Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98264 | Target Info | |||
| Target Name | Protein-tyrosine phosphatase SHP-1 (PTPN6) | ||||
| Synonyms |
Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; Protein-tyrosine phosphatase 1C; PTP1C; PTP-1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
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|
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| Target Type | Patented-recorded Target | ||||
| Gene Name | PTPN6 | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 86 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(125)I] RB129
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|
Investigative | Compound Info | ||
| Synonyms |
GLYCYRRHETINIC ACID; Uralenic acid; 18-beta-Glycyrrhetinic acid; Arthrodont; Glycyrrhetin; Jintan; Rhetinic Acid; 18beta-Glycyrrhetinic acid; Biosone; alpha-Glycyrrhetinic acid; 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid; Enoxolonum [INN-Latin]; Enoxolona [INN-Spanish]; UNII-P540XA09DR; Enoxolone [INN:BAN:DCF]; CCRIS 3962; EINECS 207-444-6; NSC 35347; 3-Glycyrrhetinic acid; BRN 2229654; Glycyrrhetinate; MLS000028748; CHEMBL230006; P540XA09DR; Glycyrrhetinic acid
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|
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| Activity |
IC50 = 65400 nM
|
[1] | |||
| Compound Name |
Novo Nordisk a/S Compound
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|
Investigative | Compound Info | ||
| Activity |
Ki = 80000 nM
|
[2] | |||
| Compound Name |
OLEANOLIC_ACID
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|
Investigative | Compound Info | ||
| Synonyms |
OLEANOLIC ACID; Oleanic acid; 508-02-1; Caryophyllin; Astrantiagenin C; Giganteumgenin C; Virgaureagenin B; 3beta-Hydroxyolean-12-en-28-oic acid; UNII-6SMK8R7TGJ; CCRIS 6493; (3-beta)-3-Hydroxyolean-12-en-28-oic acid; EINECS 208-081-6; NSC114945; 6SMK8R7TGJ; NSC-114945; 3-beta-Hydroxyolean-12-en-28-oic acid; CHEBI:37659; Olean-12-en-28-oic acid, 3-hydroxy-, (3beta)-; oleonolic acid; MFCD00064914
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(S)-2-(4-(Benzamidomethyl)-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667962; BDBM50336334
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Nle-Val-Phe-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL274087; BDBM50162435
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| Activity |
EC50 = 50000 nM
|
[5] | |||
| Compound Name |
Triazole tetra-benzyloxy-beta-D-O-glucosyl Threonine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667954; BDBM50336336
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Ethynyl-6-hydroxy-2-phenyl-benzofuran-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316901; SCHEMBL15829174; BDBM50425823; 3-ethynyl-6-hydroxy-2-phenyl-1-benzofuran-5-carboxylic acid
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Triazole tetra-benzyloxy-beta-D-O-glucosyl Serine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667953; BDBM50336335
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Triazole tetra-benzyloxy-beta-D-O-glucosyl Tyrosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667956; BDBM50336338
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-3-Hydroxy-2-(4-(((2R,3R,4S,5S,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yloxy)methyl)-1H-1,2,3-triazol-1-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667955; BDBM50336337
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-2-[2-((S)-2-{(S)-2-[(S)-2-{(S)-2-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-phenyl-butyrylamino}-3-(4-phosphonooxy-phenyl)-propionylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-acetylamino]-pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413215; BDBM50162438
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|
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| Activity |
EC50 = 50000 nM
|
[5] | |||
| Compound Name |
3,4,6-Tribromo-5-[(2,3,6-tribromo-4,5-dihydroxyphenyl)methyl]benzene-1,2-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374829; BDBM50363494; 5,5'-Methylenebis(3,4,6-tribromocatechol); bis(2,3,6-tribromo-4,5-dihydroxyphenyl)methane
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Methyl (2S)-2-[4-(benzamidomethyl)triazol-1-yl]-3-(4-hydroxyphenyl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667961; BDBM50336333; (S)-2-(4-(benzamidomethyl)-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate methyl ester
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5,5''-Methylenebis(2-hydroxybiphenyl-3-carboxylic acid)
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228397; BDBM50208359; 5-(3-carboxy-4-hydroxy-4-phenyl-benzyl)-2-hydroxy-biphenyl-3-carboxylic acid
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| Activity |
IC50 = 51000 nM
|
[8] | |||
| Compound Name |
2-Hydroxy-5-[5-[4-[[(2R,3R,4S,5R,6S)-3,4,5-tribenzoyloxy-6-methoxyoxan-2-yl]methoxymethyl]triazol-1-yl]pentoxy]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822607; BDBM50351999
