Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91940 | Target Info | |||
| Target Name | NAD-dependent deacetylase sirtuin-5 (SIRT5) | ||||
| Synonyms |
SIR2L5; SIR2-like protein 5; Regulatory protein SIR2 homolog 5
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| Target Type | Literature-reported Target | ||||
| Gene Name | SIRT5 | ||||
| Biochemical Class | Sirtuin family. Class III subfamily | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 22 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Vorinostat
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Approved | Compound Info | ||
| Synonyms |
NHNPODA; SAHA; SHH; Zolinza; Merck brand of Vorinostat; OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE; SAHA cpd; Suberanilohydroxamic acid; Suberoylanilide hydroxamic acid; Vorinostat MSD; Vorinostat [USAN]; M344; MK0683; SKI390; WIN64652; MK-0683; SAHA, Suberoylanilide hydroxamic acid; SW-064652; Zolinza (TN); Vorinostat (JAN/USAN); N1-hydroxy-N8-phenyloctanediamide; Zolinza, MK-0683, SAHA; N'-hydroxy-N-phenyloctanediamide; N-Hydroxy-N'-phenyl octanediamide; N-Hyrdroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyloctanediamide; N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide; Vorinostat (HDAC inhibitor)
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Valproate
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Approved | Compound Info | ||
| Synonyms |
99-66-1; Dipropylacetic acid; Depakine; Depakene; 2-Propylvaleric acid; Ergenyl; Di-n-propylacetic acid; Mylproin; Pentanoic acid, 2-propyl-; 4-Heptanecarboxylic acid; Propylvaleric acid; n-Dipropylacetic acid; Myproic Acid; Di-n-propylessigsaure; n-DPA; Dipropylacetate; Convulex; Depakin; Vupral; Acido valproico; Acide valproique; Acidum valproicum; Stavzor; Avugane; Baceca; Kyselina 2-propylvalerova; 2-n-Propyl-n-valeric acid; Acetic acid, dipropyl-; Abbott 44090; Valproinsaeure; Savicol; Convulsofin; Deproic; VPA; Depakin chrono; Dipropyl Acetate; Med Valproic; Valproic acid USP; Valproic acid USP24; Acide valproique [INN-French]; Acido valproico [INN-Spanish]; Acidum valproicum [INN-Latin]; Alti-Valproic; Depakote (TM); Dom-Valproic; G2M-777; Kyselina 2-propylvalerova [Czech]; N-DPA; N-Dipropylacetic acid; Novo-Valproic; Nu-Valproic; PMS-Valproic Acid; Penta-Valproic; Valproic acid (USP); Di-n-propylessigsaeure; Di-n-propylessigsaure [German]; Valproic acid [USAN:INN:BAN]; Valproic Acid, SodiumSalt (2:1); 2 PP (base)
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Phenylbutyrate
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Phase 2 | Compound Info | ||
| Synonyms |
Benzenebutyric acid; Phenyl butanoate; Phenyl butyrate; HDInhib_000004; Butanoic acid, phenyl ester; Butyric acid, phenyl ester; FR-2080; Gamma-Phenylbutyric acid; Omega-Phenylbutanoic acid; GAMMA-PHENYL-BUTYRIC ACID; Butyric acid, 4-phenyl-(8CI); 1-Phenylbutyric acid; 4-PHENYL-BUTANOIC ACID; 4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 4-phenylbutans; 4-phenylbutyrate
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
splitomicin
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Investigative | Compound Info | ||
| Synonyms |
splitomicin; 5690-03-9; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1,2-dihydro-3h-benzo[f]chromen-3-one; 1H-benzo[f]chromen-3(2H)-one; CHEMBL86537; CHEBI:75272; 1,2-dihydrobenzo[f]chromen-3-one; 1H,2H,3H-naphtho[2,1-b]pyran-3-one; Splitomycin; Bio2_000878; Tocris-1542; AC1L1JZ6; AC1Q6ML4; KBioGR_000456; BSPBio_001116; KBioSS_000456; GTPL8101; SCHEMBL2544804; ZINC27374; KBio3_000852; KBio2_003024; BDBM29590; KBio3_000851; KBio2_005592; KBio2_000456; MolPort-003-959-546; ISFPDBUKMJDAJH-UHFFFAOYSA-N; HMS1362H17; HMS1990H17; Bio2_000398
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
