Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94400 | Target Info | |||
| Target Name | Mycobacterium Thymidine monophosphate kinase (MycB tmk) | ||||
| Synonyms |
tmk; Thymidylic kinase; Thymidylic acid kinase; Thymidylate monophosphate kinase; Thymidylate kinase; Thymidine 5'-monophosphate kinase; TMPK; Deoxythymidine 5'-monophosphate kinase; DTMPkinase
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| Target Type | Literature-reported Target | ||||
| Gene Name | MycB tmk | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 39 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Trifluridine
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Approved | Compound Info | ||
| Synonyms |
Fluridine; TFDU; TRIFLUOROTHYMIDINE; Trifluoridine; Trifluoromethyldeoxyuridine; Trifluridina; Trifluridinum; Virophta; Viroptic; Trifluorothymine deoxyriboside; CF3dUrd; F3DThd; F3T; F3TDR; HS-0007; Trifluridina [INN-Spanish]; Trifluridine [USAN:INN]; Trifluridinum [INN-Latin]; Viroptic (TN); Trifluridine (USP/INN);Viroptic, Trifluorothymidine, Trifluridine; Alpha,alpha,alpha-Trifluorothymidine; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione; 2'-Deoxy-5-(trifluoromethyl)uridine; 2'-Deoxy-5-trifluoromethyluridine; 5-(Trifluoromethyl)-2'-deoxyuridine; 5-(Trifluoromethyl)deoxyuridine; 5-Trifluoro-2'-deoxythymidine; 5-Trifluoromethyl-2'-deoxyuridine; 5-Trifluoromethyl-2-deoxyuridine; 5-Trifluorothymidine
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| Activity |
Ki = 97000 nM
|
[1] | |||
| Compound Name |
6-(2-Methoxyphenyl)-4-methylsulfanyl-2-oxo-1H-pyridine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394147; BDBM50498086
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2H-Pyran-3-carbonitrile, 4-(methylthio)-2-oxo-6-(2-thienyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL110569; CTK2E1096; DTXSID50447340; BDBM50498071; ZINC26851760; AKOS022664137; MCULE-4980482935; 3-Cyano-4-(methylthio)-6-(2-thienyl)-2H-pyran-2-one; 4-methylsulfanyl-2-oxo-6-(2-thienyl)pyran-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-[(4-Chlorophenyl)methyl]-5-methyl-3H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL190616; 1-[(4-chlorophenyl)methyl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-[(4-chlorophenyl)methyl]-5-methylpyrimidine-2,4-dione; SCHEMBL5126430; KS-00003K9H; BDBM50164408; MFCD20761658; ZINC28471794; AKOS009181151; FC-0061; MCULE-1405044781; 1-(4-Chloro-benzyl)-5-methyl-1H-pyrimidine-2,4-dione; 1-[(4-chlorophenyl)methyl]-5-methyl-pyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 1-[(4-chlorophenyl)methyl]-5-methyl-
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| Activity |
Ki = 50000 nM
|
[3] | |||
| Compound Name |
1-[[4-(4-Hydroxybutyl)phenyl]methyl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL454546; SCHEMBL5718601; BDBM50271446; 1-(4-(4-hydroxybutyl)benzyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-[[4-(4-hydroxybutyl)phenyl]methyl]-5-methylpyrimidine-2,4-dione
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| Activity |
Ki = 51000 nM
|
[4] | |||
| Compound Name |
Methyl 4-[4-[(5-bromo-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]butanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL526527; BDBM50272059; methyl 4-(4-((5-bromo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)butanoate
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| Activity |
Ki = 52000 nM
|
[4] | |||
| Compound Name |
3-[4-[(5-Methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL189636; 3-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-phenyl]-propionic acid; 3-[4-[(5-methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]propanoic acid; SCHEMBL5129617; BDBM50164411; 3-(4-((5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)propanoic acid; Benzenepropanoic acid, 4-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-
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| Activity |
Ki = 55000 nM
|
[4] | |||
| Compound Name |
[(2R,3S,4R,5R)-4-Amino-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160592; CTK1D1165; DTXSID00333325; 5'-Uridylic acid, 2'-amino-2'-deoxy-5-methyl-