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|
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| Activity |
IC50 = 52600 nM
|
[9] | |||
| Compound Name |
Triazole tetra-benzyloxy-beta-D-O-galactosyl Tyrosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1667960; BDBM50336332
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|
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| Activity |
IC50 = 53100 nM
|
[4] | |||
| Compound Name |
2-(Carboxyformamido)thiophene-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342612; SCHEMBL5836577; CTK0J4945; DTXSID30658432; BDBM50118749; N-(3-Carboxy-2-thienyl)oxamidic acid; 2-(Oxaloamino)thiophene-3-carboxylic acid; 2-(Oxalyl-amino)-thiophene-3-carboxylic acid; 3-Thiophenecarboxylic acid, 2-[(carboxycarbonyl)amino]-
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|
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| Activity |
Ki = 60000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371862
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|
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| Activity |
EC50 = 60000 nM
|
[5] | |||
| Compound Name |
4-{2-[(3Z)-5-{[(2-Chlorophenyl)methyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Oxindole scaffold, 10j; CHEMBL525078; BDBM24545
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| Activity |
IC50 = 60800 nM
|
[10] | |||
| Compound Name |
Azane;[[4-[2-[[4-[difluoro(phosphono)methyl]phenyl]methoxy]ethoxymethyl]phenyl]-difluoromethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344437
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|
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| Activity |
IC50 = 61000 nM
|
[11] | |||
| Compound Name |
3-[2-(2-Nitrophenyl)hydrazinyl]-2-oxoindole-5-sulfonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
NSC-117199; NSC117199; NCIStruc1_001516; NCIStruc2_001151; CHEMBL502257; SCHEMBL4417241; SCHEMBL15896784; DTXSID90417724; BDBM152151; CCG-37248; NCGC00014175; NCI117199; ZINC13099299; NCGC00014175-02; NCGC00097284-01; NCI60_000404; US8987474, HL1-056 (NSC-117199); 3-((2-(hydroxy(oxido)amino)phenyl)hydrazono)-2-oxo-5-indolinesulfonic acid
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|
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| Activity |
IC50 = 68000 nM
|
[10] | |||
| Compound Name |
2-Hydroxy-5-[4-[4-[[(2R,3R,4S,5R,6S)-3,4,5-tribenzoyloxy-6-methoxyoxan-2-yl]methoxymethyl]triazol-1-yl]butoxy]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822606; BDBM50351998
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|
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| Activity |
IC50 = 68900 nM
|
[9] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Leu-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL273780; BDBM50162444
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|
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| Activity |
EC50 = 70000 nM
|
[5] | |||
| Compound Name |
(3Z)-3-[2-(3-Carboxyphenyl)hydrazin-1-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Oxindole scaffold, 14b; CHEMBL497509; SCHEMBL4409453; BDBM24534; BDBM152161; US8987474, HL2-052-3; 3-[2-(3-carboxyphenyl)hydrazinyl]-2-oxoindole-5-carboxylic acid
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|
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| Activity |
IC50 = 72500 nM
|
[10] | |||
| Compound Name |
3-{2-[(3Z)-5-{[2-(2,4-Dichlorophenyl)ethyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Oxindole scaffold, 10p; CHEMBL500677; BDBM24551
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|
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| Activity |
IC50 = 73400 nM
|
[10] | |||
| Compound Name |
3-{2-[(3Z)-5-({[4-Chloro-3-(trifluoromethyl)phenyl]methyl}sulfamoyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Oxindole scaffold, 10r; CHEMBL498474; BDBM24553
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|
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| Activity |
IC50 = 74200 nM
|
[10] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-phenylbutanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371864
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| Activity |
EC50 = 75000 nM
|
[5] | |||
| Compound Name |
2-(3-Bromoanilino)-5-hydroxybenzothiazole-6-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3596431; BDBM50498446
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| Activity |
IC50 = 78000 nM
|
[12] | |||
| Compound Name |
5-[(E)-2-Phenylvinyl]-2-hydroxybiphenyl-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL450560; BDBM50246948
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| Activity |
IC50 = 78000 nM
|
[8] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Abu(betaPh)-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL412186; BDBM50162443
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|
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| Activity |
EC50 = 80000 nM
|
[5] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Ser(betaPh)-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL413492; BDBM50162448