AGK2
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Investigative | Compound Info | ||
| Synonyms |
AGK-2; AGK 2
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4128509
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276139
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-Ethyl-6-hydroxy-5-[(Z)-indol-3-ylidenemethyl]-2-sulfanylidenepyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203538; BDBM50400737
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| Activity |
IC50 = 55900 nM
|
[4] | |||
| Compound Name |
(5E)-5-[4-(Benzyloxy)benzylidene]-1-(prop-2-en-1-yl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203542; ZINC4723742; BDBM50400736; STK187216; AKOS000328436
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| Activity |
IC50 = 67300 nM
|
[4] | |||
| Compound Name |
(2S)-2-Naphthalen-2-ylsulfanyl-4-oxo-4-(3-phenylpropylamino)butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072487; BDBM50255720
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| Activity |
IC50 = 72560 nM
|
[5] | |||
| Compound Name |
(2S)-4-[3-(Methylcarbamoyl)anilino]-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094155; BDBM50255728
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| Activity |
IC50 = 90000 nM
|
[5] | |||
| Compound Name |
3-[(3,5-Dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1,2-dihydroindol-2-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1794051; BDBM50358043
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| Activity |
IC50 = 97800 nM
|
[6] | |||
| Compound Name |
Sirtinol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL380797; 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; 2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide; (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide; 2-[[(Z)-(2-oxonaphthalen-1-ylidene)methyl]amino]-N-(1-phenylethyl)benzamide; 2-[(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino]-N-(1-phenylethyl)benzamide; 2-[(2-oxo-1-naphthalenylidene)methylamino]-N-(1-phenylethyl)benzamide; 2-[(2-hydroxynaphthalen-1-yl)methylideneamino]-N-(1-phenylethyl)benzamide; 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]- N -(1-phenylethyl)benzamide; Sir Two Inhibitor Naphthol; 2-[(2-oxonaphthalen-1-ylidene)methylamino]-N-[(1R)-1-phenylethyl]benzamide; Probes1_000047; Probes1_000316; Probes2_000084; Probes2_000518; Oprea1_639422; CBDivE_000728; ARONIS007637; SCHEMBL2543371; SCHEMBL8227466; Sirtinol, >=95% (NMR); KS-00003ZNW; HMS3413N18; HMS3651B13; HMS3677N18; BCP22454; EX-A4220; BDBM50156760; MFCD00810186; s2804; STL069068; AKOS000497157; AKOS016842267; AKOS030627556; AB07334; CCG-265000; CS-5291; DS-0089; MCULE-8856934531; Sirtinol - CAS 410536-97-9; VZ23394; SMP2_000018; AC-32747; AK-16605; BR-16605; HY-13515; BCP0726000065; FT-0644594; SW219185-1; W6155; S-5353; BRD-A23747351-001-01-9; Q27140353; Q27215793; 2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide; 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl) benzamide; (E)-2-(((2-HYDROXYNAPHTHALEN-1-YL)METHYLENE)AMINO)-N-(1-PHENYLETHYL)BENZAMIDE; 2-[(2-hydroxy-naphthalen-1-ylmethylene)-amino]-N-(1-phenyl-ethyl)-benzamide; 2-[[(2-HYDROXY-1-NAPHTHALENYL)METHYLENE]AMINO]-N-(1-PHENYLETHYL)BENZAMIDE; 2-{[(E)-(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-(1-phenylethyl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
