12-dihydroindolo(3,2-d)(1)benzazepin-6(5H)-one; Indolo[3,2-d][1]benzazepin-6(5H)-one,9-bromo-7,12-dihydro-; QQUXFYAWXPMDOE-UHFFFAOYSA-N; 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one; 9-Bromo-7,12-dihydro-indolo-[3,2-d]-[1]benzazepin-6(5H)-one
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
aloisine A
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Investigative | Compound Info | ||
| Synonyms |
ALOISINE A; 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)phenol; 496864-16-5; RP107; 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE; CHEMBL75680; 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine; RP-107; ALH; 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol; 1ung; SCHEMBL80147; BDBM7377; GTPL5924; AC1NS169; 4-(7-Butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-phenol; CHEBI:93641; CTK8D4068; DTXSID30416115; HMS3229A14; RM-39; BCP26893; ZINC2540737; ACT06534; IN1539; HSCI1_000219; MFCD04973541; AKOS005145972; CCG-206814; DB07364; RTC-063070; AJ-39131
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| Activity |
IC50 = 60000 nM
|
[6] | |||
| Compound Name |
JNJ-7706621
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Investigative | Compound Info | ||
| Synonyms |
JNJ-7706621; 443797-96-4; JNJ7706621; 4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide; UNII-74GK72DON8; RWJ-387252; 4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide; CHEMBL191003; 74GK72DON8; 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide; JNJ 7706621; 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzenesulfonamide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327300; Ki-6783; 6,7-Dimethoxy-4-(3,4-dimethoxyphenoxy)quinoline; SCHEMBL925876; 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline; ZQSHUGGLESWJFP-UHFFFAOYSA-N
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
JNJ-10198409
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Investigative | Compound Info | ||
| Synonyms |
JNJ-10198409; 627518-40-5; PDGFR Tyrosine Kinase Inhibitor IV; PDGF Receptor Tyrosine Kinase Inhibitor IV; CHEMBL120077; N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine; ZDNURMVOKAERHZ-UHFFFAOYSA-N; SCHEMBL3088170; GTPL6020; CTK8E8807; jnj10198409; DTXSID70430890; MolPort-009-019-131; HMS3650O03; HMS3229I11; ZINC13677843; BDBM50179207; AKOS030525202; RWJ 540973; CCG-206773; NCGC00343986-02; RT-014973; KB-274227; SR-01000946814
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
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| Activity |
IC50 ~ 50000 nM
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[10] | |||
| Compound Name |
PD158780 Analog 5h
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Investigative | Compound Info | ||
| Synonyms |
4-N-(3-bromophenyl)-6-N-[2-(dimethylamino)ethyl]pyrido[3,4-d]pyrimidine-4,6-diamine; BDBM3704; CHEMBL162034; 4-[(3-Bromophenyl)amino]-6-[[2-(dimethylamino)-ethyl]amino]pyrido[3,4-d]pyrimidine
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| Activity |
IC50 ~ 50000 nM
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[11] | |||
| Compound Name |
PD158780 Analog 5k
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Investigative | Compound Info | ||
| Synonyms |
BDBM3707; CHEMBL433520; 4-[(3-Bromophenyl)amino]-6-[[3-(diethylamino)-2-hydroxypropyl]amino]pyrido[3,4-d]pyrimidine; 4-N-(3-bromophenyl)-6-N-[3-(diethylamino)-2-hydroxypropyl]pyrido[3,4-d]pyrimidine-4,6-diamine
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| Activity |
IC50 ~ 50000 nM
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[11] | |||
| Compound Name |
1-(Tert-butyl)-3-(6-(2,6-dichlorophenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidin-7-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
PD-161570; PD 161570; CHEMBL45827; pd161570; 6-arylpyrido[2,3-d]pyrimidine deriv. 33; PF-1480232; BDBM3451; SCHEMBL4301366; DTXSID80416145; HMS3262A10; HMS3414B11; HMS3678B11; BCP24138; ZINC3952380; Tox21_500724; MFCD16618403; AKOS024457772; CCG-222028; NCGC00261409-01; NCGC00370903-02; HY-100434; B7486; CS-0018918; FT-0673535; PD-161570;PD161570; PD-161570, >=98% (HPLC); J-012464
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949788; SCHEMBL12134179; BDBM50364832; CH-4932748
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
1-[2-Amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL56236; 6-arylpyrido[2,3-d]pyrimidine deriv. 23; BDBM3441; SCHEMBL8135562; PD162628; 1-[2-Amino-6-(2,3,5,6-tetramethyl-phenyl)-pyrido-[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea; 1-[2-Amino-6-(2,3,5,6-tetramethyl-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086065; SCHEMBL959662; BDBM50443366
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| Activity |
IC50 ~ 50000 nM
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[14] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
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| Activity |
IC50 ~ 50000 nM
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[15] | |||
| Compound Name |
1-[2-[[3-(4-Methylpiperazin-1-yl)propyl]amino]-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL75188; SCHEMBL8120179; BDBM50059138