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|
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| Activity |
EC50 = 85000 nM
|
[5] | |||
| Compound Name |
3-[(3-Acetyl-2-methyl-1-benzofuran-5-yl)sulfamoyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
GNF-Pf-1973; CHEMBL579363; SCHEMBL19057890; ZINC4817936; BDBM50348091; AKOS000594229; MCULE-9659738949; SR-01000492177; SR-01000492177-1
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| Activity |
IC50 = 85000 nM
|
[13] | |||
| Compound Name |
2-(3-(Dihydroxymethyl)naphthalen-2-ylamino)-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL573989; BDBM50299462
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| Activity |
Ki = 94000 nM
|
[2] | |||
| Compound Name |
6-Hydroxy-3-[2-[(8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethynyl]-2-phenyl-1-benzofuran-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316899; BDBM50425822
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-Hydroxy-3-(3-hydroxyprop-1-ynyl)-2-phenyl-benzofuran-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2316900; BDBM50425821
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-Chloro-1-[[5-[(E)-(5-chloro-2-oxo-1H-indol-3-ylidene)methyl]furan-2-yl]methyl]indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2208259; BDBM50402181
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(Carboxyformamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL138152; SCHEMBL5837972; ZINC2007908; BDBM50118762; STL171559; AKOS005367925; MCULE-3165318221; 2-oxalylamino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid; 2-(Oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid; N-(3-Carboxy-4,5,6,7-tetrahydrobenzo[b]thiophene-2-yl)oxamidic acid
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| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
1-[[5-[(E)-(5-Bromo-2-oxo-1H-indol-3-ylidene)methyl]furan-2-yl]methyl]indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2208249; BDBM50402182
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3Z)-3-[2-(2-Nitrophenyl)hydrazin-1-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
Oxindole scaffold, 10c; CHEMBL446483; SCHEMBL4413416; BDBM24538; BDBM152107; US8987474, RPM134; 3-[2-(2-nitrophenyl)hydrazinyl]-2-oxoindole-5-sulfonamide
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| Activity |
IC50 = 103700 nM
|
[10] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[6-(3-methylphenyl)pyridin-2-yl]-1,2,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759827; BDBM50142962
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-[6-(4-Ethoxyphenyl)pyridin-2-yl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759234; BDBM50142960
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[3-(4-propoxyphenyl)phenyl]-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759036; BDBM50142938
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|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
4-[3-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]phenyl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759694; BDBM50143014
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|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[5-(3-methylphenyl)thiophen-2-yl]-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759157; BDBM50142969
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[5-(4-propylphenyl)thiophen-2-yl]-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758655; BDBM50142975
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|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(2S)-3-[[1-[[(2R,3S,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795946; BDBM50347241
Click to Show/Hide
|
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| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[3-(4-propylphenyl)phenyl]-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760020; BDBM50143001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-(3-Bromophenyl)-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758567; BDBM50142957
Click to Show/Hide
|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[5-(4-propoxyphenyl)thiophen-2-yl]-1,2,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759712; BDBM50142985
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|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
4-[5-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]thiophen-2-yl]aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357362; BDBM50142941
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|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
4-[3-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]phenyl]aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357363; BDBM50142993
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|
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| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[[1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]triazol-4-yl]methoxy]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795952; BDBM50347245