niacinamide; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Papulex; Aminicotin; Amixicotyn; Nicobion; Nicotylamide; Nikotinamid; Savacotyl; Benicot; Dipegyl; Endobion; Hansamid; Pelmine; Nicotinic amide; Delonin amide; Pelonin amide; Vi-Nicotyl; Austrovit PP; Inovitan PP; Vitamin B; Nicosylamide; Nicotilamide; Nicotililamido; Amnicotin; Niacevit; Nicamina; Nicamindon; Nicofort; Nicomidol; Nicotamide; Nicovitina; Nicovitol; Nicozymin; Niocinamide; Niozymin; Niamide; Nicasir; Nicogen; Nicota; Nicotol; Nicovit; Niko-tamin; 3-Carbamoylpyridine; Nicotine acid amide; Nandervit-N; Pyridine-3-carboxylic acid amide; Niavit PP; Nicosan 2; Nicotine amide; beta-Pyridinecarboxamide; Nikotinsaeureamid; Nicotylamidum; Mediatric; Nicotinsaureamid; Pyridine, 3-carbamoyl-; 3-Pyridinecarboxylic acid amide; Nicotinamidum; m-(Aminocarbonyl)pyridine; Acid amide; Factor pp; Nicotinamida; Nicovel; Vitamin B (VAN); Pelmin; Amid kyseliny nikotinove; Witamina PP; PP-Faktor; Amide PP; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Amid kyseliny nikotinove [Czech]; Nicotinamidum [INN-Latin]; Nicotinamida [INN-Spanish]; Nictoamide; CCRIS 1901; Dipigyl; HSDB 1237; Vi-noctyl; AI3-02906; Nicotinamide (Vitamin B3); NSC 13128; b-Pyridinecarboxamide; Niacinamide [USP]; UNII-25X51I8RD4; 3-(aminocarbonyl)pyridine; MFCD00006395; .beta.-Pyridinecarboxamide; CHEMBL1140; MLS000069714; 25X51I8RD4; NSC13128; Niacinamide (USP); NSC-13128; NSC-27452; Nicotinamide, 99%; NCGC00093354-03; NCGC00093354-05; SMR000058212; DSSTox_CID_929; Niacinamide;Nicotinic acid amide;Vitamin B3; WLN: T6NJ CVZ; DSSTox_RID_75873; DSSTox_GSID_20929; Niacinamide [USAN]; Enduramide; B3, Vitamin; Vitamin B 3; B 3, Vitamin; 3 Pyridinecarboxamide; SR-01000721872; Nicotinsaureamid Jenapharm; EINECS 202-713-4; Jenapharm, Nicotinsaureamid; Niacotinamide; Nicotinamid; nicotin-amide; Nicotinsaeureamid; 3-Amidopyridine; DEA No. 1405; Nicotinamide,(S); Vitamin B3 amide; 3-yridinecarboxamide; Nicotinamide [INN]; ACMC-20aizz; Mediatric (Salt/Mix); niacin - Vitamin B3; Opera_ID_775; Niacinamide(Vitamin B3); bmse000281; MolMap_000061; EC 202-713-4; SCHEMBL2926; Nicotinamide (JP17/INN); KSC237G2T; MLS001424246; SCHEMBL6278767; SGCUT00176; ZINC5878; DTXSID2020929; SCHEMBL19978192; BDBM27507; Nicotinamide, niacin, vitamin B3; HMS2052M21; HMS2090B05; HMS2093H03; HMS2236J03; HMS3370F21; HMS3394M21; HMS3655M20; HMS3713B22; HMS3884A16; Pharmakon1600-01505397; BCP07322; HY-B0150; Nicotinamide (Vitamin B3) solution; NSC27452; to_000073; Nicotinamide 1.0 mg/ml in Methanol; Nicotinamide, >=98.5% (HPLC); Nicotinamide, >=99.5% (HPLC); Tox21_111202; Tox21_201716; Tox21_302776; ANW-75549; BBL013003; NSC759115; s1899; SBB004283; STL163867; AKOS005715850; Tox21_111202_1; CCG-101149; CS-1968; DB02701; MCULE-3532732201; NC00399; NSC-759115; Nicotinamide, >=98% (HPLC), powder; NCGC00093354-04; NCGC00093354-06; NCGC00093354-09; NCGC00256432-01; NCGC00259265-01; AS-13845; Nicotinamide, puriss., 99.0-101.0%; SC-18039; Nicotinamide 10 microg/mL in Acetonitrile; Nicotinamide, tested according to Ph.Eur.; SBI-0206826.P001; DB-057754; FT-0631517; FT-0672696; FT-0773644; N0078; N1651; ST51037366; SW197779-3; EN300-15612; Niacinamide, meets USP testing specifications; 3418-EP2281816A1; 3418-EP2281818A1; 3418-EP2285778A1; 3418-EP2287165A2; 3418-EP2295424A1; 3418-EP2307377A1; 3418-EP2307378A1; 3418-EP2308858A1; 3418-EP2308874A1; 3418-EP2311808A1; 3418-EP2311829A1; C00153; D00036; J10422; Nicotinamide (Niacinamide), analytical standard; W-3583; 11783-EP2269610A2; 11783-EP2289510A1; 11783-EP2316457A1; 11783-EP2316458A1; 11783-EP2316825A1; 11783-EP2316826A1; 11783-EP2316827A1; 11783-EP2316828A1; AB00373895-13; AB00373895_15; AB00373895_16; Nicotinamide, Vetec(TM) reagent grade, >=98%; A845925; AC-907/25014114; Q192423; Q-201470; SR-01000721872-3; SR-01000721872-4; SR-01000721872-5; Z33546463; F2173-0513; A186B02E-6C70-4E54-9739-79398D439AAA
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601369; BDBM50106876
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
Ethyl 3-[[(5S)-6-[[(2S)-6-acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601371; BDBM50106877
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
