Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00140 | Target Info | |||
| Target Name | Arachidonate 5-lipoxygenase (5-LOX) | ||||
| Synonyms | LOG5; 5-lipoxygenase; 5-LO | ||||
| Target Type | Successful Target | ||||
| Gene Name | ALOX5 | ||||
| Biochemical Class | Oxygenase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Arachidonic acid | Ligand Info | |||||
| Structure Description | S663D Stable-5-LOX in complex with Arachidonic Acid | PDB:3V99 | ||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | Yes | [1] |
| PDB Sequence |
SYTVTVATGS
14 QEHAGTDDYI24 YLSLVGSAGC34 SEKHLLDKGS44 FERGAVDSYD54 VTVDEELGEI 64 QLVRIEKRKY74 GSNDDWYLKY84 ITLKTPHGDY94 IEFPCYRWIT104 GDVEVVLRDG 114 RAKLARDDQI124 HILKQHRRKE134 LETRQKQYRW144 MEWNPGFPLS154 IDAKCHKDLP 164 RDIQFDSFVL179 NYSKAMENLF189 QSSWNDFADF207 EKIFVKISNT217 ISERVMNHWQ 227 EDLMFGYQFL237 NGANPVLIRR247 CTELPEKLPV257 TTEMVECSLE267 RQLSLEQEVQ 277 QGNIFIVDFE287 LLDGIDCTLQ303 FLAAPICLLY313 KNLANKIVPI323 AIQLNQIPGD 333 ENPIFLPSDA343 KYDWLLAKIW353 VRSSDFHVHQ363 TITHLLRTHL373 VSEVFGIAMY 383 RQLPAVHPIF393 KLLVAHVRFT403 IAINTKAREQ413 GGHVQMVQRA439 MKDLTYASLC 449 FPEAIKARGM459 ESKEDIPYYF469 YRDDGLLVWE479 AIRTFTAEVV489 DIYYEGDQVV 499 EEDPELQDFV509 NDVYVYGMRG519 RKSSGFPKSV529 KSREQLSEYL539 TVVIFTASAQ 549 HAAVNFGQYD559 WASWIPNAPP569 TMRAPPPTAK579 GVVTIEQIVD589 TLPDRGRSCW 599 HLGAVWALSQ609 FELFLGMYPE622 EHFIEKPVKE632 AMARFRKNLE642 AIVSVIAERN 652 ENLQLPYYYL662 DPDRIPNSVA672
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. FASEB J. 2012 Aug;26(8):3222-9. | ||||
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