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| Activity |
Ki = 55000 nM
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[5] | |||
| Compound Name |
5-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520450; BDBM50271493; 5-(4-((5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)pentanamide
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| Activity |
Ki = 55000 nM
|
[4] | |||
| Compound Name |
1-(4-Aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL341264; BDBM50131909; 1-((2R,4R,5S)-4-aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione; 1-[(2R,4R,5S)-4-(aminomethyl)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione; 1-[3-(Aminomethyl)-2,3-dideoxy-ss-D-erythro-pentafuranosyl]-5-methylpyrimidine-2,4-(1H, 3H)-dione
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| Activity |
Ki = 57000 nM
|
[6] | |||
| Compound Name |
5-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]pentanoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482510; SCHEMBL5126818; BDBM50271492; 5-[4-[(5-methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]pentanoic acid; 5-(4-((5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)pentanoic acid
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| Activity |
Ki = 58000 nM
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[4] | |||
| Compound Name |
Methyl 4-[4-[(5-chloro-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]butanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448393; BDBM50271624; methyl 4-(4-((5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)butanoate
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| Activity |
Ki = 59000 nM
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[4] | |||
| Compound Name |
4-[2-Fluoro-4-[(5-methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3716712; SCHEMBL14208534
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| Activity |
Ki = 63000 nM
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[3] | |||
| Compound Name |
1-[(3,4-Difluorophenyl)methyl]-5-methylpyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL365098; SCHEMBL5126504; BDBM50164409; 1-(3,4-Difluoro-benzyl)-5-methyl-1H-pyrimidine-2,4-dione; 1-[(3,4-difluorophenyl)methyl]-5-methyl-pyrimidine-2,4-dione; 5-Methyl-1-(3,4-difluoro-benzyl)-1H-pyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 1-[(3,4-difluorophenyl)methyl]-5-methyl-
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| Activity |
Ki = 67000 nM
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[3] | |||
| Compound Name |
1-[[(2S,3R,5R)-2-(Hydroxymethyl)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-3-yl]methyl]-3-phenyl-thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392133; BDBM50223816; 3'-Deoxy-3'-{[(phenylcarbamothioyl)amino]methyl}thymidine; N-[(3''-deoxythymidin-3''-yl)methyl]-N''-phenylthiourea
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| Activity |
Ki = 69000 nM
|
[7] | |||
| Compound Name |
1-[[4-(4-Hydroxybut-1-ynyl)phenyl]methyl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485322; 1-[4-(4-Hydroxy-butyn-1-yl)-benzyl]-5-methyl-1Hpyrimidine-2,4-dione; SCHEMBL5129479; BDBM50271445; AKOS014902761; 1-[[4-(4-hydroxybut-1-ynyl)phenyl]methyl]-5-methylpyrimidine-2,4-dione; 1-[4-(4-Hydroxy-but-1-ynyl)-benzyl]-5-methyl-1H-pyrimidine-2,4-dione
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| Activity |
Ki = 70000 nM
|
[4] | |||
| Compound Name |
1-[(2R,4S,5R)-4-Hydroxy-5-[2-(1H-tetrazol-5-yl)ethyl]tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314751; BDBM50424078; 5'-(1H-Tetrazole-5-ylmethyl)-5'-deoxythymidine
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| Activity |
Ki = 70000 nM
|
[8] | |||
| Compound Name |
Methyl 4-[4-[(5-methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]butanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3718132; SCHEMBL14208524
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| Activity |
Ki = 70000 nM
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[3] | |||
| Compound Name |