Click to Show/Hide
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| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
(2S)-3-[[1-[[(2R,3R,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795944; BDBM50347239
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
3-(5-Bromothiophen-2-yl)-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758203; BDBM50142958
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[6-(2-methylphenyl)pyridin-2-yl]-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760029; BDBM50142963
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-3-[[1-[[(2R,3S,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795947; BDBM50347246
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
3-[5-(4-Ethylphenyl)thiophen-2-yl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758844; BDBM50142972
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-(6-Bromopyridin-2-yl)-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759431; BDBM50142947
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
Methyl 4-[4-[5-[5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]thiophen-2-yl]phenoxy]butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758785; BDBM50143010
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-[5-(4-Ethoxyphenyl)thiophen-2-yl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759414; BDBM50142979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
4-[6-[5-(1H-Indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758876; BDBM50142940
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-[3-(4-Ethoxyphenyl)phenyl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758728; BDBM50143004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
Methyl 4-[4-[3-[5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazol-3-yl]phenyl]phenoxy]butanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760059; BDBM50142939
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[3-(3-methylphenyl)phenyl]-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759304; BDBM50142999
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-[5-(4-Butylphenyl)thiophen-2-yl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758490; BDBM50142976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-[3-(4-Butylphenyl)phenyl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3760096; BDBM50143002
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-[[1-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]triazol-4-yl]methoxy]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795951; BDBM50347244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[3-(2-methylphenyl)phenyl]-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759130; BDBM50142995
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
3-[6-(4-Butylphenyl)pyridin-2-yl]-5-(1H-indol-3-ylmethyl)-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758715; BDBM50142961
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[6-(4-propoxyphenyl)pyridin-2-yl]-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759405; BDBM50142959
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(2S)-3-[[1-[[(2R,3R,4S,5S,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795948; BDBM50347247
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
5-(1H-Indol-3-ylmethyl)-3-[5-(2-methylphenyl)thiophen-2-yl]-1,2,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758446; BDBM50142967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[3] | |||
| Compound Name |
(2S,3S)-3-[[1-[[(2R,3R,4S,5R,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795945; BDBM50347240
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-3-[[1-[[(2R,3R,4S,5S,6S)-6-Methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]triazol-4-yl]methoxy]-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1795949; BDBM50347242
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[15] | |||
| Compound Name |
3-{2-[(3Z)-5-{[(3-Chloro-4-fluorophenyl)methyl]sulfamoyl}-2-oxo-2,3-dihydro-1H-indol-3-ylidene]hydrazin-1-yl}benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oxindole scaffold, 10o; CHEMBL502014; BDBM24550
Click to Show/Hide
|
||||
| Activity |
IC50 = 122800 nM
|
[10] | |||
| Compound Name |
5-[(E)-2-Phenylvinyl]-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL508948; Benzoic acid,2-hydroxy-5-[(1E)-2-phenylethenyl]-; SCHEMBL21385358; BDBM50246946; 2-hydroxy-5-[(E)-2-phenylethenyl]benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[8] | |||
| Compound Name |
5-Benzyl-2-hydroxybiphenyl-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390508; SCHEMBL1129730; BDBM50219482; 5-benzyl-2-hydroxy-3-phenylbenzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 129000 nM
|
[16] | |||
| Compound Name |
Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-hydroxypropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946248
Click to Show/Hide
|
||||
| Activity |
IC50 = 129000 nM
|
