Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88240 | Target Info | |||
| Target Name | Bacterial Dihydropteroate synthetase (Bact folP) | ||||
| Synonyms |
folP; H2Pte synthase; Dihydropteroate synthase; Dihydropteroate pyrophosphorylase; DHPS
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| Target Type | Successful Target | ||||
| Gene Name | Bact folP | ||||
| Biochemical Class | Alkyl aryl transferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-6-oxo-4-(4-phenylbutylamino)-1H-pyrimidine-5-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL56302; BDBM50405225
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-6-anilino-5-nitroso-3H-pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293797; BDBM50405226
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4(1H)-Pyrimidinone, 2-amino-6-(methylamino)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55588; 2-amino-6-(methylamino)pyrimidin-4-ol; 2-amino-4-hydroxy-6-methylaminopyrimidine; 2-amino-6-(methylamino)-1H-pyrimidin-4-one; SCHEMBL2072360; SCHEMBL9543645; CTK1G8007; DTXSID70343133; 4(1H)-Pyrimidinone, 2-amino-6-(methylamino)- (6CI,9CI); BDBM50405228; ZINC29550985; AKOS006375253; AKOS017407442; 2-Amino-6-(methylamino)-4-pyrimidinol #; DB-089773; 2-Amino-6-(methylamino)-4(1H)-pyrimidinone; 2-amino-6-(methylamino)pyrimidin-4(3H)-one
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| Activity |
IC50 = 110000 nM
|
[1] | |||
| Compound Name |
2-Amino-4-(diethylamino)-5-nitroso-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL301649; BDBM50405216
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| Activity |
IC50 = 197000 nM
|
[1] | |||
| Compound Name |
2-Amino-4,6-dihydroxy-5-nitrosopyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55165; NSC97327; 2-Iminodihydro-4,5,6(1H)-pyrimidinetrione 5-oxime; NSC 97327; 2-Amino-5-nitroso-4,6-pyrimidinediol; SCHEMBL7766478; SCHEMBL13833302; CTK4J5263; CTK5A3692; DTXSID30966347; ZINC8619223; BDBM50405213; NSC-97327; ZINC18251593; AKOS006271766; MCULE-1626633777; 4,6-Pyrimidinediol, 2-amino-5-nitroso-; Z1837; 2-amino-1H-pyrimidine-4,5,6-trione-5-oxime; 2-amino-4-hydroxy-5-nitroso-1H-pyrimidin-6-one; 2-Amino-6-hydroxy-5-nitrosopyrimidin-4(3H)-one; 5-hydroxyimino-2-imino-hexahydropyrimidine-4,6-dione; 2-IMINODIHYDRO-4,5,6-1H-PYRIMIDINETRIONE 5-OXIME; 5-(Hydroxyimino)-2-imino-2,5-dihydropyrimidine-4,6-diol; 2-amino-5-(hydroxyimino)-1,4,5,6-tetrahydropyrimidine-4,6-dione
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| Activity |
IC50 = 200000 nM
|
[1] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-5-nitroso-4-(propan-2-ylamino)-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55373; BDBM50405209
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| Activity |
IC50 = 208000 nM
|
[1] | |||
| Compound Name |
2-Amino-6-oxo-4-(4-phenylbutylamino)-1H-pyrimidine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL57846; BDBM50405229
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| Activity |
IC50 = 290000 nM
|
[1] | |||
| Compound Name |
2-Amino-5-formyl-6-(methylamino)pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL56748; BDBM50405214
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| Activity |
IC50 = 300000 nM
|
[1] | |||
| Compound Name |
Isocytosine
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Investigative | Compound Info | ||
| Synonyms |
2-Amino-4-hydroxypyrimidine; 2-aminopyrimidin-4-ol; 2-aminopyrimidin-4(1H)-one; 2-Amino-4-pyrimdinol; 2-Amino-4-pyrimidone; 2-Amino-4-oxypyrimidine; 2-Aminouracil; 4-Pyrimidinol, 2-amino-; 4(1H)-Pyrimidinone, 2-amino-; 2-AMINO-3,4-DIHYDROPYRIMIDIN-4-ONE; 2-amino-1H-pyrimidin-6-one; 4(3H)-Pyrimidinone, 2-amino-; MFCD00057557; 2-amino-4-pyrimidinol; 4-pyrimidinol,2-amino-; NSC 49118; CHEMBL56260; Isocytosine, 99%; 4-hydroxy-2-pyrimidineamine; Isocytosine (VAN); 2-amino-6-hydroxypyrimidine; isocytosin; EINECS 203-592-0; zlchem 273; 2-Amino-4-pyrimidol; PubChem15780; 2-Imino-6-pyrimidinon; 4(1H)-Pyrimidinone, 2-amino- (9CI); ACMC-20a0qn; Isocytosine, >=99%; AI3-52238; 2-Aminopyrimidin-4-ol,; Epitope ID:119698; SCHEMBL4825; hydroxy-(2-amino)pyrimidine; 2-amino-1H-pyrimidin-4-one; 2-aminopyrimidin-4(3H)-one; 2-Amino-3H-pyrimidin-4-one; 2-Amino-4(1H)-pyrimidinone; PYR400; SCHEMBL8852643; 2-amino-3-hydropyrimidin-4-one; CTK0E0040; CTK7E0585; CTK8H0920; CTK8H0921; 2-Amino-4(1H)-pyrimidinone #; DTXSID00148350; ZLC0091; ACT01431; EBD53112; KS-000003DQ; KS-000024IZ; NSC49118; ANW-51885; BDBM50405230; MFCD00023256; NSC-49118; s6256; ZINC14419854; 2-amino-1,4-dihydropyrimidin-4-one; 1,4-dihydro-2-amino-4-oxopyrimidine; AKOS010519665; AKOS015854926; AKOS016034248; CS-W002272; DS-0256; HY-W002272; MCULE-7474139826; NE11788; PB29007; SB10360; VP50086; AK-23592; AK-77015; BR-23592; SC-13692; SC-44636; SY013450; 2-Amino-4-hydroxypyrimidine, 2-Aminouracil; 4(1h)-pyrimidinone,2,3-dihydro-2-imino-; AB0013907; AB0070901; DB-016150; AM20080033; FT-0602441; FT-0693428; I0814; ST50974934; A-4898; K-0609; 16057-EP2281563A1; 16057-EP2316459A1; 16472-EP2281563A1; 16472-EP2316459A1; 26766-EP2314583A1; 108I532; 674A975; AC-907/25004299; W-200787; Q10859790; Z1492796832
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| Activity |
IC50 = 500000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines. J Med Chem. 1985 Dec;28(12):1870-4. | ||||
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