1-[(2R,4S,5R)-5-[[[1-[4-Chloro-3-(trifluoromethyl)phenyl]tetrazol-5-yl]amino]methyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1928433; BDBM50359623
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| Activity |
Ki = 73000 nM
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[9] | |||
| Compound Name |
1-Benzyl-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
1-benzyl-5-methylpyrimidine-2,4-dione; CHEMBL365123; 1-benzyl-5-methyl-2,4(1H,3H)-pyrimidinedione; 1-benzyl-5-methyl-3H-pyrimidine-2,4-dione; 1-Benzylthymine; 1-benzyl-5-methylpyrimidine-2,4(1h,3h)-dione; NSC42047; Oprea1_731836; MLS000533095; SCHEMBL3996660; CTK5B7356; DTXSID10285487; HMS1703K17; HMS2488P24; ZINC198568; KS-00003K9I; BDBM50164410; MFCD01469796; NSC-42047; AKOS000549820; FC-0066; MCULE-4654323255; SMR000140533; 5-Methyl-1-Benzyl-1H-pyrimidine-2,4-dione; 1-BENZYL-5-METHYL-PYRIMIDINE-2,4-DIONE; 1-benzyl-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-(phenylmethyl)-; 2,4(1H,3H)-Pyrimidinedione,5-methyl-1-(phenylmethyl)-
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| Activity |
Ki = 75000 nM
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[3] | |||
| Compound Name |
3-Benzyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520146; BDBM50271302
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| Activity |
Ki = 75000 nM
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[4] | |||
| Compound Name |
1-[(2R,3R,4R,5S)-4-(Azidomethyl)-3-fluoro-5-(fluoromethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222970; BDBM50156576; 1-(3-azidomethyl-2,5-difluoro-2,3,5-trideoxy-beta-D-ribofuranosyl)thymine
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| Activity |
Ki = 80000 nM
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[6] | |||
| Compound Name |
3-[4-[(5-Methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364887; 3-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-phenyl]-propionamide; SCHEMBL5123101; BDBM50164407; 3-(4-(thymin-1-ylmethyl)phenyl)propionamide; 3-[4-[(5-methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]propanamide; Benzenepropanamide, 4-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-
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| Activity |
Ki = 89000 nM
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[4] | |||
| Compound Name |
1-[(3-Fluorophenyl)methyl]-5-methylpyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL189491; SCHEMBL5124587; BDBM50164419; 1-(3-Fluoro-benzyl)-5-methyl-1H-pyrimidine-2,4-dione; 5-Methyl-1-(3-fluoro-benzyl)-1H-pyrimidine-2,4-dione; 1-[(3-fluorophenyl)methyl]-5-methyl-pyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 1-[(3-fluorophenyl)methyl]-5-methyl-
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| Activity |
Ki = 90000 nM
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[3] | |||
| Compound Name |
N-[[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL322925; AC1LAB0L; CTK2A8770; DTXSID90333516; 5'-(Acetylamino)-5'-deoxythymidine; BDBM50132307; Thymidine, 5'-(acetylamino)-5'-deoxy-
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| Activity |
Ki = 90000 nM
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[1] | |||
| Compound Name |
6-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]hex-5-ynoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482520; SCHEMBL5123991; BDBM50271533; 6-(4-((5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)hex-5-ynoic acid
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| Activity |
Ki = 96000 nM
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[4] | |||
| Compound Name |
3'-Azido-3'-deoxy-4-thiothymidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790742; Thymidine, 3'-azido-3'-deoxy-4-thio-; 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-4-sulfanylidenepyrimidin-2-one; N3ddThdS; N3ddThdS3; DTXSID00148552; BDBM50367920; 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-4-thioxo-pyrimidin-2-one
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| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
4-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485122; 4-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H -pyrimidin-1-yl-methyl)-phenyl]-butanamide; SCHEMBL14208573; BDBM50271444