[17] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Phe-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386749; BDBM50162442
Click to Show/Hide
|
||||
| Activity |
EC50 = 140000 nM
|
[5] | |||
| Compound Name |
5-[(E)-2-Phenylvinyl]-3-bromo-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453899; BDBM50246947
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[8] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-4-phenylbutanoyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371863
Click to Show/Hide
|
||||
| Activity |
EC50 = 140000 nM
|
[5] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Phe-Val-Phe-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269042; BDBM50162449
Click to Show/Hide
|
||||
| Activity |
EC50 = 150000 nM
|
[5] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Met-Val-Leu-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371014; BDBM50162440
Click to Show/Hide
|
||||
| Activity |
EC50 = 160000 nM
|
[5] | |||
| Compound Name |
4-[Acetyl(6,7,8,9-tetrahydrodibenzofuran-2-yl)sulfamoyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800272; ZINC5047504; BDBM50348090; MCULE-6656366858; SR-01000285894; SR-01000285894-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[13] | |||
| Compound Name |
Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-(1H-imidazol-5-yl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946249
Click to Show/Hide
|
||||
| Activity |
IC50 = 167000 nM
|
[17] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylbutanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412918; BDBM50162447
Click to Show/Hide
|
||||
| Activity |
EC50 = 180000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 25 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(Oxalyl-Amino)-Benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(oxaloamino)benzoic acid; 2-(OXALYL-AMINO)-BENZOIC ACID; CHEMBL139050; CHEBI:44493; 2-[(carboxycarbonyl)amino]benzoic acid; OBA; 2-oxaloaminobenzoic acid; AC1L9GUO; SCHEMBL4315667; 2-(Carboxyformamido)Benzoic Acid; 1c85; ZINC2007905; BDBM50118789; AKOS022649621; DB02622; SC-57508; 5651-01-4; BENZOIC ACID,2[(CARBOXYCARBONYL)AMINO]-
Click to Show/Hide
|
||||
| Activity |
Ki = 510000 nM
|
[2] | |||
| Compound Name |
2-[[(2S)-2-[[2-[[2-[4-(2-Bromoacetyl)phenyl]benzoyl]amino]acetyl]amino]-4-carboxybutanoyl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102756; BDBM50119683
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[18] | |||
| Compound Name |
{3(S)-Methylcarbamoyl-2-[3-(3-sulfoamino-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinolin-7-YL}-sulfamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204337; SCHEMBL6393262; BDBM13461; ZINC14952759; Tetrahydroisoquinoline (TIQ) deriv. 10i; Q27466911
Click to Show/Hide
|
||||
| Activity |
IC50 = 203000 nM
|
[19] | |||
| Compound Name |
H-Glu-Gly-Leu-Asn-pTyr-Ser(betaPh)-Val-leu-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386769; BDBM50162445
Click to Show/Hide
|
||||
| Activity |
EC50 = 220000 nM
|
[5] | |||
| Compound Name |
4-[(E)-2-(3-Carboxy-4-hydroxyphenyl)vinyl]-2-hydroxybenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453874; BDBM50246949
Click to Show/Hide
|
||||
| Activity |
IC50 = 231000 nM
|
[8] | |||
| Compound Name |
7-(1,1-Dioxo-1H-benzo[D]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-C]pyran-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL577144; BDBM50299461; DB02827; Q27093781
Click to Show/Hide
|
||||
| Activity |
Ki = 289000 nM
|
[2] | |||
| Compound Name |
Polyestradiol phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Estradiol phosphate; Estradiol 17-phosphate; UNII-SKL7PDP588; SKL7PDP588; CHEMBL1642763; 17-beta-Estra 1,3,5(10)-triene-3,17-diol, 17-dihydrogen phosphate, homopolymer; DSSTox_CID_25086; DSSTox_RID_80661; DSSTox_GSID_45086; SCHEMBL1526469; DTXSID6045086; Tox21_110018; BDBM50333647; Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 17-(dihydrogen phosphate); NCGC00013235-01; NCI60_001525; Q27289257
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-C]pyran-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138806; SCHEMBL4312414; BDBM50118744; DB03102; Q27094059; 2-(carboxyformamido)-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid; N-(3-Carboxy-4,5-dihydro-7H-thieno[2,3-c]pyran-2-yl)oxamidic acid; 2-[(carboxycarbonyl)amino]-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 350000 nM
|
[2] | |||
| Compound Name |
3-(Carboxyformamido)thiophene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336879; SCHEMBL5838354; BDBM50118779; N-(2-Carboxy-3-thienyl)oxamidic acid; 3-(Oxalyl-amino)-thiophene-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 2000000 nM
|
[2] | |||
| Compound Name |
2-(Oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TCS-401; CHEMBL139393; 2-(oxaloamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid; SCHEMBL4293286; TCS 401 pound>>TCS401; BCP29628; ZINC1551920; BDBM50118792; DB03670; Q27094586; N-(3-Carboxy-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-yl)oxamidic acid; 2-(carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki > 2000000 nM