Chembl4170094
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Investigative | Compound Info | ||
| Synonyms |
BDBM50449710; L5C
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
3-((2-Methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one
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Investigative | Compound Info | ||
| Synonyms |
ICL-SIRT078; CHEMBL3769975; SCHEMBL17713120; BDBM50148827
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
2-[[(5S)-6-[[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]amino]-5-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-oxohexyl]carbamothioylamino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3601367; BDBM50106875
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
(2S)-4-(Benzylamino)-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099407; BDBM50255719
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| Activity |
IC50 = 124000 nM
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[5] | |||
| Compound Name |
(2S)-4-(Butylamino)-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101891; BDBM50255717
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| Activity |
IC50 = 154000 nM
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[5] | |||
| Compound Name |
(2S)-4-Anilino-2-naphthalen-2-ylsulfanyl-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073522; BDBM50255718
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| Activity |
IC50 = 157200 nM
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[5] | |||
| Compound Name |
Chembl4295059
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 167000 nM
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[10] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 19 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
US9359293, TM
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL18103197; CHEMBL3940508; BDBM234208; US9359293, TM
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| Activity |
IC50 > 205000 nM
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[11] | |||
| Compound Name |
US9359293, TA
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL18103200; CHEMBL3892393; BDBM234205; US9359293, TA
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| Activity |
IC50 > 205000 nM
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[11] | |||
| Compound Name |
US9359293, TB
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL18103198; CHEMBL3968962; BDBM234206; US9359293, TB
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| Activity |
IC50 > 205000 nM
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[11] | |||
| Compound Name |
Chembl4287164
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Investigative | Compound Info | ||
| Activity |
IC50 > 200000 nM
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[10] | |||
| Compound Name |
5-[[3-(Pyridine-3-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806063; SCHEMBL18340304; BDBM50168918
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| Activity |
IC50 > 200000 nM
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[12] | |||
| Compound Name |
(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,14,21-tetraoxo-1,4,7,13-tetrazacyclohenicosane-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925899; BDBM50197423
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| Activity |
IC50 > 200000 nM
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[13] | |||
| Compound Name |
Thiomyristoyl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4129995; benzyl (S)-(1-oxo-1-(phenylamino)-6-tetradecanethioamidohexan-2-yl)carbamate; EX-A4227; BDBM50276140; MFCD30738003; s8245; ZINC616570764; CCG-270137; CS-6258; BS-15398; HY-101278; benzyl N-[(2S)-1-anilino-1-oxo-6-(tetradecanethioylamino)hexan-2-yl]carbamate