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| Activity |
Ki = 112000 nM
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[4] | |||
| Compound Name |
6-[4-[(5-Methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]hex-5-ynamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5121216; CHEMBL3718858
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| Activity |
Ki = 113000 nM
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[3] | |||
| Compound Name |
[(2S,3S,4R,5R)-3-(Azidomethyl)-4-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161002
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| Activity |
Ki = 116000 nM
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[10] | |||
| Compound Name |
2'-Fluorothymidine
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Investigative | Compound Info | ||
| Synonyms |
2'-Deoxy-2'-fluorothymidine; Uridine, 2'-deoxy-2'-fluoro-5-methyl-; CHEMBL105524; 2'-Deoxy-2'-fluoro-5-methyluridine; NCGC00253767-01; 2'alpha-Fluorothymidine; SCHEMBL139784; 2'-Deoxy-2'-Fluoro-thymidine; CTK8F0952; DTXSID40924276; 5-Methyl-1-(2'-deoxy-2'-fluoro-beta-D-ribofuranosyl)uracil; ZINC6069517; 2'-deoxy-2'-(R)-fluoro-thymidine; BDBM50132306; HY-128710; CS-0099248; X2153; uridine, 2'-deoxy-2'-fluoro-5-(iodo-125I)-; 799D386; 1-(2'-deoxy-2'-fluoro-b-D-ribofuranosyl)-5-methyluracil; 1-(2'-deoxy-2'-fluoro-?-D-arabinofuranosyl)-5-methyluracil; 1-(2-Deoxy-2-fluoropentofuranosyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one
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| Activity |
Ki = 122000 nM
|
[1] | |||
| Compound Name |
5,7-Diethyl-3,4-dimethyl-1H-1,6-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394239; SCHEMBL9347409; BDBM50498081
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| Activity |
IC50 = 133000 nM
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[2] | |||
| Compound Name |
[(2R,3S,5R)-5-[5-(2-Furyl)-2,4-dioxo-pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160816; SCHEMBL19699212; 5-(2-Furanyl)-2'-deoxyuridine 5'-phosphoric acid
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| Activity |
Ki = 140000 nM
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[1] | |||
| Compound Name |
1-[(2S,3S,4R,5R)-4-Hydroxy-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-3-yl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL320200; BDBM50132290; 3'-Guanidino-5-methyl-3'-deoxyuridine
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| Activity |
Ki = 140000 nM
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[1] | |||
| Compound Name |
1',5'-Anhydro-2',3'-dideoxy-2'-(thymin-1-YL)-6'-O-phosphoryl-D-arabino-hexitol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160817; Q27456412
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| Activity |
Ki = 150000 nM
|
[1] | |||
| Compound Name |
1-[4-(2-Hydroxy-ethyl)-5-hydroxymethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124814; BDBM50131917
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| Activity |
Ki = 156000 nM
|
[10] | |||
| Compound Name |
1-[(2R,3R,4R,5S)-4-(Azidomethyl)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223811; BDBM50156574; 1-(3-azidomethyl-2,3-dideoxy-2-fluoro-beta-D-ribofuranosyl)thymine; 2,4(1H,3H)-Pyrimidinedione, 1-[3-(azidomethyl)-2,3-dideoxy-2-fluoro-b-D-ribofuranosyl]-5-methyl-
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| Activity |
Ki = 165000 nM
|
[6] | |||
| Compound Name |
1-(3-Azidomethyl-2-chloro-2,3-dideoxy-beta-D-ribofuranosyl)thymine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223135; BDBM50156575
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| Activity |
Ki = 180000 nM
|
[6] | |||
| Compound Name |
(E)-3-[4-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]prop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414848; SCHEMBL5130239; BDBM50164417; (E)-3-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-phenyl]-acrylamide; 3-(4-((5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)phenyl)acrylamide; 2-Propenamide, 3-[4-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]phenyl]-, (2E)-