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| Activity |
IC50 ~ 50000 nM
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[16] | |||
| Compound Name |
3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949789; SCHEMBL12134185; BDBM50364833; CH-4932750
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| Activity |
IC50 ~ 50000 nM
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[13] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
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| Activity |
IC50 ~ 50000 nM
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[15] | |||
| Compound Name |
N-[4-[(3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methyl-1-piperazinyl)-2-pentynamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL203599; BDBM50182697; N-[4-(3-chloro-4-fluoroanilino)pyrido[3,4-d]pyrimidin-6-yl]-5-(4-methylpiperazin-1-yl)pent-2-ynamide
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| Activity |
IC50 ~ 50000 nM
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[17] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
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| Activity |
IC50 = 50000 nM
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[18] | |||
| Compound Name |
1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
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Investigative | Compound Info | ||
| Synonyms |
PD089828; PD-089828; CHEMBL57366; 1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea; 6-arylpyrido[2,3-d]pyrimidine deriv. 1; EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor; BDBM3428; SCHEMBL8124128; AOB5747; EX-A4724; ZINC3815345; AS-16916; HY-112345; CS-0045270; J-002982; 1-[2-Amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
N-(3-Bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine
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Investigative | Compound Info | ||
| Synonyms |
bpiq-ii; CHEMBL66031; Imidazoquinazoline deriv. 8; Anilinopyrimidine deriv. 7a; BDBM3570; SCHEMBL13898313; CTK0E4714; 8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]-quinazoline; DTXSID20274367; ZINC3815028; HSCI1_000062; SC-91510; BRD-K35473459-001-01-7; N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-am; 8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazoline; 1H-Imidazo[4,5-g]quinazolin-8-amine, N-(3-bromophenyl)-
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| Activity |
IC50 ~ 50000 nM
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[19] | |||
| Compound Name |
2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095873; SCHEMBL4482804; BDBM50317750
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| Activity |
IC50 ~ 50000 nM
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[20] | |||
| Compound Name |
1-[6-(2,6-Dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL301483; 6-arylpyrido[2,3-d]pyrimidine deriv. 32; SCHEMBL144075; BDBM3450; 1-[2-[4-(Diethylamino)butylamino]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-7-yl]-3-ethylurea; 1-[6-(2,6-Dichlorophenyl)-2-(4-diethylamino-butyl-amino)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethyl-urea; 1-[6-(2,6-dichlorophenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethyl-urea; 1-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
1-[2-Amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57323; 6-arylpyrido[2,3-d]pyrimidine deriv. 15; PD089828 analog 15; BDBM3433; SCHEMBL8120559
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| Activity |
IC50 ~ 50000 nM
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[16] | |||
| Compound Name |
1-Tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrido[2,3-d]pyrimidin-7-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57347; 6-arylpyrido[2,3-d]pyrimidine deriv. 47; BDBM3465; SCHEMBL8127381
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
1-[6-(2,6-Dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
6-arylpyrido[2,3-d]pyrimidine deriv. 35; CHEMBL56983; SCHEMBL143775; BDBM3453; 1-[2-[4-(Diethylamino)butylamino]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-7-yl]-3-phenylurea; 1-[6-(2,6-Dichlorophenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-3-phenyl-urea; 3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]-1-phenylurea
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| Activity |
IC50 ~ 50000 nM
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[12] | |||
| Compound Name |
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL432738; SCHEMBL8134813; BDBM50059137; 1-[2-Amino-6-(2,6-dichloro-phenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethyl-urea; 1-[2-amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-ethylurea
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| Activity |
IC50 ~ 50000 nM
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[16] | |||
| Compound Name |
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL602472; BDBM50306684; CH-5234152
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| Activity |
IC50 ~ 50000 nM
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[15] | |||
| Compound Name |
PD158780 Analog 5n
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Investigative | Compound Info | ||
| Synonyms |