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
5-({3-[4-(Morpholin-4-yl)benzamido]phenyl}methoxy)pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
compound 86 [PMID: 26982234]; CHEMBL3805692; GTPL9251; SCHEMBL18339834; BDBM50168905; J3.611.092I; Q27076816; 5-[3-(4-Morpholinobenzoylamino)benzyloxy]pyridine-3-carboxamide
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| Activity |
IC50 > 200000 nM
|
[12] | |||
| Compound Name |
5-[3-(4-Pyridinylcarbonylamino)benzyloxy]pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806257; SCHEMBL18339852; BDBM50168921; J3.611.098H
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| Activity |
IC50 > 200000 nM
|
[12] | |||
| Compound Name |
Phenyl N-[1-anilino-6-(heptanethioylamino)-1-oxohexan-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972352; SCHEMBL18103199; BDBM234207; US9359293, TH
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| Activity |
IC50 > 205000 nM
|
[11] | |||
| Compound Name |
(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964797; BDBM50197389
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| Activity |
IC50 > 300000 nM
|
[13] | |||
| Compound Name |
(2S,5S,8S)-2-Butyl-5-[4-(ethanethioylamino)butyl]-3,6,13,20-tetraoxo-1,4,7,12-tetrazacycloicosane-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917969; BDBM50197512
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| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
Anthralin
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Investigative | Compound Info | ||
| Synonyms |
Dithranol; 1,8-Dihydroxyanthrone; 1,8-Dihydroxy-9-anthrone; 1,8-Dihydroxyanthracen-9(10H)-one; Chrysodermol; Cignolin; 9(10H)-Anthracenone, 1,8-dihydroxy-; Cigthranol; 1,8-dihydroxy-10H-anthracen-9-one; Batridol; Psoriacid-Stift; Anthra-Derm; Anthrone, 1,8-dihydroxy-; Drithoscalp; DrithoCreme; 1,8-DIHYDROXY-9(10H)-ANTHRACENONE; NSC 43970; Anthraline; NSC 629313; UNII-U8CJK0JH5M; Anthralin [USP]; Anthralin (Dithranol); MFCD00053409; U8CJK0JH5M; CHEMBL46469; Anthralin (USP); Dithranol (INN); Dithranol [INN]; NSC-43970; NSC629313; NSC-629313; NCGC00091330-01; DSSTox_CID_4538; 1,8-Dihydroxy-9(10H)-anthracenone;Anthralin; DSSTox_RID_77448; DSSTox_GSID_24538; Dithranolum; 1,8,9-Trihydroxyanthracene, 97%; Dithranolum [INN-Latin]; Zithranol-RR; CCRIS 628; SR-05000002011; EINECS 214-538-0; BRN 2054360; Psodadrate; Prestwick_528; Anthralin, Dithranol; Dithranol ,(S); Anthrone,8-dihydroxy-; Spectrum_000056; ANTHRADERM (TN); Spectrum2_000111; Spectrum3_000304; Spectrum4_000151; Spectrum5_000820; Epitope ID:114081; 1,8-dihydroxy-9-anthrane; cid_2202; SCHEMBL3197; BSPBio_001868; KBioGR_000622; KBioSS_000436; 4-06-00-07602 (Beilstein Handbook Reference); MLS001332632; MLS002415712; DivK1c_000021; SPECTRUM1500127; SPBio_000122; ZINC1322; Dithranol, >=90% (HPLC); DTXSID7024538; CTK8A0163; HMS500B03; KBio1_000021; KBio2_000436; KBio2_003004; KBio2_005572; KBio3_001368; NUZWLKWWNNJHPT-UHFFFAOYSA-; NINDS_000021; HMS1920E07; HMS2091K07; HMS2271B09; HMS3715H19; Pharmakon1600-01500127; HY-B0738; NSC43970; 9(10H)-Anthracenone,8-dihydroxy-; Tox21_111115; Tox21_201851; Tox21_300290; BDBM50041802; CCG-38920; NSC755873; s4590; 1,8-dihydroxy-9-(10H)anthracenone; AKOS015914122; Tox21_111115_1; 9(10H)-Anthracenone,1,8-dihydroxy-; DB11157; KS-5183; MCULE-8492759735; NSC-755873; 1,8-dihydroxy-10-hydroanthracen-9-one; IDI1_000021; 1,8-Dihydroxy-9(10H)-anthracenone #; NCGC00091330-02; NCGC00091330-03; NCGC00091330-04; NCGC00091330-05; NCGC00091330-07; NCGC00253941-01; NCGC00259400-01; AC-14842; NCI60_004019; SC-19051; SBI-0051286.P003; AB0105711; DB-060606; 1,8-dihydroxy-9,10-dihydroanthracen-9-one; FT-0625372; ST50825759; C06831; D00233; K-1044; 9(10H)-Anthracenone, 1,8-dihydroxy- (9CI); AB00051916_07; Q419397; SR-05000002011-1; SR-05000002011-2; W-108602