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| Activity |
Ki = 195000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 23 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Doxifluridine
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Approved | Compound Info | ||
| Synonyms |
Furtulon (TN)
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| Activity |
Ki = 560000 nM
|
[1] | |||
| Compound Name |
5-fluorouridine
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Investigative | Compound Info | ||
| Synonyms |
5-Fluorouridine; 316-46-1; 5-Fur; Uridine, 5-fluoro-; FUrd; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluoro-uridine; UNII-4K0M952561; EINECS 206-260-3; 77180-80-4; 5-Fluorouracil 1beta-D-ribofuranoside; NSC 146604; fluorouridine; BRN 0033662; CHEMBL54918; CHEBI:40154; FHIDNBAQOFJWCA-UAKXSSHOSA-N; 5-fluoro-1-(beta-d-ribofuranosyl)uracil; 4K0M952561; C9H11FN2O6; 5UD; 1-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,3-dihy dropyrimidine-2,4-
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| Activity |
Ki = 521000 nM
|
[1] | |||
| Compound Name |
1-[(2R,4S,5R)-5-[[4-(4-Chlorophenyl)triazol-1-yl]methyl]-4-hydroxy-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1926703; BDBM50359624
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| Activity |
Ki = 201000 nM
|
[9] | |||
| Compound Name |
4-[4-[(2,4-Dioxopyrimidin-1-yl)methyl]phenyl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503907; 4-[4-(2,4-Dioxo-3,4-dihydro-2H -pyrimidin-1-ylmethyl)-phenyl]-butanoic acid; SCHEMBL5119597; BDBM50271447
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| Activity |
Ki = 202000 nM
|
[4] | |||
| Compound Name |
3'-Amino-3'-deoxythymidine
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Investigative | Compound Info | ||
| Synonyms |
3'-Amino-2',3'-dideoxythymidine; UNII-7W21M0C25B; 3'-Amino-3'-deoxy-D-thymidine; CHEMBL103356; 7W21M0C25B; Thymidine, 3'-amino-3'-deoxy-; 3'-Deoxy-3'-aminothymidine; MFCD00038057; NSC620059; SCHEMBL1415408; WHI-02; CTK8D4878; DTXSID00966879; ZINC6069509; BDBM50132294; HG1142; AKOS015896813; AB0088031; DB-022181; NI 2-110-2; 450A187; Q27268932; 1-(3-Amino-2,3-dideoxypentofuranosyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one
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| Activity |
Ki = 230000 nM
|
[1] | |||
| Compound Name |
3'-Deoxy-3'-aminothymidine monophosphate
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Investigative | Compound Info | ||
| Synonyms |
3'-amino-3'-deoxythymidine 5'-(dihydrogen phosphate); 3'-Amino-3'-deoxythymidine 5'-monophosphate; Amt-MP; CHEMBL1160597; CTK4I5859; DTXSID00195041; DB03233; 3'-Amino-3'-deoxy-5'-thymidylic acid; 5'-Thymidylic acid, 3'-amino-3'-deoxy-; 3'-Amino-3'-deoxythymidine 5'-phosphoric acid; Q27463987
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| Activity |
Ki = 235000 nM
|
[1] | |||
| Compound Name |
Spongothymidine
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Investigative | Compound Info | ||
| Synonyms |
Arabinosylthymine; Thymine arabinoside; 1-beta-D-Arabinofuranosylthymine; UNII-NS9U4BEG7Y; ara-T; Spongothymidin; THYMINE-beta-D-ARABINOFURANOSIDE; NS9U4BEG7Y; CHEMBL103283; 1-(b-D-Arabinofuranosyl)thymine; 1-(beta-D-arabinofuranosyl)thymine; MFCD00065474; Thymine 1-beta-D-arabinofuranoside; EINECS 210-083-7; NSC 68929; BRN 0090166; Thymine-beta-D -arabinofuranoside; Thymine, 1-beta-D-arabinofuranosyl-; 1-beta-D-Arabinofuranosyl-5-methyl-(1H,3H)-pyrimidine-2,4-dione; Thymine-b-d-arabinofuranoside; 4-24-00-01308 (Beilstein Handbook Reference); SCHEMBL1619684; CTK8G3460; ZINC5765081; 2,4(1H,3H)-Pyrimidinedione, 1-.beta.-D-arabinofuranosyl-5-methyl-; BDBM50132291; Thymine, 1-.beta.-D-arabinofuranoside; C16744; 605T232; Thymine, 1-beta-D-arabinofuranosyl- (VAN) (8CI); Q27149733; 2,4(1H,3H)-Pyrimidinedione, 1-beta-D-arabinofuranosyl-5-methyl- (9CI)
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| Activity |
Ki = 238000 nM
|
[1] | |||
| Compound Name |