BDBM3710; CHEMBL162622; PD-0165557; 4-[(3-Bromophenyl)amino]-6-[[2-(4-morpholino)ethyl]amino]pyrido[3,4-d]pyrimidine; 4-N-(3-bromophenyl)-6-N-[2-(morpholin-4-yl)ethyl]pyrido[3,4-d]pyrimidine-4,6-diamine
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| Activity |
IC50 ~ 50000 nM
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[11] | |||
| Compound Name |
Canertinib dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
Canertinib HCl; Canertinib (dihydrochloride); CI-1033; CI 1033; Canertinib 2HCl; UNII-ICJ93X8X90; PD183805; PD 183805; Canertinib dihydrochloride [USAN]; PD-0183805; ICJ93X8X90; MFCD09954112; 289499-45-2 (HCl); CI-1033 dihydrochloride;PD-183805 dihydrochloride; CHEMBL545315; Canertinib dihydrochloride (USAN); C24H25ClFN5O3.2ClH; Canertinib HCl; Canertinib.2HCL; Canertinib(dihydrochloride); cc-446; Canertinib dihydrochloride salt; SCHEMBL2052123; AOB6735; DTXSID80183143; HMS3295E05; BCP01902; KS-00000FV0; 3516AH; CI-103; HY-10367A; AKOS015924656; AC-2414; CS-0263; AK326128; AS-75065; SC-23744; SN-26606; A3276; AM20090674; FT-0724289; PD-0183805-002B; CI-1033, >=98% (HPLC); A19399; D03350; W-5427; Q-101362; Q-200787; Q27280663
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| Activity |
IC50 ~ 50000 nM
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[17] | |||
| Compound Name |
1-Tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[3-(diethylamino)propylamino]pyrido[2,3-d]pyrimidin-7-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL299026; 6-arylpyrido[2,3-d]pyrimidine deriv. 13; SCHEMBL145351; BDBM3431
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| Activity |
IC50 ~ 50000 nM
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[16] | |||
| Compound Name |
1-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL76599; PD089828 analog 4; 1-{2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl}-3-tert-butylurea; BDBM4823; SCHEMBL8130610; ZINC13763794; SC-49037; 1-(2-Amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl-urea
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| Activity |
IC50 ~ 50000 nM
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[16] | |||
| Compound Name |
(E)-5-((5-(3,4-Dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL604254; ZINC975828; BDBM50308354; STL282810; AKOS000409234; ST50973671; AB00083388-01; 5-{[5-(3,4-dichlorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione; (5E)-5-{[5-(3,4-dichlorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
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||||
| Activity |
IC50 = 57600 nM
|
[21] | |||
| Compound Name |
(E)-3-[1-[4-(3-Ethynylanilino)quinazolin-6-yl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4080295; CHEMBL3218002
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[2] | |||
| Compound Name |
(Z)-5-(3,5-Dibromo-4-methoxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591504; SCHEMBL12155713; BDBM50308343; ZINC16194447
Click to Show/Hide
|
||||
| Activity |
IC50 = 65300 nM
|
[21] | |||
| Compound Name |
(Z)-5-((5-(2-Chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226813; SCHEMBL623774; BDBM50211912; ZINC12375686; AKOS000542400; MCULE-2288618223; ST026506; AG-690/36165049; F0494-0018; 5-((5-(2-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one; 5-{[5-(2-chlorophenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one; (5z)-5-{[5-(2-chlorophenyl)-2-furyl]methylene}-2-thioxo-1,3-thiazolidin-4-one; 5-{[5-(2-chlorophenyl)(2-furyl)]methylene}-2-thioxo-1,3-thiazolidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 79500 nM
|
[21] | |||
| Compound Name |
Meridianin E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(2-aminopyrimidin-4-yl)-7-bromo-1H-indol-4-ol; CHEMBL296682; SCHEMBL2787193; BDBM10842
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[22] | |||
| Compound Name |
2-(3-Chloro-4-hydroxyanilino)-5,7-dihydropyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598000; BDBM50308189; 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benz-azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[5] | |||
| Compound Name |
2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598025; SCHEMBL1185592; BDBM50308227; 2-(4-methoxyanilino)-5,7-dihydropyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 99000 nM
|
[5] | |||
| Compound Name |
2-(4-Methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605324; BDBM50308230
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090364; KIN-281; BDBM50252338; STK542322; AKOS005471968; J3.639.819A; 2-(2,4,6-Trichlorostyryl)-N-[4-(diethylamino)-1-methylbutyl]quinazoline-4,6-diamine; N~4~-[5-(diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(E)-5-(3-Ethoxy-2-hydroxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602643; ZINC975865; BDBM50308365; STL282809; AKOS000409201; (5E)-5-(3-ethoxy-2-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(3-Hydroxy-4-methoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597393; BDBM50308195
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(E)-5-((5-(2,3-Dichlorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602518; C14H7Cl2NO3S; ZINC975814; BDBM50308350; STL121090; AKOS000542485; ST50771941; AB00684196-01; F0350-0035; 5-{[5-(2,3-dichlorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(4-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596807; BDBM50308228