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| Activity |
IC50 = 453400 nM
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[5] | |||
| Compound Name |
Chembl4129734
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276142
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| Activity |
IC50 > 500000 nM
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[3] | |||
| Compound Name |
Chembl4280942
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Investigative | Compound Info | ||
| Activity |
IC50 > 500000 nM
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[10] | |||
| Compound Name |
Chembl4128353
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276141
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| Activity |
IC50 > 500000 nM
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[3] | |||
| Compound Name |
(2S)-N-[(2S)-3-Acetamido-1-amino-1-oxopropan-2-yl]-2-[[(2S)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-6-(ethanethioylamino)hexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3608311; BDBM50498616
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| Activity |
IC50 = 2000000 nM
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[14] | |||
| Compound Name |
(2S,5S,8S)-2-(1-Benzothiophen-3-ylmethyl)-5-[4-(ethanethioylamino)butyl]-3,6,12,19-tetraoxo-1,4,7,11-tetrazacyclononadecane-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935771; BDBM50197514
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| Activity |
IC50 > 2000000 nM
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[13] | |||
| Compound Name |
(2S,5S,8S)-5-[4-(Ethanethioylamino)butyl]-2-(naphthalen-2-ylmethyl)-3,6,12,19-tetraoxo-1,4,7,11-tetrazacyclononadecane-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916893; BDBM50197390
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| Activity |
IC50 > 6000000 nM
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[13] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme. J Med Chem. 2012 Jun 14;55(11):5582-90. | ||||
| REF 2 | A FRET-based assay for screening SIRT5 specific modulators. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1671-1674. | ||||
| REF 3 | The mimics of N -acyl-lysine derived from cysteine as sirtuin inhibitors. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2375-2378. | ||||
| REF 4 | Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012 Oct 6;3(12):1050-3. | ||||
| REF 5 | Potent and Selective Inhibitors of Human Sirtuin 5. J Med Chem. 2018 Mar 22;61(6):2460-2471. | ||||
| REF 6 | Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. Bioorg Med Chem Lett. 2013 Jan 1;23(1):143-6. | ||||
| REF 7 | Novel thiourea-based sirtuin inhibitory warheads. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3319-24. | ||||
| REF 8 | X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823. | ||||
| REF 9 | Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. J Med Chem. 2017 Mar 9;60(5):1928-1945. | ||||
| REF 10 | US patent application no. 20160130246A1, THIOUREA COMPOUNDS AND THEIR USE AS INHIBITORS OF SIRT2 OR SIRT5 | ||||
| REF 11 | US patent application no. 9359293B2, Methods of treatment using modulators of SIRT2 | ||||
| REF 12 | 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. J Med Chem. 2016 Apr 14;59(7):2928-41. | ||||
| REF 13 | Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N -thioacetyl-lysine. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5234-5239. | ||||
| REF 14 | Human SIRT3 tripeptidic inhibitors containing N()-thioacetyl-lysine. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3481-7. | ||||
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