2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]-N-methyl-ethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314749; BDBM50424080
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| Activity |
Ki = 240000 nM
|
[8] | |||
| Compound Name |
1-[2-[(5-Methyl-2,4-dioxo-pyrimidin-1-yl)methoxy]ethyl]-3-phenyl-thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235304; BDBM50223821; N-[(thymin-1-yl)methoxyethyl]-N''-phenylthiourea
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| Activity |
Ki = 260000 nM
|
[7] | |||
| Compound Name |
Ethyl 3-[4-[(5-methyl-2,4-dioxopyrimidin-1-yl)methyl]phenyl]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL191010; 3-[4-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-phenyl]-propionic acid ethyl ester; SCHEMBL5129599; BDBM50164406; ethyl 3-[4-[(5-methyl-2,4-dioxo-pyrimidin-1-yl)methyl]phenyl]propanoate; Benzenepropanoic acid, 4-[(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-, ethyl ester
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| Activity |
Ki = 265000 nM
|
[3] | |||
| Compound Name |
[(2R,3S,5R)-5-[2,4-Dioxo-5-(2-thienyl)pyrimidin-1-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160806; 5-(2-Thienyl)-2'-deoxyuridine 5'-phosphoric acid
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| Activity |
Ki = 270000 nM
|
[1] | |||
| Compound Name |
[(2S,3S,4R,5R)-3-(Aminomethyl)-4-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl dihydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161001
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| Activity |
Ki = 315000 nM
|
[10] | |||
| Compound Name |
1-[(2R,4S,5R)-4-Hydroxy-5-(2-methylsulfonylethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314748; BDBM50424081
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| Activity |
Ki = 340000 nM
|
[8] | |||
| Compound Name |
1-[(2R,3R,4R,5S)-4-(Aminomethyl)-3-chloro-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL222242; BDBM50156569; 1-[3-aminomethyl-2-chloro-2,3-dideoxy-beta-D-ribofuranosyl]thymine; 2,4(1H,3H)-Pyrimidinedione, 1-[3-(aminomethyl)-2-chloro-2,3-dideoxy-b-D-ribofuranosyl]-5-methyl-
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| Activity |
Ki = 390000 nM
|
[6] | |||
| Compound Name |
1-(4-Aminomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124682; BDBM50131911; 1-[3-(Aminomethyl)-3-deoxy-beta-D-erythro-pentofuranosyl]thymine; 1-[3-(aminomethyl)-3-deoxy-ss-D-ribofuranosyl]-5-methylpyrimidine-2,4-(1H, 3H)-dione
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| Activity |
Ki = 393000 nM
|
[10] | |||
| Compound Name |
1-((2R,5S)-4-Azido-3-hydroxy-5-iodomethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL102479; BDBM50132289; 3'-Azido-5'-iodo-5-methyl-3',5'-dideoxyuridine; Uridine, 3'-azido-3',5'-dideoxy-5'-iodo-5-methyl-
Click to Show/Hide
|
||||
| Activity |
Ki = 490000 nM
|
[1] | |||
| Compound Name |
5-Methyl-7-Propyl-1,6-Naphthyridin-2(1h)-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394238; SCHEMBL9350602; BDBM50498067; 5-methyl-7-propyl-1H-1,6-naphthyridin-2-one; Q27466775
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| Activity |
IC50 = 590000 nM
|
[2] | |||
| Compound Name |
5-Methyl-2-oxo-1H-1,6-naphthyridine-3-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL356501; 1,6-Naphthyridine-3-carbonitrile, 1,2-dihydro-5-methyl-2-oxo-; 1,2-dihydro-5-methyl-2-oxo-1,6-naphthyridine-3-carbonitrile; ACMC-20lem7; Oprea1_503579; SCHEMBL6432848; CTK3A5410; DTXSID90420814; ZINC132526; BDBM50498066; CCG-42082; MCULE-3278774742; 3-Cyano-5-methyl-1,6-naphthyridin-2(1H)-one; SR-01000632110-1; 2-keto-5-methyl-1H-1,6-naphthyridine-3-carbonitrile; 5-methyl-2-oxo-1H-[1,6]naphthyridine-3-carbonitrile
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| Activity |
IC50 = 634000 nM
|
[2] | |||
| Compound Name |
1-(4-Azidomethyl-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL123912; NSC670034; CTK7J7573; BDBM50131919; 3'-(azidomethyl)-3'-deoxy-5-methyluridine; 1-[3-(Azidomethyl)-3-deoxy-beta-D-erythro-pentofuranosyl]thymine; 1-[3-C-(Azidomethyl)-3-deoxy-.beta.-D-erythro-pentofuranosyl]thymine
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| Activity |