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(4-Hydroxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597597; BDBM50308197; 2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3,8,13,15,17,18-Hexazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608427; BDBM50308215; 6,8-Dihydro-7H-pyrido[3,2-b][1,2,4]triazolo[5'',1'':2,3]pyrimido[4,5-d]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598418; BDBM50308191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(E)-{4-[2-(5-Chlorobenzothiazol-2-yl)vinyl]phenyl}dimethylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945929; SCHEMBL8387875; SCHEMBL8387877; BDBM50363750; 4-[(E)-2-(5-chloro-1,3-benzothiazol-2-yl)ethenyl]-N,N-dimethylaniline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
4-(4-Ethoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598837; BDBM50308204; 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-Anilino-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603255; SCHEMBL10309999; BDBM50308225
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(5-Benzyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylicacid isobutyl-methyl-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1164457; BDBM50320979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(Z)-5-(3-(2,4-Dichlorobenzyloxy)benzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602738; BDBM50308361; ZINC13551648; AKOS000542062
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599844; BDBM50308185
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(5E)-5-(4-Ethoxy-3-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602749; ZINC1013907; BDBM50308368; STK099714; AKOS000409203; ST50062265; (E)-5-(4-ethoxy-3-methoxybenzylidene)thiazolidine-2,4-dione; 5-[(4-ethoxy-3-methoxyphenyl)methylene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-[5-(3-Chloro-4-fluoro-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592666; ZINC1001756; BDBM50308353; STL282834; AKOS000411928; ST50973836; (5E)-5-{[5-(3-chloro-4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione; (E)-5-((5-(3-chloro-4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; 5-{[5-(3-chloro-4-fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-(4-Ethoxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605118; BDBM50308199; 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(E)-5-((5-(2-Bromo-4-methylphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592665; ZINC2119943; BDBM50308352; CCG-13254; STL282824; AKOS000409050; BIM-0021158.P001; (5E)-5-{[5-(2-bromo-4-methylphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(E)-5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CAY10505; CHEMBL590022; (5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione; (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione; SCHEMBL13479680; SCHEMBL16416080; DTXSID60360955; ZINC973810; EX-A1070; ABP000112; BDBM50308349; STK201819; AKOS000409173; BCP9000494; CCG-267369; CS-5662; AC-32657; HY-13530; S2682; ST50299246; SW113275-2; Y0226; Z-3274; AB00083720-01; J-004691; 5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione; 5-{[5-(4-fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione; (5E)-5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(4-Ethoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597191; BDBM50308193
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-(3-Nitrobenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591022; (E)-5-(3-nitrobenzylidene)thiazolidine-2,4-dione; 5-[(3-nitrophenyl)methylene]-1,3-thiazolane-2,4-dione; 2,4-Thiazolidinedione, 5-(m-nitrobenzylidene)-; 5-[(3-Nitrophenyl)methylene]-1,3-thiazolidine-2,4-dione; 5-(3-Nitro-benzylidene)-thiazolidine-2,4-dione; SCHEMBL1250596; (5E)-5-[(3-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione; CCG-7408; ZINC1774538; BDBM50308362; MFCD00817881; AKOS000400072; BIM-0019378.P001; AG-690/33044008; 5-{3-nitrobenzylidene}-1,3-thiazolidine-2,4-dione; F0385-0046
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(4-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597586; BDBM50308232
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Iodoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598024; BDBM50308226
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(4-Methoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606255; BDBM50308203; 2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-Methoxy-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599248; BDBM50308209; 10-Methoxy-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604545; BDBM50308184
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-(3-Bromo-5-ethoxy-4-hydroxy-benzylidene)-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589531; ZINC2068457; BDBM50308344; STK038278; AKOS000408868; AG-690/36165059; (E)-5-(3-bromo-5-ethoxy-4-hydroxybenzylidene)thiazolidine-2,4-dione; 5-(3-bromo-5-ethoxy-4-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione; (5E)-5-(3-bromo-5-ethoxy-4-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-propenyl)-1,6-dimethyl-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281957; SCHEMBL6621670; BDBM50126732