|
[2] | |||
| Compound Name |
2-[(S)-Diethoxyphosphoryl-(4-nitroanilino)methyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946245; BDBM50363854
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
[(S)-(4-Hydroxyanilino)-(2-hydroxyphenyl)methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946247; BDBM50363856
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Sodium;(2R)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-sulfanylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946251
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
2-[(S)-(4-Chloroanilino)-diethoxyphosphorylmethyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946243; BDBM50363852
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
2-[(S)-(4-Bromoanilino)-diethoxyphosphorylmethyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946244; BDBM50363853
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-(4-hydroxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946383
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Sodium;(2S,3R)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-hydroxybutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946389
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Sodium 2-((Ethoxy(Hydroxy)Phosphoryl)(2-Hydroxyphenyl)Methylamino)Acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946387
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Trimethylenebis[imino[(2-hydroxyphenyl)methylene]]bis(phosphonic acid)dihydrogen diethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946385; BDBM50363864
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
2-[(S)-(2-Chloroanilino)-diethoxyphosphorylmethyl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946246; BDBM50363855
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-(1H-indol-3-yl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946250
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Hexamethylenebis[imino[(2-hydroxyphenyl)methylene]]bis(phosphonic acid)dihydrogen diethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946384; BDBM50363863
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Ethylenebis[imino[(2-hydroxyphenyl)methylene]]bis(phosphonic acid)dihydrogen diethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946386; BDBM50363865
Click to Show/Hide
|
||||
| Activity |
IC50 > 10000000 nM
|
[17] | |||
| Compound Name |
Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946388
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| Activity |
IC50 > 10000000 nM
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[17] | |||
| Compound Name |
Sodium;(2S)-2-[[[ethoxy(hydroxy)phosphoryl]-(2-hydroxyphenyl)methyl]amino]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1946252
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| Activity |
IC50 > 10000000 nM
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[17] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 1 | Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. Bioorg Med Chem Lett. 2011 Jan 15;21(2):730-3. | ||||
| REF 2 | Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design. J Med Chem. 2009 Nov 12;52(21):6649-59. | ||||
| REF 3 | Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity. Bioorg Med Chem Lett. 2016 Feb 1;26(3):778-781. | ||||
| REF 4 | A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1092-6. | ||||
| REF 5 | Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1. J Med Chem. 2005 Mar 10;48(5):1528-39. | ||||
| REF 6 | Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold. J Med Chem. 2013 Feb 14;56(3):832-42. | ||||
| REF 7 | Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2827-32. | ||||
| REF 8 | Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity. Bioorg Med Chem. 2008 Sep 15;16(18):8643-52. | ||||
| REF 9 | Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold. Eur J Med Chem. 2011 Sep;46(9):4212-8. | ||||
| REF 10 | Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem. 2008 Aug 28;51(16):4948-56. | ||||
| REF 11 | Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. J Med Chem. 2001 Dec 20;44(26):4584-94. | ||||
| REF 12 | Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis. Medchemcomm. 2014 Oct;5(10):1496-1499. | ||||
| REF 13 | Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4238-42. | ||||
| REF 14 | Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7440-3. | ||||
| REF 15 | Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids. Bioorg Med Chem. 2011 Jul 1;19(13):3892-900. | ||||
| REF 16 | Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs. Bioorg Med Chem. 2007 Oct 15;15(20):6535-48. | ||||
| REF 17 | Exploration of alpha-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases. Eur J Med Chem. 2012 Mar;49:354-64. | ||||
| REF 18 | alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3047-50. | ||||
| REF 19 | 1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1574-8. | ||||
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