Ki = 770000 nM
|
[10] | |||
| Compound Name |
1-[(3-Chlorophenyl)methyl]-2,4-dioxo-pyrimidine-5-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373302; Oprea1_284928; SCHEMBL14231942; ZINC171135; BDBM50164415; CCG-247587; MCULE-8055766540; 1-(3-Chloro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile; 5-Pyrimidinecarbonitrile, 1-[(3-chlorophenyl)methyl]-1,2,3,4-tetrahydro-2,4-dioxo-
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| Activity |
Ki = 810000 nM
|
[3] | |||
| Compound Name |
1-Benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
1-benzyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbonitrile; 1-benzyl-2,4-dioxopyrimidine-5-carbonitrile; CHEMBL370674; Oprea1_131842; MLS000695137; SCHEMBL7834032; CTK5A7320; KS-00001RMV; DTXSID20384935; HMS1666I07; HMS2629A21; ZINC166402; 5944AE; BDBM50164413; MFCD00172903; SBB097129; AKOS005069401; CCG-247633; MCULE-8003918131; SMR000333560; DB-053091; FT-0640479; 1-benzyl-2,4-dioxo-pyrimidine-5-carbonitrile; 11E-926; J-504263; F2185-0372; 2,6-dioxo-3-benzyl-1,3-dihydropyrimidine-5-carbonitrile; 1-Benzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile; 5-Pyrimidinecarbonitrile, 1,2,3,4-tetrahydro-2,4-dioxo-1-(phenylmethyl)-; 5-Pyrimidinecarbonitrile,1,2,3,4-tetrahydro-2,4-dioxo-1-(phenylmethyl)-
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| Activity |
Ki = 980000 nM
|
[3] | |||
| Compound Name |
Edoxudine
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Investigative | Compound Info | ||
| Synonyms |
5-Ethyl-2'-deoxyuridine; 2'-Deoxy-5-ethyluridine; 5-Ethyldeoxyuridine; Epoxudine; Aedurid; UNII-15ZQM81Y3R; ORF 15817; RWJ 15817; MLS000069564; 15ZQM81Y3R; CHEMBL318153; Uridine, 2'-deoxy-5-ethyl-; SMR000058816; Edoxudinum [Latin]; Edoxudina [Spanish]; Edoxudinum; Edoxudin; Edoxudina; beta-5-Ethyldeoxyuridine; Edoxudine [USAN:INN]; beta-5-Ethyl-2'-deoxyuridine; CCRIS 2349; EINECS 239-226-1; BRN 0755089; EtUdR; 5-Ethyl-dUrd; 5-Ethyl-1-(2'-deoxy-beta-D-ribofuranosyl)uracil; Edoxudine (USAN/INN); Opera_ID_1297; 5-ethyl-2''-deoxyuridine; cid_1814; DSSTox_CID_25890; DSSTox_RID_81204; DSSTox_GSID_45890; SCHEMBL65579; cid_66377; MLS001076558; 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; DTXSID4045890; CTK4I9625; HMS2234L05; HY-B1011; ZINC3956771; Tox21_111390; BDBM50132292; MFCD00079191; uridine-4-14C-2'-deoxy-5-ethyl-; CS-4524; DB13421; D03956; 5-Ethyl-2 inverted exclamation mark -deoxyuridine; Q987691; BRD-K86892782-001-13-9
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| Activity |
Ki = 1140000 nM
|
[1] | |||
| Compound Name |
1-((2R,5R)-4-Amino-3-hydroxy-5-methyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102768; BDBM50132301; 3'-Amino-5-methyl-3',5'-dideoxyuridine; 1-((4S,2R,3R,5R)-4-Amino-3-hydroxy-5-methyloxolan-2-yl)-5-methyl-1,3-dihydropyrimidine-2,4-dione; 1-[(2R,3R,4S,5R)-4-amino-3-hydroxy-5-methyl-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
Click to Show/Hide
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| Activity |
Ki = 1900000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3045-8. | ||||
| REF 2 | Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors. J Med Chem. 2015 Jan 22;58(2):753-66. | ||||
| REF 3 | US patent application no. 20080096907A1, Aryl, Pyrimidyl Compounds, Pharmaceutical Compositions Comprising them, Their Use as Antimicrobial Agents | ||||
| REF 4 | Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. | ||||
| REF 5 | Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2695-8. | ||||
| REF 6 | Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem. 2004 Dec 2;47(25):6187-94. | ||||
| REF 7 | Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacteri... J Med Chem. 2007 Nov 1;50(22):5281-92. | ||||
| REF 8 | Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors. Bioorg Med Chem. 2013 Jan 1;21(1):257-68. | ||||
| REF 9 | Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. Bioorg Med Chem. 2011 Dec 15;19(24):7603-11. | ||||
| REF 10 | 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem. 2003 Aug 28;46(18):3811-21. | ||||
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