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599027; BDBM50308186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
3,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610512; BDBM50308222; 7,12-Dihydro-5H-pyrido[3,2-b]pyrimido[5'',4'':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(5E)-5-(4-Hydroxy-3-iodo-5-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589744; ZINC1012980; BDBM50308345; STK244885; AKOS000397740; AN-989/41696669; (E)-5-(4-hydroxy-3-iodo-5-methoxybenzylidene)thiazolidine-2,4-dione; 5-(4-hydroxy-3-iodo-5-methoxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934626; BDBM50360453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-(3-Chloro-4-hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598431; BDBM50308206; 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(Z)-5-(2-Fluorobenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601199; SCHEMBL7456375; BDBM50308358; ZINC17028451; AKOS002663205; (Z)-5-(2-Fluorobenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
16-Phenyl-3,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598435; BDBM50308213; 2-Phenyl-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(Z)-5-(5-Bromo-2-hydroxy-3-methoxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599645; BDBM50308356; AKOS002397689
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(5Z)-5-[(6-Ethoxy-1,3-benzodioxol-5-yl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589065; BDBM50308340; STK155146; ZINC13881360; AKOS002342129; AN-988/41719874; 5-[(6-ethoxy-1,3-benzodioxol-5-yl)methylene]-1,3-thiazolidine-2,4-dione; (Z)-5-((6-ethoxybenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606119; BDBM50308220; 7,12-Dihydro-5H-pyrido[4,3-b]pyrimido[5'',4'':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
8,15,17,19-Tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597207; BDBM50308216; 7,12-Dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606410; BDBM50308224
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
16-Phenyl-4,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598434; BDBM50308211; 2-Phenyl-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[4,3-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(2-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603545; BDBM50308187
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(3-Chloro-4-hydroxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599446; BDBM50308201; 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
8,13,17,18-Tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590769; BDBM50308207; 6,8-Dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605841; BDBM50308231
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(3-Hydroxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602043; BDBM50308200; 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
15,17-Dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603481; BDBM50308217; 10,12-Dimethyl-7,12-dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(4-Methoxyanilino)-3,5,10,14-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596988; BDBM50308198; 2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Hydroxy-2-methylanilino)-5,7-dihydropyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598201; BDBM50308190; 2-(4-Hydroxy-2-methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d]-[1]benzazepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
15,17-Dimethyl-4,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599055; BDBM50308221
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-(4-Ethylbenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493742; (5Z)-5-[(4-ethylphenyl)methylidene]-1,3-thiazolidine-2,4-dione; thiazolidine-2,4-dione, 8a; SCHEMBL2539566; SCHEMBL2539573; BDBM26630; SMSF0010623; BDBM50249828; ZINC12341773; AKOS000347481; BIM-0008761.P001; ST50237787; EC-000.2292; AG-690/37099107; (Z)-5-(4-ethylbenzylidene)thiazolidine-2,4-dione; BRD-K06075029-001-01-6; (5Z)-5-(4-ethylbenzylidene)-1,3-thiazolidine-2,4-dione; 5-[(4-ethylphenyl)methylene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-(3,5-Dimethoxy-4-hydroxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231450; SCHEMBL15421448; ZINC974070; BDBM50201788; AKOS000513092; ST50978183; AG-690/34653012; (E)-5-(4-hydroxy-3,5-dimethoxybenzylidene)thiazolidine-2,4-dione; 5-(4-hydroxy-3,5-dimethoxybenzylidene)-1,3-thiazolidine-2,4-dione; 5-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]-1,3-thiazolidine-2,4-dione; (5E)-5-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-Methoxy-15,17-dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596598; BDBM50308219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(3-Chloro-4-hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597596; BDBM50308196; 6H-Pyrimido[5,4-d][1]benzazepin-6-one, 2-[(3-chloro-4-hydroxyphenyl)amino]-5,7-dihydro-9-methoxy-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(Z)-5-(5-Bromo-3-ethoxy-2-hydroxybenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589530; BDBM50308342; STL283056; ZINC17293205; AKOS022108216; (5Z)-5-(5-bromo-3-ethoxy-2-hydroxybenzylidene)-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
15,17-Dimethyl-3,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599056; BDBM50308223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-(2,4-Dichloro-benzylidene)-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL601739; MLS002639389; NSC31150; 5-[(2,4-dichlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione; SCHEMBL1249000; (5Z)-5-[(2,4-dichlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione; BDBM50308366; NSC-31150; STL282800; ZINC13388295; AKOS000640560; ST50256993; AG-690/11081034; (Z)-5-(2,4-dichlorobenzylidene)thiazolidine-2,4-dione; (5Z)-5-(2,4-dichlorobenzylidene)-1,3-thiazolidine-2,4-dione; 5-[(2,4-dichlorophenyl)methylene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(4-Methoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606395; BDBM50308192
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-(3-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606185; BDBM50308205; 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(E)-5-(3,4-Dichlorobenzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591703; 5-[(3,4-dichlorophenyl)methylidene]-1,3-thiazolidine-2,4-dione; ZINC975836; BDBM50308367; AKOS000542626; ST50220095; AG-690/40124767; 5-(3,4-dichlorobenzylidene)-1,3-thiazolidine-2,4-dione; 5-[(3,4-dichlorophenyl)methylene]-1,3-thiazolidine-2,4-dione; (5E)-5-[(3,4-DICHLOROPHENYL)METHYLIDENE]-1,3-THIAZOLIDINE-2,4-DIONE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3,8,13,17,18-Pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591896; BDBM50308212; 6,8-Dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-Methoxy-8,13,15,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597005; BDBM50308214; 10-Methoxy-6,8-dihydro-7H-[1,2,4]triazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-Methoxy-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599666; BDBM50308218; 3-Methoxy-7,12-dihydro-5H-pyrimido[5'',4'':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(3-Hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604912; BDBM50308194
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-(4-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598633; BDBM50308202; 2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
16-Phenyl-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599247; BDBM50308208; 2-Phenyl-6,8-dihydro-7H-pyrazolo[5'',1'':2,3]pyrimido[5,4-d][1]benzazepin-7-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(E)-5-(2-(2-Methylbutoxy)benzylidene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591021; BDBM50308360
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(E)-5-((5-(4-Bromophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602919; SCHEMBL15347294; ZINC975826; BDBM50308348; AKOS000542539; ST50299247; AB00083732-01; 5-{[5-(4-bromophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione; (5E)-5-[[5-(4-bromophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(E)-5-((6-Bromobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589499; ZINC973806; CCG-7799; BDBM50308341; BIM-0019661.P001; AG-690/34470055; 5-[(6-bromo-1,3-benzodioxol-5-yl)methylene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[4-(3-bromoanilino)quinazolin-6-yl]oxymethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3663540; CHEMBL3217993
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[2] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
AG-213
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 = 640000 nM
|
[30] | |||
| Compound Name |
Ro-0505124
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
RO0505124
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000000 nM
|
[31] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
Click to Show/Hide
|
||||
| Activity |
IC50 = 622000 nM
|
[32] | |||
| Compound Name |
[4-Amino-2-[[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]amino]-5-thiazolyl](3-methoxyphenyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956069; SCHEMBL5741716; HMS3401E09; BDBM50365217; Ro-0506220; [4-amino-2-[4-(4-propan-2-ylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(3-methoxyphenyl)methanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 24000000 nM
|
[31] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 2 | Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases. Medchemcomm. 2012;3:829-35. | ||||
| REF 3 | Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. Bioorg Med Chem Lett. 1997 Sep 23;7(18):2415-20. | ||||
| REF 4 | Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase. J Med Chem. 2012 Jun 14;55(11):5003-12. | ||||
| REF 5 | Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation. J Med Chem. 2010 Mar 25;53(6):2433-42. | ||||
| REF 6 | Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. | ||||
| REF 7 | 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. | ||||
| REF 8 | A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation. Bioorg Med Chem Lett. 1997 Dec 2;7(23):2935-40. | ||||
| REF 9 | (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. | ||||
| REF 10 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
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